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Ralph J. DeBerardinis, M.D., Ph.D.

• Mallow EB, Harris A, Salzman N, Russell JP, DeBerardinis RJ, Ruchelli E and Bevins CL. Human enteric defensins: gene structure and developmental expression. J Biol Chem 271, 4038-4045 (1996).
• Moran JV, Holmes SE, Naas TP, DeBerardinis RJ, Boeke JD and Kazazian HH. High frequency retrotransposition in cultured mammalian cells. Cell 87, 917-927 (1996).
• Sassaman DM, Dombroski BA, Moran JV, Kimberland ML, Naas TP, DeBerardinis RJ, Gabriel A, Swergold GD and Kazazian HH. Many human L1s are capable of retrotransposition. Nature Genetics 16, 37-43 (1997).
• Naas TP, DeBerardinis RJ, Moran JV, Ostertag EM, Kingsmore SF, Seldin MF, Hayashizaki Y, Martin SL and Kazazian HH. An actively-retrotransposing, novel subfamily of mouse L1 elements. EMBO J 17, 590-597 (1998).
• DeBerardinis RJ and Kazazian HH. Full-length L1 elements have retrotransposed into the same 1 kb region of the human and gorilla genomes. J Mol. Evol. 47, 292-301 (1998).
• DeBerardinis RJ, Goodier JL, Ostertag EM and Kazazian HH. Rapid amplification of a retrotransposon subfamily is evolving the mouse genome. Nature Genetics 20, 288-290 (1998).
• Moran JV, DeBerardinis RJ and Kazazian HH. Exon shuffling by L1 retrotransposition. Science 283, 1530-1534 (1999).
• DeBerardinis RJ and Kazazian HH. Analysis of the promoter from an expanding mouse retrotransposon subfamily. Genomics 56, 317-323 (1999).
• Ostertag EM, Prak ET, DeBerardinis RJ, Moran JV and Kazazian HH. Determination of L1 retrotransposition kinetics in cultured cells. Nucleic Acids Res 28, 1418-1423 (2000).
• DeBerardinis RJ, Conforto C, Russell K, Kaplan J, Kollros PR, Zackai EH and Emanuel BS. Myoclonus in a patient with a deletion of the e-sarcoglycan locus on chromosome 7q21. American J Med Genet 121A, 31-36 (2003).
• Ostertag EM, DeBerardinis RJ, Goodier JL, Zhang Y, Yang N, Gerton GL and Kazazian HH Jr. A mouse model of human L1 retrotransposition. Nature Genetics 32, 655-60 (2002).
• Buzzai M, Bauer, DE, Jones, RG, DeBerardinis RJ, Hatzivassiliou G, Elstrom RL and Thompson CB.  The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene 24:4165-4173 (2005).
• Lum JJ, DeBerardinis RJ and Thompson CB. Metazoan autophagy: cell survival in the land of plenty.  Nat Rev Cell Mol Biol 6, 439-448 (2005).
• DeBerardinis RJ, Medne L and Zackai EH. DiGeorge syndrome in a patient with isochromosome 18p born to a diabetic mother. Am J Med Genet 138, 155-159 (2005).
• DeBerardinis RJ, Lum JJ and Thompson CB. PI3K-dependent modulation of CPT1A expression plays a critical role in regulating lipid metabolism during cell growth.  J. Biol. Chem 281:37372-37380 (2006).
• Lum JJ, Bui T, Covello KL, DeBerardinis RJ, Simon MC and Thompson CB.  The transcription factor HIF-1a plays a critical role in growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 21:1037-1049 (2007).
• Buzzai M, Jones RG, Amaravadi R, Lum JJ, DeBerardinis RJ and Thompson CB.  Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth in vivo.  Cancer Research 67:6745-6752 (2007).
• DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S and Thompson CB.  Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.  PNAS USA 104:19345-19350 (2007).
• DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB.  The biology of cancer: metabolic reprogramming that fuels growth and proliferation.  Cell Metab 7:11-20 (2008).
• DeBerardinis RJ, Sayed N, Ditsworth D and Thompson CB.  Brick by brick: metabolism and tumor cell growth.  Curr Opin Genet Dev 18:54-61 (2008).
• DeBerardinis RJ, Coughlin CR 2nd and Kaplan P.  Penicillamine therapy in pediatric cystinuria: experience from a cohort of American children.  J Urol 180:2620-2623 (2008).
• DeBerardinis RJ.  Is cancer a disease of abnormal cellular metabolism?  New angles on an old idea.  Genet Med 10:767-777 (2008).
• Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang X-Y, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB and Thompson CB.  Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.  PNAS USA 105:18782-18787 (2008). 
• Yang C, Sudderth J, Dang T, Bachoo RG, McDonald JG and DeBerardinis RJ.  Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.  Cancer Research 69: 7986-7993 (2009).
• DeBerardinis RJ and Cheng T.  Q’s next: the diverse functions of glutamine in metabolism, cell biology and cancer.  Oncogene 29:313-324 (2010).
• Krawczyk CM, Jones RG, Sun J, Holowka T, Jung E, DeBerardinis RJ, Cross JR, Thompson CB and Pearce EJ. Toll-like receptor induced changes in glycolytic metabolism regulate dendritic cell activation.  Blood 115:4742-4749 (2010).
• DeBerardinis RJ. 2010 Keystone Symposium: Metabolism and Cancer Progression. Future Oncol 6:893-895 (2010).
• Rogers R, DeBerardinis R, Klesse L, Margraf L, Boriack R and Rakheja D.  Wilms tumor in a child with L-2-hydroxyglutaric aciduria.  Pediatr Devel Pathol (2010).  PMID: 20064066
• Rakheja D and DeBerardinis RJ.  The expanded newborn screening: a review for the pediatric pathology fellow. Pediatr Devel Pathol (2010).  PMID: 20233065
• Rakheja D, Mitui M, Boriack RL, DeBerardinis RJ. Isocitrate dehydrogenase 1 and 2 mutational analyses and 2-hydroxyglutarate measurements in Wilms tumors.  In press, Pediatric Blood & Cancer (2010).
• Simsek T, Zheng J, Kocabas F, DeBerardinis RJ, Zhang CC, Schneider JW, Olson EN and Sadek HA. Metabolic footprint of hematopoietic stem cells. In press, Cell Stem Cell (2010).