Frederick Grinnell, Ph.D.

Robert McLemore Professor of Medical Science

Department of Cell Biology

Ethics in Science and Medicine Program

TEL: 214-633-1969

email: frederick.grinnell@utsouthwestern.edu

 

 

Education:

1966 AB, Chemistry, Clark University, Worcester, MA
1970 Ph.D., Biochem, Tufts Univ Sch Med, Boston, MA (with Jon Nishimura)
1970-1972 Research Fellow, Biochem Res Sect, VA Hosp, Dallas, TX (with Paul Srere)


Professional Experience:

1972-1977 Assistant Professor of Cell Biology, UT Southwestern
1977-1981 Associate Professor of Cell Biology, UT Southwestern
1981 Visiting Fellow, Departments of Biology (with J.P. Trinkaus) and Philosophy (with Maurice Natanson), Yale Univ, New Haven, CT
since 1981 Professor of Cell Biology, UT Southwestern
1998-2004 Founding Director, Ethics in Science and Medicine Program, UT Southwestern
2011 Interim Chair, Department of Cell Biology, UT Southwestern
since 2013 Robert McLemore Professor of Medical Science, UT Southwestern


Honors:

1982-1984 President, UT Southwestern Sigma Xi Society
1984 Meyerhoff Visiting Professor, Weizmann Institute, Rehovot, Israel
1988 Forchheimer Visiting Professor, Hebrew University, Jerusalem, Israel
1990 Visiting Scholar, The Hastings Center, Briarcliff Manor, NY
1995-1997 School Board President, Solomon Schechter Academy of Dallas
1999 Chair, Gordon Research Conference on Wound Repair
1999-2008 MERIT Award, NIGMS, NIH
2006 Co-Chair, Gordon Research Conference on Science and Technology Policy
2006-2007 President, UT Southwestern Faculty Senate
2010 Everyday Practice of Science shortlisted for the (U.K.) Royal Society 2010 Science Book Prize

2012 UT System Regents' Outstanding Teaching Award
2012 Elected AAAS Fellow, Section on History and Philosophy of Science
2013 Appointed Robert McLemore Professor of Medical Science, UT Southwestern


National Advisory Committees:

1990-1994 NIH Cell Biol and Physiology (II) Study Section
1992-1997 ASCB Public Policy Committee
1992 NIH Strategic Plan Task Force (Code of Ethics Panel)
1993-2009 ASBMB Public Policy Committee (1997, drafted the society’s Code of Ethics)
1994-1997 Board of Directors, Wound Healing Society
1995-1996 AAAS, Scientific Integrity Video Project
1996-1997 AAAS, Dialog Between Science and Religion Project
1998-2004 FASEB, Science Policy Committee, (1999-2001; Chair: Human Subjects and Bioethics Subcommittee)
2001-2002 Institute of Medicine, Committee on Assessing Integrity in Research Environments
2000-2004 NIH, Peer Review Oversight Group (Advisory committee to the deputy director for extramural research)
2011-2013 Healthpoint/Smith&Nephew, Cellular Therapy Scientific Advisory Board
since 2011 Shriners Hospitals for Children Research Advisory Board
since 2013 AAAS, National Conference of Lawyers and Scientists
since 2015 AAAS, Council Delegate (Representing Section L -- History and Philosophy of Science)


Local Advisory Committees:

1988-1999 UT Southwestern Institutional Review Board for Human Research
since 1994 UT Southwestern Institutional Review Committee for Conflict of Interest (Vice-chair, 2013-)
since 2002 Faculty Advisory Committee, Cary M. Maguire Center for Ethics and Public Responsibility, Southern Methodist University
since 2004 Convener, North Texas Bioethics Network


Editorial Boards: Experimental Cell Research


Memberships: American Association for the Advancement of Science; American Society of Bioethics and Humanities; American Society for Cell Biology; Philosophy of Science Association; Society for Social Studies of Science; Wound Healing Society


Patents:

1. Grinnell, F. (September 18, 1990) US Patent# 4,957,902, Peptide inhibitors of wound contraction.
2. Grinnell, F. (December 14, 1993), US Patent# 5,270,168, Method for diagnosing non-healing ulcers.
3. Grinnell, F. and Lin, Y-C. (April 21, 1998) US Patent# 5,741,777, Modulation of wound contraction by blocking protein tyrosine phosphatase


Bibliography

Books:

1. The Scientific Attitude, (1987) 1st Edition, Westview Press, Boulder, Co.; (1992) 2nd Edition, Guilford Press, New York, NY.

2. Grinnell, F. (2009) Everyday Practice of Science: Where Intuition and Passion Meet Objectivity and Logic, Oxford University Press, New York, N.Y. Everyday Practice of Science shortlisted for the Royal Society 2010 Science Book Prize


Philosophy-Related Publications:

1. Grinnell, F. (1983) Studies on intersubjectivity: A comparison of Martin Buber and Alfred Schutz. Human Studies 6: 185-195.

2. Grinnell, F. (1984) Approaching religion positively: An existential Jewish perspective. Religion and Intellectual Life 1: 88-98.

3. Grinnell, F. (1986) Complementarity: An approach to understanding the relationship between science and religion. Perspectives in Biology and Medicine 29: 292-301.

