Selected Recent Publications
2005
Janowski, B. A., Kaihatsu, K., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Mendelson, C. R., and Corey D. R. (2005) "Inhibiting transcription of chromosomal DNA using antigene peptide nucleic acids" Nature Chemical Biology 1, 210-215.

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Shames, D. S., Minna, J. D., and Corey D. R. (2005) "Inhibiting gene expression at transcription start sites in chromosomal DNA by antigene RNAs" Nature Chemical Biology 1, 216-222.

Corey, D. R. (2005) "Regulating Mammalian Transcription with RNA" Trends Biochem. Sci 30, 655-658.

2006
Hardy, D. B., Janowski, B. A., Corey, D. R., and Mendelson, C. R. (2006). "Progesterone impairs the interleukin-1ß (IL-1ß) stimulation of cyclooxygenase 2 (COX-2) gene expression in human myometrial cells." Mol. Endo. 20, 2724-2733.

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Nordsell, R., Shames, D. S., Minna, J. D., and Corey, D. R. (2006) "Ago1 and Ago2 link mammalian transcriptional silencing with RNAi." Nature Structural Molecular Biology 13, 787-792.

Janowski, B. A., Hu, J., and Corey, D. R. (2006) "Antigene inhibition by peptide nucleic acids and duplex RNAs" Nature Protocols 1, 436-443.

2007
Janowski, B. A., Younger, S. T., Hardy, D. B., Ram, R., Huffman, K. E., and Corey, D. R. (2007) “Activating gene expression in mammalian cells with promoter-targeted duplex RNAs.” Nat. Chem. Biol. 3 166-173.

Hu, J. and Corey, D. R. (2007) "Inhibiting Gene Expression with PNA-Peptide Conjugates that Target Chromosomal DNA" Biochemistry in Press.

Beane, R., Ram, R., Gabillet, S., Arar, K., Monia, B., and Corey D. R. (2007) “Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA” Biochemistry in Press.

Corey, D. R. (2007) “RNAi learns from antisense.” Nat. Chem. Biol. 3, 8-11.

2008
Schwartz JC, Younger ST, Nguyen NB, Hardy DB, Monia BP, Corey DR, Janowski BA. (2008) "Antisense transcripts are targets for activating small RNAs." Nat Struct Mol Biol. 15, 842-848.

2009
Hu J, Matsui M, Gagnon KT, Schwartz JC, Gabillet S, Arar K, Wu J, Bezprozvanny I, Corey DR. (2009) "Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs." Nat Biotechnol. 27, 478-484.

Younger ST, Pertsemlidis A, Corey DR. (2009) "Predicting potential miRNA target sites within gene promoters." Bioorg Med Chem Lett. 19(14):3791-4

RNAi and agRNAs
2002
Braasch, D. A. and Corey, D. R. (2002) “Novel Antisense Strategies for Controlling Gene Expression” Biochemistry 41, 4503-4510.

2003
Braasch, D. A., Jensen, S., Liu, Y., Arar, K., White, M. A., and Corey, D. R. (2003) “RNA interference in mammalian cells by chemically modified RNA” Biochemistry 42, 7967-7975.

2004
Braasch, D. A., Paroo, Z., Constantinescu, A., Ren, G., Oz, O., Mason, R. P. and Corey, D. R. (2004) "Biodistribution of phosphodiester and phosphorothioate siRNA" Bioorg. Med. Chem. Lett. 14, 1139-1143.

Paroo, Z. and Corey D. R. (2004) "Challenges for RNA interference in vivo" Trends Biotech. 22, 390-394.

2005
Huffman, K. E. and Corey, D. R. (2005) "Inhibition of Expression of Major Vault Protein Does not Alter Chemoresistance or Drug Localization in Cancer Cells" Biochemistry 44, 2253-2261.

Janowski, B. A., Kaihatsu, K., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Mendelson, C. R., and Corey D. R. (2005) "Inhibiting transcription of chromosomal DNA using antigene peptide nucleic acids" Nature Chemical Biology 1, 210-215.

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Shames, D. S., Minna, J. D., and Corey D. R. (2005) "Inhibiting gene expression at transcription start sites in chromosomal DNA by antigene RNAs" Nature Chemical Biology 1, 216-222.

