2011-present

  1. Soniat, M., Sampathkumar, P., Collett, G., Gizzi, A.S., Banu, R.N., Bhosle, R.C., Chamala, S., Chowdhury, S., Fiser, A., Glenn, A.S., Hammonds J., Hillerich, B., Khafizov, K., Love, J.D., Matikainen, B., Seidel, R.D., Toro, R., Rajesh Kumar, P., Bonanno J.B., Chook, Y.M., Almo, S.C. "Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2" J Struct Funct Genomics 2013; 14(2):31-5
  2. Sun, Q, Carrasco, Y.P., Hu, Y., Guo, X., Mirzaei, H., Macmillan, J., Chook, Y.M. "Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1" PNAS 2013; 10(4):1303-8
  3. Lapalombella, R., Sun, Q., Williams, K., Tangeman, L., Jha, S., Zhong, Y., Goettl, V., Mahoney, E., Berglund, C., Gupta, S., Farmer, A., Mani, R., Johnson, A.J., Lucas, D., Mo, X., Daelemans, D., Sandanayaka, V., Shechter, S., McCauley, D., Shacham, S., Kauffman, M., Chook, Y.M., Byrd, J.C. "Selective inhibitors of nuclear export (SINE) show that CRM1/XPO1 is a target in chronic lymphocytic leukemia", Blood 2012;120(23):4621-34
  4. Etchin, J. Sun, Q., Kentsis A., Farmer A., Zhang Z.C., Sanda T., Mansour M.R., Barcelo C., McCauley D., Kauffman M., Shacham S., Christie A.L., Kung A.L., Rodig S.J., Chook Y.M., and Look A.T. (2012) “Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells”, Leukemia 2012; 27(1):66-74
  5. Xu, D., Grishin N.V. and Chook, Y.M. (2012) "NESdb: a database of NES-containing CRM1 cargoes" Mol. Biol. Cell 2012;23(18):3673-6
  6. Xu, D., Farmer, A. , Collet G., Grishin N.V. and Chook, Y.M. (2012) "Sequence and structural analyses of nuclear export signals in the NESdb database" Mol. Biol. Cell 23(18):3677-93
  7. Zhang Z.C. and Chook Y.M. (2012) "Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)" Proc. Natl. Acad. Sci. USA 109(30):12017-21
  8. Zhang Z.C., Satterly N., Fontoura B.M., and Chook Y.M. (2011) "Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1", Mol. Biol. Cell 22(23):4657-68

