Contact Information
Department of Pharmacology
Univ. of Texas, Southwestern Medical Center at Dallas
Dallas, TX 75390-9041
(214) 645-6155
(214) 645-6156 (FAX)

Curriculum Vitae

Date of Birth: August 13, 1963, Cambridge Massachusetts

1985      B.A., cum laude, Chemistry, Harvard University
1990      Ph.D., Chemistry, University of California, Berkeley in the Laboratory of Dr.
                Peter G. Schultz. Thesis: “Sequence-Specific Hybrid Nucleases”

1990-1992     Damon Runyon Walter Winchell Postdoctoral Fellowship in the Laboratory
                                 of Dr. Charles S. Craik, University of California, San Francisco.
1992-2000     Assistant Investigator, Howard Hughes Medical Institute
1992-1998     Assistant Professor, Department of Pharmacology, The University of Texas,
                               Southwestern Medical Center at Dallas (UTSWMC)
1998-2003     Associate Professor, UTSWMC
2003-             Professor UTSWMC

1985-1987     University Fellowship
1987-             Member, American Chemical Society
1989-1990     Pfizer Graduate Fellowship
1993-             Member, Biophysics Training Program, UTSWMC
1993-             Member, Biochemistry and Molecular Biology Training Program, UTSWMC
1996              Recipient (w. Drs. Jerry Shay and Woodring Wright) of CaP Cure Research Award
1997-             Secondary Appointment, Department of Biochemistry, UTSWMC
1997-             Member, American Society for Pharmacology and Experimental Therapeutics
1997-             Member, American Association For Cancer Research
1998-2003     Head, Proteins Thread, first year graduate core curriculum UTSWMC
2001              Guest Editor for Methods “Applications of Engineered Nucleic Acids”
2002-2005     Consultant, ISIS Pharmaceutical
2002-2003     Consultant, Praecis Pharmaceutical
2003              Welch Lectureship
2003-             Full Member, Simmons Cancer Center
2006-2008             Scientific Advisory Board, Panagene SA
2006-2009             External Advisory Panel, Program in Excellence in Nanotechnology
2007              AACR Program committee
2008              Bristol Myers Squibb Lectureship, Harvard University
2009              Hirschman Lectureship, Oberlin University
2009              McKnight Neuroscience of Brain Disorder Award
2009-              Board of Directors, Oligonucleotide Therapeutic Society
2009-2010              Organizing Committee, 2010 Oligonucleotides Therapeutic Society Symposium
2010              Excellence in Postdoctoral Mentoring Award (UT Southwestern)
2012-             Executive Editor, Nucleic Acids Research

2003-             Tetrahedron and Tetrahedron Letters
2003-             Cancer Research
2005-             Journal of RNAi and Gene Silencing
2006-             Chemical Biology and Drug Design
2008-             Nucleic Acids Research
2008-             Nucleic Acid Therapeutics
2009-             Artificial DNA



  1. Zucker-Franklin, D., Nabi, Z. F., Corey, E. J., Corey, D. R., “A Substrate Analog Inhibitor for Arylsulfatase Reduces NK Cell Cytotoxicity” Biochem. Biophys. Res. Comm., 126, 540-543, (1985).
  2. Corey, E. J., Cashman, J. R., Eckrich, T. M., Corey, D. R. “A New Class of Irreversible Inhibitors of Leukotriene Biosynthesis” J. Am. Chem. Soc., 107, 713-715, (1985).
  3. Zuckermann, R., Corey, D., Schultz, P. “Efficient Methods for the Attachment of Thiol Specific probes to the 3’-ends of Synthetic Oligodeoxyribonucleotides” Nucl. Acids Res., 15, 5305-5321, (1987).
  4. Corey, D. R. and Schultz, P. G., “Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease” Science, 238, 1401-1403, (1987).
  5. Zuckermann, R. N., Corey, D. R., Schultz, P. G. “Site-Selective Cleavage of RNA by a Hybrid Enzyme” J. Am. Chem. Soc., 110, 1614-1615, (1988).
  6. Corey, D. R. and Schultz, P. G. “Introduction of a Metal-Dependent Regulatory Switch into an Enzyme” J. Biol. Chem., 264, 3666-3669, (1989).
  7. Corey, D. R., Pei, D., Schultz, P. G. “The Generation of a Catalytic Oligonucleotide-Directed Nuclease” Biochemistry, 28, 8277-8286, (1989).
  8. Corey, D. R., Pei, D., Schultz, P. G., “The Sequence-Selective Hydrolysis of Duplex DNA by an Oligonucleotide-Directed Nuclease” J. Am. Chem. Soc., 111, 8523-8525, (1989).
  9. Pei, D., Corey, D. R., Schultz, P. G. “Site-Specific cleavage of Duplex DNA by a Semi-synthetic Nuclease via triple helix formation” Proc. Natl. Acad. Sci., 87, (1990), 9858-9862.
  10. Corey, D. R. and Craik, C. S. “An Investigation into the Minimum Requirements for Peptide Hydrolysis by Mutation of the Catalytic Triad of Trypsin” J. Am. Chem. Soc., 114, 1784-1790, (1992).
  11. Corey, D. R., McGrath, M. E., Vasquez, J. R., Fletterick, R. J., Craik, C. S. “An Alternate Geometry for the Catalytic Triad of Serine Proteases” J. Am. Chem. Soc., 114, 4905-4907, (1992).
  12. Corey, D. R., Shiau, A. K., Yang, Q., Janowski, B. A., Craik, C. S. “Trypsin display on the surface of bacteriophage” Gene , 128, 129-134, (1993).