Corey, D. R. (2005) "Regulating Mammalian Transcription with RNA" Trends Biochem. Sci 30, 655-658.

2006
Hardy, D. B., Janowski, B. A., Corey, D. R., and Mendelson, C. R. (2006). "Progesterone impairs the interleukin-1ß (IL-1ß) stimulation of cyclooxygenase 2 (COX-2) gene expression in human myometrial cells." Mol. Endo. 20, 2724-2733.

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Nordsell, R., Shames, D. S., Minna, J. D., and Corey, D. R. (2006) "Ago1 and Ago2 link mammalian transcriptional silencing with RNAi." Nature Structural Molecular Biology 13, 787-792.

Janowski, B. A., Hu, J., and Corey, D. R. (2006) "Antigene inhibition by peptide nucleic acids and duplex RNAs" Nature Protocols 1, 436-443.

2007
Janowski, B. A., Younger, S. T., Hardy, D. B., Ram, R., Huffman, K. E., and Corey, D. R. (2007) “Activating gene expression in mammalian cells with promoter-targeted duplex RNAs.” Nat. Chem. Biol. 3 166-173.

Corey, D. R. (2007) “RNAi learns from antisense.” Nat. Chem. Biol. 3, 8-11.

2008
Schwartz JC, Younger ST, Nguyen NB, Hardy DB, Monia BP, Corey DR, Janowski BA. (2008) "Antisense transcripts are targets for activating small RNAs." Nat Struct Mol Biol. 15, 842-848.

2009
Younger ST, Corey DR. (2009) "The puzzle of RNAs that target gene promoters." Chembiochem. 10(7):1135-9.

Younger ST, Pertsemlidis A, Corey DR. (2009) "Predicting potential miRNA target sites within gene promoters." Bioorg Med Chem Lett. 19(14):3791-4

PNAs
1995
Norton, J. C., Waggenspack, J. H., Varnum, E., Corey, D. R. “Targeting Peptide Nucleic Acid Protein Conjugates to Structural Features Within Duplex DNA” Bioorg Med. Chem, 3, 437-445, (1995).

Iyer, M., Norton, J. C., Corey, D. R. “Accelerated Hybridization of Oligonucleotides to Duplex DNA” J. Biol. Chem., 270, 14712-14717, (1995).

1996
Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., Corey, D. R. “Inhibition of Human Telomerase Activity by Peptide Nucleic Acids” Nature Biotech., 14, 615-620, (1996).

Smulevitch, S. V., Simmons, C. G., Norton, J. C., Wise, T. W., Corey, D. R. “Enhanced Strand Invasion by Oligonucleotides through Manipulation of Backbone Charge” Nature Biotech, 14, 1700-1705, (1996).

Hamilton, S. E., Iyer., M., Norton, J. C., Corey, D. R. “Specific and Nonspecific Inhibition of RNA Synthesis by DNA, PNA and Phosphorothioate Promoter Analog Duplexes” Bioorg. Med. Chem. Lett., 6, 2897-2900, (1996).

1997
Hamilton, S. E., Pitts, A. E., Katipally, R. R., Jia, X. Davies, B. A., Rutter, J. P., Wright, W. R., Shay, J. W., Corey, D. R. “Identification of Determinants for Inhibitor Binding within the RNA Active Site of Human Telomerase Using PNA Scanning” Biochemistry, 36, 11873-11880, (1997).

Corey, D. R. “Peptide Nucleic Acids - Expanding the options for nucleic acid recognition” Trends Biotech. 15, 224-229, (1997).

Simmons, C. G., Pitts, A. E., Mayfield, L. D., Shay, J. W., Corey, D. R. “Synthesis and Membrane Permeability of PNA-Peptide Conjugates” Bioorg. Med. Chem. Lett., 7, 3001-3007, (1997).

1999
Mayfield, L. D. and Corey, D. R. “Automated Synthesis of Peptide Nucleic Acids (PNAs) and Peptide Nucleic Acid-Peptide Conjugates” Anal. Biochem, 268, 401-404. (1999).

