Articles

1. Miller, L.L., Stermitz, F.R., and J.R. FALCK, "Electrooxidative Cyclization of Laudanosine. A Novel Nonphenolic Coupling Reaction". J. Am. Chem. Soc. 93: 5941-5942, l97l.

2. Miller, L.L., Stermitz, F.R., and J.R. FALCK, "Electrooxidative Cyclization of l-Benzyltetrahydroisoquinolines. A novel Nonphenolic Coupling Reaction". J. Am. Chem. Soc 95: 265l-2656, l973.

3. Coomes, R.M., FALCK, J.R., Williams, D.K., and F.R. Stermitz, "Alkaloids of the Papaveraceae. XX. 2,9-Dimethoxy-3-hydroxypavinane, a New Alkaloid from Argemone munita subsp. rotundata". J. Org. Chem. 38: 370l-3704, l973.

4. FALCK, J.R., Miller, L.L., and F.R. Stermitz, "Electrooxidative Synthesis of Morphinandienones from l-Benzyltetrahydroisoquinolines". Tetrahedron 30: 93l-934, l974.

5. FALCK, J.R., Miller, L.L., and F.R. Stermitz, "Anodic Cyclization-Rearrangement of Methoxybibenzyls to Dihydrophenanthrones". J. Am. Chem. Soc. 96: 298l-2986, l974.

6. Cohen, T., Herman, G., FALCK, J.R., and A.J. Mura, Jr., "Copper(I) Promoted Thiophenoxide Ionization in Solution. A Simple Synthesis of Vinyl Phenyl Sulphides". J. Org. Chem. 40: 8l2-8l3, l975.

7. Cohen, T., Kuhn, D., and J.R. FALCK, "Application of Copper(l)-Induced Thiophenoxide Removal to Ring Expansions or Chain Extensions of Ketones and Aldehydes. Detection, Isolation, and Independent Preparation of the ?-Epoxy Thioether Intermediate." J. Am. Chem. Soc. 97: 4749-475l, l975.

8. Cohen, T., Mura, A.J., Shull, D.W., Fogel, E.R., Ruffner, R.J., and J.R. FALCK, "Removal of Sulfur Groups from Molecules by Copper (I). Preparation of Sulfur-Substituted l,3-Dienes for Diels-Alder Reactions". J. Org. Chem. 4l: 32l8-32l9, l976.

9. Corey, E.J., Trybulski, E.J., Melvin, L.S., Nicolaou, K.C., Secrist, J., Lett, R., Sheldrake, P., FALCK, J.R., Brunelle, D.J., Haslanger, M.F., Kim, S., and S.-E. Yoo, "Total Synthesis of Erythromycins (Part III). Stereoselective Routes to Intermediates Corresponding to C(1) to C(9) and C(10) to C(13) Fragments of Erythronolide B." J. Am. Chem. Soc. l00: 46l8-4620, l978.

10. Corey, E.J., Kim, S., Yoo, S.-E., Nicolaou, K.C., Melvin, L.S., Brunelle, D.J., J.R. FALCK, Trybulski, E.J., Lett, R., and P. Sheldrake, "Total Synthesis of Erythromycins (Part IV). Total Synthesis of Erythronolide B". J. Am. Chem. Soc. l00: 4620-4622, l978.

11. Corey, E.J., Niwa, H., and J.R. FALCK, "Selective Epoxidation of Eicosa-cis-5,8,ll,l4-tetraenoic (Arachidonic) Acid and Eicosa-cis-8,ll,l4-trienoic Acid". J. Am. Chem. Soc. l0l: l586-l587, l979.

12. Barrett, A.G.M., Barton, D.H.R., FALCK, J.R., Papaioannou, D., and D. Widdowson, "Phenol Oxidation and Biosynthesis. Part 26. Isonitriles in the Synthesis of Benzylisoquinoline Derivatives". J.C.S. Perkin I: 652-66l, l979.

13. Corey, E.J., Hopkins, P.B., Kim, S., Yoo, S.-E., Nambiar, K.P., and J.R. FALCK, "Total Synthesis of Erythromycins (Part V). Total Synthesis of Erythronolide A". J. Am. Chem. Soc. l0l: 7l3l-7l34, l979.

14. Corey, E.J., Marfat, A., FALCK, J.R., and J.O. Albright, "Controlled Chemical Synthesis of the Enzymatically Produced Eicosanoids ll-, l2-, and l5-HETE from Arachidonic Acid and Conversion into the Corresponding Hydroperoxides (HPETE)". J. Am. Chem. Soc. l02: 1433-1435, l980.

