UT Southwestern Medical Center at Dallas

 

Chiang Lab Group

Hsien-Tsung Lai , Jang Won Park, Jennifer Samford, Cheng-Ming Chiang, Shwu-Yuan Wu, Ching En "Ellen" Lee. (l. to r.)

Updated on May 13, 2010

 


Shwu-Yuan Wu

Shwu-Yuan Wu

Assistant Professor

I am a research assistant professor now working with Cheng-Ming at the Simmons Comprehensive Cancer Center, UT Southwestern Medical Center. My secondary appointment is in the Department of Biochemistry. I received my B.S. from Department of Agricultural Chemistry, National Taiwan University in 1984, and M.S. from Department of Biochemistry at National Yang-Ming University in 1986. In 1988, I came to University of Rochester pursuing my Ph.D. degree under the supervision of Terry Platt. After obtaining my Ph.D. in 1993, I did a one-year postdoctoral training with Robert Roeder at Rockefeller University and then with Cheng-Ming from 1995-2000. In 2000, I moved to Case Western Reserve University in Cleveland, Ohio as a research assistant professor and then to UT Southwestern in July 2007. My primary research is on HPV transcriptional regulation, but also on the general transcription machinery and general cofactors. I work closely with postdoctoral fellows, graduate students and technicians, and help manage daily operations in the lab. I enjoy working on new projects and exploring new ideas. This is the fun part of my research.


Hsien-Tsung Lai

Hsien-Tsung Lai

Postdoctoral Fellow

I joined Dr. Cheng-Ming Chiang's Lab in May 2008. My core work is to study the interactions between transcription factors and chromatin-remodeling factors, which can activate or repress HPV gene expression through the HPV upstream regulatory region. By utilizing novel techniques and available high-risk and low-risk HPVs, I believe we can elucidate more about mechanisms of HPV carcinogenesis. I received my B.S. in 1994 from Fu-Jen Catholic University and followed M.S. at the National Tsing Hua University, both in Taiwan. I worked as a research assistant in Dr. Kun-Yuan Jan's lab in Academia Sinica, Taipei, from 1998-2001. In 2001, I was accepted into Joint Doctoral Program in Cell and Molecular Biology from University of California, San Diego & San Diego State University. Under the guidance of Dr. William E. Stumph, I received my Ph.D. in September 2007.


Jang Won Park

Jang Won Park

Postdoctoral Fellow

I joined Dr. Cheng-Ming Chiang's lab in April 2010. Since then, I am studying functional roles of various posttranslational modifications of HPV E6 protein. I expect that this study will elucidate more mechanisms of oncogenesis mediated by the viral protein. I received B.S. in Life Science from POSTECH in 1998 and M.S. in virology from Seoul National University in 2000, both in South Korea. I completed my Ph. D in Microbiology under the guidance of Dr. Robert M. Krug in the University of Texas at Austin in August 2009 with the study of the interaction of the NS1 protein of influenza B virus and Brd2, a cellular protein.


Jennifer Samford

Jennifer Samford

Research Assistant

I received my B.A. in Interdisciplinary Studies from the University of Texas at Dallas in 2006 and then attended the University of North Texas as a post-baccalaureate student. I have just begun working in Dr. Chiang's lab and thus far have learned how to purify epitope-tagged HPV- and transcription-related proteins, which will be used to create in vitro reconstituted chromatin systems in order to study HPV signaling pathways. I am also creating mutant forms of high-risk HPV E2 and Brd4 proteins via site-directed mutagenesis in preparation for studying E2's interaction with a newly discovered E2 binding-site on Brd4. Additionally, I will be learning methods of mammalian cell culture.


Ching En Ellen Lee

Ching En "Ellen" Lee

Graduate Student

A graduate student in Dr. Cheng-Ming Chiang's laboratory in the Molecular Microbiology program in the UT Southwestern Graduate School, I received my B.S. in Microbiology from the University of Maryland, College Park in May 2009. While at the University of Maryland, I worked as a research assistant in the laboratory of Dr. Kevin McIver. Joining Dr. Chiang's lab in May 2010, my work focuses on how post-translational modifications, such as methylation, of transcription factors can be modulated by bromodomain-containing proteins. Additionally, I am also investigating the potential of viral oncoproteins to modulate the methylation status of transcription factors.

 


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