James Allen Bibb, Ph.D.

April 26, 2005

Department of Psychiatry                                                                                         

University of Texas Southwestern Medical Center                                           

NC 5.410                                                                                                             Voice Phone:        (214) 648-4168

5323 Harry Hines Boulevard                                                                               TeleFAX:             (214) 649-1293

Dallas, Texas 75318-7090                                                                    E-mail: James.Bibb@UTSouthwestern.edu

 

EDUCATION:                         Doctor of Philosophy, 1994

                                                   Cellular and Developmental Biology Program  

                                                   Department of Biochemistry and Cellular Biology

                                                   State University of New York at Stony Brook

                                                   Stony Brook, New York

                                                   ÒMolecular and Cellular Characterization of the Poliovirus Receptor

   and Cell-Virus InteractionsÓ

                                                   Eckard Wimmer, Research Advisor

 

                                                   Master of Science, 1986

                                                   Department of Microbiology

                                                   University of Kentucky

                                                   Lexington, Kentucky

 

                                                   Bachelor of Science, cum laude, 1984

                                                   Biology and Chemistry

                                                   Murray State University

                                                   Murray, Kentucky

 

EMPLOYMENT RECORD:

 

8/2001-present     Assistant Professor and Laboratory Director, Department of Psychiatry, University of Texas Southwestern Medical Center, Graduate Faculty in Neuroscience

 

1998-8/2001:       Research Associate, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University

 

1996-1998:          Postdoctoral Fellow, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University

 

1994-1996:          Postdoctoral Associate, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University

 

1989-1994:          Doctoral Candidate, Research, and Teaching Assistant, Cellular and Developmental Biology Program, Department of Biochemistry and Cellular Biology, State University of New York at Stony Brook

 

1987-1989:          Research Instructor, Department of Cell Biology and Physiology, Washington University School of Medicine

 

1984-1987:          MasterÕs Candidate, Research and Teaching Assistant, Department of Microbiology, University of Kentucky

 

1982-1984:          Research and Teaching Assistant, Department of Biology, Murray State University

 

 

 

 

 

RESEARCH:

 

Neural Biochemistry Laboratory, University of Texas Southwestern Medical Center

The laboratory studies novel protein phosphorylation/dephosphorylation signaling events as they relate to normal cell function and neural disease.  This work seeks to biochemically characterize these events and determine their physiological function at the levels of individual cells, tissue, and the whole organism.  A question interest is the regulatory relationship between neurotransmission and neural outgrowth.  Clearly, such regulatory mechanisms involve neuronal protein kinases and phosphatases.  We are interested in identifying novel signaling events which regulate both neurotransmission and neurite outgrowth.  Other areas of interest include drug addiction, neurodegenerative diseases, and novel drug discovery.  Methodological approaches in the laboratory center around protein biochemistry and neuropharmacology.  A variety of molecular biological methods are used to generate purified proteins and reagents to characterize phosphorylation/dephosphorylation events in vitro.  Physical biochemistry techniques including phosphopeptide mapping, phosphoamino acid analysis, HPLC, and mass spectrometry are used to identify novel sites of phosphorylation.  Phosphorylation state-specific antibodies are then generated to study the signaling event of interest in vivo, using acutely prepared brain slices or whole animals.  Additionally, behavioral analysis, confocal microscopy and electrophysiological approaches are often  incorporated.

 

Research Associate, The Rockefeller University

April 1994-8/2001:  (Postdoctoral research) Signal transduction in neostriatal medium spiny neurons of the basal ganglia area of the brain, with emphasis on dopaminergic neurotransmission.  Study of normal brain function, and the causes and potential therapeutic treatments of neurological disorders including schizophrenia, drug abuse, ParkinsonÕs disease, HuntingtonÕs disease, and attention deficit hyperactive disorder.  One of the goals of this work was to correlate in vitro biochemical analysis with in situ signal transduction pathway modulation, electrophysiology, immunocytochemistry, and animal behavior.

 

HuntingtonÕs Disease Society of America Research Fellow, The Rockefeller University

August 1996-present:  Characterization of severe presymptomatic deficits in dopaminergic neurotransmission and neuronal function in HuntingtonÕs disease (HD) model animals.  Analysis of the normal cellular and aberrant (disease causing) function of huntingtin, the protein encoded by the Huntington's disease in medium spiny neurons of the basal ganglia.  The goal of this work was to determine why dopaminoceptive neurons of the striatum are specifically targeted in HD and how early events leading to neurodegeneration can be prevented.