4. Grinnell, F. (1987) Harry Redner's "Pathologies of science." Social Epistemol. 1: 269-271. (Comment)

5. Grinnell, F. (1990) The endings of clinical research protocols: Understanding the difference between therapy and research. IRB. 12: 1-4

6. Grinnell, F. (1993) Industrial sponsors and the scientist. J. NIH Research. 5: 50-51.

7. Grinnell, F. (1994) Radical intersubjectivity: Why naturalism is an assumption necessary for doing science. In Darwinism: Science or Philosophy? ed. J. Buelland V. Hearn, Foundation for Thought and Ethics, Richardson, pp 99-106

8. Grinnell, F. (1994) Response to Peter van Inwagen: The problem of knowledge. In Darwinism: Science or Philosophy? ed. J. Buell and V. Hearn, Foundation for Thought and Ethics, Richardson, pp 192-194 (Comment)

9. Grinnell, F. (1995) COSEPUP on responsible science. Biology and Philosophy, 10: 229-233. (Book Review)

10. Grinnell, F. (1996) Publishing science responsibly. Biology and Philosophy, 11: 121-125. (Book Review)

11. Grinnell, F. (1996) Ambiguity in the practice of science. Science, 272: 333. (Editorial)

12. Grinnell, F. (1996) UT Southwestern and the Impact of the Nobels. Nobel
Foundation Virtual Museum: http://www.as.nobel.se/essays/impact/index.html

13. Grinnell, F. (1997) Truth, fairness, and the definition of scientific misconduct, J. Lab. Clin. Med. 129: 189-192.

14. Grinnell, F. (1999) Ambiguity, trust, and the responsible conduct of science. Science and Engineering Ethics. 5: 205-214.

15. Grinnell, F. (1999) Responsibility, conflict, and ambiguity in the management of biomedical research laboratories. In: “Management of Biomedical Research Laboratories,” ed. T.P. Davis, University of Arizona Board of Regents, Tuscon, Arizona. pp 29-38.

16. Grinnell, F. (1999) Are scientific papers examples of rhetoric? Science and Engineering Ethics. 5: 487-488. (Comment)

17. Grinnell, F. (2000) Philosophy of biology and the human genome project. Biology and Philosophy. 15: 595-601. (Book Review)

18. Grinnell, F. (2000) The practice of science at the edge of knowledge. Chronicle of Higher Education. 46(29): B11-12.

19. Grinnell, F., Bishop, J.P., and McCullough, L.B. (2002) Bioethical pluralism and complementarity. Perspectives in Biology and Medicine. 45: 338-349.

20. Grinnell, F. (2002) The impact of ethics on research. Chronicle of Higher Education. 49(6): B15.

21. Grinnell, F. (2002) Doing science. Knowledge, Technology & Policy, 15: 204-210.

22. Grinnell, F. (2003) Defining embyro death would permit important research. Chronicle of Higher Education. 49(36): B13.

23. Grinnell, F. (2004) Human embryo research: From moral uncertainty to death. American Journal of Bioethics. 4: 12-13. (Comment)

24. Grinnell, F. (2004) Subject vulnerability: The precautionary principle of human research. American Journal of Bioethics. 4: 72-74 (Comment)

25. Grinnell, F. (2005) Misconduct: acceptable practices differ by field. Nature. 436: 776. (Letter)

26. Grinnell, F. (2006) Intelligent design: fallacy recapitulates ontogeny. FASEB J. 20: 410-1.

27. Grinnell, F. (2009) Intelligent design or intelligible design: It’s a matter of faith. Chronicle of Higher Education. 55(18): B5

28. Grinnell, F. (2009) Discovery in the lab: Plato’s paradox and Delbrück’s principle of limited sloppiness. FASEB J. 23: 7-9.

29. Grinnell, F. (2011) Evolution of credibility. TheScientist 25: 76.

30. Grinnell, F. (2011) The Age of Wonder (Book Review). J. Interdisciplinary Studies. 23:201-202.

31. Grinnell, F. (2013) Research integrity and responsible conduct of science. Science and Engineering Ethics. 9: 685-701.

32. Grinnell, F. (2013) It is time to update US biomedical funding. Nature. 501:137. (WorldView)

33. Grinnell, F. (2014) Objectivity in Vocabulary for the Study of Religion. Ed. Robert Segal and Kocku von Stuckrad. Leiden: Brill.

34. Fischer, B. A., Grinnell, F., and Zigmond, M. J. (2014) Introductory comments for the scientific ethics theme. J. Microbiol. & Biol. Educat. 15:2 (Editors for special journal issue bringing together >25 essays on the topic.)

35. Grinnell, F. (2014) The interrelationship between research integrity, conflict of interest, and the research environment. J. Microbiol. & Biol. Educat. 15:162-164.

Experimental Science (Refereed Papers):

1. Grinnell, F. L. and Nishimura, J. S. (1969) Succinic thiokinase of Escherichia coli. Purification of the enzyme and exchange reactions catalyzed by the enzyme. Biochemistry 8: 562-567.

2. Grinnell, F. L. and Nishimura, J. S. (1969) The mechanism of the succinic thiokinase reaction. Effector role of desulfo-CoA in succinyl phosphate formation. Biochemistry 8: 568-574.

3. Grinnell, F. L. and Nishimura, J. S. (1969) Studies on the catalytic mechanism of Escherichia coli succinic thiokinase. Biochemistry 8: 4126-4130.

4. Grinnell, F. L., Stollar, B. D., and Nishimura, J. S. (1969) Reversible disaggregation of Escherichia coli succinyl-CoA synthetase. Biochim. Biophys. Acta 185: 471-474.