  13. Corey, D. R. and Phillips, M. A “Cyclic Peptides as Proteases: A Re-evaluation” Proc. Natl. Acad. Sci., 91, 4106-4109, (1994).
  14. Corey, D. R., Willett W. S., Coombs, G. C., Craik, C. S. “Trypsin Specificity Increased through Substrate-Assisted Catalysis” Biochemistry, 34, 11521-11527, (1995).
  15. Madison, E. L., Coombs, G. S., Corey, D. R. “Substrate specificity of Tissue Plasminogen Activator: Characterization of the fibrin independent specificity of t-PA for Plasminogen”      J. Biol. Chem., 270, 7558-7562, (1995).
  16. Corey, D. R., Munoz-Medellin, D., Huang, A. “Strand Invasion by Oligonucleotide-Nuclease Conjugates” Bioconjugate Chemistry, 6, 93-100, (1995).
  17. Norton, J. C., Waggenspack, J. H., Varnum, E., Corey, D. R. “Targeting Peptide Nucleic Acid Protein Conjugates to Structural Features Within Duplex DNA” Bioorg Med. Chem, 3, 437-445, (1995).
  18. Ding, L., Coombs, G. S., Strandberg, L., Navre, M., Corey, D. R., Madison, E. L. “The Origins of Specificity of Tissue-Type Plasminogen Activator” Proc. Natl. Acad. Sci., 92, 7627-7631, (1995).
  19. Coombs, G. S., Hazzard, J., Corey, D. R. “Kinetic Characterization of a Peptide Inhibitor of Trypsin Isolated from a Synthetic Peptide Combinatorial Library” Bioorg. Med. Chem. Lett., 5, 611-614, (1995).
  20. Iyer, M., Norton, J. C., Corey, D. R. “Accelerated Hybridization of Oligonucleotides to Duplex DNA” J. Biol. Chem., 270, 14712-14717, (1995).
  21. Corey, D. R. “48 000-fold Acceleration of Hybridization of Chemically Modified Oligomers to Duplex DNA” J. Am. Chem. Soc., 117, 9373-9374, (1995).
  22. Coombs, G. S., Dang, A. T., Madison, E. L., Corey, D. R. “Distinct Mechanisms Contribute to Stringent Specificity of Tissue-Type Plasminogen Activator” J. Biol. Chem., 271, 4461-4467, (1996).
  23. Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., Corey, D. R. “Inhibition of Human Telomerase Activity by Peptide Nucleic Acids” Nature Biotech., 14, 615-620, (1996).
  24. Smulevitch, S. V., Simmons, C. G., Norton, J. C., Wise, T. W., Corey, D. R. “Enhanced Strand Invasion by Oligonucleotides through Manipulation of Backbone Charge” Nature Biotech, 14, 1700-1705, (1996).
  25. Hamilton, S. E., Iyer., M., Norton, J. C., Corey, D. R. “Specific and Nonspecific Inhibition of RNA Synthesis by DNA, PNA and Phosphorothioate Promoter Analog Duplexes” Bioorg. Med. Chem. Lett., 6, 2897-2900, (1996).
  26. Ke, S-H., Coombs, G. S., Tachias, K., Navre, M., Corey, D. R., Madison, E. L. “Distinguishing the Specificities of Closely Related Proteases: Role of P3 in Substrate and Inhibitor Discrimination between Tissue-Type Plasminogen Activator and Urokinase” J. Biol. Chem., 272, 16603-16609, (1997).
  27. Ke, S-H., Coombs, G. S., Tachias, K., Corey, D. R., Madison, E. L. “Optimal Subsite Occupancy and Design of a Selective Inhibitor of Urokinase” J. Biol. Chem., 272, 20456-20462 (1997).
  28. Hamilton, S. E., Pitts, A. E., Katipally, R. R., Jia, X. Davies, B. A., Rutter, J. P., Wright, W. R., Shay, J. W., Corey, D. R. “Identification of Determinants for Inhibitor Binding within the RNA Active Site of Human Telomerase Using PNA Scanning” Biochemistry, 36, 11873-11880, (1997).
  29. Simmons, C. G., Pitts, A. E., Mayfield, L. D., Shay, J. W., Corey, D. R. “Synthesis and Membrane Permeability of PNA-Peptide Conjugates” Bioorg. Med. Chem. Lett., 7, 3001-3007, (1997).
  30. Coombs, G. S., Bergstrom, R. C., Madison, E. L., Corey, D. R. “Directing Sequence-Specific Proteolysis to New Targets. The Influence of Loop Size and Target Sequence on Sequence-Selective Proteolysis by Tissue-type Plasminogen Activator and Urokinase-type Plasminogen Activator” J. Biol. Chem., 273, 4323-4328, (1998).
  31. Peet, D. J., Doyle, D. F., Corey, D. R., Mangelsdorf, D. J. “Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR” Chem. Biol., 5, 13-25, (1998).
  32. Coombs, G. S., Bergstrom, R. C., Pellequer, J-L., Baker, S. I., Navre, M., Smith, M. M., Tainer, J. A., Madison, E. L., and Corey, D. R. “Substrate Specificity of Prostate Specific Antigen (PSA)” Chem. Biol., 5, 475-488, (1998).
  33. Pitts, A. E. and Corey, D. R. “Inhibition of Human Telomerase by 2’-O-Methyl RNA Oligonucleotides” Proc. Natl. Acad. Sci., 95, 11549-11554, (1998).
  34. Mayfield, L. D. and Corey, D. R. “Automated Synthesis of Peptide Nucleic Acids (PNAs) and Peptide Nucleic Acid-Peptide Conjugates” Anal. Biochem, 268, 401-404. (1999).