                                           

Doctoral Candidate, Department of Microbiology, State University at Stonybrook

1989-1994:  Characterization of the poliovirus receptor (PVR) with regard to expression, posttranslational modification, and virus-receptor interactions.  Study of the cellular function of PVR.

 

Research Instructor, Department of Cell Biology and Physiology, Washington University

1987-1989:  Study of the role of cell membrane cationic/anionic conductance and intracellular pH in polymorphonuclear leukocyte activation, and development of therapeutic treatments for rheumatoid arthritis.

 

Graduate Student, Department of Microbiology, University of Kentucky

1985-1986:  Biochemical characterization and comparison of the capsid proteins of the 190S and 145S virus like particles of the yeast Helminthosporium victoria, the causitive agent of oat blight.

 

Undergraduate, Department of Biology, Murray State University

1982-1984  Coliphage detection in water.  Development of a novel filter elution method in order to quantify contamination levels in rural water sources.  Correlation of coliform, coliphage, and enteric virus quantification.  Field testing of hypothesis during an outbreak of hepatitis in rural Appalachia.

 

FELLOWSHIPS AND AWARDS:

 

PresidentÕs Research Council Distinguished Young Researcher Award, ÒThe Role of the Neuronal Protein Kinase Cdk5 in Modulating Neurotransmission and Plasticity in the Adult BrainÓ May 2002, Total Award: $60,000

 

National Institute of Health, National Institute of Neurological Diseases and Stroke, National Research Service Award, (5 F32 NS10161-02), ÒNovel Signal Transduction Pathways of the Basal GangliaÓ May, 1996-June 1998, Total Award: $64,000.

 

Huntington's Disease Society of America, Inc. Research Fellowship, Title: ÒPhospho-huntingtin, A Novel Approach to the Cause of HuntingtonÕs DiseaseÓ, May 1997-June 1998 Total Award:  $30,000.

 

Sigma Xi Scientific Research Society Award for Excellence in Research, 1993.

 

Honorary Membership to Sigma Xi Scientific Research Society, 1990.

 

Sigma Xi Scientific Research Society Award for Excellence in Research, 1984.

 

GRANTS AND SUPPORT:

 

Ongoing

 

2005, National Heart, Lung, and Blood Institute, Program Project 1 P50 HL077101-01, ÒGenetic and Molecular Signaling in Heart FailureÓ, Gerald W. Dorn, Principle Investigator, Funding start date: 1/1/2005

 

2004, National Institute of Mental Health, R01 Grant Application, ÒThe Role of Adenosine in Wake/Sleep TransitionÓ, Robert W. Greene and James A. Bibb, Coinvestigators, Amount allocated for studies conducted in the Bibb Lab: $67,500/year for 5 years.

 

2004 Sponsored Agreement with Intracellular Therapies, Inc., ÒCharacterization of Intracellular Signaling Pathways Activated by Caffeine and Adenosine Analogs  $123,750.

 

2003, NIH National Institute of Drug Abuse R01 DA016672-01, ÒRole of Cdk5 in Drug AddictionÓ, Total Award $175,000/year, 5 years.  Started 6/03.

 

2004 Tourette Syndrome Association Research Award Renewal, ÒIdentification of Proteins Involved in Tourette SyndromeÓ,Total Award 67.500 for 2004,   $75,000 for 2003.  Renewal started 6/04.

 

2003 Young Investigator Award from National Alliance for Research on Schizophrenia and Depression (NARSAD), ÒRole of Cdk5 in schizophreniaÓ, July, 2000-June, 2002, Total Award: $60,000.

 

2001, Department of Psychiatry Laboratory Startup Funding from the Hillcrest Foundation, Fritz and Marty Lyne Fund, Ella McFadden Charitable Trust Fund, Total Award: $500,000.

 

Recently completed

2002, Pilot Study Award from the Dorothy L. and John P. Harbin Chair Endowment for AlzheimerÕs Disease Research, Myron F. Weiner, M.D. Ò The Role of Cdk5 in AlzheimerÕs DiseaseÓ, May 2002-May 2003, Total Award: $30,000.