5. Grinnell, F. and Nishimura, J. S. (1970) The inactivation and dissociation of Escherichia coli succinyl-CoA synthetase by sulfhydryl reagents. Biochim. Biophys. Acta 212: 150-157.

6. Grinnell, F. and Srere, P. A. (1971) Inhibition of cellular adhesiveness by sulfhydryl blocking reagents. J. Cell. Physiol. 78: 153-158.

7. Grinnell, F. and Lee, J. C. (1972) Alterations in hemoglobin synthesis during chick embryogenesis. J. Cell. Physiol. 79: 111-116.

8. Grinnell, F., Milam, M., and Srere, P. A. (1972) Studies on cell adhesion. II. Adhesion of cells to surfaces of diverse chemical composition and inhibition of adhesion of sulfhydryl binding reagents. Arch. Biochem. Biophys. 153: 193-198.

9. Nishimura, J. S., Mitchell, J. P., and Grinnell, F. (1973) Immunological studies of Escherichia coli succinic thiokinase. Effects of sulfhydryl reagents and other treatments of the enzyme. J. Biol. Chem. 248: 743-748.

10. Grinnell, F., Milam, M., and Srere, P. A. (1973) Attachment of normal and transformed hamster kidney cells to substrata varying in chemical composition. Biochem. Med. 7: 87-90.

ll. Grinnell, F., Milam, M., and Srere, P. A. (1973) Cyclic AMP does not affect cell stickyness. Nature New Biol. 241: 82-83.

12. Grinnell, F., Milam, M., and Srere, P. A. (1973) Studies on cell adhesion. III. Adhesion of Baby hamster kidney cells. J. Cell Biol. 56: 659-665.

13. Milam, M., Grinnell, F., and Srere, P. A. (1973) The effect of centrifugation on cell adhesion. Nature New Biol. 244: 83-84.

14. Grinnell, F. (1973) Concanavalin A increases the strength of cell attachment to a substratum. J. Cell Biol. 58: 602-607.

15. Grinnell, F. (1974) Studies on the mechanism of cell attachment to a substratum: Evidence for three biochemically distant processes. Arch. Biochem. Biophys. 160: 304-310.

16. Grinnell, F. (1974) Studies on the mechanism of cell attachment to a substratum with serum in the medium: Further evidence supporting a requirement for two biochemically distinct processes. Arch. Biochem. Biophys. 165: 524-530.

17. Grinnell, F. (1975) Cell Adhesion and cell surface proteases. Arch. Biochem. Biophys. 169: 474-482.

18. Grinnell, F., Tobleman, M. Q., and Hackenbrock, C. R. (1975) The Distribution and mobility of anionic sites on the surfaces of baby hamster kidney cells. J. Cell Biol. 66: 470-479.

19. Grinnell, F. (1976) The serum dependence of baby hamster kidney cell attachment to a substratum. Exp. Cell Res. 97: 265-274.

20. Grinnell, F., Anderson, R. G. W., and Hackenbrock, C. R. (1976) Glutaraldehyde induced alterations of membrane anionic sites. Biochim. Biophys. Acta. 426: 772-775.

21. Grinnell, F. (1976) Cell spreading factor: Occurrence and specificity of action. Exp. Cell Res. 102: 51-62.

22. Grinnell, F., Tobleman, M. Q., and Hackenbrock, C. R. (1976) Initial attachment of baby hamster kidney cells to a non-living substratum: Ultrastructural analysis. J. Cell Biol. 70: 707-713.

23. Grinnell, F., Hays, D. G., and Minter, D. (1977) Cell adhesion and spreading factor: Partial purification and properties. Exp. Cell Res. 110: 175-190.

24. Grinnell, F. and Hays, D. G. (1978) Cell adhesion and spreading factor: Similarity to cold insoluble globulin in human serum. Exp. Cell Res. 115: 221-229.

25. Grinnell, F. and Hays, D. G. (1978) Induction of active cell spreading by substratum adsorbed ligands directed against the cell surface. Exp. Cell Res. 116: 275-284.

26. Grinnell, F. and Minter, D. (1978) Attachment and spreading of baby hamster kidney cells to collagen substrata. Proc. Natl. Acad. Sci. USA 75: 4408-4412.

27. Grinnell, F. and Minter, D. (1979) Cell adhesion and spreading factor: The effect of chemical modifications on factor activity. Biochem. Biophys. Acta. 550: 92-99.

28. Grinnell, F. and Feld, M. (1979) Initial adhesion of human fibroblasts in serum-free medium: Possible role of secreted fibronectin. Cell 17: 117-129.

29. Grinnell, F., Feld, M., and Snell, W. (1979) The influence of cold in-soluble globulin on platelet morphological response to substrata. Cell Biol. Internat. Reports 3: 585-592.

30. Grinnell, F. and Hays, D. (1979) Measurement of anionic sites on the surfaces of baby hamster kidney cells using radiolabeled polycationic ferritin. Anal. Biochem. 97: 400-402.

31. Hewitt, K., Beer, A. E., and Grinnell, F. (1979) Disappearance of anionic sites from the surface of the rat endometrial endothelium at the time of blastocyst implantation. Biol. Reprod. 21: 691-707.

32. Grinnell, F., Feld, M., and Minter, D. (1980) Cell adhesion to fibrinogen and fibrin substrata: Requirement for cold insoluble globulin. Cell 19: 517-525.

