Journal Articles

[1] Lu, H., Golay, X., and van Zijl, P.C. Intervoxel Heterogeneity of Event-Related Functional Magnetic Resonance Imaging Responses as a Function of T1 Weighting. NeuroImage 17: 943-955, 2002.

[2] Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Functional Magnetic Resonance Imaging Based on Changes in Vascular Space Occupancy. Magnetic Resonance in Medicine 50: 263-274, 2003.

[3] Hendrikse, J., Lu, H., van der Grond, J., van Zijl, P.C., and Golay, X. Fast Measurements of Cerebral Perfusion and Arterial Hemodynamics during Visual Stimulation with TURBO-TILT fMRI. Magnetic Resonance in Medicine 50: 429-433, 2003.

[4] Lu, H., van Zijl, P.C., Hendrikse, J., Golay, X. Multiple Acquisition with Global Inversion Cycling (MAGIC): a Multi-slice Technique for Vascular-Space-Occupancy Dependent fMRI. Magnetic Resonance in Medicine 51: 9-15, 2004.

[5] Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Sustained post-stimulus elevation in cerebral oxygen utilization following vascular recovery. Journal of Cerebral Blood Flow and Metabolism 24: 764-770, 2004.

[6] Lu, H., Clingman, C., Golay, X., and van Zijl, P.C. Determination of Longitudinal Relaxation Time (T1) of Blood at 3.0 Tesla. Magnetic Resonance in Medicine 52: 679-682, 2004.

[7] Lu, H., and van Zijl, P.C. Experimental Separation of Intra and Extravascular BOLD Effects using Multi-echo VASO and BOLD fMRI at 1.5T and 3.0T. Magnetic Resonance in Medicine 53: 808-816, 2005.

[8] Jensen, J.H., Helpern, J.A., Ramani, A., Lu, H., and Kaczynski, K. Diffusional Kurtosis Imaging: The Quantification of Non-Gaussian Water Diffusion by Means of MRI. Magnetic Resonance in Medicine 53: 1432-1440, 2005.

[9] Lu, H., Nagae-Poetscher, L.M., Golay, X., Lin D., Pomper M.G., and van Zijl, P.C. Routine Clinical Brain MRI Sequences for Use at 3.0 Tesla. Journal of Magnetic Resonance Imaging 22: 13-22, 2005.

[10] Lu, H., Basso, G., Serences, J.T., Yantis, S., Golay, X., and van Zijl, P.C. Retinotopic mapping in human visual cortex using Vascular-Space-Occupancy (VASO) dependent fMRI. NeuroReport 16: 1635-1640, 2005.

[11] Lu, H., Law, M., Johnson, G., Ge, Y., van Zijl, P.C., and Helpern, J.A. A Novel Approach to Measure Absolute Cerebral Blood Volume using Vascular-Space-Occupancy (VASO) Dependent MRI. Magnetic Resonance in Medicine 54: 1403-1411, 2005.

[12] van Laar P.J., Hendrikse, J., Golay X., Lu, H., van Osch, M.J. and van der Grond, J. In vivo Flow Territory Mapping of Major Brain Feeding Arteries. NeuroImage 29: 136-144, 2006.

[13] Gu, H., Lu, H., Ye, F.Q., Stein, E.A. and Yang, Y. Noninvasive Quantification of Cerebral Blood Volume in Humans during Functional Activation. NeuroImage 30: 377-387, 2006.

[14] Lu, H., Jensen, J.H., Ramani, A., and Helpern, J.A. Three-dimensional Characterization of Non-Gaussian Water Diffusion in Humans using Diffusion Kurtosis Imaging. NMR in Biomedicine 19: 236-247. 2006.

[15] Jensen, J.H., Chandra, R., Helpern, J.A., Ramani, A., Lu, H., Johnson, G., Lee, S.P., and Kaczynski, K. Magnetic Field Correlation Imaging. Magnetic Resonance in Medicine 55: 1350-1361, 2006.

[16] Strouse, J.J., Cox, C., Melhem, E., Lu, H., Kraut, M., Razumovsky, A., Yohay, K., van Zijl, P.C., Casella, J.F. Inverse Correlation Between Cerebral Blood Flow and Neurocognitive Function in Children with Sickle Cell Anemia (SCA). Blood 108: 379-381, 2006.

