• Carroll, T.J. and Vize, P. The Wilms’ tumor suppresser gene is involved in the development of disparate kidney forms: evidence from expression in the Xenopus pronephros. Developmental Dynamics 206:131-138, 1996.
  • Wallingford, J., Carroll, T.J., and Vize, P. Precocious expression of the WT1 gene product blocks differentiation of the pronephros. Developmental Biology 202, 103-112, 1998.
  • Carroll, T.J., Wallingford, J, B. and Vize, P. Dynamic patterns of gene expression in the developing pronephros of Xenopus laevis. Developmental Genetics, 24 (3/4), 199-207, 1999.
  • Carroll, T. J. and Vize, P. Synergism between Pax-8 and Lim-1 in embryonic kidney development. Developmental Biology, 214(1), 46-59, 1999.
  • Yu, J., Carroll, T.J., and McMahon, A.P. Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development, 129:5301-12, 2002.
  • Rubera I., Loffing J., Palmer L.G., Frindt G., Fowler-Jaeger N., Sauter D., Carroll T., McMahon A., Hummler E., Rossier B.C. Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest. 112(4):554-65, 2003.
  • Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, Wilson PD, Costantini FD, Mason IJ, Licht JD. Sprouty1 Is a Critical Regulator of GDNF/RET-Mediated Kidney Induction. Developmental Cell. 8(2):229-239, 2005.
  • Carroll TJ, Park JP, Hayashi S, Majumdar A, McMahon AP. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Developmental Cell. 9: 283-292, 2005.
  • Lobov I, Rao S, Carroll T, Vallance J, Ito M, Ondr J, Glass D, Patel M, Shu W, Morrisey E, McMahon A, Karsenty G, Lang R, Kurup S. Wnt7b mediates macrophage-induced programmed cell death. Nature, 437: 417-421, 2005.
  • Batourina, E., Tsai, S., Lambert, S., Sprenkle, P., Viana, R., Dutta, S., Hensle, T., Wang, F., Niederreither, K., McMahon, A.P., Carroll, TJ and Mendelsohn, C. Distal ureter morphogenesis depends on apoptosis induced by signals from the urogenital sinus: A new model of ureter maturation. Nature Genetics,37(10) 1082-9, 2005.
  • Juriloff, DM, Harris, MJ, McMahon, AP, Carroll, TJ and Lidral, AC. Wnt9b is the Mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test. Birth Defects Research (Part A) 76(8): 574-9, 2006.
  • Tu, X, Joeng, KS, Nakayama, KI, Nakayama, K, Rajagopal, J, Carroll, TJ, McMahon, AP, Long, F. Noncanonical Wnt Signaling through G Protein-Linked PKCdelta Activation Promotes Bone Formation. Dev. Cell, 12(1): 113-27, 2007.
  • Ma, Z., Gong, Y., Patel, V., Karner, C.M., Fischer. E., Hiesberger. T., Carroll, T.J., Pontoglio, M., Igarashi, P. Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3. Proc Natl Acad Sci U S A. 104:20386-91, 2007.
  • Marose, TD, Merkel, CE, McMahon, AP, Carroll, TJ. beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev. Biol.; 314; 112-26, 2008.
  • Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development. 135:1625-34, 2008.
  • Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, McMahon AP. Six2 governs a multipotent nephron progenitor population. Cell Stem Cell, 3(2):169-81, 2008.
  • Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science, 322:1247-50, 2008.
  • Grote D, Boualia SK, Souabni A, Merkel C, Chi X, Costantini F, Carroll T, Bouchard M. Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genetics 4(12) 2008.
  • Yu, J., Carroll, T.J., Rajagopal, J., Kobayashi, A., Ren, Q., McMahon, A.P. A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development; 136: 161-171, 2009.
  • Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ. Wnt9b Signaling regulates planar cell polarity and kidney tubule morphogenesis. Nature Genetics, 41: 793-9, 2009.
  • Li L, Zepeda-Orozco D, Patel V, Truong P, Karner CM, Carroll TJ, Lin F. Aberrant planar cell polarity induced by urinary tract obstruction. Am J Physiol Renal Physiol. Dec;297(6):F1526-33, 2009.