33. Grinnell, F. (1980) The fibroblast receptor for cell-substratum adhesion: Studies on the interaction of baby hamster kidney cells with latex beads coated by cold insoluble globulin (plasma fibronectin). J. Cell Biol. 86:104-112.

34. Grinnell, F. and Feld, M. (1980) Spreading of human fibroblasts in serum free medium: Inhibition by dithiothreitol and the effect of cold insoluble globulin (plasma fibronectin). J. Cell. Physiol. 104: 321-334.

35. Grinnell, F. (1980) Visualization of cell-substratum adhesion plaques by antibody exclusion. Cell Biol. Internat. Reports. 4: 1031-1036.

36. Grinnell, F., Billingham, R. E., and Burgess, L. (1981) Distribution of fibronectin during wound healing in vivo. J. Invest. Dermatol. 76: 181-189.

37. Grinnell, F. and Bennett, M. H. (1981) Fibroblast adhesion on collagen substrata in the presence and absence of plasma fibronectin. J. Cell Science. 48: 19-34.

38. Oppenheimer-Marks, N. and Grinnell, F. (1981) Effect of plant lectins on the adhesive properties of baby hamster kidney cells. European J. Cell Biol. 23: 286-294.

39. Grinnell, F. and Feld, M. (1981) Adsorption properties of fibronectin in relationship to biological activity. J. Biomed. Materials Res. 15: 363-381.

40. Grinnell, F. and Feld, M., (1981) Distribution of fibronectin on peripheral blood cells in freshly clotted blood. Thromb. Res. 24: 397-404.

41. Grinnell, F. and Feld, M. (1982) Fibronectin adsorption on hydrophilic and hydrophobic surfaces detected by antibody binding and analyzed during cell adhesion in serum-containing medium. J. Biol. Chem. 257: 4888-4893.

42. Grinnell, F., Head, J. R., and Hoffpauir, J. (1982) Fibronectin and cell shape in vivo: Studies on the endometrium during pregnancy. J. Cell Biol. 94: 597-606.

43. Grinnell, F. (1982) Migration of human neutrophils in hydrated collagen lattices. J. Cell Science. 58: 95-108.

44. McAbee, D. D. and Grinnell, F. (1982) Sulfhydryl sensitive sites in cell adhesion: Decreased entry of -SH binding reagents into attached BHK cells. Biochem. J. 208: 473-478.

45. Oppenheimer-Marks, N. and Grinnell, F. (1982) Inhibition of fibronectin receptor function by antibodies against BHK cell wheat germ agglutinin receptors. J. Cell Biol. 95: 876-884.

46. Grinnell, F., Lang, B. R., and Phan, T. V. (1982) Detection of fibronectin receptors on the surfaces of BHK cells in suspension. Exp. Cell Res. 142: 499-504.

47. Grinnell, F. and Marshall, J. (1982) Coating bacteriological dishes with fibronectin permits spreading and growth of human diploid fibroblasts. Cell Biol. Int. Reports 6: 1013-1018.

48. Grinnell, F. and Phan, T. V. (1983) Deposition of Fibronectin onto artificial material surfaces from human plasma and blood under clotting and non-clotting conditions. J. Cell. Physiol. 116: 289-296.

49. McAbee, D. D. and Grinnell, F. (1983) Fibronectin-mediated binding and phagocytosis of polystyrene latex beads by baby hamster kidney cells. J. Cell Biol. 97: 1515-1523.

50. Grinnell, F. (1984) Manganese-dependent cell-substratum adhesion. J. Cell Sci. 65: 61-72.

51. Grinnell, F. and Lamke, Cheryl R. (1984) Reorganization of hydrated collagen lattices by human skin fibroblasts. J. Cell Science. 66: 51-63.

52. Grinnell, F. (1984) Fibroblast spreading and phagocytosis: Similar cell responses to different sized substrata. J. Cell Physiol. 119: 58-64.

53. Oppenheimer-Marks, N., Border, B., and Grinnell, F. (1984) BHK cell variants with defective fibronectin receptor function. Cell Biol. Int. Reports 8: 171-178.

54. Oppenheimer-Marks, N. and Grinnell, F. (1984) Calcium ions protect cell substratum adhesion receptors against proteolysis: Evidence from immunoabsorption and electoblotting studies. Exp. Cell Res. 152: 467-475.

55. Takashima, A. and Grinnell, F. (1984) Human keratinocyte adhesion and phagocytosis promoted by fibronectin. J. Invest. Dermatol. 83: 352-358.

56. Takashima, A. and Grinnell, F. (1985) Fibronectin-mediated keratinocyte migration and onset of fibronectin receptor function in vitro. J. Invest. Dermatol. 85: 304-308.

57. McAbee, D. D. and Grinnell, F. (1985) Binding and phagocytosis of fibronectin-coated beads by BHK cells: Receptor specificity and dynamics. J. Cell Phys., 124: 240-246.

58. Grinnell, F. and Phan, T. V. (1985) Platelet attachment and spreading on polystyrene surfaces: Dependence of fibronectin and plasma concentration. Thrombosis Research 39: 165-171.

59. Guidry, C. and Grinnell, F. (1985) Studies on the mechanism of hydrated collagen gel reorganization by human skin fibroblasts. J. Cell Sci. 79: 67-81.

60. Shiba, Y. and Grinnell, F. (1985) Characteristics of a BHK cell variant defective in the cell-substratum contact process. J. Cell. Phys. 125: 449-455.

61. Grinnell, F. and Geiger, B. (1986) Interaction of fibronectin-coated beads with attached and spread fibroblasts. Binding, phagocytosis, and cytoskeletal reorganization. Exp. Cell Res. 162: 449-461.