  35. Ishihara, T. and Corey, D. R. “Rules for Strand Invasion by Chemically Modified Oligonucleotides” J. Am. Chem. Soc. 121, 2012-2020, (1999).
  36. Hamilton, S. E., Simmons, C. G., Kathriya, I, and Corey, D. R. “Cellular delivery of peptide nucleic acids and inhibition of human telomerase” (1999) Chem. Biol. 6, 343-351.
  37. Mayfield, L. D. and Corey, D. R. “Enhancing Solid Phase Synthesis by a Noncovalent Protection Strategy - Efficient Coupling of Rhodamine to Peptide Nucleic Acids” (1999) Bioorg. Med. Chem. Lett. 9, 1419-1422.
  38. Shammas, M. A., Simmons, C. G., Corey, D. R., and Shmookler-Reis, R. J. “Telomerase Inhibition by Peptide Nucleic Acids Reverses “Immortality” of Transformed Cells” (1999) Oncogene18, 6191-6200.
  39. Herbert, B-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W. and Corey, D. R. “Inhibition of telomerase leads to eroded telomeres, reduced proliferation, and cell death” (1999) Proc. Natl. Acad. Sci. USA 96, 14726-14781.
  40. Hervio, L., Bergstrom, R. C., Coombs, G. C., Trivedi, K., Corey, D. R. and Madison, E. L. “Negative selectivity and the evolution of protease cascades: The specificity of plasmin for peptide and protein substrates” (2000) Chem. Biol. 7, 443-453.
  41. Zhang, X., Ishihara, T., and Corey D. R. (2000) “Strand Invasion by Mixed Base PNAs and PNA-Peptide Chimera” Nucl. Acids. Res. 28, 3332-3338.
  42. Bergstrom, R. C., Mayfield, L. D and Corey D. R. (2001) “A First Step into a Protein World: Accelerating Delivery of Chemical Reactivity to DNA” Chem. Biol. 8, 199-205.
  43. Doyle D. F., Braasch, D. A, Simmons, C. G., Janowski, B. A. and Corey, D. R. (2001) “Intracellular Delivery and Inhibition of Gene Expression by Peptide Nucleic Acids” Biochemistry 40, 53-64.
  44. Braasch, D. A. and Corey, D. R. (2001) “Synthesis, Analysis, Purification, and Intracellular Delivery of Peptide Nucleic Acids” Methods 23, 97-107.
  45. Doyle, D. F., Braasch, D. A., Boehm, M., Jackson, L., Mangelsdorf, D., and Corey D. R. “Engineering gene activation using orthogonal ligand receptor pairs”. (2001) J. Am. Chem. Soc. 123, 11367-11371.
  46. Zhang, X., Simmons, C. G., and Corey, D. R. (2001) “Synthesis and Intracellular Delivery of Lactose-Labeled PNAs”. Bioorg. Med. Chem. Lett. 11, 1269-1272.
  47. Elayadi, A., Demieville, A., Wancewicz, E. V., Monia, B. P., Corey, D. R. (2001) “Inhibition of telomerase by 2’-O-(2’-methoxyethyl)RNA oligomers: Effect of length, phosphorothioate substitution, and time inside cells”. Nucl. Acids. Res. 29, 1683-1689.
  48. Ye, S., Cech, A., Belmares, R., Bergstrom, R. C., Corey, D. R., Kanost, M. R., and Goldsmith, E. J. (2001) “An Inhibitory Triad in the Michaelis Serpin-Protease Complex” Nat. Struc. Biol. 8, 979-983.
  49. Yegorov, Y. E., Kazimirchuk, E. V., Terekhov, S. M., Karachentsev, D. N., Shirokova, E. A., Khandazhinskaya, A. L., Meshcheryakova, J. A., Corey, D. R., and Zelenin, A. V. (2002) "Macrophages require telomerase activity to reactivate DNA synthesis in their nuclei in heterokaryons with proliferating cells." Cell Biol. Int., 26, 1019-1027.
  50. Liu, B. Han, Y., Corey, D. R., Kodadek, T. K. (2002). “Towards synthetic transcriptional activators: recruitment of transcription factors to DNA by a PNA-peptide chimera.” J. Am. Chem. Soc. 124, 1838-1839.
  51. Tackett, A. J., Corey, D. R., and Raney, K. D. (2002) “Non-Watson-Crick Interactions between PNA and DNA inhibit the ATPase activity of T4 DdA helicase.” Nucl. Acids. Res. 30, 950-957.
  52. Elayadi, A. N., Braasch, D. A., and Corey, D. R. (2002) “Implications of high affinity hybridization by locked nucleic acids for inhibition of human telomerase” Biochemistry 41, 9973-9981.
  53. Lee, H. J., Boado, R. J., Braasch, D. A., Corey, D. R., and Pardridge, W. M. (2002) “Imaging gene expression in the brain in vivo in a transgenic mouse model of Huntington’s Disease with an antisense radiopharmaceutical and drug targeting technology” J. Nucl. Med. 43, 948-956.
  54. Nulf, C. J. and Corey, D. R. (2002) “Assembly of DNA oligonucleotides using peptide nucleic acids” Nucl. Acids Res. 30, 2782-2789.
  55. Kaihatsu, K., Braasch, D. B., Canizoglu, A., and Corey, D. R. (2002) “Enhanced Strand Invasion by Hybrid Peptide Nucleic Acids: Synthetic Mimics of DNA Binding Proteins” Biochemistry 41, 11118-11125.