1999-2010

  1. Xu, D., Farmer, A. and Chook, Y.M. (2010) Recognition of nuclear targeting signals by Karyopherin-β proteins. Curr Opin Struct Biol. 20(6):782-90
  2. Chook, Y. M. and Süel, K. E. (2010) Nuclear import by karyopherin-βs: Recognition and inhibition. Biochim Biophys Acta. 1813(9):1593-606
  3. Süel, K. E. and Chook, Y. M. (2009) Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus. J. Biol. Chem. 284(23):15416-24
  4. Dong, X., Biswas, A. and Chook, Y. M. (2009) Structural basis for assembly and disassembly of the CRM1 nuclear export complex. Nature Structural and Molecular Biology, 16(5):558-560.
  5. Dong, X., Biswas, A., Süel, K. E, Jackson, L. K., Martinez, R., Gu, H. and Chook, Y. M. (2009) Structural basis for leucine-rich nuclear export signal recognition by CRM1. Nature, 458: 1136-1141.
  6. Zhang, Z. C. and Chook, Y. M. (2008) Structural Analysis of Karyopherin-mediated nucleocytoplasmic transport. Nuclear Transport, edited by Ralph Kehlenbach, Landes Bioscience.
  7. Süel, K. E., Gu, H. and Chook, Y. M. (2008) Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals. PLoS Biology, 6(6):e137.
  8. Cansizoglu, A. E. and Chook, Y. M. (2007) Conformational heterogeneity of Karyopherinβ2 is segmental. Structure, 15(11):1431-1441.
  9. Cansizoglu, A. E., Lee, B. J., Zhang, Z. C., Fontoura, B. M. A. and Chook, Y. M. (2007) Structure-based design of a pathway-specific nuclear import inhibitor. Nat. Struc. & Mol. Biol., 14(5):452-454.
  10. Süel, K. E., Cansizoglu, A. E. and Chook, Y. M. (2006) Atomic resolution structures in nuclear transport. Methods, 39(4):342-5.
  11. Lee, B. J., Cansizoglu, A. E., Süel, K. E., Louis, T. H., Zhang, Z. and Chook, Y. M. (2006) Rules for nuclear localization sequence recognition by Karyopherinβ2. Cell, 126:543-558.
  12. Faria, A.M.C, Levay, A., Kamphorst, A. O., Rosa, M. L. P., Nussenzveig, D. R., Balkan, W., Chook, Y. M., Wang, Y., Levy, D. E., and Fontoura, B.M.A. (2006) The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions. Immunity, 24(3):295-304. .
  13. Wang W., Yang X., Kawai T., de Silanes I.L., Mazan-Mamczarz K., Chen P , Chook Y.M., Quensel C., Kohler M. and Gorospe M. (2004) AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. J. Biol Chem. 2004 279(46):48376-88.
  14. Chook, Y.M., Jung, A., Rosen, M.K. and Blobel, G. (2002) Uncoupling Ran binding and substrate dissociation in the Karyopherin b2 nuclear import pathway. Biochemistry  41, 6955-6966.
  15. Chook, Y.M. and Blobel, G. (2001) Karyopherins and nuclear import. Current Opinions in Structural  Biology 11(6):703-715.
  16. Chook, Y.M., Cingolani, G., Conti, E., Stewart, M., Vetter, I., Wittinghofer, A. (1999) Pictures in cell biology. Structures of nuclear-transport components. Trends Cell Biol. 9(8), 310-311.
  17. Chook, Y.M. and Blobel, G. (1999) Structure of the nuclear transport complex karyopherin-β2-Ran•GppNHp. Nature 399, 230-237.

Earlier Publications

  1. Chook, Y.M., Lipscomb, W.N. and Ke, H. (1998) Detection and Use of Pseudo Translation in Determination of Protein Structures. Acta Cryst. D54, 822-827.
  2. Lipscomb, W.N., Chook, Y.M. and Ke, H. (1997) Chorismate Mutase, essentially a template enzyme. Chapter 17, 235-244. Biological NMR Spectroscopy. John L. Markley, Stanley Opella (editors) and Richard Ernst. Oxford University Press.
  3. Kubiseski, T.J., Chook, Y.M., Parris, W.E., Rozakis-Adcock, M. and Pawson, T. (1997) High Affinity Binding of the Pleckstrin Homology Domain of mSos1 to Phosphatidylinositol (4,5) Bisphosphate. J. Biol. Chem. 272 (3), 1799-1804.
  4. Chook, Y.M., Gish, G.D., Kay, C.Y., Pai, E.F. and Pawson, T. (1996) The Grb2-mSos1 Complex Binds Phosphopeptides with Higher Affinity than Grb2. J. Biol. Chem. 271(48), 30472-30478.
  5. Chook, Y.M., Ke, H., Gray, J.V. and Lipscomb, W.N. (1994) The monofunctional chorismate mutase from Bacillus subtilis:  Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications on the mechanism of enzymatic reaction. J. Molec. Biol. 240(5), 476-500.
  6. Chook, Y.M., Ke, H. and Lipscomb, W.N. (1993) Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog. Proc. Natl. Acad. Sci. USA, 90, 8600-8603.
  7. Stevens, R.C., Chook, Y.M., Cho, C.Y., Lipscomb, W.N. and Kantrowitz, E.R. (1991) Escherichia coli aspartate carbamoyltransferase:  The probing of crystal structure analysis via site-specific mutagenesis. Protein Engineering  4(4), 391-408.
  8. Chey, J., Choe, H.S., Chook, Y.M., Jensen, E., Seida, P.R. and Francl, M.M. (1990) -Complexes of alkenes to trivalent aluminum. Organometallics, 9(9), 2430-2436.