 

2000 Young Investigator Award from National Alliance for Research on Schizophrenia and Depression (NARSAD), ÒNovel Mechanisms of Dopamine RegulationÓ, July, 2000-June, 2002, Total Award: $60,000.

 

Huntington's Disease Society of America, Inc. Research Grant, ÒEffects of HuntingtonÕs Disease on Signal Transduction in the Basal GangliaÓ, July 1996- August, 1997, Total Award:  $35,000.00.

 

Pending Grant:

 

2005 National Institute of Mental Health, RO1 Grant Application MH071668-01, ÒThe Role of Cdk5 in Neuronal PlasticityÓ James A. Bibb, Principle Investigator, Revised proposal submitted March 1, 2004, Amounted Requested $250,000/year for 5 years.

 

 

PATENTS:

 

ÒMethods of identifying agents that regulate phosphorylation/dephosphorylation in dopamine signalingÓ, Filed Oct. 13, 2000, by J.A. Bibb and P. Greengard.

 

 

PUBLICATIONS:

 

Research Papers

 

Ohshima, T., Ogura H., Tomizawa, K., Hayashi, K,  Saito, T.,  Kamei, H., Bibb,  J.A., Hisanaga, S., Matsui, H. and K. Mikoshiba (2005) Defective learning and memory in p35-deficient mice, under revision J. Neurochem.

 

Wei, F.-Y., Tomizawa K., Ohshima, T.,Asada, A., Nguyen, C., Bibb, J.A., Ishiguro, K., Saito, T., Kulkarni, A.B., Pant H.C., Mikoshiba, K., Matsui, H., and S. Hisanaga (2005) Control of Cdk5 activity by glutamatergic regulation of p35 stability, J. Neurochem. 25:2933-2940.

 

Georgescu, D, Sears, R.M., Hommel, J.D., Barrot, M., Marsh, D.J., Bibb, J.A., Maratos-Flier, E., Nestler, E.J. and  DiLeone, R.J. (2005) The neuropeptide MCH controls feeding behavior via a novel hypothalamic-limbic circuit, J. Neurosci. 25:2933-2940.

 

Kansy, J., Daubner, S.C., Nishi, A., Soogaku, N., Lloyd M.D., Nguyen, C., Lu, L., Haycock , J., Hope, B.T., Fitzpatrick, P.F., and J.A. Bibb (2004) Identification of tyrosine hydroxylase as a physiological substrate of Cdk5,  J. Neurochem. 91:374-84.

 

Sahin, B., Kansy, J.W., Nairn, A.C., Spychala, J. Ealich, S.E., Fienberg, A.A., Greene, R.W., and J.A. Bibb (2004) Molecular characterization of mouse adenosine kinase, Eur. J. Biochem. 271:3547-3555.

 

Braz, J.C., Gregory, K., Pathak, A., Zhao, W, Sahin, B., Jones, F., Klevitsky, R., Kimball, T.R. John N. Lorenz, J.N., Nairn, A.C. Stephen B., Liggett, S.B.,  Bodi, I., Su Wang, S., Schwartz, A., Lakatta, E.G., DePaoli-Roach, A.A., Hewett, T.E., Bibb, J.A., Westfall, M.V., Kranias, E.G., and J.D. Molkenti (2004) PKCa regulates cardiac contractility and propensity towards heart failure, Nature Med. 10:248-54. Epub 2004 Feb 15.

 

Sahin, B. and J.A. Bibb (2004) Protein kinases talk to lipid phosphatases at the synapse, Proc. Natl. Acad. Sci. USA 101:112-113

 

Nguyen, C. and J.A. Bibb (2003) Cdk5 and the mystery of synaptic vesicle endocytosis, J. Cell Biology, 163:697-9.

Saito T., Onuki R., Fujita Y., Kusakawa G., Ishiguro K., Bibb J.A., Kishimoto T.,  and S. Hisanaga (2003), Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation, J. Neurosci. 23:1189-97.

Norholm, S., Bibb, J.A., Ouimet, C.C., Nestler, E.J., Taylor, J.R., and P. Greengard. (2003) Cocaine-induced proliferation of dendritic spines is dependent on the activity of cyclin-dependent kinase 5, Neuroscience 116:19-22.

