RECENT PUBLICATIONS


Visit PubMed: Philip W. Shaul, Ph.D.

Visit PubMed: Chieko Mineo, Ph.D.

Visit PubMed: Michihisa Umetani, Ph.D.

SHAUL, MINEO

Selected Previous Publications
Shaul PW, Kinane B, Farrar MA, Buja LM, Magness RR: Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery: alterations following prolonged hypoxia in the rat. J. Clin. Invest. 88:447-455, 1991.

Shaul PW, Campbell WB, Farrar MA, Magness RR: Oxygen modulates prostacyclin synthesis in ovine fetal pulmonary arteries by an effect on cyclooxygenase. J. Clin. Invest. 90:2147-2155, 1992.

Brannon TS, North AJ, Wells LB, Shaul PW: Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression. J. Clin. Invest. 93:2230-2235, 1994.

Shaul PW, North AJ, Wu LC, Wells LB, Brannon TS, Lau KS, Michel T, Margraf LR, Star RA: Endothelial nitric oxide synthase is expressed in cultured human bronchiolar epithelium. J. Clin. Invest. 94:2231-2236, 1994.

Shaul PW, Smart EJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, Anderson RGW, Michel T: Acylation targets endothelial nitric oxide synthase to plasmalemmal caveolae. J. Biol. Chem. 271:6518-6522, 1996.

Roberts JD, Fineman JR, Morin FC III, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM, for the Inhaled Nitric Oxide Study Group: Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. New Engl. J. Med. 336:605-610, 1997.

Jun SS, Chen Z, Pace MC, Shaul PW: Estrogen upregulates cyclooxygenase-1 gene expression in ovine fetal pulmonary artery endothelium. J. Clin. Invest. 102:176-183, 1998.

Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW: Estrogen receptor α mediates nongenomic activation of eNOS by estrogen. J. Clin. Invest. 103:401-406, 1999.

Blair A, Shaul PW, Yuhanna IS, Conrad PA, Smart EJ: Oxidized low-density lipoprotein displaces eNOS from plasmalemmal caveolae and impairs eNOS activation. J. Biol. Chem. 274:32512-32519, 1999.

Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME: Specific association of estrogen receptor β with the cell cycle spindle assembly checkpoint protein, MAD2. Proc. Natl Acad. Sci. USA. 97:2836-2839, 2000.

German Z, Chambliss KL, Pace MC, Arnet UA, Lowenstein CJ, Shaul PW: Molecular basis of cell-specific endothelial nitric oxide synthase expression in airway epithelium. J. Biol. Chem. 275:8183-8189, 2000.

Uittenbogarrd A, Shaul PW, Yuhanna IS, Blair A, Smart EJ: HDL prevents OxLDL-induced inhibition of eNOS localization and activation in caveolae. J. Biol. Chem. 275:11278-11283, 2000.

Lin S, Fagan KA, Shaul PW, Cooper DMF, Rodman DM: Sustained endothelial nitric oxide synthase activation requires capacitative Ca2+ entry. J. Biol. Chem. 275:17979-17985, 2000.

Yuhanna IS, Zhu Y, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, Anderson RGW, Mendelsohn ME, Hobbs HH, Shaul PW: High density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nature Med. 7:853-857, 2001.

Wyckoff MH, Chambliss KL, Mineo C, Yuhanna IS, Mendelsohn ME, Mumby SM, Shaul PW: Plasma membrane estrogen receptors are coupled to eNOS through G1.  J. Biol. Chem. 276:27071-27076, 2001.

Zhu Y, Bian Z, Lu P, Karas RH, Bao L, Cox D, Hodgin J, Shaul PW, Thorén P, Smithies O, Gustafsson J-A, Mendelsohn ME: Abnormal vascular function and hypertension in mice deficient in estrogen receptor β. Science 295:505-508, 2002.

Chambliss KL, Yuhanna IS, Anderson RGW, Mendelsohn ME, Shaul PW: Estrogen receptor beta has nongenomic action in caveolae. Mol. Endocrinol. 16:938-946, 2002.

Venugopal SK, Devaraj S, Yuhanna IS, Shaul PW, Jialal I: Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 106:1439-1441, 2002.

 Recent Publications

Chambliss KL, Simon L, Yuhanna IS, Mineo C, Shaul PW: Dissecting the basis of nongenomic activation of eNOS by estradiol: Role of  ERα domains with known nuclear functions. Mol. Endocrinol. 19:277-289, 2005.

McCurnin DC, Pierce RA, Chang LY, Gibson LL, Osborne-Lawrence S, Yoder BA, Kerecman JD, Albertine KH, Winter VT, Coalson JJ, Crapo JD, Grubb PH, Shaul PW: Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 288:L450-L459, 2005.

