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UT Southwestern Medical Center

The Altschuler & Wu Computational and Systems Biology Laboratory

Altschuler & Wu
Steve Altschuler, Ph.D. E-mail
Associate Professor

UTSW Endowed Scholar in Biomedical Research
Biographical Sketch
Lani Wu, Ph.D.E-mail
Associate Professor

UTSW Endowed Scholar in Biomedical Research
Biographical Sketch

Drs. Altschuler and Wu combine their backgrounds in biology, mathematics, and engineering in their current focus in understanding cell polarity and signaling heterogeneity in cancer and metabolism. Prior to arriving at the UT Southwestern, Drs. Altschuler and Wu have worked at the Bauer Center for Genomics Research at Harvard University, Rosetta Informatics, Microsoft, and Princeton University.



Lab Members


Dhruba Deb ( ধ্রুব দেব ) E-mail
Graduate Student

After earning his B.Sc. in Biotechnology with Chemistry and Microbiology double minors and his M.Sc. in Bioinformatics, Dhruba worked at the Indian Institute of Science to gather experience in understanding protein structures from a network percolation perspective. As a graduate student, he is interested in the correlation of signaling state heterogeneity with drug response in cancer cells. Dhruba likes to dance hip-hop, swim and paint during his spare time.
Adam Coster E-mail
Graduate student

Adam left the rolling corn fields of Iowa to get a B.A. in Biology at the University of Chicago, where he developed a love for both teaching and high-throughput drug screening. Following another round of drug screen development at Washington University in St Louis, Adam began his graduate career at UT Southwestern, where he hopes to inhabit a midpoint between biology and computer science. He is currently developing novel reagents and software for the exploration of the cell-cycle dependence of, and cross-talk between, dynamic protein networks.
Chien-Hsiang (Charles) Hsu E-mail
Research Scientist

Chien-Hsiang received his Master degree in bioinformatics from National Taiwan University. He is interested in applying statistics and machine learning techniques to analyze high-throughput data in biology. As a graduate student, he is trying to get a balance between being an pure analyst and an experimentalist. During his leisure time, he reads novels, plays guitar, or drives around the city.

Shanshan Liu (姗姗 刘), Ph.D. E-mail
Postdoctoral Researcher

Shanshan received her Ph.D. in Cancer Biology from Vanderbilt University, where she studied the role played by extracellular matrix proteins in cancer progression. She is interested in heterogeneity of cancer cell populations in vivo. In her spare time, she enjoys reading, games and shopping.


Jungseog Kang (강정석), Ph.D. E-mail
Assistant Instructor

Jungseog obtained his PhD in Biology in the University of Texas at Austin and received postdoctoral training in Hongtao Yu lab at Southwestern medical center. He is currently studying heterogeneity of cancer cells upon drug response. He likes to play wii games with his kids in his free time.
Nicholas Norris E-mail
Graduate Student

Nick originally hails from the beaches of Southern California. He earned his B.S. in Cellular and Molecular Biology from The Master's College, and is interested in the hormonal regulation of glucose metabolism. An amateur powerlifter, Nick also enjoys cooking, camping, and a well made cup of coffee.
Satwik Rajaram (सात्विक राजाराम), Ph.D. E-mail
Postdoctoral Researcher

Satwik received his Ph.D in Physics from the University of Illinois at Urbana-Champaign. He brings with him experience in bioinformatics, particularly in the context of variability in gene expression. Satwik would like to better understand the significance of such variability in the context of microscopy. Presently he is developing the framework for the next generation of image analysis tools for our lab. In his free time Satwik enjoys reading, listening to music and spending time with cats.
Michael Ramirez E-mail
Graduate Student

Mike was born in El Paso, TX, but spent his formative years in America’s Finest City, where he received his B.S. in Human Biology from the University of California, San Diego. Towards his Ph.D., he is exploiting the inevitable cellular heterogeneity in cancer cell populations as a tool for uncovering new targeted therapy resistance mechanisms. In his spare time, he enjoys playing guitar, cooking, and training his dog Myc.
Robert (Joey) Steininger III E-mail
Graduate Student

Joey, a native of Cambridge, Massachusetts, earned his S.B. in Chemical Engineering with a minor in Chemistry from M.I.T. As a graduate student, he hopes to use his engineering and biological training to understand biological systems and their responses to perturbations. In his spare time, Joey likes to play volleyball and piano.
Curtis Andrew Thorne, Ph.D. E-mail
Postdoctoral Researcher

Curtis received his Ph.D. in Cell and Developmental Biology from Vanderbilt University, where he took a chemical biology and systems-level approach to understanding Wnt signal transduction. His obsession with quantifying cellular events and understanding the structure of signaling pathways lead him to the Altschuler and Wu lab. Now Curtis is studying the physiological role of non-genetic cellular heterogeneity in development and cancer. In his free time, Curtis enjoys playing the guitar, canoeing, BBQing and doing anything with his lovely wife and son.
Chonlarat (Pearl) Wichaidit (ชลรัตน์ วิชัยดิษฐ), Ph.D. E-mail
Postdoctoral Researcher

Chonlarat has a Ph.D. in Electrical and Computer Engineering from the University of Wisconsin at Madison. After obtaining her Ph.D., she worked on problems in electromagnetics and plasma before joining the Altschuler and Wu laboratory. She has been fascinated by biology and wishes to apply her computational and analysis skills to understand biological phenomena.

Previous lab members.