62. Takashima, A., Billingham, R. E., and Grinnell, F. (1986) Activation of rabbit keratinocyte fibronectin receptor function in vivo during wound healing. J. Invest. Dermatol. 86: 585-590.

63. Grinnell, F., Takashima, A., and Lamke-Seymour, C. (1986) Morphological appearance of epidermal cells cultured on fibroblast reorganized collagen gels. Cell and Tissue Research 246: 13-21.

64. Grinnell, F. (1986) Focal adhesion sites and the removal of substratum-bound fibronectin. J. Cell Biol. 103: 2697-2706.

65. Guidry, C. and Grinnell, F. (1986) Contraction of hydrated collagen gels by fibroblasts: Evidence for two mechanisms by which collagen fibrils are stabilized. Collagen and Related Research. 6: 515-529.

66. Toda, K.-I. and Grinnell, F. (1987) Activation of human keratinocyte adhesion during cell culture. J. Invest. Dermatol. 88: 412-417.

67. Grinnell, F., Toda, K.-I. and Lamke-Seymour, C. (1987) Reconstitution of human epidermis in vitro is accompanied by transient activation of basal keratinocyte spreading. Exp. Cell Res. 172: 439-449.

68. Guidry, C. and Grinnell, F. (1987) Heparin modulates the supramolecular organization of hydrated collagen gels and inhibits gel contraction by fibroblasts. J. Cell Biol. 104: 1097-1103.

69. Toda, K-I., Tuan, T-L., Brown, P.J., and Grinnell, F. (1987) Fibronectin receptors of human keratinocytes and their expression during cell culture. J. Cell Biol. 105: 3097-3104

70. Wysocki, A., Baxter, C.R., Bergstresser, P.R., Grinnell, F., Horowitz, M.S., and Horowitz, B. (1988) Topical fibronectin therapy for treatment of a patient with chronic stasis ulcers. Arch. Dermatol. 124: 175-177.

71. Tuan, T.-L. and Grinnell, F. (1998) Wheat germ and Ricinus communis agglutinin binding sites of BHK cells compared to each other and to 140 kDa fibronectin receptors. Biochem. J. 251: 269-277

72. Grinnell, F., Ho, C-H., and Tuan, T-L. (1988) Cell adhesion and phagocytosis promoted by monoclonal antibodies not directed against fibronectin receptors. J. Cell Sci. 90: 201-214.

73. Grinnell, F., Fukazmizu, H., Pawelek, P., and Nakagawa, S. (1989) Collagen production, crosslinking, and fibril bundle assembly in matrix produced by fibroblasts in long term cultures supplemented with ascorbic acid. Exp. Cell Res. 181: 483-491.

74. Shiba, Y., Sasaki, Y., Kanno, Y., and Grinnell, F. (1989) Enhanced binding of fibronectin-coated latex beads to quiescent 3T3-L1 cells correlated with escape from growth arrest. Exp. Cell Res. 182: 144-151.

75. Nakagawa, S., Pawalek, P., and Grinnell, F. (1989) Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness. Exp. Cell Res. 182: 572-582.

76. Grinnell, F., Nakagawa, S., and Ho, C-H. (1989) The collagen recognition sequence for fibroblasts depends on collagen topography. Exp. Cell Res. 182: 668-672.

77. Guo, M. and Grinnell, F. (1989) Basement membrane and human epidermal differentiation in vitro. J. Invest. Dermatol. 93: 372-378.

78. Tuan, T-L. and Grinnell, F. (1989) Fibronectin and fibrinolysis are not required for fibrin gel contraction by human skin fibroblasts. J. Cellular Phys. 140: 577-583.

79. Nakagawa, F., Pawalek, P., and Grinnell, F. (1989) Long term culture of fibroblasts in contracted collagen gels: Effects on cell growth and biosynthetic activity. J. Invest. Dermatol. 93: 792-798

80. Guo, M. and Grinnell, F. (1990) Activation of human keratinocyte migration on type I collagen and fibronectin. J. Cell Sci. 96: 197-205.

81. Fukamizu, H. and Grinnell, F. (1990) Spatial organization of extracellular matrix and fibroblast activity: Effects of serum, transforming growth factor-beta, and fibronectin. Exp. Cell Res. 190: 276-282.

82. Wysocki, A.B. and Grinnell, F. (1990) Fibronectin profiles in normal and chronic wound fluid. Lab. Investigation. 63:825-831.

83. Mochitate, K., Pawelek, P., and Grinnell, F. (1991) Stress-relaxation of contracted collagen gels: Disruption of the actin cytoskeleton, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis. Exp. Cell Res. 193: 198-207.

84. Grinnell, F. and Backman, R. (1991) Role of integrin receptors in manganese-dependent BHK cell spreading on albumin-coated substrata. Exp Cell Res. 195: 218-223.

85. Guo, M., Kim, L.T., Akiyama, S.K., Gralnick, H.R., Yamada, K.M., and Grinnell, F. (1991) Altered processing of integrin receptors during keratinocyte activation. Exp. Cell Res. 195: 315-322.