  56. Chen, Z., Monia, B. P., and Corey, D. R., (2002) “Telomerase Inhibition, Telomere Shortening, and Decreased Cell Proliferation by Cell Permeable 2’-O-Methoxyethyl Oligonucleotides” J. Med. Chem. 45, 5423-5425.
  57. Braasch, D. B., Liu, Y., and Corey, D. R. (2002) “Antisense gene inhibition by locked nucleic acids.” Nucl. Acids Res 30, 5160-5167.
  58. Gamper, H. B., Corey, D. R., Nulf, C. J., and Kmiec, E. B. (2003) “Hybridization and Strand Exchange within the RecA Synaptic Complex” Biochemistry 42, 2643-2655.
  59. Zhao, X., Kaihatsu, K., and Corey, D. R. (2003) “Inhibition of Transcription by PNA-peptide conjugates” Nucleosides, Nucleotides, and Nucleic Acids 22, 535-546.
  60. Bergstrom, R. C., Coombs, G. C., Ye, S., Goldsmith, E. J., Madison, E. L., and Corey, D. R. (2003). “Binding of Nonphysiological Protein and Peptide Substrates to Proteases: Differences Between urokinase-type plasminogen activator and Trypsin and Contributions to the Evolution of Regulated Proteolysis.” Biochemistry 42, 5395-5402.
  61. Braasch, D. A., Jensen, S., Liu, Y., Arar, K., White, M. A., and Corey, D. R. (2003) “RNA interference in mammalian cells by chemically modified RNA” Biochemistry 42, 7967-7975.
  62. Chen, Z., Koeneman, K., and Corey, D. R. (2003) “Effect of Telomerase Inhibition and Combination Treatments on Cancer Cell Proliferation” Cancer Research 63, 5917-5925.
  63. Barma, D. K., Elayadi, A., Falck, J. R., and Corey, D. R. (2003) “Inhibition of telomerase by BIBR1532 and related analogs” Bioorg. Med. Chem. Lett. 13, 1333-1336.
  64. Kaihatsu, K., Shah, R. H., Zhao, X., and Corey, D. R. (2003) "Extending Duplex Recognition by Peptide Nucleic Acids (PNAs): Strand Invasion and Inhibition of Transcription by Tail Clamp PNAs and PNA-Peptide Conjugates" Biochemistry, 42, 13996-14003.
  65. Liu, B., Han, Y., Ferdous, A., Corey, D. R., and Kodadek, T. (2003) "Transcription activation by a PNA-peptide chimera in a mammalian cell extract". Chem. Biol. 10, 909-916.
  66. Liu, Y., Braasch, D. A., Nulf, C. J., and Corey, D. R. (2004) "Isoform-specific inhibition of cellular gene expression by peptide nucleic acid" Biochemistry 43, 1921-1927.
  67. Braasch, D. A., Paroo, Z., Constantinescu, A., Ren, G., Oz, O., Mason, R. P. and Corey, D. R. (2004) "Biodistribution of phosphodiester and phosphorothioate siRNA" Bioorg. Med. Chem. Lett. 14, 1139-1143.
  68. Paroo, Z., Bollinger, R. A., Braasch, D. A., Corey, D. R., Richer, E., Antich, P. A., and Mason, R. P. (2004) "Bioluminescence imaging as a high throughput, quantitative tool for accessing tumor burden" Molecular Imaging, 3, 117-124.
  69. Nulf, C. J. and Corey D. R. (2004) Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs). Nucl. Acids Res. 32, 3792-3798.
  70. Kaihatsu, K., Huffman, K, E. and Corey, D. R. (2004) Cellular Uptake, Localization, and Inhibition of Gene Expression by PNAs and PNA-Peptide Conjugates. Biochemistry 43, 14340-14347.
  71. Natarajan, S., Chen, Z., Wancewicz, E. V., Monia, B. P., and Corey, D. R. (2004) "Telomerase Reverse Transcriptase (hTERT) mRNA and Telomerase RNA (hTR) as Targets for Downregulation of Telomerase Activity" Oligonucleotides 14, 263-273.
  72. Huffman, K. E. and Corey, D. R. (2005) "Inhibition of Expression of Major Vault Protein Does not Alter Chemoresistance or Drug Localization in Cancer Cells" Biochemistry 44, 2253-2261.
  73. Janowski, B. A., Kaihatsu, K., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Mendelson, C. R., and Corey D. R. (2005) "Inhibiting transcription of chromosomal DNA using antigene peptide nucleic acids" Nature Chemical Biology 1, 210-215.
  74. Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Shames, D. S., Minna, J. D., and Corey D. R. (2005) "Inhibiting gene expression at transcription start sites in chromosomal DNA by antigene RNAs" Nature Chemical Biology 1, 216-222.
  75. Canales, B. K, Li, Y, Thompson, M. G., Gleason, J. M., Chen, Z., Malaeb, B., Corey, D. R., Herbert, B. S., Shay, J. W., and Koeneman, K. S. (2006) "Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model". Urol. Oncol. 24, 141-51.
  76. Hardy, D. B., Janowski, B. A., Corey, D. R., and Mendelson, C. R. (2006). "Progesterone impairs the interleukin-1ß (IL-1ß) stimulation of cyclooxygenase 2 (COX-2) gene expression in human myometrial cells." Mol. Endo. 20, 2724-2733.
  77. Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Nordsell, R., Shames, D. S., Minna, J. D., and Corey, D. R. (2006) "Ago1 and Ago2 link mammalian transcriptional silencing with RNAi." Nature Structural Molecular Biology 13, 787-792.
  78. Janowski, B. A., Hu, J., and Corey, D. R. (2006) "Antigene inhibition by peptide nucleic acids and duplex RNAs" Nature Protocols 1, 436-443.