Hamilton, S. E., Simmons, C. G., Kathriya, I, and Corey, D. R. “Cellular delivery of peptide nucleic acids and inhibition of human telomerase” (1999) Chem. Biol. 6, 343-351.

Mayfield, L. D. and Corey, D. R. “Enhancing Solid Phase Synthesis by a Noncovalent Protection Strategy - Efficient Coupling of Rhodamine to Peptide Nucleic Acids” (1999) Bioorg. Med. Chem. Lett. 9, 1419-1422.

Shammas, M. A., Simmons, C. G., Corey, D. R., and Shmookler-Reis, R. J. “Telomerase Inhibition by Peptide Nucleic Acids Reverses “Immortality” of Transformed Cells” (1999) Oncogene18, 6191-6200.

Herbert, B-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W. and Corey, D. R. “Inhibition of telomerase leads to eroded telomeres, reduced proliferation, and cell death” (1999) Proc. Natl. Acad. Sci. USA 96, 14726-14781.

2000
Zhang, X., Ishihara, T., and Corey D. R. (2000) “Strand Invasion by Mixed Base PNAs and PNA-Peptide Chimera” Nucl. Acids. Res. 28, 3332-3338.

2001
Bergstrom, R. C., Mayfield, L. D and Corey D. R. (2001) “A First Step into a Protein World: Accelerating Delivery of Chemical Reactivity to DNA” Chem. Biol. 8, 199-205.

Doyle D. F., Braasch, D. A, Simmons, C. G., Janowski, B. A. and Corey, D. R. (2001) “Intracellular Delivery and Inhibition of Gene Expression by Peptide Nucleic Acids” Biochemistry 40, 53-64.

Braasch, D. A. and Corey, D. R. (2001) “Synthesis, Analysis, Purification, and Intracellular Delivery of Peptide Nucleic Acids” Methods 23, 97-107.

2002
Liu, B. Han, Y., Corey, D. R., Kodadek, T. K. (2002). “Towards synthetic transcriptional activators: recruitment of transcription factors to DNA by a PNA-peptide chimera.” J. Am. Chem. Soc. 124, 1838-1839.

Lee, H. J., Boado, R. J., Braasch, D. A., Corey, D. R., and Pardridge, W. M. (2002) “Imaging gene expression in the brain in vivo in a transgenic mouse model of Huntington’s Disease with an antisense radiopharmaceutical and drug targeting technology” J. Nucl. Med. 43, 948-956.

Nulf, C. J. and Corey, D. R. (2002) “Assembly of DNA oligonucleotides using peptide nucleic acids” Nucl. Acids Res. 30, 2782-2789.

Braasch, D. A. and Corey, D. R. (2002) “Novel Antisense Strategies for Controlling Gene Expression” Biochemistry 41, 4503-4510.

Kaihatsu, K., Braasch, D. B., Canizoglu, A., and Corey, D. R. (2002) “Enhanced Strand Invasion by Hybrid Peptide Nucleic Acids: Synthetic Mimics of DNA Binding Proteins” Biochemistry 41, 11118-11125.

Braasch, D. A., Nulf, C., and Corey, D. R. (2002) “Synthesis and Purification of Peptide Nucleic Acids” in Current Protocols in Nucleic Acid Chemistry” 4.11.1-4.11.18.

2003
Kaihatsu, K., Shah, R. H., Zhao, X., and Corey, D. R. (2003) "Extending Duplex Recognition by Peptide Nucleic Acids (PNAs): Strand Invasion and Inhibition of Transcription by Tail Clamp PNAs and PNA-Peptide Conjugates" Biochemistry, 42, 13996-14003.

Liu, B., Han, Y., Ferdous, A., Corey, D. R., and Kodadek, T. (2003) "Transcription activation by a PNA-peptide chimera in a mammalian cell extract". Chem. Biol. 10, 909-916.

Paroo, Z. and Corey, D. R. (2003) "Imaging gene expression with oligonucleotides and peptide nucleic acids" J. Cell. Biochem. 90, 437-442.

Zhao, X., Kaihatsu, K., and Corey, D. R. (2003) “Inhibition of Transcription by PNA-peptide conjugates” Nucleosides, Nucleotides, and Nucleic Acids 22, 535-546.