15. Brown, M.S., Basu, S.K., FALCK, J.R., Ho, Y.K., and J.L. Goldstein, "The Scavenger Cell Pathway for Lipoprotein Degradation: Specificity of the Binding Site that Mediates the Uptake of Negatively-Charged LDL by Macrophages". J. Supra. Struct. 13: 67-81, 1980.

16. FALCK, J.R. and S. Manna, "An Intramolecular Passerini Reaction: Synthesis of Hydrastine". Tetrahedron Lett. 22: 619-620, 1981.

17. FALCK, J.R., Manna, S., and C. Mioskowski, "Oxazoline Chemistry. Preparation of Isoquinolines and 2,2'-Bisoxazolines". J. Org. Chem. 46: 3742-3745, 1981.

18. Mosley, S.T., Goldstein, J.L., Brown, M.S., FALCK, J.R., and R.G.W. Anderson, "Targeted Killing of Cultured Cells by Receptor-dependent Photosensitization". Proc. Natl. Acad. Sci. USA 78: 5717-5721, 1981.

19. FALCK, J.R., Krieger, M., Goldstein, J.L., and M.S. Brown, "Preparation and Spectral Properties of Lipophilic Fluorescein Derivatives: Application to Plasma Low-Density Lipoprotein". J. Am. Chem. Soc. 103: 7396-7398, 1981.

20. Chacos, N., FALCK, J.R., Wixtrom, C., and J. Capdevila, "Novel Epoxides Formed During the Liver Cytochrome P-450 Oxidation of Arachidonic Acid". Biochem. Biophys. Res. Comm. 104: 916-922, 1982.

21. FALCK, J.R. and S. Manna, "8,9-Epoxyarachidonic Acid: A Cytochrome P-450 Metabolite". Tetrahedron Lett. 23: 1755-1756, 1982.

22. Manna, S., FALCK, J.R., and C. Mioskowski, "Isoquinolinium Cycloadditions: Regiospecific Synthesis of 1-Naphthaldehydes and Conversion to 1-Naphthylamines". J. Org. Chem. 47: 5021-5023, 1982.

23. Yang, Y.-L. and J.R. FALCK, "Mevinic Acids and Analogues: Preparation of a Key Chiral Intermediate". Tetrahedron Lett. 23: 4305-4308, 1982.

24. Manna, S., FALCK, J.R., Chacos, N., and J. Capdevila, "Synthesis of Arachidonic Acid Metabolites Produced by Purified Kidney Cortex Microsomal Cytochrome P-450". Tetrahedron Lett. 24: 33-36, 1983.

25. FALCK, J.R., Manna, S., and C. Mioskowski, "Isoquinolinium Cycloadditions: Total Synthesis of (±)-14-Epicorynoline and O-Methylarnottianamide". J. Am. Chem. Soc. 105: 631-633, 1983.

26. Chacos, N., Capdevila, J., FALCK, J.R., Manna, S., Martin-Wixtrom, C., Gill, S.S., Hammock, B.D., and R.W. Estabrook, "The Reaction of Arachidonic Acid Epoxides (Epoxyeicosatrienoic Acids) with a Cytosolic Epoxide Hydrolase". Arch. Biochem. Biophys. 223: 639-648, 1983.

27. Snyder, G.D., Capdevila, J., Chacos, N., Manna, S., and J.R. FALCK, "Action of Luteinizing Hormone-Releasing Hormone: Involvement of Novel Arachidonic Acid Metabolites". Proc. Natl. Acad. Sci. USA 80: 3504-3507, 1983.

28. FALCK, J.R., Manna, S., Moltz, J., Chacos, N., and J. Capdevila, "Epoxyeicosatrienoic Acids Stimulate Glucagon and Insulin Release from Isolated Pancreatic Islets". Biochem. Biophys. Res. Comm. 114: 743-749, 1983.

29. Krieger, M., Ho, Y.K., and J.R. FALCK., "Reconstitution of LDL with Lipophilic Fluorescein Derivatives: Quantitative Analysis of the LDL Receptor-Activity of Human Lymphocytes". J. Receptor Res. 3: 361-375, 1983.

30. Capdevila, J., Chacos, N., FALCK, J.R., Manna, S., Negro-Vilar, A., and S.R. Ojeda, "Novel Hypothalamic Arachidonate Products Stimulate Somatostatin Release from the Median Eminence". Endocrinology 113: 421-423, 1983.

