I am a research assistant professor now working with Cheng-Ming at the Simmons
Comprehensive Cancer Center, UT Southwestern Medical Center. My secondary
appointment is in the Department of Biochemistry. I received my B.S. from
Department of Agricultural Chemistry, National Taiwan University in 1984, and
M.S. from Department of Biochemistry at National Yang-Ming University in 1986.
In 1988, I came to University of Rochester pursuing my Ph.D. degree under the
supervision of Terry Platt. After obtaining my Ph.D. in 1993, I did a one-year
postdoctoral training with Robert Roeder at Rockefeller University and then
with Cheng-Ming from 1995-2000. In 2000, I moved to Case Western Reserve
University in Cleveland, Ohio as a research assistant professor and then to UT
Southwestern in July 2007. My primary research is on HPV transcriptional
regulation, but also on the general transcription machinery and general
cofactors. I work closely with postdoctoral fellows, graduate students and
technicians, and help manage daily operations in the lab. I enjoy working on
new projects and exploring new ideas. This is the fun part of my research.
I joined Dr. Cheng-Ming Chiang's Lab in May 2008. My core work is to study the interactions
between transcription factors and chromatin-remodeling factors, which can activate or
repress HPV gene expression through the HPV upstream regulatory region. By utilizing novel
techniques and available high-risk and low-risk HPVs, I believe we can elucidate more about
mechanisms of HPV carcinogenesis. I received my B.S. in 1994 from Fu-Jen Catholic University
and followed M.S. at the National Tsing Hua University, both in Taiwan. I worked as a
research assistant in Dr. Kun-Yuan Jan's lab in Academia Sinica, Taipei, from 1998-2001.
In 2001, I was accepted into Joint Doctoral Program in Cell and Molecular Biology from
University of California, San Diego & San Diego State University. Under the guidance of Dr.
William E. Stumph, I received my Ph.D. in September 2007.
Jang Won Park
I joined Dr. Cheng-Ming Chiang's lab in April 2010. Since then, I am studying functional roles of
various posttranslational modifications of HPV E6 protein. I expect that this study will elucidate
more mechanisms of oncogenesis mediated by the viral protein. I received B.S. in Life Science
from POSTECH in 1998 and M.S. in virology from Seoul National University in 2000, both in South
Korea. I completed my Ph. D in Microbiology under the guidance of Dr. Robert M. Krug in the
University of Texas at Austin in August 2009 with the study of the interaction of the NS1 protein
of influenza B virus and Brd2, a cellular protein.
I received my B.A. in Interdisciplinary Studies from the University of Texas at Dallas
in 2006 and then attended the University of North Texas as a post-baccalaureate student.
I have just begun working in Dr. Chiang's lab and thus far have learned how to purify
epitope-tagged HPV- and transcription-related proteins, which will be used to create
in vitro reconstituted chromatin systems in order to study HPV signaling pathways.
I am also creating mutant forms of high-risk HPV E2 and Brd4 proteins via site-directed
mutagenesis in preparation for studying E2's interaction with a newly discovered E2
binding-site on Brd4. Additionally, I will be learning methods of mammalian cell
Ching En "Ellen" Lee
A graduate student in Dr. Cheng-Ming Chiang's laboratory in the Molecular Microbiology
program in the UT Southwestern Graduate School, I received my B.S. in Microbiology from
the University of Maryland, College Park in May 2009. While at the University of Maryland,
I worked as a research assistant in the laboratory of Dr. Kevin McIver. Joining Dr.
Chiang's lab in May 2010, my work focuses on how post-translational modifications, such
as methylation, of transcription factors can be modulated by bromodomain-containing
proteins. Additionally, I am also investigating the potential of viral oncoproteins
to modulate the methylation status of transcription factors.