Lindskog, M., Pozzi, L., Svenningsson, P., Fienberg, A., Bibb, J.A., Fredholm, B.B., Greengard, P., and G. Fisone (2002), The stimulant action of caffeine is mediated by an increase in the state of phosphorylation at the Cdk5 site of DARPP-32, Nature 428:774-748

 

Yan, Z., Chi, P., Bibb, J.A., Ryan, T.A., and P. Greengard (2002) Roscovitine: A novel regulator of P/Q-type calcium channels and transmitter release in central neurons, J. Physiol. 540:761-70.

 

Nishi, A., Bibb, J.A., Matsuyama, S., Hamada, M., Higashi, H., Nairn, A.C. and P. Greengard (2002) Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A, J. Neurochem. 81:832-41.

 

Bibb, J.A., Nishi, A., OÕCallaghan, J.P., Snyder, G.L., Horiuchi, A., Lan M., Ule, J., Pelech, S.L., Meijer, L., Saito, T., Hisanaga, T., Czernik, A.J., Nairn, A.C., and P. Greengard (2001) Phosphorylation of Protein Phosphatase Inhibitor-1by Cdk5, J. Biol. Chem. 276: 14490-14497.

 

Liu, F., Ma, X.-H., Ule, J., Bibb, J.A., Nishi, J.A., DeMaggio, A.J., Yan, Z., Nairn, A.C., and P.  Greengard (2001) Regulation of cyclin-dependent kinase 5 and casein kinase I by glutamate receptors, Proc. Natl. Acad. Sci. USA 98:11062-8

 

Bibb, J.A., Chen, J., Taylor, J.R., Svenningsson, P., Nishi, A., Snyder G.L., Yan, Z., Sagawa, Z.K., Nairn, A.C., Nestler, E.J., and P. Greengard (2001) Regulation of the effects of cocaine by Cdk5 in dopaminoceptive neurons in the brain, Nature 410:376-380.

 

Bibb, J.A., Snyder, G.L., Yan, Z., Pieribone, V.A., Nairn, A.C., Messer, A. and P. Greengard (2000) Severe deficits in dopamine signaling in presymptomatic HuntingtonÕs disease mice, Proc. Natl. Acad. Sci. USA 97:6809-6814.

 

Nishi, A., Bibb, J.A., Higashi, H., Nairn, A.C. and P. Greengard (2000) Amplification of dopaminergic signaling by a novel positive feedback loop, Proc. Natl. Acad. Sci. USA 97: 12840-12845.

 

Mani, S.K., Fienberg, A.A., OÕCallaghan, J.P., Snyder, G.L., Allen, P.B., Mitchell, A.J., Bibb, J.A., Greengard, P., and B.W. OÕMalley (2000) The neuronal phosphoprotein DARPP-32 is required for dopamine and progesterone-facilitated sexual behavior in female rodents, Science 287:1053-6.

 

Caporaso, G., Bibb, J.A., Snyder, G.L., Valle, C., Rakhilin, S, Fienberg, A.A., Hemmings Jr., H.H., Nairn, A.C., and P. Greengard (2000) Dopamine and drugs of abuse modulate phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the neostriatum, Neuropharmacology 39:1637-1644.

 

LeClerc, S, Garnier, M., Hoessel, R., Marko, D., Bibb, J.A., Mandelkow, E.-M., Eisenbrand, G., & L. Meijer (2000) Indirubins inhibit glycogen synthase kinase-3b and cdk5/p35, two protein kinases involved in abnormal tau phosphorylation in AlzheimerÕs disease – A property common to most cdk inhibitors?, J. Biol. Chem. 276: 251-260.

 

Leost, M., Schultz, C., Wu, Y.-Z., Biernat, J., Mandelkow, E.-M., Bibb, J.A., Snyder, G.L., Greengard, P., Zaharezvitz, D.W., Gussio, R., Senderovitz, A. Sausville, E.A., Kunick, C., and L. Meijer (2000) Paullones are potent inhibitors of glycogen synthase kinase-3b and cyclin-dependent kinase 5/p25, Eur. J. Biochem. 267:5983-5994.