[17] Lu, H., Donahue, M.J., and van Zijl, P.C. Detrimental Effects of BOLD Signal in Arterial Spin Labeling fMRI at High Field Strength. Magnetic Resonance in Medicine in press.

[18] Donahue, M.J., Lu, H., Jones, C.K., Pekar, J.J., and van Zijl, P.C. An Account of the Discrepancy between MRI and PET Cerebral Blood Flow Measures: A High-field MRI Investigation. NMR in Biomedicine in press.

[19] Donahue, M.J., Lu, H., Jones, C.K., Pekar, J.J., and van Zijl, P.C. An Investigation of the VASO Contrast Mechanism Reveals a Novel Method for Quantifying Cerebral Blood Flow. Magnetic Resonance in Medicine in revision.

[20] Jensen, J.H., Lu, H., and Inglese, M. Microvessel Density Estimation in Human Brain by Means of Dynamic Contrast-Enhanced Echo Planar Imaging. Magnetic Resonance in Medicine in revision.

Conference Papers

[1] Lu, H., Golay, X., and van Zijl, P.C. TR and Flip Angle Dependent Increases and Decreases in Activation-Related Signal Changes in Event-Related fMRI Experiments at 1.5 T, in “Proc. ISMRM., 10th Annual Meeting, Honolulu” p. 1401, 2002.

[2] Lu, H., Golay, X., Pekar, J.J., van Zijl, P.C. Vascular-Space-Occupancy (VASO) Dependent fMRI: Theory, Implementation, and Spatial/Temporal Characterization, in “Proc. 44th ENC, Savannah, Georgia” p. 3, 2003 (Oral presentation).

[3] Golay, X., Lu, H., Pekar, J.J., van Zijl, P.C. Multiple Acquisition with Global Inversion Cycling (MAGIC): A Multi-slice Acquisition Technique for T1-prepared Imaging Sequences, in “Proc. 44th ENC, Savannah, Georgia” p. 259, 2003.

[4] Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Vascular-Space-Occupancy (VASO) dependent fMRI, in “Proc., ISMRM., 11th Annual Meeting, Toronto” p. 742, 2003 (Oral presentation).

[5] Lu, H., Clingman, C., Golay, X., and van Zijl, P.C. What is the longitudinal relaxation time (T1) of blood at 3.0 Tesla?, in “Proc., ISMRM., 11th Annual Meeting, Toronto” p. 669, 2003 (Oral presentation).

[6] Hendrikse, J., Lu, H., van der Grond, J., van Zijl, P.C., and Golay, X. Fast measurements of cerebral perfusion and arterial hemodynamics during visual stimulation with TURBO-TILT fMRI, in “Proc., ISMRM., 11th Annual Meeting, Toronto” p. 2179, 2003 (Oral presentation).

[7] Lu, H., Golay, X., Pekar, J.J., van Zijl, P.C. Vascular-Space-Occupancy (VASO) Dependent fMRI: Theory, Implementation, and Spatial/Temporal Characterization, in “Proc., HBM 9th Annual Meeting, New York, NY” p. 681, 2003.

[8] Lu, H., Golay, X., Pekar J.J., van Zijl, P.C. Water shifts and microvascular cerebral blood volume (CBV) effects during functional activation, in “XXI International Symposium on Cerebral Blood Flow, Metabolism and Function (Brain03), Calgary, Canada” p. 108, 2003 (Oral presentation).

[9] Lu, H., Golay, X., Pekar, J.J., van Zijl, P.C. Vascular-Space-Occupancy (VASO) Dependent fMRI: Theory, Implementation, and Spatial/Temporal Characterization, in “Minnesota Workshops on High Field MR Imaging and Spectroscopy & MRI of Brain Function” p. 75, 2003 (Oral presentation).

[10] Prabhakaran, V., Raman, S.P., Grunwald, M.R., Mahadevia, J.K., Werner, L.E., Hussain, N., Alphs, H.H., Sun, P., Lu, H., Barker, P.B., Wityk, R.J., Rypma, B., Hillis, A.E. Neural Substrates Involved in Cognition for Stroke Patients and Control Subjects, in “Annual Meeting of Cognitive Neuroscience Society”, p. 40, 2004

[11] Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Elevated Cerebral Energy Use Without Vascular Response, in “Proc., ISMRM., 12th Annual Meeting, Kyoto, Japan” p. 271, 2004 (Oral presentation).

