Boothman Laboratory
Research Personnel Contact About Dr. Boothman

Dr. Boothman grew up in Detroit, Michigan and went to the University of Michigan-Ann Arbor for his B.S.  He received his Ph.D. in Microbiology and Immunology (Mentor: Dr. Sheldon Greer), University of Miami Medical School, focusing on the Biochemistry and Pharmacology of anticancer drugs, specifically 5-fluorouracil derivatives.  He then traveled to the Dana-Farber Cancer Institute, Harvard Medical School to train with Dr. Arthur B. Pardee.  He investigated the cell cycle checkpoint regulation, molecular biology and gene expression changes in cancer cells before and after cell stress.  Studies on ß-lapachone as a radiosensitizer and DNA repair inhibitor were initiated at this time.  Dr. Boothman also discovered and cloned the first ionizing radiation (IR)-inducible proteins and transcripts.

           In 1990, Dr. Boothman accepted his first Assistant Professor position at the University of Michigan-Ann Arbor and continued his investigations of x-ray-inducible proteins, discovering xip8, clusterin, and its induction by super-low levels of IR exposure.  Dr. Boothman then joined the faculty in the Department of Human Oncology at the University of Wisconsin-Madison, where he rose to Associate Professor with tenure and became the Vice Chairman of Radiation Oncology, Division Head of Molecular Radiation Oncology.  In 1998, Dr. Boothman accepted an Endowed Professorship at Case Western Reserve University and became heavily involved in the Cancer Center.  In 2000, he became the Associate Director for Basic Science and headed the research effort in the Cancer Center’s Wolstein Research Building.

     In 2005, Dr. Boothman and his close colleague Dr. Jinming Gao moved to the University of Texas Southwestern Medical Center at Dallas to start the “Cell Stress and Cancer Nanomedicine Program”.  Dr. Boothman is also the Associate Director for Translational Research within the Simmons Comprehensive Cancer Center and the Robert and Virginia Payne Endowed Professor of Oncology.

           Dr. Boothman has trained over ten Ph.D. students and nearly thirty post-doctoral fellows, and residents who enjoy positions around the nation and in seven different countries in various aspects of scientific research.  Dr. Boothman’s laboratory is supported by grants from the Department of Defense, Department of Energy and the National Institutes of Health.  We have been fortunate to have the continuing support of Dr. and Mrs. Sara Hildebrand.

University of Texas Southwestern Medical Center at Dallas - Simmons Comprehensive Cancer Center