 

Bibb, J.A., Snyder, G.L., Nishi, A., Zhen, Y., Meijer, L., Fienberg, A.A., Tsai, L.-H, Kwon, Y.T., Girault, J.-A., Czernik, A.J., Huganir, R.L., Hemmings Jr., H.C., Nairn, A.C., and P. Greengard (1999) Protein kinase and phosphatase control by distinct phosphorylation sites within a single regulatory protein, Nature 402:669-671.

 

Bibb, J.A., Bernhardt, G., and E. Wimmer (1994) The human poliovirus receptor PVR alpha is a serine phosphoprotein, J. Virol. 68:6111-6115.

 

Bibb, J.A., Bernhardt, G., and E. Wimmer (1994) Cleavage site of the poliovirus receptor signal sequence, J. Gen. Virol.  75:1875-1881.

 

Bibb, J.A., Witherell, G., Bernhardt, G., and E. Wimmer (1994) Interaction of poliovirus with its cellular binding site, Virology 201:107-115.

 

Bernhardt, G.*, Bibb, J.A.*, and E. Wimmer, (*equal contributors) (1994) Molecular characterization of the cellular receptor for poliovirus, Virology 199:105-113.

 

Ghabrial, S.A., Bibb, J.A., Price, K.H., Havens, W.M., and J.A. Lesnaw (1987) The capsid polypeptides of the 190S virus of Helminthosporium Victoria, J. Gen. Virol. 68:1791-1800.

 

 

Book Chapters and Reviews

 

Bibb, J.A., and Nestler, E.J. (2004) Serine and Threonine Phosphorylation, in Basic Neurochemistry: Molecular,  Cellular and Medical Aspects, 7h Ed., edited by G.J. Siegel et al., Lippincott-Raven Publishers, Philadelphia.

 

Benavides, D.R. and Bibb, J.A., (2004) The Role of Cdk5 in Drug Abuse and Plasticity, Current Status of Dependence/Abuse Studies: Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxcity, Volume 1025 of the Annals of the NewYork Adademy of Sciences, Ali, S.F., Nbeshima, T, and Yanagita, T eds.

 

Bibb, J.A. (2003) Role of Cdk5 in Neuronal Signaling, Plasticity, and Drug Abuse, Neurosignals ;12:191-199

 

Bibb, J.A. and E.F. da Cruz e Silva (1996) Identification of posttranslational modification sites by site-directed mutagenesis, in "Neuromethods, Vol. 30: Regulatory Protein Modification: Techniques and Protocols", pp. 275-307.  H.C. Hemmings Jr. (ed.), Humana Press Inc., Totowa, N.J.

 

Hemmings, H.C., Jr., Nairn, A.C., Bibb, J.A. and P. Greengard (1995) Signal transduction in the striatum:  DARPP-32, a molecular integrator of multiple signaling pathways, in "The Basal Ganglia" J. Surmeiyer (ed.).

 

Gromeier, M., Lu, H.-H., Bernhardt, G., Harbor, J.J., Bibb, J.A., and E. Wimmer (1994) The human poliovirus receptor:  Receptor-virus interaction and parameters of disease specificity, Annals of the New York Academy of Science 753:19-36.

 

Wimmer, E., Harbor, J.J., Bibb, J.A., Gromeier, M., Lu, H.-H., and G. Bernhardt (1994) Poliovirus receptors, in "Cellular Receptors for Animal Viruses",  pp 1-24. Wimmer (ed.), Cold Spring Harbor Laboratory Press.

 

Simchowitz, L. and J.A. Bibb, Functional analysis of the modes of anion transport in neutrophils and HL-60 cells (1990) Annual Review of Cell Physiology , 52, 381-397.

 

Abstracts

Kansy, J.W., Brown, A., Hendryx, A.D., Zabriskie, J.B, Lombroso, P.J., LEckman, J.F., Bibb, J.A.  (2004) Identification of pyruvate kinase as a protein associated with Tourette syndrome.  Program No 800.12. 2004 Abstract Viewer/Itinerary Planner. Washington DC: Society of Neuroscience.

