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The spindle checkpoint helps to ensure the fidelity of chromosome segregation during mitosis and meiosis. We are investigating the molecular mechanism of the spindle checkpoint using a combination of cell biological, biochemical, and biophysical methods. Below is a time-lapse movie of a HeLa cell undergoing mitosis. The cell stably expresses GFP-tubulin and DsRed-histone H2B. (more details...)

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