Our research has centered on the interactions between body adiposity, nutrients, and the hormones estrogen, insulin, and leptin and their influence on energy homeostasis. Specifically, we have focused on whether fatty acids are involved in the modulation of the major bioenergetic and/or biosynthetic pathways that normally are critical for hypothalamic energy homeostasis.
A second over-arching theme of our research is to understand the impact of sex hormones on metabolic function. Specifically, we are testing whether androgens and estrogens are involved in the modulation of pathways that normally support metabolic function.
Our goal is to extend these findings into understanding interactions between nutrients, estrogens, and obesity with breast cancer.