 

Bibb, J.A. (2004) 7th Annual Chinese-American Beckman Frontiers of Science Symposium, Arnold and Mabel Beckman Center Irvine California, Oct. 23, ÒNeuronal Plasticity and Drug AddictionÓ

 

Bibb, J.A. (2003) Role of Cdk5 in Drug Abuse and Plasticity, Speaker and Co-Chair of Panel on Cdk5 and Neuropsychatric Disorders, American College of Neuropsychopharmacology 42nd Annual Meeting, Dec. 7-11, San Juan, Puerto Rico

 

Bibb, J.A. (2003) Role of Cdk5 in Drug Abuse and Plasticity, Speaker in Symposium Session on Signal Transduction Mechanisms in Drug Abuse and Addiction, Frontiers in Addiction Research, 2003 NIDA Mini-Convention, Society for Neuroscience Annual Meeting, Nov. 7, New Orleans, LA.

 

D.R. Benavides, M.D. Lloyd, S.C. Daubner, J. Kansy, L. Lu, J.W, Haycock, B.T. Hope, P. Fitzpatrick, and J.A. Bibb (2003) Phosphorylation of tyrosine hydroxylase by Cdk5.  Presented at 2003 NIDA Frontiers in Addiction Research Mini-Convention satellite conference at 33rd Annual Society for Neuroscience Conference in New Orleans, LA.

 

Bibb, J.A., (2003) Role of Cdk5 in Drug Abuse and Plasticity, Speaker in Session on ÒThe Neuronal Kinase Cdk5Ó The 26th Annual Meeting of the Japan Neuoroscience Society, Nagoya, Japan, July 23-25, also cited as:  Neuroscience Reseaerch Volume 46, sup. S18-1:S21.

 

Bibb, J.A. (2003) Role of Cdk5 in Neuronal Plasticity and Drug Abuse, Speaker in Session on Signal Transduction, International Society for Neurochemistry/Asian Pacific Society for Neurochemistry Sponsored Satellite Meeting: Cellular Mechanisms of Drugs of Abuse and Neurotoxicity, Jul 30-Aug. 1, Kyoto, Japan

 

Bibb, J.A. and A.A. Fienberg (2002) The role of Cdk5 in addiction, Frontiers in Addiction Research NIDA Satellite Symposium at the Annual Meeting of the Society for Neuroscience, Orlando, FL.

 

Norrholm, S., Bibb J.A., Nestler, E., Ouimet, C.C., Taylor, J.R., and P. Greengard (2001) Cocaine-induced dendritic spine proliferation is prevented by intra-accumbens infusions of the Cdk5 inhibitor roscovitine, Annual Meeting of the Society for Neuroscience, San Diego, CA.

 

Bibb, J.A., Chen, J., Svenningsson, P., Snyder, G.L., Yan, Z. Huganir, R.L., Nairn, A.C., Taylor, J.R., Nestler, E.J., and P. Greengard (2001) Regulation of the effects of chronic cocaine by Cdk5, Winter Conference on Brain Research, Jan. 20-27, Steamboat Springs, CO.

 

Snyder, G.L., Galdi, S., Bibb, J.A., Huganir, R.L., Nairn, A.C., and P. Greengard (2000) AMPA receptor phosphorylation during cocaine withdrawal, Winter Conference on Brain Research, Jan. 20-27, Steamboat Springs, CO.

 

Snyder, G.L., Bibb, J.A., Galdi, S., Huganir, R.L., Nairn, A.C., and P. Greengard (2000) Phosphorylation of the GluR1 AMPA receptor during cocaine exposure and withdrawal, Annual Meeting of the Society for Neuroscience, New Orleans, LA.

 

Lindskog, M., Svenningsson, P., Fienberg, A., Bibb, J.A., Greengard, P., Fredholm, B., and G. Fisone (2000) The effects of adenosine and caffeine on locomotor activity are mediated via DARPP-32 phosphorylation, Annual Meeting of the Society for Neuroscience, New Orleans, LA.

 

Bibb, J.A., Nishi, A., Nairn, A.C., and P. Greengard (2000) Novel mechanisms for regulation of dopamine neurotransmission, International Symposium on Neuronal Signaling and Protein Phosphorylation – Dephosphorylation, Spring Symposium of the Japanese Biochemical Society, June 3-5, Fukuoka, Japan.

 

Nishi, A., Bibb, J.A., Higashi, H., Nairn, A.C., and P. Greengard (2000) Dopaminergic regulation of DARPP-32 Thr75 phosphorylation by Cdk5 in neostriatal neurons, International Symposium on Neuronal Signaling and Protein Phosphorylation – Dephosphorylation, Spring Symposium of the Japanese Biochemical Society, June 3-5, Fukuoka, Japan.