31. Kutsky, P., FALCK, J.R., Weiss, G.B., Manna, S., Chacos, N., and J. Capdevila, "Effects of Newly Reported Arachidonic Acid Metabolites on Microsomal Ca2+ Binding, Uptake, and Release". Prostaglandins 26: 13-21, 1983.

32. FALCK, J.R., Manna, S., Siddhanta, A.K., Capdevila, J., and J.D. Buynak, "Transformation of 15-HETE to 14,15-Dihydroxyeicosatrienoic Acid and 11,14,15- and 13,14,15-Trihydroxyeicosatrienoic Acid". Tetrahedron Lett. 24: 5715-5718, 1983.

33. FALCK, J.R., Manna, S., Capdevila, J., and J.D. Buynak, "Synthesis of 14(R),15(S)- and 14(S),15(S)-Dihydroxy-5,8-Z-10,12-E-eicosatetraenoic Acid". Tetrahedron Lett. 24: 5719-5720, 1983.

34. Mioskowski, C., Manna, S., and J.R. FALCK, "1,5-Addition of Dialkylcuprate Reagents to Alkylcyclopropyl Ketones". Tetrahedron Lett. 24: 5521-5524, 1983.

35. Mioskowski, C., Manna, S., and J.R. FALCK, "Reactivity of (,(-Unsaturated Acetals and Ketals Toward Organolithium Reagents in Pentane". Tetrahedron Lett. 25: 519-522, 1984.

36. FALCK, J.R., Siddhanta, A.K., Estabrook, R.W., Capdevila, J., and C. Mioskowski, "5- and 8-HETE Production By Rat Hepatic Microsomal Cytochrome P-450". Tetrahedron Lett. 25: 1457-1458, 1984.

37. Firestone, R.A., Pisano, J.M., FALCK, J.R., McPhaul, M.M., and M. Krieger, "Selective Delivery of Cytotoxic Compounds to Cells by the LDL Pathway". J. Med. Chem. 27: 1037-1043, 1984.

38. Capdevila, J., Saeki, Y., and J.R. FALCK, "The Mechanistic Plurality of Cytochrome P-450 and Its Biological Ramifications". Xenobiotica 14: 105-118, 1984.

39. Yang, Y.-L., Manna, S., and J.R. FALCK, "Total Synthesis of (+)-Dihydrocompactin". J. Am. Chem. Soc. 106: 3811-3814, 1984.

40. FALCK, J.R., Manna, S., and J. Capdevila, "Enantiospecific Synthesis of Methyl 11,12- and 14,15-Epoxyeicosatrienoate". Tetrahedron Lett. 25: 2443-2446, 1984.

41. Capdevila, J., Pramanik, B., Napoli, J.L., Manna, S., and J.R. FALCK, "Arachidonic Acid Epoxidation: Epoxyeicosatrienoic Acids are Endogenous Constituents of Rat Liver". Arch. Biochem. Biophys. 231: 511-517, 1984.

42. FALCK, J.R., Manna, S., Jacobson, H.R., Estabrook, R.W., Chacos, N., and J. Capdevila, "Absolute Configuration of Epoxyeicosatrienoic Acids (EETs) Formed During Catalytic Oxygenation of Arachidonic Acid By Purified Rat Liver Microsomal Cytochrome P-450". J. Am. Chem. Soc. 106: 3334-3336, 1984.

43. FALCK, J.R. and Y.-L. Yang, "Total Synthesis of (+)-Dihydromevinolin". Tetrahedron Lett. 25: 3563-3566, 1984.

44. Anderson, R.G.W., FALCK, J.R., Goldstein, J.L., and M.S. Brown, "Visualization of Acidic Organelles in Intact Cells by Electron Microscopy". Proc. Natl. Acad. Sci. USA 81: 4838-4842, 1984.

45. Capdevila, J., Snyder, G.D., and J.R. FALCK, "Epoxygenation of Arachidonic Acid by Rat Anterior Pituitary Microsomal Fractions". FEBS Lett. 178: 319-322, 1984.

46. Ousset, J.B., Mioskowski, C., Yang, Y.-L., and J.R. FALCK, "Enol Ethers: Preparation and Synthetic Applications". Tetrahedron Lett. 25: 5903-5906, 1984.