  79. Johnson, A. A., Sayer, J. M., Jerina, D. M., Burke, T. R., Marquez, V. E., Debart, F., Vasseur, J., Corey, D. R., Maier, M. A., and Pommier, Y. (2006) "Effect of DNA Modifications on DNA processing by HIV Integrase and inhibitor binding: Role of DNA Backbone Flexibility and an Open Catalytic Site." (2006). J. Biol. Chem. 281, 32428-32438.
  80. Janowski, B. A., Younger, S. T., Hardy, D. B., Ram, R., Huffman, K. E., and Corey, D. R. (2007) “Activating gene expression in mammalian cells with promoter-targeted duplex RNAs.” Nat. Chem. Biol. 3 166-173.
  81. Hu, J. and Corey, D. R. (2007) "Inhibiting Gene Expression with PNA-Peptide Conjugates that Target Chromosomal DNA" Biochemistry 46(25):7581-9.
  82. Beane, R., Ram, R., Gabillet, S., Arar, K., Monia, B., and Corey D. R. (2007) “Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA” Biochemistry 46(25):7572-80.
  83. Schwartz JC, Younger ST, Nguyen NB, Hardy DB, Monia BP, Corey DR, Janowski BA. (2008) "Antisense transcripts are targets for activating small RNAs." Nat Struct Mol Biol. 15(8):842-8.
  84. Beane R, Gabillet S, Montaillier C, Arar K, Corey DR. (2009) "Recognition of chromosomal DNA inside cells by locked nucleic acids." Biochemistry 47(50):13147-9.
  85. Hu J, Matsui M, Gagnon KT, Schwartz JC, Gabillet S, Arar K, Wu J, Bezprozvanny I, Corey DR. (2009) "Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs." Nat Biotechnol. 27(5):478-84.
  86. Younger ST, Pertsemlidis A, Corey DR. (2009) "Predicting potential miRNA target sites within gene promoters." Bioorg Med Chem Lett. 19(14):3791-4.
  87. Hu J, Dodd DW, Hudson RH, Corey DR. (2009) "Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine." Bioorg Med Chem Lett. 19(21):6181-4.
  88. Hu J, Matsui M, Corey DR. (2009) "Allele-selective inhibition of mutant huntingtin by peptide nucleic acid-peptide conjugates, locked nucleic acid, and small interfering RNA." Ann N Y Acad Sci. 1175:24-31.
  89. Li Y, Malaeb BS, Li ZZ, Thompson MG, Chen Z, Corey DR, Hsieh JT, Shay JW, Koeneman K (2009) "Telomerase enzyme inhibition (TEI) and cytolytic therapy in the management of androgen independent osseous metastatic prostate cancer." Prostate.
  90. Wancewicz, E. V., Maier, M. A., Siwkowski, A. M. Albertshofer, K. Kinberger, G. A., Winger, T. M., Berdeja, A., Gaus, H., C. Bennett, C. F., Monia, B. P., Griffey, R. H., Nulf, C. J., Hu, J., Corey, D. R. and Swayze, E. E. (2007) "Short Basic Peptides Improve the Pharmacokinetics and Antisense Activity of Systemically Delivered Peptide Nucleic Acids" manuscript in preparation.
  91. Yue, X., Schwartz, J. C., Younger, S. T., Chu, Y., Gagnon, K.T., Elbashir, S., Janowski, B. A., Corey, D. R. Regulation of transcription by small RNAs complementary to sequences downstream from the 3' termini of genes. Nat. Chem. Biol. 6, 621-629 (2010).
  92. Watts, J. K., Yu, D., Charisse, K., Montaillier, C., Potier, P., Manoharan, M., and Corey, D. R. Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs (agRNAs) that are complementary to gene promoters. Nucl. Acids Res. 38, 5242-5259 (2010).
  93. Chu, Y., Yue, X., Janowski, B. A., Younger S. T., and Corey, D. R. Argonaute proteins and modulation of progesterone receptor expression by promoter-targeted RNAs. Nucl. Acids Res. 38, 7736-7748 (2010).
  94. Gagnon, K. T., Pendergraff, H., Deleavey, G., Swayze, E., Potier, P., Randolph, J., Roesch, E., Chattopadhyaya, J., Damha, M., Bennett, C. F., Chrisophe, M., Lemaitre, M., and Corey, D. R. Allele-selective silencing of huntingtin expression with antisense oligonucleotides targeting the mRNA expanded CAG repeat. Biochemistry 49, 10166-10178 (2010).
  95. Hu, J., Liu, J., and Corey, D. R. Allele-selectivity by switching to an miRNA-like RNAi mechanism. Chem. Biol. 17, 1183-1188 (2010).
  96. Matsui, M, Sakurai, F., Elbashir, S., Foster, D, Manoharan, M., and Corey, D. R. Activation of LDL Receptor (LDLR) Expression by Small RNAs Complementary to a Noncoding Transcript that Overlaps the LDLR Promoter. Chem. Biol. 17, 1344-1355 (2010).
  97. Pena-Llopis, Schwartz, J. C., Wolff, N., Vega-Rubin-de-Celis, S., Zou, L., Xie, X-J., Corey, D. R., Brugarolas, J. Regulation of V-ATPases and endocytosis by mTORC1. EMBO J. 30, 3242-3258 (2011).
  98. Younger, S. T. and Corey, D. R. Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters. Nucl. Acids Res. 39, 5682-5691 (2011).
  99. Younger, S. T. and Corey, D. R. Regulation of Transcription by miRNAs Complementary to Sequences Downstream from the 3' Termini of Genes. Mol. Biosystems 8, 2383-2388 (2011).
