Tolga Cağatay

Tolga Cağatay, Ph.D.

Education and Training


Honors and Awards


  1. Xu D, Marquis K, Pei J, Fu SC, Cağatay, T., Grishin NV, Chook YM. “LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins” Bioinformatics. 2014 Dec 15. pii: btu826. [Epub ahead of print]
  2. Espinar, L., Cağatay, T., Süel G. M., and Garcia-Ojalvo J. "Circuit-level input integration in bacterial gene regulation", Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7091-6. doi: 10.1073/pnas.1216091110. Epub 2013 Apr 9.
  3. Asally, M., Kittisopikul, M., Rué, P., Du, Y., Hu, Z., Cağatay, T., Robinson, A.B., Lu, H., Garcia-Ojalvo, J., and Süel G. M. "Localized cell death focuses mechanical forces during 3D patterning in a biofilm" PNAS, September 24, 2012, doi: 10.1073/pnas.1212429109
  4. Kuchina, A., Espinar, L., Cağatay, T., Balbin, A.O., Zhang, F., Alvarado, A., Garcia-Ojalvo, J., and Süel G. M. "Temporal competition between differentiation programs determines cell fate choice" Mol. Syst. Biol., (7) Article number: 557 (2011)
  5. Cağatay, T., Turcotte, M., Elowitz, M.B., Garcia-Ojalvo, J., and Süel G. M."Architecture-Dependent Noise Discriminates Functionally Analogous Differentiation Circuits", Cell 139(3):512-22. (2009)
  6. Gou, J*., Cağatay, T.*, Zhou G*, Chan, C.C., Blythe, S., Suyama, K., Zheng, L., Pan, Qian, C., Hamelin, R., Thibodeau, S.N., Klein, P.S., Wharton, K.A. Jr, and Liu, W. "Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling" *joint first authors. PLoS ONE 4(11):e7982.(2009)
  7. Chan, C.C., Zhang, S., Cağatay, T., and Wharton, K.A. Jr. "Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd)" Dev Biol. 15; 311(2): 538–553. (2007)
  8. Zhang, S., Cağatay, T., Amanai, M., Zhang, M., Kline, J., Castrillon, D.H., Ashfaq, R., Oz, O.K., and Wharton, K.A. Jr "Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2", Mol. Cell. Biol., 27(12):4454-64 (2007)
  9. Waldrop, S., Chan, C.C., Cağatay, T., Zhang, S., Rousset, R., Mack, J., Zeng, W., Fish, M., Zhang, M., Amanai, M., and Wharton, K.A. Jr "An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle", Genetics, 174(1):331-48 (2006)
  10. Erdal, E., Ozturk, N., Cağatay, T., Eksioglu-Demiralp, E., and Ozturk, M. "Lithium-mediated down-regulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells", Int. J. of Cancer, 20;115(6):903-10 (2005).
  11. Cağatay, T. and Ozturk, M. "p53 mutation as a source of aberrant β-catenin accumulation in cancer cells" Oncogene, 21(52):7971-80 (2002).
  12. Erdemir, T., Bilican, B., Cağatay, T., Goding, C.R. and Yavuzer, U. "Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination", Mol. Microbiol. 46(4):947-957 (2002).
  13. Cağatay, T., Sayan, B. and Ozturk, M. "β-catenin status in hepatacellular carcinoma cells correlates with c-myc and cyclin E over-expression", European Association for Cancer Research (EACR XVI) meeting, WS6 (2000).
  14. Morel, A.P., Unsal, K., Cağatay, T., Ponchel, F., Carr, B., and Ozturk, M. "p53 but not p16 (INK4a) induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells", J. Hepatol. , 33:254-265 (2000).