| 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 |
Targeting
telomerase for cancer therapeutics
British Journal
of Cancer 1-8 (2008)
Telomere
Dynamics in Macaques and Humans
Journal of Gerontology: BIOLOGICAL SCIENCES 62A(4):
367374 (2007)
Immortalization
of epithelial progenitor cells mediated by resveratrol
Oncogene
1–10 (2007)
Human
diseases of telomerase dysfunction: insights into tissue aging
Nucleic Acids Research
1-11 (2007)
Seeding
drug discovery: integrating telomerase cancer biology and cellular senescence
to uncover new therapeutic opportunities in targeting cancer stem cells
Drug Discovery Today 12(15/16):
611-621 (2007)
Tissue
Culture as a Hostile Environment: Identifying Conditions for Breast Cancer
Progression Studies
Cancer Cell 12: 100-101 (2007)
Cellular
senescence in human myoblasts is overcome by human telomerase reverse
transcriptase and cyclindependent kinase 4: consequences in aging muscle
and therapeutic strategies for muscular dystrophies
Aging Cell online (2007)
Adult-onset
pulmonary fibrosis caused by mutations in telomerase
PNAS 104(18); 7552-7557 (2007)
Antiadhesive
Effects of GRN163LAn Oligonucleotide N3' P5' Thio-Phosphoramidate Targeting
Telomerase
Cancer Research
67(3): 1121-1129 (2007)
Hallmarks
of telomeres in ageing research
Journal of Pathology 211:
114-123 (2007)
Inexpensive
low-oxygen incubators
Nature Protocols 1(4): 2088-2090 (2006)
Nonradioactive
detection of telomerase activity using the telomeric repeat amplification
protocol
Nature Protocols 1(3): 1583-1590 (2006)
Telomerase
therapeutics for cancer: challenges and new directions
Nature Reviews Drug Discovery (online) 2006
POT1
protects telomeres from a transient DNA
damage response and determines how human
chromosomes end
The EMBO Journal 24: 2667-2678 (2006)
Time,
tumours and telomeres
Meeting on Cancer and Aging
EMBO Reports
7(5): 479-483 (2006)
A
three-dimensional model of differentiation of immortalized human bronchial
epithelial cells
Differentiation 74: 141-148
(2006)
Multiple
Oncogenic Changes (K-RASV12, p53 Knockdown, Mutant EGFRs, p16 Bypass,
Telomerase) Are Not Sufficient to Confer a Full Malignant Phenotype on
Human Bronchial Epithelial Cells
Cancer Research 66(4):. 2116-2128 (2006)
Human
Telomeres Have Different Overhang Sizes at Leading versus Lagging Strands
Molecular
Cell 21: 427435 (2006)
The
involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs
at human telomeres
EMBO reports 7: 225230
(2006)
Use
of Telomerase to Create Bioengineered Tissues
Ann. N.Y. Acad. Sci. 1057: 479491 (2005).
Effects
of a novel telomerase inhibitor, GRN163L, in human breast cancer
Breast Cancer
Research and Treatment
DOI 10.1007/s10549-005-9043-5 (2005)
Telomere
Biology in Aging and Cancer
Journal of the
American Geriatrics Society 53 S292-S294 (2005)
Fine-Tuning
the Chromosome Ends
The Last Base of Human Telomeres
Cell Cycle 4(11)
108-111 (2005)
In
vivo Inhibition of Lung Cancer by GRN163L: A Novel Human Telomerase Inhibitor
Cancer Research
65(17) 7866-7873 (2005)
Function
of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene
(TERT) in Human and Mouse Cells
Molecular
and Cellular Biology 25(18) 8037–8043 (2005)
BRAF(E600)-associated
senescence-like cell cycle arrest of human naevi
Nature 436(4) 720-724 (2005)
Telomerase
as a therapeutic target in cancer
Drug Discovery
Today: Disease Mechanisms 2 (2) 159-164 (2005)
Lipid
modification of GRN163, an N30'-P50; thio-phosphoramidate oligonucleotide,
enhances the potency of telomerase inhibition
Oncogene Short Report 17 (2005)
Lagomorphs
(rabbits, pikas and hares) do not use
telomere-directed replicative aging in vitro
Mechanisms of Ageing
and Development 126; 685–691 (2005)
The
Longevity Gender Gap: Are Telomeres the Explanation?
Sci. Aging Knowl.
Environ.