2004
Liu, Y., Braasch, D. A., Nulf, C. J., and Corey, D. R. (2004) "Isoform-specific inhibition of cellular gene expression by peptide nucleic acid" Biochemistry 43, 1921-1927.

Nulf, C. J. and Corey D. R. (2004) Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs). Nucl. Acids Res. 32, 3792-3798.

Kaihatsu, K., Huffman, K, E. and Corey, D. R. (2004) Cellular Uptake, Localization, and Inhibition of Gene Expression by PNAs and PNA-Peptide Conjugates. Biochemistry 43, 14340-1434781.      

Corey, D. R. (2004) “PNA antisense in Eukaryotic Systems” in “Peptide Nucleic Acids: A Laboratory Manual” 2nd edition, (Nielsen, P. ed.) Horizon Bioscience Press, 281-290.

Kaihatsu, K., and Corey, D. R. (2004) "Synthesis and Properties of PNA-Peptide Conjugates" Methods in Mol. Biol. (C. Niemeyer, ed.), 283, 207-14.

Corey D. R. (2004) Peptide Nucleic acids: Cellular Delivery and Recognition of DNA and RNA targets. Letts. Pep. Sci. 10, 347-352.

Kaihatsu, K., Janowski, B. A., and Corey D. R. (2004) "Recognition of Duplex DNA by Oligonucleotides and Peptide Nucleic Acids" Chem. Biol. 11, 749-758.

2005
Janowski, B. A., Kaihatsu, K., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Mendelson, C. R., and Corey D. R. (2005) "Inhibiting transcription of chromosomal DNA using antigene peptide nucleic acids" Nature Chemical Biology 1, 210-215.

Corey, D. R. (2005) "Endosomal release: Making molecules active in cells" Chem. Biol. 12, 864-865.

Corey, D. R. (2005) "Recognition of Chromosomal DNA in human cells by peptide nucleic acids and small duplex RNAs." Annals New York Acad. Sci. 1058, 16-25.

2006
Janowski, B. A., Hu, J., and Corey, D. R. (2006) "Antigene inhibition by peptide nucleic acids and duplex RNAs" Nature Protocols 1, 436-443.

2007
Hu, J. and Corey, D. R. (2007) "Inhibiting Gene Expression with PNA-Peptide Conjugates that Target Chromosomal DNA" Biochemistry 46, 7581-7589.

2009
Hu J, Matsui M, Gagnon KT, Schwartz JC, Gabillet S, Arar K, Wu J, Bezprozvanny I, Corey DR. (2009) "Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs." Nat Biotechnol. 27, 478-484.

Hu J, Dodd DW, Hudson RH, Corey DR. (2009) "Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine." Bioorg Med Chem Lett. 19(21):6181-4.

LNAs
2001
Braasch, D. A. and Corey, D. R. (2001) “Locked Nucleic Acids: Fine-tuning nucleic acid recognition” Chem. Biol. 8, 1-7.

2002
Elayadi, A. N., Braasch, D. A., and Corey, D. R. (2002) “Implications of high affinity hybridization by locked nucleic acids for inhibition of human telomerase” Biochemistry 41, 9973-9981.

Braasch, D. B., Liu, Y., and Corey, D. R. (2002) “Antisense gene inhibition by locked nucleic acids.” Nucl. Acids Res 30, 5160-5167.

Braasch, D. A. and Corey, D. R. (2002) “Novel Antisense Strategies for Controlling Gene Expression” Biochemistry 41, 4503-4510.

Braasch, D. A. and Corey, D. R. (2002) “Cellular Effects of Locked Nucleic Acids” in Current Protocols in Nucleic Acid Chemistry” 4.13.1-4.13.10.

2003
Braasch, D. A., Jensen, S., Liu, Y., Arar, K., White, M. A., and Corey, D. R. (2003) “RNA interference in mammalian cells by chemically modified RNA” Biochemistry 42, 7967-7975.

2004
Nulf, C. J. and Corey D. R. (2004) Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs). Nucl. Acids Res. 32, 3792-3798.

2007
Beane, R., Ram, R., Gabillet, S., Arar, K., Monia, B., and Corey D. R. (2007) “Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA” Biochemistry 46, 7572-7580.