Gibson LL, Hahner L, Osborne-Lawrence S, German Z, Wu KK, Chambliss KL, Shaul PW: Molecular basis of estrogen-induced cyclooxygenase type-1 upregulation in endothelial cells. Cir. Res. 96:518-525, 2005.

Assanasen C, Mineo C, Seetharam D, Yuhanna IS, Marcel YL, Connelly MA, Williams DL, de la Llera-Moya M, Shaul PW*, Silver DL*: Cholesterol binding, efflux and a PDZ-interacting domain of SR-BI mediate HDL-initiated signaling. J. Clin. Invest. 115:969-977, 2005. * shared senior authorship.

Valasek MA, Weng J, Shaul PW, Anderson RGW, Repa JJ: Caveolin-1 is not required for cholesterol absorption in the mouse. J. Biol. Chem. 280:28103-28109, 2005.

Munson DA, Grubb PH, Kerecman JD, McCurnin DC, Yoder BA, Hazen SL, Shaul PW, Ischiropoulos H: Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease. Am. J. Respir. Cell Molec. Biol. 33:582-588, 2005.

McCurnin DC, Yoder BA, Coalson J, Grubb P, Kerecman J, Kupferschmid J, Breuer C, Siler-Khodr T, Shaul PW, Clyman R: Effect of ductus ligation on cardiopulmonary function in premature baboons. Am. J. Respir. Crit. Care Med. 172:1569-1574, 2005.

Mineo C, Gormley AK, Yuhanna IS, Osborne-Lawrence S, Gibson LL, Hahner L, Shohet RV, Black S, Salmon JE, Samols D, Karp DR, Thomas GD, Shaul PW: FcγRIIB mediates C-reactive protein inhibition of endothelial NO synthase.  Circ. Res. 97:1124-1131, 2005.

Seetharam D, Mineo C, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW: High-density lipoprotein promotes endothelial cell migration and reendothelializaton via scavenger receptor-B type I.  Circ. Res. 98:63-72, 2006.

Ballard PL, Gonzales LW, Godinez RI, Godinez M, Savani RC, McCurnin DC, Gibson LL, Yoder BA, Kerecman JD, Grubb PH, Shaul PW: Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxide.  Pediatr. Res. 59:157-162, 2006.

Vongpatanasin W, Thomas GD, Schwartz R, Cassis LA, Osborne-Lawrence S, Hahner L, Gibson LL, Black S, Samols D, Shaul PW: CRP causes downregulation of vascular AT2 receptors and systolic hypertension in mice.  Circulation 115:1020-1028, 2007.

Kumar P, Tall GG, Chambliss KL, Yuhanna IS, Wu Q, Mumby SM, Mineo C, Shaul PW: Direct interactions with Gαi and Gβγ mediate nongenomic signaling by ERα. Mol. Endocrinol. 21:1370-1380, 2007.

Schwartz R, Osborne-Lawrence S, Hahner L, Gibson LL, Gormley AK, Vongpatanasin W, Zhu W, Word RA, Seetharam D, Black S, Samols D, Mineo C, Shaul PW: C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice.  Circ. Res., 100:1452-1459, 2007.

Rees SM, Camm EJ, Loeliger M, Cain S, Diiieni S, McCurnin D, Shaul P, Yoder B, McLean C, Inder TE: Inhaled nitric oxide: effects on cerebral growth and injury in a baboon model of premature delivery. Pediatr. Res. 61:552-558, 2007.

Jain R, Shaul PW, Borok Z, Willis BC: Endothelin-1 induces alveolar epithelial-mesenchymal transition through ET-A-mediated production of transforming growth factor-b1. Am. J. Respir. Cell Molec. Biol., 37:38-47, 2007.

Vyas-Read S, Shaul PW, Willis BC: Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells. Am. J. Respir. Cell Molec. Biol. 293:L212-L221, 2007.

Joshi MS, Mineo C, Shaul PW, Bauer JA: Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: Altered caveolar localization and impaired response to shear.  FASEB J. 21:2655-2663, 2007.

Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Liverman AB, Javitt NB, Shaul PW, Mangelsdorf DJ: 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that inhibits the cardiovascular effects of estrogen.  Nat. Med. 13:1185-1192, 2007.

DuSell, CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP: 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator (SERM). Mol. Endocrinol. 22:65-77, 2008.

Chang LY, McCurnin D, Yoder B, Shaul PW, Clyman RI: Ductus arteriosus ligation and alveolar growth in    preterm baboons with a patent ductus arteriosus. Pediatr. Res. 63:299-302, 2008.

Zhu W, Seetharam D, Chambliss KL, Silver DL, Yuhanna IS, Shaul PW*, Mineo C*: The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity. Circ. Res. 102:480-487, 2008.  * shared senior authorship.