  100. Hu, J., Liu, J., Gagnon, K., T., Watts, J. K., Swayze, E., Randolph, J., Chattopadhyaya, J., Bennett, C. F. and Corey, D. R. Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biol. Chem. 392, 315-325 (2011).
  101. Gagnon, K. T., Watts, J. K., Pendergraff, H. M., Montaillier, C., Potier, P., and Corey D. R. Antisense and antigene inhibition of gene expression by cell permeable oligonucleotides-oligospermine conjugates. J. Am. Chem. Soc. 133, 8484-8407 (2011).
  102. Yu, D., Sakurai, F. and Corey, D. R. (2011). Development of clonal Rett-syndrome cell lines to test compounds for epigenetic activation of wild-type MeCP2 expression. Bioorg. Med. Chem. Lett. 21, 5202-5205 (2011).
  103. Liu, J., Hu, J. and Corey, D. R. (2012). Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing. Nucl. Acids Res. 40, 1240-1250.
  104. Yu, D., Pendergraff, H., Liu, J., Kordasiewicz, H., Sweayze, E., Lima, W., Crooke, S. T., Prakash, T., and Corey, D. R. (2012). Single-stranded RNAs that function through RNAi are potent and allele-selective inhibitors of huntingtin expression. Manuscript submitted.
  105. Matsui, M., Zhang, H., Chu, Y., Gagnon, K. T., Manoharan, M., Corey, D. R., and Janowski, B. A. (2012), A Network of noncoding RNAs links transcription of inflammatory pathway genes COX-2 and PLAG24A. Manuscript in preparation.
  106. Hu, J., Liu, J., and Corey, D. R. (2012). Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats. Manuscript in preparation.


  1. Corey, D. R. “Not Just Circus Tricks Anymore” Trends Biotech., 14, 486-487, (1996).
  2. Hamilton, S. E. and Corey, D. R. “Telomerase: Anti-Cancer Target or Just a Fascinating Enzyme?” Chem. Biol., 3, 863-867, (1996).
  3. Corey, D. R. “Peptide Nucleic Acids - Expanding the options for nucleic acid recognition” Trends Biotech. 15, 224-229, (1997).
  4. Doyle, D. F. and Corey D. R. “Engineering Proteins: Keeping up with Biology” Chem. Biol., 5, R157-R160, (1998).
  5. Pitts, A. E. and Corey, D. R. “The Telomerase Challenge-An Unusual Problem for Drug Discovery” Drug Discovery Today, 4, 155-161, (1999).
  6. Doyle, D. F., Mangelsdorf, D. F., and Corey, D. R. “Alteration of ligand specificity of gene regulatory proteins” (2000) Curr. Op. Chem. Biol. 4, 60-63.
  7. Corey, D. R. (2000) “Telomerase: an unusual target for cytotoxic agents” Chem. Res. Toxicol. 13, 957-962.
  8. Braasch, D. A. and Corey, D. R. (2001) “Locked Nucleic Acids: Fine-tuning nucleic acid recognition” Chem. Biol. 8, 1-7.
  9. Corey, D. R. (2001) “Editorial” Methods 23, 95-96.
  10. Corey, D. R. and Abrams J. M. “Morpholino antisense oligonucleotides: Tools for investigating vertebrate development” (2001) Genome Biology 2, reviews 1015.1-1015.3.
  11. Elayadi, A., N. and Corey, D. R. (2001) “Applications of LNA and PNA oligomers to chemotherapy” Curr. Op. Investigational New Drugs 2, 558-561.
  12. Corey D. R. (2002) “Telomerase inhibition, oligonucleotides, and clinical trials” Oncogene 21, 631-637.
  13. Braasch, D. A. and Corey, D. R. (2002) “Novel Antisense Strategies for Controlling Gene Expression” Biochemistry 41, 4503-4510.
  14. Paroo, Z. and Corey, D. R. (2003) "Imaging gene expression with oligonucleotides and peptide nucleic acids" J. Cell. Biochem. 90, 437-442.
  15. Corey D. R. (2004) Peptide Nucleic acids: Cellular Delivery and Recognition of DNA and RNA targets. Letts. Pep. Sci. 10, 347-352.
  16. Kaihatsu, K., Janowski, B. A., and Corey D. R. (2004) "Recognition of Duplex DNA by Oligonucleotides and Peptide Nucleic Acids" Chem. Biol. 11, 749-758.
  17. Paroo, Z. and Corey D. R. (2004) "Challenges for RNA interference in vivo" Trends Biotech. 22, 390-394.
  18. Corey, D. R. (2005) "Endosomal release: Making molecules active in cells" Chem. Biol. 12, 864-865.
  19. Corey, D. R. (2005) "Regulating Mammalian Transcription with RNA" Trends Biochem. Sci 30, 655-658.
  20. Janowski, B. A and Corey, D. R. (2005) "Inhibiting transcription of chromosomal DNA using antigene RNAs" Nucl. Acids. Symp. Series 49, 367-368.
  21. Corey, D. R. (2007) “RNAi learns from antisense.” Nat. Chem. Biol. 3, 8-11.
  22. Corey, D. R. (2007) “Chemical Modification: The Key to Clinical RNAi?” J Clin Invest. 117(12):3615-22.
  23. Corey DR. (2009) "Telomeres and telomerase: from discovery to clinical trials." Chem Biol. 16(12):1219-23.
  24. Corey, D.R. review "Handbook of RNA Biochemistry:Student edition." Chembiochem 10, 1568-1569 (2009).
  25. Younger ST, Corey DR. (2009) "The puzzle of RNAs that target gene promoters." Chembiochem. 10(7):1135-9.
  26. Janowski, B. A. and Corey D. R. Modulation of gene expression by promoter-targeted RNAs. Mol. Endo. 24, 2243-2252 (2010).