47. Mosley, S.T., Yang, Y.-L., FALCK, J.R., and R.G.W. Anderson, "Receptor-Mediated Delivery of Photoprotective Agents by Low-Density Lipoprotein". Exp. Cell Res. 155: 389-396, 1984.

48. FALCK, J.R., Manna, S., Viala, J., Siddhanta, A.K., Moustakis, C.A., and J. Capdevila, "Arachidonate Epoxygenase: Inhibitors and Metabolite Analogues". Tetrahedron Lett. 26: 2287-2290, 1985.

49. Negro-Vilar, A., Snyder, G.D., FALCK, J.R., Manna, S., Chacos, N., and J. Capdevila, "Involvement of Eicosanoids in Release of Oxytocin and Vasopressin from the Neural Lobe of the Rat Pituitary". Endocrinology 116: 2663-2668, 1985.

50. Spearman, M.E., Prough, R.A., Estabrook, R.W., FALCK, J.R., Manna, S., Leibman, K.C., Murphy, R.C., and J. Capdevila, "Novel Glutathione Conjugates formed from Epoxyeicosatrienoic Acids (EETs)". Arch. Biochem. Biophys. 242: 225-230, 1985.

51. Capdevila, J., Kim, R.Y., Martin-Wixtrom, C., FALCK, J.R., Manna, S., and R.W. Estabrook, "Influence of a Fibric Acid-Type of Hypolipidemic Agent on the Oxidative Metabolism of Arachidonic Acid by Liver Microsomal Cytochrome P-450". Arch. Biochem. Biophys. 243: 8-19, 1985.

52. Manna, S., FALCK, J.R., and C. Mioskowski, "A Convenient Preparation of Alkyl Halides and Cyanides from Alcohols by Modification of the Mitsunobu Procedure". Syn. Commun. 15: 663-668, 1985.

53. Moustakis, C.A., Viala, J., Capdevila, J., and J.R. FALCK, "Total Synthesis of the Cytochrome P-450 Epoxygenase Metabolites 5(R),6(S)-, 5(S),6(R)-, and 14(R),15(S)-Epoxyeicosatrienoic Acid (EET) and Hydration Products 5(R),6(R)- and 14(R),15(R)-Dihydroxyeicosatrienoic Acid (DHET)". J. Am. Chem. Soc. 107: 5283-5285, 1985.

54. Campbell, W.B., FALCK, J.R., Okita, J.R., Johnson, A.R., and K.S. Callahan, "Synthesis of Dihomoprostaglandins from Adrenic Acid (7,10,13,16-Docosatetraenoic Acid) by Human Endothelial Cells". Biochim. Biophys. Acta 837: 67-76, 1985.

55. Mosset, P., Manna, S., Viala, J., and J.R. FALCK, "Isomerization of Epoxides to Allylic Alcohols Using Methylmagnesium N-Cyclohexylisopropylamide". Tetrahedron Lett. 27: 299-302, 1986.

56. Moustakis, C.A., Weerasinghe, D.K., Mosset, P., FALCK, J.R., and C. Mioskowski, "Synthesis of 12(R),13(S)-Oxido-9Z-octadecenoic (Vernolic) and 13(S)-Hydroxy-9Z,11E-octadecadienoic (Coriolic) Acid". Tetrahedron Lett. 27: 303-304, 1986.

57. Manna, S., Viala, J., Yadagiri, P., and J.R. FALCK, "Synthesis of 12(S),20- ,12(S),19(R)-, and 12(S),19(S)-Dihydroxyeicosa-cis-5,8,14-trans-10-tetraenoic Acids, Metabolites of 12(S)-HETE". Tetrahedron Lett. 27: 2679-2682, 1986.

58. Snyder, G., Lattanzio, F., Yadagiri, P., FALCK, J.R., and J. Capdevila, "5,6-Epoxyeicosatrienoic Acid Mobilizes Ca2+ in Anterior Pituitary Cells". Biochem. Biophys. Res. Comm. 139: 1188-1194, 1986.

59. Mosset, P., Yadagiri, P., Lumin, S., Capdevila, J., and J.R. FALCK, "Arachidonate Epoxygenase: Total Synthesis of Both Enantiomers of 8,9- and 11,12-Epoxyeicosatrienoic Acid". Tetrahedron Lett. 27: 6035-6038, 1986.

