I am interested in understanding how chromatin modifications affect stem cell identify. To answer this question, we are using ends-out homologous recombination to knock-out entire gene families of chromatin-modifying enzymes. Specifically, we are characterizing histone demethylases and histone deacetylases and assessing their null phenotypes on stem cell populations of the Drosophila ovary.
I am interested in translational regulation during differentiation. Currently, I am trying to elucidate the molecular function of A2BP1 in the germline. This is a RNA binding protein required for proper oocyte differentiation as the mutant ovaries cannot enter into meiosis and developed tumors.
I study the role certain chromatin modifiers in stem cell maintenance. The focus is on members of a transcriptional complex. Interestingly, these genes have a chronology and context dependent phenotype.