2005(23) (2005)
Meeting
Report: The Role of Telomeres and Telomerase in Cancer
Cancer Research 65(9); 3513-3517 (2005)
Telomere-End
Processing: the Terminal Nucleotides of Human Chromosomes
Molecular Cell 18; 131138
(2005)
Shared
Phenotypes Among Segmental Progeroid Syndromes Suggest Underlying Pathways
of Aging
Journal of Gerontology: BIOLOGICAL SCIENCES
60A(1); 10-20 (2005)
Telomere-binding
factors and general DNA repair
Nature Genetics
37(2); 116-118 (2005)
Human
Telomeres Maintain Their Overhang Length at Senescence
Molecular and Cellular Biology 25(6); 2158-2168
(2005)
Does
Telomerase Moonlight?
The Scientist 19(4);
18-19 (2005)
Characterization
of Growth and Differentiation in a Telomerase-Immortalized Human Corneal
Epithelial Cell Line
Investigative Ophthalmology & Visual Science
46(2); 470-8 (2005)
Mechanism-based
combination telomerase inhibition therapy
Cancer Cell 7; 1--2 (2005)
Senescence
and immortalization: role of telomeres and telomerase
Carcinogenesis 26(5); 867-874 (2005)
Immortalization
of Human Bronchial Epithelial Cells in the Absence of Viral Oncoproteins
Cancer Research 64; 90279034 (2004)
Disparate
effects of telomere attrition on gene expression during replicative senescence
of human mammary epithelial cells cultured under different conditions
Oncogene 23; 61936198 (2004)
Analysis
of Mammalian Telomere Position Effect
Methods Mol Biol.
287; 121-136 (2004)
Asynchronous
replication timing of telomeres at opposite arms of mammalian chromosomes
PNAS 101(35); 1292812933
(2004)
A
Reproducible Laser-Wounded Skin Equivalent Model to Study the Effects
of Aging In Vitro
Rejuvenation Research 7(2); 99-110 (2004)
Does
a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?
Molecular Biology
of the Cell 15; 37093718 (2004)
The
Frequency of Homologous Recombination in Human ALT Cells
Cell Cycle 3(5); 547-549
(2004)
Telomeres
Are Double-Strand DNA Breaks Hidden from DNA Damage Responses
Molecular Cell 14(4); 420-421 (2004)
Telomeric
Recombination in Mismatch Repair Deficient Human Colon Cancer Cells after
Telomerase Inhibition
Cancer Research 64; 34443451 (2004]
Telomeres
in dyskeratosis congenita
Nature Genetics 36(5); 437-438 (2004)
Hallmarks
of senescence in carcinogenesis and cancer therapy
Oncogene 23; 29192933 (2004)
Modification
of Subtelomeric DNA
Molecular and Cellular
Biology 24(10); 4571-4580 (2004)
Spontaneous
Immortalization of Clinically Normal Colon-Derived Fibroblasts from a
Familial Adenomatous Polyposis Patient
Neoplasia 6(3); 265272
(2004)
Spontaneous
reactivation of a silent telomeric transgene in a human cell line
Chromosoma 112; 240–246 (2004)
Analysis
of Telomeres and Telomerase
CURRENT PROTOCOLS
IN CELL BIOLOGY
CHAPTER 18. CELLULAR AGING AND DEATH
UNIT 18.6 Analysis of Telomeres and Telomerase (2003)
Differential
Gene Expression Profiles Between Neuroblastomas With High Telomerase Activity
and Low Telomerase Activity
Journal of Pediatric Surgery
38 (12); 730-1734 (2003)
Homologous
Recombination in Human Telomerase-Positive and ALT Cells Occurs With the
Same Frequency
EMBO reports 4(12); 1138-1143 (2003)
Telomerase
Therapeutics: Telomeres Recognized as a DNA
Damage Signal
Clinical Cancer Research
9(10); 3521–3525 (2003)
Developmental
Differences in the Immortalization of Lung Fibroblasts by Telomerase
Aging Cell 2(5); 1-9
(2003)
Telomere
Dysfunction: A Potential Cancer Predisposition Factor
Journal of the National Cancer Institute,
95(16); 1211-1218 (2003)
Myofibroblast
Differentiation of Normal Human Keratocytes and hTERT, Extended-Life Human
Corneal Fibroblasts
Investigative Ophthalmology & Visual Science
44(5);1850-1858 (2003)
A
Peroxisome Proliferator-activated Receptor-gamma Agonist and the p53 Rescue
Drug CP-31398 Inhibit the Spontaneous Immortalization of Breast Epithelial
Cells
Cancer Research
63; 1914–1919 (2003)
Characterisation
of telomerase immortalised normal human oesophageal squamous cells
Gut 52; 327-333 (2003)
Bypass
of telomere-dependent replicative senescence (M1) upon overexpression
of Cdk4 in normal human epithelial cells
Oncogene 22; 433444
(2003)
Human
Telomerase Can Immortalize Indian Muntjac Cells
Experimental Cell
Research
281; 6376 (2002)
p16INK4a
inactivation is not required to immortalize human mammary epithelial cells
Oncogene 21; 7897–7900
(2002)
Is
There an "Anti-aging" Medicine?