86. Grinnell, F., Ho, C-H., and Wysocki, A. (1992) Degradation of fibronectin and vitronectin in wound fluid: Analysis by cell blotting, immunoblotting, and cell adhesion assays. J. Invest. Dermatol. 98: 410-416

87. Kim, L.T., Ishihara, S., Lee, C-C., Akiyama, S.K., Yamada, K.M. and Grinnell, F. (1992) Altered glycosylation and cell surface expression of ? 1 integrin receptors during keratinocyte activation. J. Cell Sci. 103: 743-754

88. Altankov, G. and Grinnell, F. (1993) Depletion of intracellular potassium disrupts coated pits and reversibly inhibits cell polarization during fibroblast spreading. J. Cell Biol. 120: 1449-1459

89. Wysocki, A.B., Staiano-Coico, L., and Grinnell, F. (1993) Wound fluid from chronic ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J. Invest. Dermatol. 101: 64-68

90. Lee, T-L., Lin, Y-C., Mochitate, K., and Grinnell, F. (1993) Stress-relaxation of fibroblasts in collagen matrices triggers ectocytosis of plasma membrane vesicles containing actin, annexins II and VI, and b1 integrin receptors. J. Cell Sci. 105: 167-177

91. Lin, Y-C. and Grinnell, F. (1993) Fibroblasts in mechanically-relaxed collagen matrices show decreased levels of PDGF-stimulated receptor autophosphorylation. J. Cell Biol. 122: 663-672.

92. Grinnell, F., Yin, H.L., Baxter, C.R., and Zhu, M. (1993) The extracellular actin-scavenging system in wound fluid. Wound Repair and Regeneration. 1: 236-243.

93. Grinnell, F. and Zhu, M. (1994) Identification of neutrophil elastase as the proteinase in burn wound fluid responsible for degradation of fibronectin. J. Invest. Dermatol. 103: 155-161.

94. He, J. and Grinnell, F. (1994) Stress relaxation of fibroblasts activates a cyclic AMP signaling pathway. J. Cell. Biol. 126: 457-464.

95. Young, P. and Grinnell, F. (1994) Metalloproteinase activation cascade after burn injury: A longitudinal analysis of the human wound environment. J. Invest. Dermatol. 103: 660-664.

96. Altankov, G. and Grinnell, F. (1995) Fibronectin receptor internalization and AP-2 complex reorganization in potassium-depleted fibroblasts. Exp. Cell Res. 216: 299-309.

97. Grinnell, F. and Ho, C.-H. (1995) Non-muscle myosin II heavy chain has a cryptic cell adhesion domain. Biochem J., 309: 569-574.

98. He, J. and Grinnell, F. (1995) Role of phospholipase D in the cyclic AMP signal transduction pathway activated during fibroblast contraction of collagen matrices. J. Cell Biol. 130: 1197-1205.

99. Lin, Y-C. and Grinnell, F. (1995) Treatment of human fibroblasts with vanadate and platelet-derived growth factor in the presence of serum inhibits collagen matrix contraction. Exp. Cell Res. 221: 73-82.

100. Grinnell, F. and Zhu, M (1996) Fibronectin degradation in chronic wounds depends on the relative levels of elastase, ?1-proteinase inhibitor, and ?2 macroglobulin. J. Invest. Dermatol. 106: 335-341

101. Altankov, G., Grinnell, F., and Groth, T. (1996) Studies on the biocompatibility of materials: Fibroblast reorganization of substratum-bound fibronectin on surfaces varying in wettability. J. Biomed. Mat. Res. 30: 385-391

102. Lin, Y-C., Ho, C-H., and Grinnell, F. (1997) Fibroblasts contracting collagen matrices form transient plasma membrane passages through which the cells take up FITC-dextran and Ca2+. Mol. Biol. Cell, 8: 59-71

103. He, Y., Young, P.K., and Grinnell, F. (1998) Identification of proteinase 3 as the major caseinolytic activity in acute human wound fluid. J. Invest. Dermatol., 110: 67-71

104. Lin, Y-C., Ho, C-H., and Grinnell, F. (1998) Decreased PDGF receptor kinase activity in fibroblasts contracting stressed collagen matrices. Exp Cell Res., 240: 377-387

105. Grinnell, F., Zhu, M, and Parks, W.C. (1998) Collagenase-1 complexes with ?2-macroglobulin complexes in the acute and chronic wound environments. J. Invest. Dermatol., 110: 771-776

106. Rosenfeldt, H., Lee, D. L., and Grinnell, F. (1998) Increased c-fos mRNA expression by human fibroblasts contracting stressed collagen matrices. Mol. Cell. Biol., 18: 2659-2667

107. Grinnell, F., Ho, C-H., Lin, Y-C., and Skuta, G. (1999) Differences in the regulation of fibroblast contraction of floating versus stressed collagen matrices. J. Biol. Chem. 274: 918-923.

108. Grinnell, F., Zhu, M., Carlson, M.A., Abrams, J.M. (1999) Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue. Exp. Cell Res. 248: 608-619.

109. Skuta, G., Ho, C-H., and Grinnell, F. (1999) Evidence that growth factor-dependent contraction of collagen matrices by human fibroblasts is not coupled to an increase in myosin light chain phosphorylation. J. Biol. Chem. 274: 30163-30168.

110. Rosenfeldt, H. and Grinnell, F. (2000) Fibroblast quiescence and the disruption of ERK signaling in mechanically-unloaded collagen matrices. J. Biol. Chem. 275: 3088-3092.

111. Lee, D.L., Rosenfeldt, H., and Grinnell, F. (2000) Activation of ERK and p38 MAP kinases in human fibroblasts during collagen matrix contraction. Exp. Cell Res. 257: 190-197.