[12] Lu, H., van Zijl, P.C., Hendrikse, J., and Golay, X. Multiple Acquisition with Global Inversion Cycling (MAGIC): a Multi-slice Technique for Vascular-Space-Occupancy Dependent fMRI, in “Proc., ISMRM., 12th Annual Meeting, Kyoto, Japan” p. 513, 2004 (Oral presentation).

[13] Lu, H., and van Zijl, P.C. Experimental Separation of Intra and Extravascular BOLD effects using multi-echo VASO and BOLD fMRI at 1.5T and 3.0T, in “Proc., ISMRM., 12th Annual Meeting, Kyoto, Japan” p. 275, 2004 (Oral presentation).

[14] Lu, H., Basso, G., Serences, J.T., Yantis, S., Golay, X., and van Zijl, P.C. Retinotopic mapping in human visual cortex using Vascular-Space-Occupancy (VASO) dependent fMRI, in “Proc., ISMRM., 12th Annual Meeting, Kyoto, Japan” p. 115, 2004 (Oral presentation).

[15] Hendrikse, J., von der Grond, J., Lu, H., van Osch, M.J., van Zijl, P.C., and Golay, X. Flow territory mapping of the cerebral arteries with regional perfusion MRI (RPI), in “Proc., ISMRM., 12th Annual Meeting, Kyoto, Japan” p. 718, 2004 (Oral presentation).

[16] Golay, X., Lu, H., Hong, W.T., Lee, W.L., Sitoh, Y.Y., and van Zijl, P.C. Simultaneous Measurements of CBV and CBF Changes using VASO-FAIR, in “Proc., ISMRM., 12th Annual Meeting, Kyoto, Japan” p. 720, 2004 (Oral presentation).

[17] Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Activation-related Increases in Brain Oxygen Metabolism Do Not Require Increased Cerebral Blood Flow, in “Proc. 45th ENC, Pacific Grove, California” p. 21, 2004.

[18] Lu, H., Golay, X., Pekar, J.J., and van Zijl, P.C. Elevated Cerebral Energy Use Without Vascular Response, in “Gordon Research Conference on Brain Energy Metabolism & Blood Flow, Waterville, Maine”, 2004.

[19] Hillis, A., Prabhakaran, V., Lu, H., Sun, P.Z., van Zijl, P.C. fMRI BOLD effect in response to word generation in regions of baseline hypoperfusion (but no infarct) among patients with large vessel arterial stenosis, in “Scientific Sessions of American Heart Association”, 2004.

[20] Jensen, J.H., Helpern, J.A., Ramani, A., Lu, H., Kaczynski, K., and Nusbaum, A. Diffusional Kurtosis Imaging: The Quantification of Non-Gaussian Water Diffusion by Means of MRI, in “Proc., White Matter in the Cognitive Neurosciences: Advances in Diffusion Tensor Imaging and Its Applications Workshop, New York” p. 31, 2004 (Oral presentation).

[21] Lu, H., Donahue, M.J. and van Zijl, P.C. Noise or Artifact: Detrimental Effects of BOLD Signal in Arterial Spin Labeling fMRI at High Field Strength, in “Proc., ISMRM., 13th Annual Meeting, Miami”, p. 35, 2005 (Oral presentation).

[22] Lu, H., Law, M., Johnson, G., van Zijl, P.C. and Helpern, J.A. A Novel Approach to Measure Absolute CBV using Gd-DTPA Contrast Agent, in “Proc., ISMRM., 13th Annual Meeting, Miami”, p. 38, 2005 (Oral presentation).

[23] Lu, H., Jensen, J. and Helpern, J.A. Characterization of Non-Gaussian Water Diffusion in Humans using Diffusion Kurtosis Imaging, in “Proc., ISMRM., 13th Annual Meeting, Miami”, p. 581, 2005 (Oral presentation).

[24] Lu, H., Donahue, M.J., Jones, C.K. and van Zijl, P.C. Spatial Characteristics of VASO fMRI at Ultra-high Resolution, in “Proc., ISMRM., 13th Annual Meeting, Miami”, p. 27, 2005 (Oral presentation).

[25] Jensen, J., Lu, H. and Inglese, M. In Vivo Human Brain Q-maps by Means of Dynamic Contrast-Enhanced Echo Planar Imaging, in “Proc., ISMRM., 13th Annual Meeting, Miami”, p. 1129, 2005.