International Longevity Center - USA
Journal of Gerontology: BIOLOGICAL SCIENCES 57A (9); B333-B338
(2002)
Telomerase:A
target for cancer therapeutics
Cancer Cell 2; 257-265 (2002)
Human
Ku70/80 Associates Physically with Telomerase through Interaction with
hTERT
The Journal of Biological Chemistry 277 (49);4724247247
(2002)
Human
Telomerase and Its Regulation
Microbiology and Molecular Biology Reviews 66(3);
407425 (2002)
Telomerase
Immortalization of Human Myometrial Cells
Biology of Reproduction 67; 506514 (2002)
Historical
claims and current interpretations of replicative aging
Nature Biotechnology 20; 682-688 (2002)
Telomerase
in cancer and aging
Critical Reviews in Oncology/Hematology 41; 29-40
(2002)
Telomerase
and differentiation in multicellular organisms: Turn it off, turn it on,
and turn it off again
Differentiation 69; 188197 (2002)
Oligonucleotide
N3'–›P5' phosphoramidates as efficient telomerase inhibitors
Oncogene 21; 638-642
(2002)
A
model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase
regulation
Oncogene
21; 580-583 (2002)
Telomere
Biology and Cellular Aging in Nonhuman Primate Cells
Experimental Cell
Research 272; 146152 (2002)
Telomerase
regulation: not just flipping the switch
Current Opinion
in Genetics & Development 12; 8085 (2001)
Quantitation
of telomerase components and hTERT mRNA splicing patterns in immortal
human cells
Nucleic Acids Research 29(23); 4818-4825 (2001)
Telomerase
inhibitors -- Oligonucleotide phosphoramidates as potential therapeutic
agents
Nucleosides, Nucleotides & Nucleic Acids 20(47);
401410 (2001)
Treatment
of Malignant Glioma Cells with the Transfer of Constitutively Active Caspase-6
Using the Human Telomerase Catalytic Subunit (Human Telomerase Reverse
Transcriptase) Gene Promoter
Cancer Research 61; 5796-5802 (2001)
Telomere
shortening and decline in replicative potential as a function of donor
age in human adrenocortical cells
Mechanisms of Ageing and Development 122; 1685-1694
(2001)
Telomerase
Can Inhibit the Recombination-based Pathway of Telomere Maintenance in
Human Cells
The Journal of
Biological Chemistry 276(34); 32198-32203 (2001)
Immunohistochemical
Detection of Telomerase (hTERT) Protein in Human Cancer Tissues and a
Subset of Cells in Normal Tissues
Neoplasia 3(1);
17-26 (2001)
The
La antigen associates with the human telomerase ribonucleoprotein and
influences telomere length in vivo
RNA 7; 1068-1075
(2001)
Telomere
Position Effect in Human Cells
Science 292:
2075-2077 (2001)
Telomeresand
Telomerase: Implications for Cancer and Aging
Radiation Research 155:188193 (2001)
Characterization
of ataxia telangiectasis fibroblasts with extended life-span through telomerase
expression
Oncogene 20:278-288 (2001)
Telomerase
and cancer
Human Molecular Genetics 10(7) 677-685 (2001)
Putative
telomere-independent mechanisms of replicative aging reflect inadequate
growth conditions
Genes and Development 15:398-403 (2001)
Telomerase
and breast cancer
Breast Cancer Research 3:146-149 (2001)
Telomerase
inhibitors
TRENDS in Biotechnology 19(3):114-120 (2001)
Immortalizing
Human Cells with Telomerase
WWW.Ergito.com
When
Do Telomeres Matter?