 

Onofri, F, Giovedi, S., Bibb, J.A., Czernik, A.J., Valtorta, F., Greengard, P., and F. Benfenati (1999) Synapsin I is an endogenous activator of synaptic vesicle cSrc,  Annual Meeting of the Society for Neuroscience, Miami, FL.

 

Fernandez, J., Bibb, J. A., Mische, S., Greengard, P., and B. Imai (1999) Localization of HPLC purified phosphorylated peptides after enzymatic digestion of PVDF-bound proteins, Annual Meeting of the Associated Biopolymer Resource Facilities (ABRF), Raleigh NC March 19-22, 1999.

 

Bibb, J.A., Snyder, G.L., Yan, Z., Valle, C.G., Nairn A.C., and P. Greengard (1998) HD mice show attenuation of dopamine signaling targets, HuntingtonÕs Disease: New Progress, Neurology Service, Massachusetts General Hospital, New Seabury, MA.

 

Bibb, J.A., OÕCallaghan, J.P., Nishi, A., Nairn, A.C., Greengard, P., and A.J. Czernik (1997) Regulation of proline-directed phosphorylation of DARPP-32 and inhibitor-1 in the neostriatum, Annual Meeting of the Society for Neuroscience, New Orleans, LA.

 

Bibb, J.A., O'Callaghan, J.P., Pelech, S.L., Girault, J.-A., Nairn, A.C., Wang, J.H., Greengard P., and A.J. Czernik (1995) Phosphorylation of DARPP-32 and Inhibitor-1 by cyclin-dependent protein kinases, Annual Meeting of the Society for Neuroscience, San Diego, CA. November 11-16, 1995.

 

Bernhardt, G., Harbor, J., Zibert, A., Bibb, J., De Crombrugghe, M., and E. Wimmer (1993) Molecular and mutational analysis of the human poliovirus receptor, The IXth International Congress of Virology, Glasgow, Scotland.

 

Bibb, J.A., Bernhardt G., and E. Wimmer (1993) Characterization of the glycosylation of the poliovirus receptor, In Jour. Cell Biol. Suppl. 1993, Keystone Symposia Meeting on the Molecular Biology of Human Pathogenic Viruses.

 

Zibert, A., Selinka, H.-C., Bibb, J. and E. Wimmer (1990) Characterization of the human poliovirus receptor and its virus binding site, VIIIth International Congress of Virology, Berlin, Germany.

 

 Selinka, H.-C. Zibert, A.Harbor, J. Lu, H.-H., Bibb, J., and E. Wimmer (1990) Functional domain of the human poliovirus receptor, VIIIth International Congress of Virology, Berlin, Germany.

 

Ghabrial, S.A., Havens, W.M., Price, K.G., Bibb, J.A. and J.A. Lesnaw (1986) In vitro synthesis of capsid protein of the 190S virus from Helminthosporium victoria: Cell free translation of denatured dsRNA, American Society for Virology Annual Meeting.

 

Bibb, J.A.and T.W. Hejkal, (1984) A new method for detection of coliphage in water, American Society for Microbiology Annual Meeting, St. Louis, MO.

 

Bibb, J.A and T.W. Hejkal, (1983) The adsorption of coliphage to positively charged filters, American Society Microbiology Mid-South Regional Meeting, Louisville, Kentucky.

 

APPOINTMENTS, SOCIETIES AND JOURNAL AFFILIATIONS:     

 

Adjunct Faculty, The Rockefeller University 8/01-present

 

American Society for Neuroscience

 

American Association for the Advancement of Science

 

Reviewer to the Editor of the following journals:

 Biotechniques

European Journal of Biochemistry

Journal of Biological Chemistry

Journal of Neurochemistry

Neuropsychopharmacology

 

 

INVITED LECTURES:

 

ÒThe Genetics of AddictionÓ, Invited Speaker, 7th Annual Chinese-American Beckman Frontiers of Science Symposioum, Irvine California, 10.22-24, 2004

 

Conducting Basic Research on Tourette, Speaker to the Dallas Chapter of the TSA, Presbetarian Hospital,Dallas TX, 6/4/03.