Park KW, Kwon YW, Cho HJ, Shin JI, Kim YJ, Lee SE, Youn SW, Lee HC, Kang HJ, Shaul PW, Oh BH, Park YB, Kim HS: G-CSF exerts dual effects on endothelial cells: Opposing actions of direct eNOS induction versus indirect CRP elevation.  J. Mol. Cell Cardiol. 45:670-678, 2008.

Loeliger M. Inder TE, Dalitz PA, Cain S, Camm EJ, Yoder B, McCurnin D, Shaul PW, Clyman R, Rees SM: Developmental and neuropathological consequences of ductal ligation in the preterm baboon.  Pediatr. Res. 65:209-214, 2009.

McCurnin DC, Pierce WR, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard PL, Clyman RI, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW: Postnatal estradiol upregulates lung NO synthases and improves lung function in bronchopulmonary dysplasia. Am. J. Resp. Crit.Care Med. 179:492-500, 2009.

Tanigaki K, Mineo C, Yuhanna IS, Chambliss KL, Quon MJ, Bonvini E, Shaul PW: C-reactive protein inhibits insulin activation of endothelial NO synthase via the immunoreceptor tyrosine-based inhibition motif of FcγRIIB and SHIP-1.  Circ. Res. 104:1275-1282, 2009.

UMETANI

Selected Previous Publications

Morikawa, S., Umetani, M., Nakagawa, S., Yamazaki, H., Suganami, H., Inoue, K., Kitahara, M., Hamakubo, T., Kodama, T., and Saito, Y. (2000) Relative Induction of mRNA for HMG CoA Reductase and LDL Receptor by Five Different HMG-CoA Reductase Inhibitors in Cultured Human Cells. J. Atheroscler. Thromb. 7, 138-144.

Umetani, M., Nakao, H., Doi, T., Iwasaki, A., Ohtaka, M., Nagoya, T., Mataki, C., Hamakubo, T., and Kodama, T. (2000) A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem. Biophys. Res. Commun. 272, 370-374.

Saiura, A., Mataki, C., Murakami, T., Umetani, M., Wada, Y., Kohro, T., Aburatani, H., Harihara, Y., Hamakubo, T., Yamaguchi, T., Hasegawa, G., Naito, M., Makuuchi, M., and Kodama, T. (2001) A comparison of gene expression in murine cardiac allografts and isografts by means DNA microarray analysis.  Transplantation 72, 320-329.

Umetani, M., Mataki, C., Minegishi, N., Yamamoto, M., Hamakubo, T., and Kodama, T. (2001) Function of GATA transcription factors in the induction of endothelial VCAM-1 by TNF-alpha. Arterioscler. Thromb. Vasc. Biol. 21, 917-922.

Goodwin, BJ., Gauthier, KC., Umetani, M., Watson, MA., Lochansky, MI., Collins, JL., Leitersdorf, E., Mangelsdorf, DJ., Kliewer, SA., and Repa, JJ. (2003) Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic receptor PXR.  Proc. Natl. Acad. Sci. USA 100, 223-228.

 Recent Publications

Yang, C., McDonald, JG., Patel, A., Zhang, Y., Umetani, M., Xu, F., Mangelsdorf, DJ., Westover, EJ., Covey, DF., Cohen, JC., and Hobbs, HH. (2006) Sterol intermediates from cholesterol biosynthetic pathway as LXR ligands. J. Biol. Chem. 281, 27816-27826.

Choi, M., Moschetta, A., Bookout, AL., Peng, L., Umetani, M., Holmstrom, SR., Suino-Powell, K., Xu, HE., Richardson, JA., Gerard, RD., Mangelsdorf, DJ., and Kliewer, SA. (2006) Identification of a hormonal basis for gallbladder filling. Nat. Med. 12, 1253-1255.

Horiuchi, K.*, Umetani, M.*, Minami, T., Okayama, H., Takada, S., Yamamoto, M., Aburatani, H., Reid, PC., Housman, DE., Hamakubo, T., and Kodama, T. (2006) Wilms’ tumor 1-associating protein regulated G2/M transition through stabilization of cyclin A2 mRNA. Proc. Natl. Acad. Sci. USA 103, 17278-17283.   (* contributed equally)

Umetani, M., Domoto, H., Gormley, AK., Yuhanna, IS., Cummins, CL., Javitt, NB., Korach, KS., Shaul, PW., and Mangelsdorf, DJ. (2007) 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat. Med. 13, 1185-1192.

Dusell, CD., Umetani, M., Shaul, PW., Mangelsdorf, DJ., and McDonnell, DP. (2008) 27-Hydroxycholesterol is an endogenous Selective Estrogen Receptor Modulator (SERM). Mol. Endocrinol. 22, 65-77.