60. Yadagiri, P., Lumin, S., Mosset, P., Capdevila, J., and J.R. FALCK, "Enantiospecific Total Synthesis of 8- and 12-Hydroxyeicosatetraenoic Acid". Tetrahedron Lett. 27: 6039-6040, 1986.

61. Capdevila, J., Yadagiri, P., Manna, S., and J.R. FALCK, "Absolute Configuration of the Hydroxyeicosatetraenoic Acids (HETEs) Formed During Catalytic Oxygenation of Arachidonic Acid by Microsomal Cytochrome P-450". Biochem. Biophys. Res. Comm. 141: 1007-1011, 1986.

62. Toto, R., Siddhanta, A., Manna, S., Pramanik, B., FALCK, J.R., and J. Capdevila, "Arachidonic Acid Epoxygenase: Detection of Epoxyeicosatrienoic Acids (EETs) in Human Urine". Biochim. Biophys. Acta 919: 132-139, 1987.

63. Sun, L., Yadagiri, P., FALCK, J.R., Capdevila, J., Mosset, P., and R. Gree, "Total Synthesis of 5(S),20- and 15(S),20-Dihydroxyeicosatetraenoic Acid and 5(S),6(R)-Epoxy-20-hydroxy- and 14(R),15(S)-Epoxy-20-hydroxyeicosatrienoic Acid". J.C.S. Chem. Commun., 389-390, 1987.

64. FALCK, J.R., Schueler, V.J., Jacobson, H.R., Siddhanta, A.K., Pramanik, B., and J. Capdevila, "Arachidonate Epoxygenase: Identification of Epoxyeicosatrienoic Acids (EETs) in Rabbit Kidney". J. Lipid Res. 28: 840-846, 1987.

65. Proctor, K.G., FALCK, J.R., and J. Capdevila, "Intestinal Vasodilation by Epoxyeicosatrienoic Acids: Arachidonic Acid Metabolites Produced by a Cytochrome P450 Monooxygenase". Circ. Res. 60: 50-59, 1987.

66. Capdevila, J.H., Kishore, V., Dishman, E., Blair, I.A., and J.R. FALCK, "A Novel Pool of Rat Liver Inositol and Ethanolamine Phospholipids Contains Epoxyeicosatrienoic Acids (EETs)". Biochem. Biophys. Res. Comm. 146: 638-644, 1987.

67. Carroll, M.A., Schwartzman, M., Capdevila, J., FALCK, J.R., and J.C. McGiff, "Vasoactivity of Arachidonic Acid Epoxides". Eur. J. Pharm. 138: 281-283, 1987.

68. Manna, S., Yadagiri, P., and J.R. FALCK, "Terpenoid Precursors via Steroid Degradation: Synthesis of (-)-Warburganal". J.C.S. Chem. Commun., 1324-1325, 1987.

69. Declercq, P.E., FALCK, J.R., Kuwajima, M., Tyminski, H., Foster, D.W., and J.D. McGarry, "Characterization of the Mitochondrial Carnitine PalmitoyLettansferase Enzyme System. I. Use of Inhibitors". J. Biol. Chem. 262: 9812-9821, 1987.

70. Capdevila, J.H., Mosset, P., Yadagiri, P., Lumin, S., and J.R. FALCK, "NADPH-Dependent Microsomal Metabolism of 14,15-Epoxyeicosatrienoic Acid to Diepoxides and Epoxyalcohols". Arch. Biochem. Biophys. 261: 122-133, 1988.

71. Capdevila, J., Gil, L., Orellana, M., Marnett, L.J., Mason, J.I., Yadagiri, P., and J.R. FALCK, "Inhibitors of Cytochrome P-450 Dependent Arachidonic Acid Metabolism". Arch. Biochem. Biophys. 261: 257-263, 1988.

72. Marcus, A.J., Safier, L.B., Ullman, H.L., Islam, N., Broekman, M.J., FALCK, J.R., Fischer, S., and C. von Schacky, "Platelet-Neutrophil Interactions. (12S)-Hydroxyeicosatetraen-1,20-dioic Acid: A New Eicosanoid Synthesized by Unstimulated Neutrophils from 12(S),20-Dihydroxyeicosatetraenoic Acid". J. Biol. Chem. 263: 2223-2229, 1988.

73. Reddy, P.S., Yadagiri, P., Lumin, S., Shin, D.-S., and J.R. FALCK, "Modified Pyridinium Chlorochromate Oxidation of Aldehydes to Carbamoyl Azides/Acyl Azides or Carboxylic Acids". Syn. Commun. 18: 545-551, 1988.