  27. Watts, J. K. and Corey, D. R. Therapeutic RNAi. Bioorg. Med. Chem. Lett. 20, 3203-3207, (2010).
  28. Watts, J. K. and Corey, D. R. Gene silencing by synthetic nucleic acids in the laboratory and the clinic. J. Pathol. 226, 365-379, (2012).
  29. Gagnon, K. T. and Corey, D. R. (2012). Nuclear Argonaute. Nucl. Acids Therapeutics 22, 3-16.
  30. Matsui, M. and Corey, D. R. (2012). Allele-selective inhibition of trinucleotide repeat genes. Drug Discov. Today in press.
  31. Chu, Y. and Corey, D. R. (2012). Platform selection, Experimental Design, and data interpretation. in preparation.


  1. Corey, D. R., Zuckermann, R. N., Schultz, P. G., “Hybrid Enzymes”, in “Bioorganic Chemistry Frontiers Vol. II”, 1-32, (1991) Hermann Dugas editor.
  2. Corey, D. R. and Craik, C. S. “Serine Proteases as a Model for the Introduction of Novel Properties into Protein Scaffolds” in “Proteases and their Inhibitors; Fundamental and Applied Aspects”, Aviles F. X. ed., Walter De Gruyer, 425-444 (1993).
  3. Coombs, G. S. and Corey, D. R. "Site-Directed Mutagenesis and Protein Engineering" in "Protein Structure" Angeletti, R. H. ed., Academic Press, 259-311, (1998).
  4. Corey, D. R. “Design and Engineering of Proteins as Therapeutic Agents” in “Biopharmaceutical Drug Design and Development” Wu Pong, S. ed. Humana Press, 187-203, (1999).
  5. Raney, K. D., Hamilton, S. E and Corey, D. R. “Interference of DNA processing enzymes by PNAs” in “PNA protocols and Applications” Nielsen, P. and Egholm, M. eds. Horizon Scientific Press, 241-251, (1999).
  6. Braasch, D. A. and Corey D. R. (2002) “Cellular Delivery of PNA-DNA-Lipid Complexes” Methods Mol. Biol. (P. Nielsen ed.) Humana Press, Totowa NJ, 208, 211-223.
  7. Braasch, D. A., Nulf, C., and Corey, D. R. (2002) “Synthesis and Purification of Peptide Nucleic Acids” in Current Protocols in Nucleic Acid Chemistry” 4.11.1-4.11.18.
  8. Braasch, D. A. and Corey, D. R. (2002) “Cellular Effects of Locked Nucleic Acids” in Current Protocols in Nucleic Acid Chemistry” 4.13.1-4.13.10.
  9. Chen, Z. and Corey, D. R. (2002) “Telomerase inhibitors - A novel option for chemotherapy” in “Advances in Cancer Research” (Klein and Vanderwoude eds.) Academic Press, 87, 31-58.
  10. Corey, D. R. (2004) “PNA antisense in Eukaryotic Systems” in “Peptide Nucleic Acids: A Laboratory Manual” 2nd edition, (Nielsen, P. ed.) Horizon Bioscience Press, 281-290.
  11. Corey, D. R. (2004) "Synthesis and Properties of Oligonucleotide-Protein and Oligonucleotide-Peptide Conjugates" Methods in Mol. Biol. (C. Niemeyer, ed.), 283, 197-206.
  12. Kaihatsu, K., and Corey, D. R. (2004) "Synthesis and Properties of PNA-Peptide Conjugates" Methods in Mol. Biol. (C. Niemeyer, ed.), 283, 207-14.
  13. Corey, D. R. (2005) "Recognition of Chromosomal DNA in human cells by peptide nucleic acids and small duplex RNAs." Annals of the New York Academy of Sciences (Y. S. Cho-Chung ed.), 1058, 16-25.
  14. Corey, D. R. (2007) “RNA mediated recognition of chromosomal DNA” in “RNA and the regulation of gene expression” Horizon Press (K. Morris ed.) Manuscript submitted.
  15. Schwartz, J. C. and Corey, D. R. Practical considerations for analyzing antigene RNAs (agRNAs): RNA immunoprecipitation of argonaute protein. Methods Mol. Biol. Humana Press, Totowa NJ in Press 764, 301-315 (2011).
  16. Younger, S. T. and Corey, D. R. Identification and validation of miRNA target sites within Non-traditional miRNA targets. Methods Mol. Biol. Humana Press, Totowa NJ in Press (2012).

1. US 6,015,710 Shay, J. W., Wright, W. E., Piatyszek, M.A., Corey, D. R., and Norton, J. C. "Modulation of mammalian telomerase by peptide nucleic acids" filed 4/9/1996, allowed 1/18/2000.
2. Corey, D. and Janowski B. Antigene oligomers inhibit transcription. U.S. patent application Ser. No. 11/376,483, filed 3/14/2006.
3. US 7,709,456 Corey, D. R., Janowski, B. A., Shames, D. S., and Minna, J. D. Modulation of gene expression by oligomers targeted to chromosomal DNA. Filed 11/13/2006, allowed 12/10/09, issued 5/4/2010.
4. Schwartz, J. C., Younger, S., Nguyen, N., Janowski, B., and Corey, D. R. Modulating transcription with antigene RNA targeting antisense transcripts. U.S. patent application Ser. No. 60/977,631 filed 10/4/2007.
5. US 7,858,592 Shames, D. S., Corey, D. R., Greer, R. S., and Minna, J. D. Interfering RNAs against the promoter regions of p53. U.S. patent application 60/891,615 filed 2/24/2008, allowed 09/10/2010.