2008
Beane R, Gabillet S, Montaillier C, Arar K, Corey DR. (2008) "Recognition of chromosomal DNA inside cells by locked nucleic acids." Biochemistry 47, 13147-13149.

2009
Hu J, Matsui M, Gagnon KT, Schwartz JC, Gabillet S, Arar K, Wu J, Bezprozvanny I, Corey DR. (2009) "Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs." Nat Biotechnol. 27, 478-484.

Telomerase
1996
Hamilton, S. E. and Corey, D. R. “Telomerase: Anti-Cancer Target or Just a Fascinating Enzyme?” Chem. Biol., 3, 863-867, (1996).

Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., Corey, D. R. “Inhibition of Human Telomerase Activity by Peptide Nucleic Acids” Nature Biotech., 14, 615-620, (1996).

1997
Hamilton, S. E., Pitts, A. E., Katipally, R. R., Jia, X. Davies, B. A., Rutter, J. P., Wright, W. R., Shay, J. W., Corey, D. R. “Identification of Determinants for Inhibitor Binding within the RNA Active Site of Human Telomerase Using PNA Scanning” Biochemistry, 36, 11873-11880, (1997).

1998
Pitts, A. E. and Corey, D. R. “Inhibition of Human Telomerase by 2’-O-Methyl RNA Oligonucleotides” Proc. Natl. Acad. Sci., 95, 11549-11554, (1998).

1999
Pitts, A. E. and Corey, D. R. “The Telomerase Challenge-An Unusual Problem for Drug Discovery” Drug Discovery Today, 4, 155-161, (1999).

Hamilton, S. E., Simmons, C. G., Kathriya, I, and Corey, D. R. “Cellular delivery of peptide nucleic acids and inhibition of human telomerase” (1999) Chem. Biol. 6, 343-351.

Shammas, M. A., Simmons, C. G., Corey, D. R., and Shmookler-Reis, R. J. “Telomerase Inhibition by Peptide Nucleic Acids Reverses “Immortality” of Transformed Cells” (1999) Oncogene18, 6191-6200.

Herbert, B-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W. and Corey, D. R. “Inhibition of telomerase leads to eroded telomeres, reduced proliferation, and cell death” (1999) Proc. Natl. Acad. Sci. USA 96, 14726-14781.

2000
Corey, D. R. (2000) “Telomerase: an unusual target for cytotoxic agents” Chem. Res. Toxicol. 13, 957-962.

2001
Zhang, X., Simmons, C. G., and Corey, D. R. (2001) “Synthesis and Intracellular Delivery of Lactose-Labeled PNAs”. Bioorg. Med. Chem. Lett. 11, 1269-1272.

Elayadi, A., Demieville, A., Wancewicz, E. V., Monia, B. P., Corey, D. R. (2001) “Inhibition of telomerase by 2’-O-(2’-methoxyethyl)RNA oligomers: Effect of length, phosphorothioate substitution, and time inside cells”. Nucl. Acids. Res. 29, 1683-1689.

Elayadi, A., N. and Corey, D. R. (2001) “Applications of LNA and PNA oligomers to chemotherapy” Curr. Op. Investigational New Drugs 2, 558-561.

2002
Elayadi, A. N., Braasch, D. A., and Corey, D. R. (2002) “Implications of high affinity hybridization by locked nucleic acids for inhibition of human telomerase” Biochemistry 41, 9973-9981.

Chen, Z., Monia, B. P., and Corey, D. R., (2002) “Telomerase Inhibition, Telomere Shortening, and Decreased Cell Proliferation by Cell Permeable 2’-O-Methoxyethyl Oligonucleotides” J. Med. Chem. 45, 5423-5425.

Corey D. R. (2002) “Telomerase inhibition, oligonucleotides, and clinical trials” Oncogene 21, 631-637.
Chen, Z. and Corey, D. R. (2002) “Telomerase inhibitors - A novel option for chemotherapy” in “Advances in Cancer Research” (Klein and Vanderwoude eds.) Academic Press, 87, 31-58.