74. Lapuerta, L., Chacos, N., FALCK, J.R., Jacobson, H., and J.H. Capdevila, "Renal Microsomal Cytochrome P-450 and the Oxidative Metabolism of Arachidonic Acid". Am. J. Med. Sci. 295: 275-279, 1988.

75. Proctor, K.G., Shatkin, S., Jr., Kaminski, P.M., FALCK, J.R., and J.H. Capdevila, "Modulation of Arteriolar Blood Flow by Inhibitors of Arachidonic Acid Oxidation After Thermal Injury: Possible Role for a Novel Class of Vasodilator Metabolites". Circ. 77: 1185-1196, 1988.

76. Coceani, F., Breen, C.A., Lees, J.G., FALCK, J.R., and P.M. Olley, "Further Evidence Implicating a Cytochrome P-450-Mediated Reaction in the Contractile Tension of the Lamb Ductus Arteriosus". Circ. Res. 62: 471-477, 1988.

77. Bolitt, V., Mioskowski, C., Reddy, S.P., and J.R. FALCK, "A Convenient Synthesis of Pyrido[3,4-G]isoquinoline via Ortho-Directed Metallation/ Dimerization". Synthesis: 388-389, 1988.

78. Escalante, B., FALCK, J.R., Yadagiri, P., Sun, L., and M. Laniado-Schwartzman, "19(S)-Hydroxyeicosatetraenoic Acid is a Potent Stimulator of Renal Na+-K+-ATPase". Biochem. Biophys. Res. Comm. 152: 1269-1274, 1988.

79. Lumin, S., Yadagiri, P., and J.R. FALCK, "Synthesis of Trioxilin B3". Tetrahedron Lett. 29: 4237-4240, 1988.

80. Bolitt, V., Mioskowski, C., Shin, D.-S., and J.R. FALCK, "Triphenylphosphine Hydrobromide: A Mild and Efficient Catalyst for Tetrahydropyranylation of Tertiary Alcohols". Tetrahedron Lett. 29: 4583-4586, 1988.

81. Yadagiri, P., Shin, D.-S., and J.R. FALCK, "Enantiospecific Synthesis of Isomeric 8,9,12-Trihydroxyeicosa-5(Z),10(E),14(Z)-trienoic Acids". Tetrahedron Lett. 29: 5497-5500, 1988.

82. Murphy, R.C., FALCK, J.R., Lumin, S., Yadagiri, P., Zirrolli, J.A., Balazy, M., Masferrer, J.L., Abraham, N.G., and M.L. Schwartzman, "12(R)-Hydroxyeicosatrienoic Acid: A Vasodilator Cytochrome P-450 Dependent Arachidonate Metabolite from the Bovine Cornea Epithelium". J. Biol. Chem. 263: 17197-17202, 1988.

83. Mosset, P., Gree, R., and J.R. FALCK, "Synthesis of Two Intermediate Phosphonium Salts for 5,20- and 15,20-DiHETEs". Syn. Commun. 19: 645-658, 1989.

84. Snyder, G.D., Yadagiri, P., and J.R. FALCK, "Effect of Epoxyeicosatrienoic Acids on Growth Hormone Release from Somatotrophs". Am. J. Physiol. 256: E221-E226, 1989.

85. Escalante, B., Sessa, W.C., FALCK, J.R., Yadagiri, P., and M.L. Schwartzman, "Vasoactivity of 20-Hydroxyeicosatetraenoic Acid is Dependent on Metabolism by Cyclooxygenase". J. Pharm. Exp. Ther. 248: 229-232, 1989.

86. Yadagiri, P., Lumin, S., FALCK, J.R., Karara, A., and J. Capdevila, "Total Synthesis of 5(S),12(S)- and 5(S),12(R)-Dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic Acids, Metabolites of Leukotriene B4". Tetrahedron Lett. 30: 429-432, 1989.

87. Proctor, K.G., Capdevila, J.H., FALCK, J.R., Fitzpatrick, F.A., Mullane, K.M., and J.C. McGiff, "Cardiovascular and Renal Actions of Cytochrome P-450 Metabolites of Arachidonic Acid". Blood Vessels 26: 53-64, 1989.

88. Chabert, P., Mioskowski, C., and J.R. FALCK, "Synthesis of (±)-Hepoxilin A3 Utilizing Arsonium Ylides". Tetrahedron Lett. 30: 2545-2548, 1989.