6. Corey, D. R. and Younger, S. T. Endogenous small RNA targets gene promoters in mammalian cells. U.S. patent application 61/058,909 filed 4/04/08.
7. Hu, J., Matsui, M., and Corey D. R. Selective inhibition of polyglutamine protein expression. US patent application 61/048,350 filed 7/29/08.
8. Yue, X and Corey, D. R. Inhibition of gene expression by duplex RNAs that target sequence beyond the 3' terminus of mRNAs. US Patent Application 61/172,528. Filed 3/24/09.
9. Corey, D. R., Matsui, M., Manoharan, M., and Elbashir, S. Modulation of LDL Receptor gene expression with double-stranded RNAs targeting the LDL receptor gene promoter. Filed 11/02/2009.
10. Corey, D. R., Hu., J. Sah, D. W. Y. Selective inhibition of polyglutamine protein expression by duplex RNAs. U.S. Patent Application 61/301067. Filed 02/03/2010.
11. Corey, D. R., Gagnon, K., Swayze, E., Bennett, F. Selective inhibition of polyglutamine protein expression by oligonucleotides, Patent application 61/302450. Filed 02/08/10.
12. Liu, J., Hu, J., and Corey, D. R. Oligonucleotide modulation of splicing. Patent application. 61/472957. Filed 04/07/2011.
13. Prakash, T. P., Swayze, E. E., Corey, D. R. Methods and compounds useful in conditions related to triplet expansion (filed 8/29/2011).

1/25/06      Wayne State University, Department of Pharmaceutical Sciences
3/8/06        UT Austin, Dept. of Microbiology
3/25/06      PNA Symposium, Carnegie Mellon University
6/20/06      National Biotechnology Conference, Boston MA
9/1/06      UT Austin, Dept. of Chemistry
10/06/06      National Institutes of Health, NIDDK
12/5/06      Brown University, Department of Chemistry
1/17/07      University of North Carolina, Division of Medicinal Chemistry and Natural Products
1/22/07      University of Pennsylvania, Hematological Malignancies Translocational Research Group
2/8/07      University of South Florida, Department of Chemistry
2/9/07      University of South Florida, Moffitt Cancer Center
3/2/07      Ambion/Applied Biosystems
5/7/07      City of Hope, Beckman Institute, Division of Molecular Biology
6/15/07      ISIS Pharmaceutical
2/1/08      Alnylam Pharmaceutical
4/15/08      University of Idaho, Department of Chemistry
4/15/08      Washington State University, Department of Chemistry
6/1908      Bioorganic Chemistry Gordon Conference
8/3/08      Telluride Workshop on Nucleic Acids
9/24/08      Alnylam Pharmaceutical, Scientific Advisory Board Meeting
10/16/08      4th Annual Oligonucleotide Therapeutics Symposium, Boston MA
10/20/08      Harvard University, Department of Chemistry, Bristol Myers Squibb Lecture
11/08      58th Annual Meeting of the American Society of Human Genetics, Philadelphia PA
2/9/09      University of Texas Health Science Center
2/27/09      Virginia Tech, Department of Chemistry
4/6/09      University of Minnesota, Chemical Biology Colloquium Series
4/17/09      Scripps Research Institute - Florida
6/18/09      Albany 2009, the 16th Conversation
8/12/09      Alnylam Pharmaceutical
10/17/09      SACNAS Dallas, Texas
10/21/09      Broad Institute
11/4/09 and 11/5/09      Oberlin College, Hirschmann Lectureship
12/29/08      Alnylam Pharmaceutical
2/08/10      University of Colorado, Department of Chemistry
3/03/10      University of Massachusetts Medical School
4/06/10      Texas Women's University
4/08/10      Cold Spring Harbor Meeting, RNA and Oligonucleotide Therapeutics
5/03/10      Rett Syndrome Workshop
5/14/10      Yale University, Chemical Biology Symposium
5/18/10      CHDI, Los Angeles
8/7/2010      HD2010 "The Milton Wexler Celebration of Life"
9/9/10      Enzon Pharmaceutical
9/16/10      NIH, Chemical Biology Laboratory
10/23/10      Oligonucleotide Therapeutics Society Symposium, session chair
11/14/10      American Association of Pharmaceutical Sciences
12/15/10      Pacifichem 2010, Nucleic Acids Based Therapeutics, Honolulu, Hawaii
2/4/11      Scripps Research Institute, 22nd Annual Frontiers in Chemistry Symposium
2/15/11      Keystone Meeting, MicroRNAs and Human Disease, Banff, Canada
4/7/11      Mossbacher Kolloquium, Mosbach Germany
5/10/11      ISIS Pharmaceutical
7/1/11      10th International Bioforum, Tokyo Japan
8/12/11      Alnylam Pharmaceuticals
9/7/11      6th Annual Symposium on Nucleic Acid Chemistry, Cambridge England
9/9/11      Oligonucleotide Therapeutics Society Symposium, Copenhagen, session chair
9/30/11      UT Arlington, Department of Chemistry and Biochemistry
10/14/11      American Society of Human Genetics, Montreal, Canada
1/10/12      AACR Noncoding RNAs in Cancer, Miami Beach
2/09/12      University of Utah, Department of Chemistry
2/27/12      RaNA Therapeutics
4/10/12      Texas Christian University, Department of Chemistry
4/20/12      University of North Texas, Federation of North Texas Universities Symposium
6/9/12      McKnight Foundation Neuroscience meeting
8/6/12      International Nucleic Acids Roundtable, Montreal, Canada