2003
Chen, Z., Koeneman, K., and Corey, D. R. (2003) “Effect of Telomerase Inhibition and Combination Treatments on Cancer Cell Proliferation” Cancer Research 63, 5917-5925.

Barma, D. K., Elayadi, A., Falck, J. R., and Corey, D. R. (2003) “Inhibition of telomerase by BIBR1532 and related analogs” Bioorg. Med. Chem. Lett. 13, 1333-1336.

2004
Natarajan, S., Chen, Z., Wancewicz, E. V., Monia, B. P., and Corey, D. R. (2004) "Telomerase Reverse Transcriptase (hTERT) mRNA and Telomerase RNA (hTR) as Targets for Downregulation of Telomerase Activity" Oligonucleotides 14, 263-273.

2006
Canales, B. K, Li, Y, Thompson, M. G., Gleason, J. M., Chen, Z., Malaeb, B., Corey, D. R., Herbert, B. S., Shay, J. W., and Koeneman, K. S. (2006) "Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model". Urol. Oncol. 24, 141-51.

2009
Li Y, Malaeb BS, Li ZZ, Thompson MG, Chen Z, Corey DR, Hsieh JT, Shay JW, Koeneman KS. (2009) "Telomerase enzyme inhibition (TEI) and cytolytic therapy in the management of androgen independent osseous metastatic prostate cancer". Prostate.

Corey DR. (2009) "Telomeres and telomerase: from discovery to clinical trials". Chem Biol. 16(12):1219-23.

     

Oligonucleotide Conjugates
1987
Zuckermann, R., Corey, D., Schultz, P. “Efficient Methods for the Attachment of Thiol Specific probes to the 3’-ends of Synthetic Oligodeoxyribonucleotides” Nucl. Acids Res., 15, 5305-5321, (1987).

Corey, D. R. and Schultz, P. G., “Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease” Science, 238, 1401-1403, (1987).

1988
Zuckermann, R. N., Corey, D. R., Schultz, P. G. “Site-Selective Cleavage of RNA by a Hybrid Enzyme” J. Am. Chem. Soc., 110, 1614-1615, (1988).

1989
Corey, D. R., Pei, D., Schultz, P. G. “The Generation of a Catalytic Oligonucleotide-Directed Nuclease” Biochemistry, 28, 8277-8286, (1989).

Corey, D. R., Pei, D., Schultz, P. G., “The Sequence-Selective Hydrolysis of Duplex DNA by an Oligonucleotide-Directed Nuclease” J. Am. Chem. Soc., 111, 8523-8525, (1989).

1990
Pei, D., Corey, D. R., Schultz, P. G. “Site-Specific cleavage of Duplex DNA by a Semi-synthetic Nuclease via triple helix formation” Proc. Natl. Acad. Sci., 87, (1990), 9858-9862.

1995
Corey, D. R., Munoz-Medellin, D., Huang, A. “Strand Invasion by Oligonucleotide-Nuclease Conjugates” Bioconjugate Chemistry, 6, 93-100, (1995).

Iyer, M., Norton, J. C., Corey, D. R. “Accelerated Hybridization of Oligonucleotides to Duplex DNA” J. Biol. Chem., 270, 14712-14717, (1995).

Corey, D. R. “48 000-fold Acceleration of Hybridization of Chemically Modified Oligomers to Duplex DNA” J. Am. Chem. Soc., 117, 9373-9374, (1995).

1999
Ishihara, T. and Corey, D. R. “Rules for Strand Invasion by Chemically Modified Oligonucleotides” J. Am. Chem. Soc. 121, 2012-2020, (1999).

2004
Corey, D. R. (2004) "Synthesis and Properties of Oligonucleotide-Protein and Oligonucleotide-Peptide Conjugates" Meth. Mol. Biol. 283, 197-206.

Protein Engineering
1987
Corey, D. R. and Schultz, P. G., “Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease” Science, 238, 1401-1403, (1987).

1988
Zuckermann, R. N., Corey, D. R., Schultz, P. G. “Site-Selective Cleavage of RNA by a Hybrid Enzyme” J. Am. Chem. Soc., 110, 1614-1615, (1988).