89. Ibe, B.O., FALCK, J.R., Johnson, A.R., and W.B. Campbell, "Regulation of Synthesis of Prostacyclin and HETES in Human Endothelial Cells". Am. J. Physiol. 256: C1168-C1175, 1989.

90. Karara, A., Dishman, E., Blair, I., FALCK, J.R., and J.H. Capdevila, "Endogenous Epoxyeicosatrienoic Acids (EETs): Cytochrome P-450 Controlled Stereoselectivity of the Hepatic Arachidonic Acid Epoxygenase". J. Biol. Chem. 264: 19822-19827, 1989.

91. Schwartzman, M.L., FALCK, J.R., Yadagiri, P., and B. Escalante, "Metabolism of 20-Hydroxyeicosatetraenoic Acid by Cyclooxygenase: Formation and Identification of Novel Endothelium - Dependent Vasoconstrictor Metabolites". J. Biol. Chem. 264: 11658-11662, 1989.

92. Shin, D.-S., Yadagiri, P., FALCK, J.R., Masferrer, J.L., and M.L. Schwartzman, "Synthesis and Structure Confirmation of Compound D, A Proinflammatory Arachidonate Metabolite". Tetrahedron Lett. 30: 3923-3926, 1989.

93. Belardetti, F., Campbell, W.B., FALCK, J.R., Demontis, G., and M. Rosolowsky, "Products of Heme-Catalyzed Transformation of the Arachidonate Derivative 12-HPETE Open S-Type K+-Channels in Aplysia". Neuron 3: 497-505, 1989.

94. Hammonds, T.D., Blair, I.A., FALCK, J.R., and J.H. Capdevila, "Resolution of Epoxyeicosatrienoate Enantiomers by Chiral Phase Chromatography". Anal. Biochem. 182: 300-303, 1989.

95. Boubia, B., Mioskowski, C., Manna, S., and J.R. FALCK, "Homologation of Aldehydes Using (Phenylthiomethylene)triphenylarsorane: Selective Preparation of (-Thiophenoxyepoxides and Phenylthioenol Ethers". Tetrahedron Lett. 30: 6023-6026, 1989.

96. Bolitt, V., Mioskowski, C., and J.R. FALCK, "Direct Anomeric Substitution of Pyranyl Esters using Organocopper Reagents." Tetrahedron Lett. 30: 6027-6030, 1989.

97. FALCK, J.R. and P. Yadagiri, "Enantiospecific Synthesis of D-myo-Inositol 1,4,5-Trisphosphate from (-)-Quinic Acid". J. Org. Chem. 54: 5851-5852, 1989.

98. Hirt, D.L., Capdevila, J., FALCK, J.R., Breyer, M.D., and H.R. Jacobson, "Cytochrome P450 Metabolites of Arachidonic Acid are Potent Inhibitors of Vasopressin Action on Rabbit Cortical Collecting Duct". J. Clin. Invest. 84: 1805-1812, 1989.

99. Rosolowsky, M., FALCK, J.R., Willerson, J.T., and W.B. Campbell, "Synthesis of Lipoxygenase and Epoxygenase Products of Arachidonic Acid by Normal and Stenosed Canine Coronary Arteries". Circ. Res. 66: 608-621, 1990.

100. Henrich, W.L., FALCK, J.R., and W.B. Campbell, "Inhibition of Resin Release by 14,15-Epoxyeicosatrienoic Acid in Renal Cortical Slices". Am. J. Physl. 258: E269-E274, 1990.

101. Wainwright, S., FALCK, J.R., Yadagiri, P. and W.S. Powell, "Stereochemistry of Leukotriene B4 Metabolites formed by the Reductase Pathway in Porcine Polymorphonuclear Leukocytes: Inversion of Stereochemistry of the 12-Hydroxyl Group". Biochem. 29: 1180-1185, 1990.

102. FALCK, J.R., Wittenberger, S.J., Rajapaksa, D., Mioskowski, C. and B. Boubia, "Heterocyclic [4++2] Cycloadditions: The Reactivity of Pyridinium Salts with Electron-Rich Olefins". J.C.S. Perkin Trans. I: 413-414, 1990.

103. Junier, M.P., Dray, F., Blair, I., Capdevila, J., Dishman, E., FALCK, J.R., and S.R. Ojeda, "Epoxygenase Products of Arachidonic Acid are Endogenous Constituents of the Hypothalamus Involved in D2 Receptor-Mediated, Dopamine-Induced Release of Somatostatin". Endocrinol. 126: 1534-1540, 1990.