Science 291:839-840 (2001)
Cellular
senescence as a tumor-protection mechanism: the essential role of counting
Current Opinions in Genetics and Development 11:98-103
(2001)
Effects
of Chemopreventive and Antitelomerase Agents on the Spontaneous Immortalization
of Breast Epithelial Cells
Journal of National Cancer Institute
93(1):39-45 (2001)
Ageing
and cancer: the telomere and telomerase connection
Novartis Foundaton
Symposium
(2001)
An
Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits
Telomerase Activity
Neoplasia 2(5):433-440 (2000)
Heterogeneous
Nuclear Ribonucleoproteins C1 and C2 Associate with the RNA Component
of Human Telomerase
Molecular and Cellular Biology 20(23):
9084-9091 (2000)
Hayflick,
his limit, and cellular ageing
Nature 1:72-76 (2000)
Telomere
Dynamics in Cells with Introduced Telomerase: A Rapid Assay for Telomerase
Activity on Telomeres
Molecular Cell Biology Research Communications
3:312-318 (2000)
Telomere
dynamics in cancer progression and prevention: fundamental differences
in human and mouse telomere biology
Nature Medicine 6(8):849-851
(2000)
Transient
Expression of Human Telomerase Extends the Life Span of Normal Human Fibroblasts
Biochemical and Biophysical Research Communications
273:1095-1098 (2000)
Implications
of mapping the human telomerase gene (hTERT) as the most distal gene on
chromosome 5p
Neoplasia
2(3):195-196 (2000)
Telomere
shortening is proportional to the size of the 3' G-rich telomeric overhang
The Journal of Biological Chemistry
275(26):19719-19722 (2000)
Subsenescent
telomere lengths in fibroblasts immortalized by limiting amounts of telomerase
The Journal of Biological Chemistry
275(14):10072-10076 (2000)
The
establishment of telomerase-immortalized cell lines representing human
chromosome instability syndrome
Human Molecular Genetics 9(3):403-411
(2000)
The
use of telomerized cells for tissue engineering
Nature Biotechnology 18:22-23
(2000)
Telomerase
Cancer Research, An Encylopedic Reference
880-886 (1999)
Inhibition
of human telomerase in immortal human cells leads to progressive telomere
shortening and cell death
PNAS 96(25):14276-14281
(1999)
At
the end of the millennium, a view of the end
Nature Genetics 23:382-383
(1999)
Mutant
dyskerin ends relationship with telomerase
Science 286:2284-2285 (1999)
Two
inactive fragments of the integral RNA cooperate to assemble active telomerase
with the human protein catalytic subunit (hTERT) in vitro
Molecular and Cellular Biology 19(9):6207-6216
(1999)
Both
transcriptional and posttranscriptional mechanisms regulate human telomerase
template RNA levels
Molecular and Cellular Biology
19(6):3989-3997 (1999)
Functional
requirement of p23 and Hsp90 in telomerase complexes
Genes and Development 13:817-826
(1999)
Telomeres
and telomerase in the regulation of human cellular aging
Molecular Biology of Aging: Alfred Benzon Symposium 44:
148-158 (1999)
Toward
identifying a cellular determinant of telomerase repression
Journal of the National Cancer Institute 91(1):
4-9 (1999)
Telomerase
activity does not always imply telomere maintenance
Biochemistry and Biophysics Research Communications
254:795-803 (1999)
Absence
of cancer-associated changes in human fibroblasts immortalized with telomerase
Nature Genetics 21:115-118
(1999)
Telomerase
Activity in Lung Cancer Cells Obtained from Bronchial Washings
Journal of the National Cancer Institute 90(9); 684-690 (1998)
Extension
of life-span by introduction of telomerase into normal human cells
Science 279:349-353 (1998)
Reconstitution
of human telomerase with the template RNA component hTR and the catalytic
protein subunit hTRT
Nature Genetics
17: 498-502
(1997)
A
Survey of Telomerase Activity in Human Cancer
European Journal of Cancer 33(5):787-791
(1997)
Regulation
of telomerase activity in immortal cell lines
Molecular and Cellular Biology 16(6):2932-2939
(1996)
Refining
the telomere-telomerase hypothesis of aging and cancer
Nature Biotechnology 14 836-839 (1996)
Telomerase
Activity in Human Germline and Embryonic Tissues and Cells
Developmental Genetics 18: 173-179 (1996)
Time,
telomeres and tumours: is cellular senescence more than an anticancer
mechanism?
Trends in Cell Biology 5: 293-297 (1996)
Modifications
of a telomeric repeat amplification protocol (TRAP) result in increased
reliability, linearity and sensitivity
Nucleic Acids Research
23(18); 3794-3795 (1995)
Correlating
telomerase activity levels with human neuroblastoma outcomes
Nature Medicine
1(3); 249-255 (1995)
Telomerase
Activity in Small-Cell and Non-Small-
Cell Lung Cancers
Journal
of the National Cancer Institute 87(12); 895-902 (1995)
Specific
Association of Human Telomerase Activity with Immortal Cells and Cancer
Science 266: 2011-2015 (1994)
The
Frequency of Imoortalization of Human Fibroblasts and Mammary Epithetiial
Cells Transfected with SV40 Large T-Antigen
Experimental Cell
Research 209: 45-52 (1993)
Defining
the molecular mechanisms of human cell immortalization
Biochimica et Biophysica Acta 1072: 1-7 (1991)
