Selected
Publications
Castañeda TR, Abplanalp W, Um SH, Pfluger PT, Schrott B, Brown K, Grant E, Carnevalli L, Benoit SC, Morgan DA, Gilham D, Hui DY, Rahmouni K, Thomas G, Kozma SC, Clegg DJ, Tschöp MH. Metabolic control by s6 kinases depends on dietary lipids. PLoS One. 2012;7(3):e32631. Epub 2012 Mar 7. PMID: 22412899
Speakman JR, Levitsky DA, Allison DB, Bray MS, de Castro JM, Clegg DJ, Clapham JC, Dulloo AG, Gruer L, Haw S, Hebebrand J, Hetherington MM, Higgs S, Jebb SA, Loos RJ, Luckman S, Luke A, Mohammed-Ali V, O'Rahilly S, Pereira M, Perusse L, Robinson TN, Rolls B, Symonds ME, Westerterp-Plantenga MS. Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Dis Model Mech. 2011 Nov;4(6):733-45. Review. PMID:22065844
Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK, Clegg DJ. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab. 2011 Oct 5;14(4):453-65. PMID:21982706
Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent
KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR,
Pagliassotti MJ, Scherer PE, Summers SA. Lipid-induced
insulin resistance mediated by the proinflammatory
receptor TLR4 requires saturated fatty acid-induced
ceramide biosynthesis in mice. J Clin Invest.
2011 May;121(5):1858-70. doi: 10.1172/JCI43378. Epub
2011 Apr 1. PMID: 21490391
Meyer MR, Clegg DJ,
Prossnitz ER, Barton (2011) M. Obesity, insulin
resistance and diabetes: sex differences and role of
oestrogen receptors. Acta Physiol (Oxf). 2011 Feb 1. doi:
10.1111/j.1748-1716.2010.02237.x. [Epub ahead of
print] PMID: 21281456
Park CJ,
Zhao Z, Glidewell-Kenney C, Lazic M, Chambon P,
Krust A, Weiss J, Clegg
DJ, Dunaif A, Jameson JL, Levine JE. (2011)
Genetic rescue of nonclassical ERα signaling
normalizes energy balance in obese Erα-null mutant
mice. J Clin Invest. 2011 Feb 1;121(2):604-12. doi:
10.1172/JCI41702. Epub 2011 Jan 18. PMID: 21245576
Clegg DJ,
Gotoh K, Kemp C, Wortman MD, Benoit SC, Brown LM,
D'Alessio D, Tso P, Seeley RJ, Woods SC. (2011)
Consumption of a high-fat diet induces central insulin
resistance independent of adiposity. Physiol Behav.
2011 Jan 15. [Epub ahead of print] PMID: 21241723
Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ. (2010) Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging. 2010 Dec 2. [Epub ahead of print] PMID: 21130529
Zheng Q, Zhu J, Shanabrough M, Borok E, Benoit SC, Horvath TL, Clegg DJ, Reizes O (2010) Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice Neuroscience Oct 2 [Epub] PMID: 20923696
Irani BG, Donato J Jr, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CF, Clegg DJ (2010) Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus Neuroscience Nov 10;170(4):1065-79 PMID: 20691763
Brown LM, Gent L, Davis K, Clegg DJ (2010) Metabolic impact of sex hormones on obesity. Brain Research Sep 2 (1350) 77-85 PMID: 20441773
Grove KL, Fried SK, Greenberg AS, Xiao XQ and Clegg DJ (2010) A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice International Journal of Obesity: Jun;34(6):989-1000 PMID: 20157318
Shi H, Sorrell JE, Clegg DJ, Woods SC, Seeley RJ (2010) The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis Physiol Behav. May 11;100(2):165-72 PMID: 20193700
Davidson TL, Kanoski SE, Chan K, Clegg DJ, Benoit SC, Jarrard LE (2010) Hippocampal lesions impair retention of discriminative responding based on energy state cues Behav Neurosci Feb;124(1):97-105 PMID: 20141284
Brown LM, Clegg DJ (2009) Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Mol Biol. Dec 24 PMID: 20035866
Jessen L, Clegg DJ, Bouman SD (2009) Evaluation of the lack of anorectic effect of intracerebroventricular insulin in rats Am J Physiol Regul Integr Comp Physiol Jan;298(1):R43-50 PMID: 19864335