  • Lin SL, Li B, Rao S, Yeo EJ, Hudson TE, Nowlin BT, Pei H, Chen L, Zheng JJ, Carroll TJ, Pollard JW, McMahon AP, Lang RA, Duffield JS. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A. 107(9):4194-9, 2010.
  • Karner, CM, Dietrich, M, Johnson, EM, Carroll, TJ*, Herz, J*. Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation in mice and humans. P.L.O.S One. 5(4):e10418. * Co-corresponding authors.
  • Karner, CM, Merkel, CE, Dodge, M, Ma, Z, Lu, J , Chen, C, Lum, L, Carroll TJ. Tankyrase is necessary for canonical Wnt signaling during kidney development. Developmental Dynamics, 239: 2014-23, 2010.
  • Smeeton, J., Zhang, X., Bulus, N., Mernaough, G., Lange, A., Karner, CM., Carroll, TJ., Faessler, R., Pozzi, A., Rosenblum, ND., Zent, R. Integrin linked kinase regulates p38MAPK-dependent cell cycle arrest in ureteric bud development. Development, 137(19): 3233-43, 2010.
  • Karner CM, Das A, Ma Z, Self M, Oliver G, Chen C, Lum L, Carroll TJ. Canonical Wnt9b signaling balances progenitor cell expansion during renal development. Development, 138(7): 1247-57, 2011.
  • Peng, Y., Clark, C., Luong, R., Tu, W.H., Lee, J., Johnson, D.T., Das, A., Carroll, T.J., Sun, Z. Leucine Zipper Putative Tumor Suppressor 2, LZTS2, Regulates Kidney Development. J Biol Chem. 2011 Nov 18;286(46):40331-42.
  • Liu Y, Sugiura Y, Wu F, Mi W, Taketo MM, Cannon S, Carroll T, Lin W. ?-Catenin stabilization in skeletal muscles, but not in motor neurons, leads to aberrant motor innervation of the muscle during neuromuscular development in mice. Dev Biol. 2012 Jun 15;366(2):255-67.
  • Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L. Diverse chemical scaffolds support direct inhibition of the membrane bound O-acyltransferase Porcupine. J Biol Chem. 2012 May 15.



  • Vize, P.D., Seufert, D.W., Carroll, T. J., and Wallingford, J.B. (1997) Model Systems for the Study of Kidney Development: Use of the Pronephros in the Analysis of Organ Induction and Patterning. Developmental Biology 188, 189-204.
  • Carroll, T.J., Wallingford, J., Seufert, D., and Vize, P. (1999. Molecular mechanisms of pronephros development. Current Topics in Developmental Biology, vol. 44, 67-100.
  • Carroll, T.J. and McMahon, A.P. (2000) Secreted Molecules in Metanephric Induction. American Journal of Nephrology. 11, S116-9.
  • Karner, C, Wharton, KA, Carroll, TJ. (2006) Planar cell polarity and vertebrate organogenesis. Seminars in Cell and Developmental Biology. 17(20 194-203.
  • Karner, C, Wharton, KA, Carroll, TJ. (2006) Apical-basal polarity, Wnt signaling and vertebrate organogenesis. Seminars in Cell and Developmental Biology, 17(2):214-222.
  • Merkel, C.E., Karner, C.M. and Carroll, TJ (2007) Molecular Regulation of Kidney Development; Is the answer blowing in the Wnt? Pediatric Nephrology; Nov; 22(11): 1825-38.
  • Carroll TJ, Das A. (2011) Planar cell polarity in kidney development and disease. Organogenesis. 2011 Jul 1;7(3). [Epub ahead of print]
  • Carroll TJ. (2011) PCP goes organic. Organogenesis. 2011 Jul 1;7(3). [Epub ahead of print]



  • Vize P.D., Carroll T.J. and Wallingford J.B. (2003) Induction, Development, and Physiology of the Pronephric Tubules. In: The Kidney; From Normal Development to Congenital Disease Eds. Vize, P.D., Woolf, A.S. and Bard, J.B.L., Academic Press Boston.
  • Carroll, T.J. and McMahon, A.P. (2003) Overview: The Molecular Basis of Kidney Development. In: The Kidney; From Normal Development to Congenital Disease Eds. Vize, P.D., Woolf, A.S. and Bard, J.B.L., Academic Press Boston.