1989
Corey, D. R., Pei, D., Schultz, P. G. “The Generation of a Catalytic Oligonucleotide-Directed Nuclease” Biochemistry, 28, 8277-8286, (1989).

Corey, D. R., Pei, D., Schultz, P. G., “The Sequence-Selective Hydrolysis of Duplex DNA by an Oligonucleotide-Directed Nuclease” J. Am. Chem. Soc., 111, 8523-8525, (1989).

Corey, D. R. and Schultz, P. G. “Introduction of a Metal-Dependent Regulatory Switch into an Enzyme” J. Biol. Chem., 264, 3666-3669, (1989).

1990
Pei, D., Corey, D. R., Schultz, P. G. “Site-Specific cleavage of Duplex DNA by a Semi-synthetic Nuclease via triple helix formation” Proc. Natl. Acad. Sci., 87, (1990), 9858-9862.

1992
Corey, D. R. and Craik, C. S. “An Investigation into the Minimum Requirements for Peptide Hydrolysis by Mutation of the Catalytic Triad of Trypsin” J. Am. Chem. Soc., 114, 1784-1790, (1992).

Corey, D. R., McGrath, M. E., Vasquez, J. R., Fletterick, R. J., Craik, C. S. “An Alternate Geometry for the Catalytic Triad of Serine Proteases” J. Am. Chem. Soc., 114, 4905-4907, (1992).

1993
Corey, D. R., Shiau, A. K., Yang, Q., Janowski, B. A., Craik, C. S. “Trypsin display on the surface of bacteriophage” Gene , 128, 129-134, (1993).

Corey, D. R. and Craik, C. S. “Serine Proteases as a Model for the Introduction of Novel Properties into Protein Scaffolds” in “Proteases and their Inhibitors; Fundamental and Applied Aspects”, Aviles F. X. ed., Walter De Gruyer, 425-444 (1993).

1994
Corey, D. R. and Phillips, M. A “Cyclic Peptides as Proteases: A Re-evaluation” Proc. Natl. Acad. Sci., 91, 4106-4109, (1994).

1995
Corey, D. R., Willett W. S., Coombs, G. C., Craik, C. S. “Trypsin Specificity Increased through Substrate-Assisted Catalysis” Biochemistry, 34, 11521-11527, (1995).

Corey, D. R., Munoz-Medellin, D., Huang, A. “Strand Invasion by Oligonucleotide-Nuclease Conjugates” Bioconjugate Chemistry, 6, 93-100, (1995).

Iyer, M., Norton, J. C., Corey, D. R. “Accelerated Hybridization of Oligonucleotides to Duplex DNA” J. Biol. Chem., 270, 14712-14717, (1995).

1998
Peet, D. J., Doyle, D. F., Corey, D. R., Mangelsdorf, D. J. “Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR” Chem. Biol., 5, 13-25, (1998).

Coombs, G. S., Bergstrom, R. C., Madison, E. L., Corey, D. R. “Directing Sequence-Specific Proteolysis to New Targets. The Influence of Loop Size and Target Sequence on Sequence-Selective Proteolysis by Tissue-type Plasminogen Activator and Urokinase-type Plasminogen Activator” J. Biol. Chem., 273, 4323-4328, (1998).

Coombs, G. S. and Corey, D. R. "Site-Directed Mutagenesis and Protein Engineering" in "Protein Structure" Angeletti, R. H. ed., Academic Press, 259-311, (1998).

2000
Doyle, D. F., Mangelsdorf, D. F., and Corey, D. R. “Alteration of ligand specificity of gene regulatory proteins” (2000) Curr. Op. Chem. Biol. 4, 60-63.

2001
Doyle, D. F., Braasch, D. A., Boehm, M., Jackson, L., Mangelsdorf, D., and Corey D. R. “Engineering gene activation using orthogonal ligand receptor pairs”. (2001) J. Am. Chem. Soc. 123, 11367-11371.

Proteases
1992
Corey, D. R. and Craik, C. S. “An Investigation into the Minimum Requirements for Peptide Hydrolysis by Mutation of the Catalytic Triad of Trypsin” J. Am. Chem. Soc., 114, 1784-1790, (1992).