112. Fringer, J. and Grinnell, F. (2001) Fibroblast quiescence in floating or released collagen matrices: Contribution of the ERK signaling pathway and actin cytoskeletal organization. J. Biol. Chem. 276: 31047-31052.

113. Grinnell, F. and Ho, C.-H. (2002) Transforming growth factor ? stimulates fibroblast-collagen matrix contraction by different mechanisms in mechanically loaded and unloaded matrices Exp. Cell Res. 273: 248-255.

114. Tamariz, E. and Grinnell, F. (2002) Modulation of fibroblast morphology and adhesion during collagen matrix remodeling. Mol. Biol. Cell. 13: 3915-3929.

115. Grinnell, F., Ho, C.H., Tamariz, E., Lee, D.J., and Skuta, G. (2003). Dendritic fibroblasts in three dimensional collagen matrices. Mol Biol Cell. 14: 384-395.

116. Fringer, J. and Grinnell, F. (2003) Fibroblast quiescence in floating collagen matrices: Decrease in serum activation of MEK and RAF but not RAS. J. Biol. Chem. 278: 20612-20617.

117. Lee, D.J., Ho, C.H., and Grinnell, F. (2003) LPA-stimulated fibroblast contraction of floating collagen matrices does not require Rho kinase activity or retraction of fibroblast extensions. Exp. Cell Res. 289: 86-94.

118. Abe, M., Ho, C.H., Kamm, K.E., and Grinnell, F. (2003) Different molecular motors mediate PDGF and LPA-stimulated floating collagen matrix contraction. J. Biol. Chem. 278: 47707-47712.

119. Jiang, H. and Grinnell, F. (2005) Cell-matrix entanglement and mechanical anchorage of fibroblasts in three dimensional collagen matrices. Molecular Biology of the Cell. 16: 5070-6

120. Grinnell, F., Rocha, L. B., Iucu, C., Rhee, S. and Jiang, H. (2006) Nested collagen matrices: A new model to study migration of human fibroblast populations in three dimensions. Exp Cell Res. 312: 86–94

121. Rhee, S. and Grinnell, F. (2006) p21-activated kinase 1: Convergence point in PDGF and LPA-stimulated collagen matrix contraction by human fibroblasts. J. Cell Biol. 172: 423-432.

122. Rhee, S., Jiang, H., Ho, C.H., and Grinnell, F. (2007) Microtubule function in fibroblast spreading is modulated according to the tension state of cell-matrix interactions. Proc. Nat. Acad. Sci. USA. 104: 5425-5430.

123. Miron-Mendoza, M., Seemann, J. and Grinnell, F. (2008) Collagen fibril flow and tissue translocation coupled to fibroblast migration in 3D collagen matrices. Mol Biol.Cell. 19: 2051-8.

124. Jiang, H., Rhee, S., Ho, C.H. and Grinnell, F. (2008) Distinguishing fibroblast promigratory and procontractile growth factor environments in 3D collagen matrices. FASEB J. 22: 2151-2160

125. Menezes, G. C., Miron-Mendoza, M., Ho, C. H., Jiang, H., Grinnell, F. (2008) Oncogenic Ras-transformed human fibroblasts exhibit differential changes in contraction and migration in 3D collagen matrices. Exp Cell Res. 314: 3081-3091.

126. Rhee, S. Ho, C. H., and Grinnell, F. (2010) Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. Exp Cell Res. 316: 232-244.127. Miron-Mendoza, M., Seemann, J. and Grinnell, F. (2010) The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices. Biomaterials. 31: 6425-6435.

128. Teo, K.Y., Dehoyos, T.O., Dutton, J.C., Grinnell, F., and Han, B. (2011) Effects of freezing-induced cell-fluid-matrix interactions on the cells and extracellular matrix of engineered tissues. Biomaterials. 32: 5380-5390.

129. Grinnell, F. and Ho, C.H., (2013) The effect of growth factor environment on fibroblast morphological response to substrate stiffness. Biomaterials. 34: 965-974.

130. da Rocha-Azevedo, B., Ho, C.H., and Grinnell, F. (2013) Fibroblast cluster formation on 3D collagen matrices requires cell contraction dependent fibronectin matrix organization. Exp Cell Res. 319: 546-555.

131. Han B, Teo KY, Ghosh, S., Dutton, J.C., and Grinnell, F. (2013) Thermomechanical analysis of freezing-induced cell-fluid-matrix interactions in engineered tissues. J Mech Behav Biomed Mater. 18: 67-80.

132. Velasquez, L.S., Sutherland, L.B., Liu, Z., Grinnell, F., Kamm, K.E., Schneider, J.W., Olson, E.N., Small, E.M. (2013) Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing. Proc Natl Acad Sci USA. 110:16850-16855.

132. Liu Z, Ho CH, Grinnell F., (2014) The different roles of myosin IIA and myosin IIB in contraction of 3D collagen matrices by human fibroblasts. Exp Cell Res. 326:295-306


Science Reviews and Book Chapters

1. Nishimura, J. S. and Grinnell, F. (1972) Mechanism of action and other properties of succinyl-CoA synthetase. Adv. Enzymol. 36: 183-202.

2. Grinnell, F. (1976) Biochemical analysis of cell adhesion to a substratum and its possible relationship to metastases. In: Membranes and Neoplasia: New Approaches and Strategies, ed. V. T. Marchesi. Alan R. Liss, Inc., New York, pp. 227-236.

