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Selected Publications

  • Chen,P. Tu, X., Akdemir, F., Chew, S., Rothenfluh, A. and Abrams, J.M. Genome-wide Silencing Identifies Effectors of Ethanol Induced Cell Death. (In Press, Cell Death and Differentiation: advance online publication, 27 April 2012; doi:10.1038/cdd.2012.47)
  • Lu, W.J., Chapo, J., Roig, I. and Abrams, J.M. (2010).  Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328: 1278-81 Reprint: http://www.sciencemag.org/cgi/rapidpdf/328/5983/1278?ijkey=nCwTuaZfb7/nk&keytype=ref&siteid=sci
    Full Text: http://www.sciencemag.org/cgi/content/full/328/5983/1278?ijkey=nCwTuaZfb7/nk&keytype=ref&siteid=sci
  • Lu, W.J., Amatruda, J. and Abrams, J.M. (2009) p53 Ancestry: gazing through an evolutionary lens. Nature Reviews Cancer 9:758-62
  • Chew, S.,Chen, P., Link, N., Pogue, K. and Abrams, J.M. Genome-Wide Silencing Captures Obligate Apoptotic Components in Drosophila (2009). Nature 460: 123-7
  • Akdemir, F., Christich, A., Sogame, N., Chapo, J., and Abrams, J.M. p53 Directs Focused Genomic Responses in Drosophila (2007). Oncogene 26: 5184-93
  • Link, N., Chen, P., Lu, WJ, Pogue, K., Chuong, A., Mata, M., Checketts, J., Abrams,J.M. A Collective Form of Cell Death Requires Homeodomain Interacting Protein Kinase. (2007) J. Cell Biology 178:567-74
  • Akdemir, F., Farkas, R., Chen, P., Juhasz, G., Medvedova, L., Sass, M., Wang, L., Wang,X., Chittaranjan, S., Gorski, S.M., Rodriguez, A., Abrams, J.M. Autophagy Occurs Upstream or Parrallel to the Apoptosome During Histolytic Cell Death. (2006) Development (133) 1457-1465
  • Chew, S., Akdemir, F.,Chen, P., Lu, W., Mills, K.,Daish, T.,Kumar, S., Rodriguez,, A. and Abrams, J.M. The Apical Caspase, dronc, Governs Programmed and Unprogrammed Cell Death in Drosophila (2004). Developmental Cell (7): 897-907
  • Sogame, N., Kim, M. and Abrams, J.M. Drosophila p53 preserves genomic stability by regulating cell death (2003). Proc. Natl Acad. Sci, USA 100 (8): 4696-4701
  • Abrams, J.M. Competition and Compensation: Coupled to Death in Development and Cancer (2002). Cell 110, 403-406
  • Rodriguez, A., Oliver, H. and Abrams, J.M. Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog Dark (2002). EMBO J 21(9): 2189-2197
  • Christich, A. Kauppila, S., Chen, P., Sogame, N., Ho, S., and Abrams, J.M. The damage-responsive Drosophila gene, sickle, encodes a novel IAP binding protein similar to, but distinct from, reaper, grim and hid (2002). Current Biology 12: 137-140
  • Brodsky, M. H., Nordstrom, W., Tsang, G., Kwan, E., Rubin, G. M., and Abrams, J.M. Drosophila p53 binds a damage response element at the reaper locus (2000). Cell 101: 103-113
  • Abrams, J.M. An emerging blueprint for apoptosis in Drosophila (1999). Trends in Cell Biology 9: 435-440
  • Rodriguez, A., Oliver, H., Zou, H., Chen, P., Wang, X. and Abrams, J.M. Dark, is a Drosophila Homologue of Apaf-1/Ced-4 and Functions in an Evolutionarily Conserved Death Pathway (1999). Nature Cell Biology 1: 272-279
  • Varkey, J., Chen, P., Jemmerson, R. and Abrams, J.M. Altered cytochrome c display precedes apoptosis in Drosophila (1999). J Cell Biol 144: 701-710
  • Chen, P., Rodriguez, A., Erskine, R., Thach, T. and Abrams J M. Dredd, a novel Drosophila caspase, is an effector of the apoptosis activators Reaper, Grim and Hid (1998). Dev Biol 201: 202-216
  • Nordstrom, W., Chen, P., Steller, H. and Abrams, J.M. Activation of the reaper gene during ectopic cell killing in Drosophila (1996). Dev Biol 180: 213-226
  • Chen, P., Nordstrom, W., Stuart, B. and Abrams, J.M. Grim, a novel cell death gene in Drosophila (1996). Genes & Development 10: 1773-1782