Nedungadi TP, Clegg DJ (2009) Sexual Dimorphism in Body Fat Distribution and Risk for Cardiovascular Diseases. Journal of Cardiovascular Translational Research: Sep;2(3):321-7 PMID: 20560019
Kemp CJ, Benoit SC, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre A, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ (2009) Palmitic Acid mediates hypothalamic insulin resistance via Protein kinase-C (PKC) theta. Journal of Clinical Investigation: Sep:119(9):2577-89; PMID: 19726875; PMCID: PMC2735917
Wang HH, Liu M, Clegg DJ, Portincasa P, Wang DQ. (2009) New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formation. Biochem Biophys Acta. Epub: Nov:1791(11):1037-47; PMID: 19589396; PMCID: PMC2756670
Liu S, Le May C, Wong WP, Ward RD, Clegg DJ, Marcelli M, Korach KS, Mauvais-Jarvis F. (2009) Importance of extranuclear estrogen receptor-{alpha} and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes: Oct;58(10):2292-302 PMID: 19587358
Medvedovic M, Gear R, Freudenberg JM, Schneider J, Bornschein R, Yan M, Mistry MJ, Hendrix H, Karyala S, Halbleib D, Heffelfinger S, Clegg DJ, Anderson MW (2009) Influence of Fatty Acid Diets on Gene Expression in Rat Mammary Epithelial Cells. Physiol Genomics Jun 10;38(1):80-8 PMID: 19351911
Shi H, Seeley RJ, Clegg DJ (2009) Sexual differences in the control of energy homeostasis. Front Neuroendocrinology: Aug;30(3):396-404; PMID: 19341761
Shi H, Clegg DJ (2009) Sex differences in the regulation of body weight. Physiol Behav. May 25;97(2):199-204: PMID: 19250944; doi: 10.1016/j.physbeh.2009.02.017
Haas E, Bhattacharya I, Brailoiu E, Damjanovic M, Brailoiu GC, Gao X, Mueller-Guerre L, Marjon NA, Gut A, Minotti R, Meyer MR, Amann K, Ammann E, Perez-Dominguez A, Genoni M, Clegg DJ, Dun NJ, Resta TC, Prossnitz ER, Barton M. (2009) Regulatory Role of G Protein-Coupled Estrogen Receptor for Vascular Function and Obesity. Circ Res. Feb 13;104(3):288-91: PMID: 19179659; PMCID: PMC2782532
Posey K, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, Pennathur S, Baskin DG, Heinecke JW, Woods SC, Schwartz MW, Niswender KD (2008). Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab. May;296(5):E1003-12: PMID: 19116375: PMCID: PMC2681305
Davis JF, Tracy AL, Schurdak JD, Tschöp MH, Lipton JW, Clegg DJ, Benoit SC (2008). Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat. Behav Neurosci. Dec;122(6):1257-63: PMID: 19045945; PMCID: PMC2597276
Benoit SC, Tracy AL, Davis JF, Choi D, Clegg DJ (2008). Novel functions of orexigenic hypothalamic peptides: from genes to behavior. Nutrition. Sep;24(9):843-7: PMID: 18725081; PMCID: PMC2556279
Shen L, Tso P, Woods SC, Clegg DJ, Barber KL, Carey K, Liu M (2008). Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes. Aug;57(8):2092-8: PMID: 18559657; PMCID: PMC2494691
Davidson TL, Chan K, Jarrard LE, Kanoski SE, Clegg DJ, Benoit SC (2008). Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation. Hippocampus. Mar;19(3):235-52: PMID: 18831000; PMCID: PMC2649976
Kendig EL, Schneider SN, Clegg DJ, Genter MB, Shertzer HG (2008). Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochem Pharmacol. Jul 15;76(2):216-24: PMID: 18554574; doi: 10.1016/j.bcp.2009.05.001
Shertzer HG, Schnieder SN, Kendig EL, Clegg DJ, D’Alessio DA, Genter MB (2008). Acetaminophen normalizes glucose homestasis in mouse models for diabetes. Biochem Pharmacol. Mar 15;75(6):1402-10: PMID: 18237716; doi: 10.1016/j.bcp.2007.12.003
Kemp CJ, Barerra JG, D’Alessio DA, Scott RO, Kelm GR, Meller ST, Clegg DJ, Benoit SC (2008). Voluntary consumption of ethyl oleate reduces food intake and body weight in rats. Physiol Behav. 93:912-8: PMID: 18234242; PMCID: PMC2372161
Tracy AL, Davis J, Clegg DJ, Heiman J, Johnson J, Davidson TL, Benoit SC (2008). Agouti-related peptide (AgRP, 83-132) selectively promotes learned responses for dietary fats. Pharmacol Biochem Behav. 89:263-271