3. Grinnell, F. (1978) Cellular adhesiveness and extracellular substrata. Int. Rev. Cytol. 53: 65-144.

4. Grinnell, F. (1980) Fibroblast cell substratum interactions: Role of cold insoluble globulin (plasma fibronectin). Experientia 36: 505-508.

5. Grinnell, F. (1981) Overview on the interactions of cells with collagen. Meth. Enzymol. 82: 499-503.

6. Grinnell, F. and Bennett, M. H. (1981) Ultrastructural studies on the interactions of cells with collagen. Meth. Enzymol. 82: 535-544.

7. Grinnell, F. (1981) The role of cold insoluble globulin (plasma fibronectin) in cell adhesion in vitro. In: Tissue Growth Factors, ed. R. Baserga. Springer Verlag, Heidelberg, pp. 277-299.

8. Grinnell, F. (1982) Fibronectin and wound healing. Am. J. Dermatopathology 4: 185-188.

9. Grinnell, F. (1982) The role of fibronectin in the bioreactivity of material surfaces. In: Biocompatible Polymers, Metals and Composites, ed., M. Szycher. American Society of Polymer Chemists pp. 673-679.

10. Grinnell, F. (1983) Cell Adhesion and spreading factors. In: Growth and Maturation Factors, ed., G. Guroff. John Wiley & Sons, New York, pp. 454-486.

11. Grinnell, F. (1984) Fibronectin and wound healing. J. Cell Biochem. 26:107-116.

12. Grinnell, F. (1987) Fibronectin adsorption on material surfaces. Ann. N. Y. Acad. Sci. 516: 280-290.

13. Grinnell, F., Toda, K.-I., and Takashima, A. (1987) Activation of keratinocyte fibronectin receptor function during cutaneous wound healing. J. Cell Sci. Supplement 8: 199-209.

14. Grinnell, F., Toda, K.-I., and Takashima, A. (1988) Role of fibronectin in epithelialization and wound healing. In: Tissue Repair: Biological and Clinical Aspects. ed. A. Barbul, Alan R. Liss Inc., New York, pp. 259-272.

15. Grinnell, F. (1990) Cell-Substratum Adhesion - A Citation Classic Commentary. Current Contents/Life Sciences 24: 24.

16. Grinnell, F. (1990) The activated keratinocyte: Up-regulation of cell adhesion and migration during wound healing. J. Trauma. 30:S144-S149.

17. Grinnell, F. (1991) Spatial regulation of fibroblast proliferation: An explanation for cell regression at the end of wound repair. In Clinical and Experimental Approaches to Dermal and Epidermal Repair: Normal and Chronic Wounds, ed. A. Barbul et al., Alan R. Liss Inc., New York, pp 155-166

18. Grinnell, F. (1991) Fibroblast reorganization of three-dimensional collagen gels and regulation of cell biosynthetic function. In Fundamental Investigations on the Creation of Biofunctional Materials, ed. S. Okamura, S. Tsuruta, Y. Imanishi, and J. Sunamoto, Kagaku-Dojin, Kyoto, Japan, pp 33-43.

19. Grinnell, F. (1992) Cell adhesion and wound repair. In Wound Healing: Biochemical and Clinical Aspects, ed. I.K. Cohen, R.F. Diegelmann, and W.J. Lindblad, W.A. Saunders, Philadelphia, pp 209-222.

20. Grinnell, F. (1992) Wound repair, keratinocyte activation, and integrin modulation. J. Cell Sci. 101: 1-5

21. Grinnell, F. (1992) More matrix (book review). Cell. 69: 903-904.

22. Falanga, V., Grinnell, F., Gilcrest, B., Maddox, Y.T., and Moshell, A. (1994) Workshop on the pathogenesis of chronic wounds. J. Invest. Dermatol. 102: 125-127.

23. Grinnell, F. (1994) Fibroblasts, myofibroblasts, and wound contraction. J. Cell Biol. 124: 401-404.

24. Shoshan, S., Babayof, I., Peleg, I., Grinnell, F., Ron, N., Funk, S., and Sage, E.H. (1994) Macrophage activity, fibronectin, and SPARC protein in experimentally induced granuloma. In Dupuytren’s Disease: Pathobiochemistry and Clinical Management. ed. A. Berger, P. Brenner, and A. Delbruck, Springer-Verlag, Berlin, pp 213-221.

25. Grinnell, F. (1999) Signal transduction pathways activated during fibroblast contraction of collagen matrices. Current Topics in Pathology. 93: 61-73.

26. Grinnell, F. (2000) Fibroblast-collagen matrix contraction: Growth factor signalling and mechanical loading. Trends in Cell Biology. 10: 362-365.

27. Grinnell, F. (2003) Fibroblast biology in three-dimensional collagen matrices. Trends in Cell Biology. 13: 264-269.

28. Rhee, S. and Grinnell, F. (2007) Fibroblast mechanics in 3D collagen matrices. Advance Drug Delivery Reviews. 59:1299-305

29. Grinnell, F. (2008) Fibroblast mechanics in three-dimensional collagen matrices. J Bodywork Movement Therapy. 12:191-3.

30. Grinnell, F. and Petroll, M. (2010) Cell motility and mechanics in three dimensional collagen matrices. Annu. Rev. Cell Devel. Biol. 26:335-61.

31. da Rocha-Azevedo, B. and Grinnell, F. (2013) Fibroblast morphogenesis on 3D collagen matrices: The balance between cell clustering and cell migration. Exp Cell Res. 319: 2440-2446.