[26] Donahue, M.J., Jones, C.K., Lu, H. and van Zijl, P.C. A Proposed Solution for Reconciling the Cerebral Blood Flow Discrepancy Between PET and MRI, in “Proc., ISMRM., 13th Annual Meeting, Miami”, p. 1148, 2005.

[27] Gu, H., Lu, H., Ye, F.Q., Stein, E.A. and Yang, Y. Noninvasive Quantification of Cerebral Blood Volume in Humans during Functional Activation, in “Proc., ISMRM., 13th Annual Meeting, Miami”, p. 492, 2005 (Oral presentation).

[28] van Laar, P.J., Hendrikse, J., Golay X., Lu, H., van Osch, M.J. and van der Grond, J. In vivo Flow Territory Mapping of Major Brain Feeding Arteries. in “Proc., ISMRM., 13th Annual Meeting, Miami”, p. 1134, 2005 (Oral presentation).

[29] Donahue, M.J., Jones, C.K., Lu, H., and van Zijl, P.C. Resolution and Inversion Time Dependence of CBF Measurements Using MRI: A Possible Explanation for Discrepancy between MRI and PET, in “XXIInd International Symposium on Cerebral Blood Flow, Metabolism and Function & VIIth International Conference on Quantification of Brain Function with PET, Amsterdam, The Netherlands” p. 354, 2005 (Oral presentation).

[30] Lu, H., Jensen, J.H., Hu, C., Falangola, M.F., Ramani, A., Ferris, S., and Helpern, J.A. Alterations in Cerebral Microstructual Integrity in Normal Aging and in Alzheimer’s Disease: A Multi-contrast Diffusion MRI study, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 723, 2006 (Oral presentation).

[31] Ge, Y., Lu, H., Jensen, J.H., Helpern, J.A., Reaume, J., and Grossman, R.I. Thalamic Involvement Following Mild Brain Injury: In Vivo Occult Pathology Demonsstrated by Diffusion Kurtosis Imaging, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 729, 2006 (Oral presentation).

[32] Lu, H., Pollack, E., Young, R., Babb, J.S., Johnson, G., Jensen, J.H., Helpern, J.A., and Law, M. Predicting Grade of Cerebral Glioma Using Vascular-Space-Occupancy (VASO) MRI, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 757, 2006 (Oral presentation).

[33] Lu, H., Law, M., Hesseltine, S.M., Rapalino, O., Jensen, J.H., and Helpern, J.A. Quantitative Measurement of Spinal Cord Blood Volume (ScBV) in Humans Using Vascular-Space-Occupancy (VASO) MRI, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 884, 2006 (Oral presentation).

[34] Falangola, M.F., Lee, S., Jensen, J.H., Lu, H., Nixel, R.A., Duff, K., and Helpern, J.A. MRI Assessment of A-beta Iron Complex in PS/APP Mouse Brain, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 946, 2006.

[35] Lee, S., Falangola, M.F., Jensen, J.H., Lu, H., Nixon, R.A., Duff, K., and Helpern, J.A. Mouse Brain Iron Distribution: Histochemical and Quantitative MRI (7T) Assessment, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 975, 2006.

[36] Ramani, A., Jensen, J.H., Krain, A.L., Yang, J., Hu, C., Lu, H. and Helpern, J.A. In Vivo Detection of Age-Related Brain Iron Differences with MFC, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 1559, 2006.

[37] Ramani, A., Szulc, K.U., Jensen, J.H., Lu, H., Hu, C., Ferris, S., and Helpern, J.A. Evidence for Elevated Brain Iron Concentration in Patient with Alzheimer’s Disease, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 2655, 2006.

[38] Donahue, M.J., Lu, H., Jones, C.K., Pekar, J.J., and van Zijl, P.C. An Investigation of the VASO Contrast Mechanism Reveals a Novel Method for Quantifying Cerebral Blood Flow, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 2769, 2006.

[39] Young, R.J., Pollack, E., Lu, H., Babb, J., Johnson, G., and Law, M. Region-of-interest Analysis vs. Non-Region-of-interest Histogram Analysis in the Evaluation of Cerebral Gliomas, in “Proc., ISMRM., 14th Annual Meeting, Seattle, WA”, p. 3158, 2006.

[40] Lu, H. Quantitative Evaluation of Cerebral Venous Oxygen Saturation using MRI, in “Proc., Human Brain Mapping 12th Annual Meeting, Florence, Italy”, p. Th 261, 2006