 

Role of Cdk5 in Drug Abuse and Plasticity, Speaker and Co-Chair of Panel on Cdk5 and Neuropsychatric Disorders, American College of Neuropsychopharmacology 42nd Annual Meeting, 7-11/03, San Juan, Puerto Rico.

 

The Role of Cdk5 in Neuronal Plasticity and Drug Abuse, Case Western Reserve University, Department of Neurosciences Seminar Series, 11/3/03, Cleveland, OH.

 

Role of Cdk5 in Drug Abuse and Plasticity, Speaker in Symposium Session on Signal Transduction Mechanisms in Drug Abuse and Addiction, Frontiers in Addiction Res., 2003 NIDA Mini-Convention, Society for Neuroscience, Annual Meeting, 11/7/03, New Orleans, LA.

 

Role of Cdk5 in Drug Abuse and Plasticity, Speaker in Session on ÒThe Neuronal Kinase Cdk5Ó The 26th Annual Meeting of the Japan Neuroscience Society, Nagoya, Japan, July 23-25/03

 

Role of Cdk5 in Neuronal Plasticity and Drug Abuse, Speaker in Session on Signal Transduction, International Society for Neurochemistry/Asian Pacific Society for Neurochemistry Sponsored Satellite Meeting: Cellular Mechanisms of Drugs of Abuse and Neurotoxicity, 7/30-8/1/03, Kyoto, Japan

 

The Role of Cdk5 in the Regulation of Dopamine Neurotransmission and Addiction, Speaker in Panel on A Pivotal Role for Cdk5 in Mechanisms of Neurodegeneration and Addiction at Winter Conference on Brain Research, Snowmass, Colorado, January 29, 2002.

 

ÒThe Role of Cdk5 in the Regulation of Dopamine Neurotransmission and AddictionÓ, Winter Conference on Brain Research, Snowmass, Colorado, January 29, 2002.

 

ÒDevelopment of Novel Reagents and Techniques for the Study of Neurological DisordersÓ, Cell Signaling Technology, Inc., Beverly, Massachusetts, scheduled May 10, 2001.

 

ÒTargeting Signal Transduction in the Development of Treatments for Neurological DisordersÓ, Advanced Medicine, Inc., Department of Biochemistry, South San Francisco, California, January 29.2001.

 

ÒThe Role of Cdk5 in Regulating the Dopamine Signaling CascadeÓ, CNS Discovery, Pfizer Global Research and Discovery, Groton, Connecticut, December 8, 2000

 

ÒThe Role of the Neuronal Kinase Cdk5 in Dopamine Signaling and Cocaine AbuseÓ, Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan, June 9, 2000.

 

ÒNovel Dopamine Signaling Pathways and Attenuation Mechanisms in Cocaine AbuseÓ, Department of Psychiatry, Yale University, New Haven, Connecticut, March 27, 2000.

 

ÒRegulation and Dysregulation of Dopamine SignalingÓ Department of Neurobiology and Behavior, State University of New York at Stony Brook, January 27, 2000.

 

ÒNew Information on Signal Transduction in the Basal GangliaÓ, Center for Molecular Medicine, The Karolinska Institute, Stockholm, Sweden, January 13, 2000.

 

Ò"Molecular Mechanisms Mediating Effects of Dopamine in the Brain"Ó, Department of Neurochemistry, School of Medicine, University of Olso, Norway, January 17, 2000.

 

ÒDevelopment of Novel Therapeutic Treatments for Neurological Disorders Involving Dysregulation of Dopaminergic NeurotransmissionÓ, Hoechst Marion Roussel, Inc., Division of Neuroscience, Bridgewater, New Jersey, July 16, 1999.

 

ÒRegulation of Dopamine Neurotransmission by Cyclin-dependent KinasesÓ National Institutes of Occupational Safety and Health, Center for Disease Control, Morgantown West Virginia, February 23, 1999.

 

ÒHD Mice Show Attenuation of Dopamine Signaling TargetsÓ HuntingtonÕs Disease: New Progress, Neurology Service, Massachusetts General Hospital, New Seabury, Massachusetts, August 23, 1998.

 

ÒThe Role of Cdk5 in Dopamine Signaling in the BrainÓ, Centre Nationale de la Recherche Scientifique

Station Biologique, Roscoff, France, April 15, 1998.