Corey, D. R., McGrath, M. E., Vasquez, J. R., Fletterick, R. J., Craik, C. S. “An Alternate Geometry for the Catalytic Triad of Serine Proteases” J. Am. Chem. Soc., 114, 4905-4907, (1992).

1993
Corey, D. R., Shiau, A. K., Yang, Q., Janowski, B. A., Craik, C. S. “Trypsin display on the surface of bacteriophage” Gene , 128, 129-134, (1993).

1994
Corey, D. R. and Phillips, M. A “Cyclic Peptides as Proteases: A Re-evaluation” Proc. Natl. Acad. Sci., 91, 4106-4109, (1994).

1995
Corey, D. R., Willett W. S., Coombs, G. C., Craik, C. S. “Trypsin Specificity Increased through Substrate-Assisted Catalysis” Biochemistry, 34, 11521-11527, (1995).

Madison, E. L., Coombs, G. S., Corey, D. R. “Substrate specificity of Tissue Plasminogen Activator: Characterization of the fibrin independent specificity of t-PA for Plasminogen”      J. Biol. Chem., 270, 7558-7562, (1995).

Ding, L., Coombs, G. S., Strandberg, L., Navre, M., Corey, D. R., Madison, E. L. “The Origins of Specificity of Tissue-Type Plasminogen Activator” Proc. Natl. Acad. Sci., 92, 7627-7631, (1995).

Coombs, G. S., Hazzard, J., Corey, D. R. “Kinetic Characterization of a Peptide Inhibitor of Trypsin Isolated from a Synthetic Peptide Combinatorial Library” Bioorg. Med. Chem. Lett., 5, 611-614, (1995).

1996
Coombs, G. S., Dang, A. T., Madison, E. L., Corey, D. R. “Distinct Mechanisms Contribute to Stringent Specificity of Tissue-Type Plasminogen Activator” J. Biol. Chem., 271, 4461-4467, (1996).

1997
Ke, S-H., Coombs, G. S., Tachias, K., Navre, M., Corey, D. R., Madison, E. L. “Distinguishing the Specificities of Closely Related Proteases: Role of P3 in Substrate and Inhibitor Discrimination between Tissue-Type Plasminogen Activator and Urokinase” J. Biol. Chem., 272, 16603-16609, (1997).

Ke, S-H., Coombs, G. S., Tachias, K., Corey, D. R., Madison, E. L. “Optimal Subsite Occupancy and Design of a Selective Inhibitor of Urokinase” J. Biol. Chem., 272, 20456-20462 (1997).

1998
Coombs, G. S., Bergstrom, R. C., Pellequer, J-L., Baker, S. I., Navre, M., Smith, M. M., Tainer, J. A., Madison, E. L., and Corey, D. R. “Substrate Specificity of Prostate Specific Antigen (PSA)” Chem. Biol., 5, 475-488, (1998).

Coombs, G. S., Bergstrom, R. C., Madison, E. L., Corey, D. R. “Directing Sequence-Specific Proteolysis to New Targets. The Influence of Loop Size and Target Sequence on Sequence-Selective Proteolysis by Tissue-type Plasminogen Activator and Urokinase-type Plasminogen Activator” J. Biol. Chem., 273, 4323-4328, (1998).

2000
Hervio, L., Bergstrom, R. C., Coombs, G. C., Trivedi, K., Corey, D. R. and Madison, E. L. “Negative selectivity and the evolution of protease cascades: The specificity of plasmin for peptide and protein substrates” (2000) Chem. Biol. 7, 443-453.

2001
Ye, S., Cech, A., Belmares, R., Bergstrom, R. C., Corey, D. R., Kanost, M. R., and Goldsmith, E. J. (2001) “An Inhibitory Triad in the Michaelis Serpin-Protease Complex” Nat. Struc. Biol. 8, 979-983.

2003
Bergstrom, R. C., Coombs, G. C., Ye, S., Goldsmith, E. J., Madison, E. L., and Corey, D. R. (2003). “Binding of Nonphysiological Protein and Peptide Substrates to Proteases: Differences Between urokinase-type plasminogen activator and Trypsin and Contributions to the Evolution of Regulated Proteolysis.” Biochemistry 42, 5395-5402.