104. Lin, W.-K., FALCK, J.R., and P.-K. Wong, "Effect of 14,15-Epoxyeicosatrienoic Acid Infusion on Blood Pressure in Normal and Hypertensive Rats". Biochem. Biophys. Res. Commun. 167: 977-981, 1990.

105. Takahashi, K., Capdevila, J., Karara, A., FALCK, J.R., Jacobson, H.R., and K.F. Badr, "Cytochrome P-450 Arachidonate Metabolites in Rat Kidney: Characterization and Hemodynamic Responses". Am. J. Physiol. 258: F781-F789, 1990.

106. Lumin, S. and J.R. FALCK, "Synthesis and Stereochemical Revision of a Bioactive Dihydroxyeicosanoid Isolated from the Red Marine Alga Farlowia mollis". Tetrahedron Lett. 31: 2971-2974, 1990.

107. FALCK, J.R., Lumin, S., Blair, I., Dishman, E., Martin, M.V., Waxman, D.J., Guengerich, F.P., and J.H. Capdevila, "Cytochrome P-450-Dependent Oxidation of Arachidonic Acid to 16-, 17-, and 18-Hydroxyeicosatetraenoic Acids". J. Biol. Chem. 265: 10244-10249, 1990.

108. FALCK, J.R., Abdali, A., and S.J. Wittenberger, "Total Synthesis of the 5-Methylenephosphonate Analogue of D-myo-Inositol 1,4,5-Trisphosphate". J.C.S. Chem. Commun., 953-955, 1990.

109. Capdevila, J.H., Karara, A., Waxman, D.J., Martin, M.V., FALCK, J.R., and F.P. Guenguerich, "Cytochrome P-450 Enzyme-specific Control of the Regio- and Enantiofacial Selectivity of the Microsomal Arachidonic Acid Epoxygenase". J. Biol. Chem. 265: 10865-10871, 1990.

110. Kumlin, M., FALCK, J.R., Raud, J., Harada, Y., Dahlen, S.E., and E. Granström, "Identification and Biological Activity of Dihydro-Leukotriene B4: A Prominent Metabolite of Leukotriene B4 in the Human Lung". Biochem. Biophys. Res. Comm. 170: 23-29, 1990.

111. Karara, A., Dishman, E., Jacobson, H., FALCK, J.R., and J.H. Capdevila, "Arachidonic Acid Epoxygenase: Stereochemical Analysis of the Endogenous Epoxyeicosatrienoic Acids of Human Kidney Cortex". FEBS Lett. 268: 227-230, 1990.

112. Escalante, B., Sessa, W.C., FALCK, J.R., Yadagiri, P., and M. L. Schwartzman, "Cytochrome P450-Dependent Arachidonic Acid Metabolites, 19- and 20-Hydroxyeicosatraenoic Acids, Enhance Sodium-Potassium ATPase Activity in Vascular Smooth Muscle". J. Cardiovas. Pharm. 16: 438-443, 1990.

113. Bolitt, V., Mioskowski, C., Lee, S.-G., and J.R. FALCK, "Direct Preparation of 2-Deoxy-D-glucopyranosides from Glucals without Ferrier Rearrangement". J. Org. Chem. 55: 5812-5813, 1990.

114. Wainwright, S., FALCK, J.R., Yadagiri, P., and W.S. Powell, "Metabolism of 12(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid and Other Hydroxylated Fatty Acids by the Reductase Pathway in Porcine Polymorphonuclear Leukocytes". Biochem. 29: 10126-10135, 1990.

115. Carroll, M.A., Garcia, M.P., FALCK, J.R., and J.C. McGiff, "5,6-Epoxyeicosatrienoic Acid, a Novel Arachidonate Metabolite: Mechanism of Vasoactivity in the Rat". Circ. Res. 67: 1082-1088, 1990.

116. Escalante, B., Erlij, D., FALCK, J.R., and J.C. McGiff, "Effect of Cytochrome P450 Arachidonate Metabolites on Ion Transport in Rabbit Kidney Loop of Henle". Science 251: 799-802, 1991.

117. Bernstrom, K., Malcolm, K., McGee, J., Maclouf, J., Levy-Toledano, S., FALCK, J.R., and F.A. Fitzpatrick, "14,15-cis-Episulfide-eicosatrienoic Acid, an 'Epoxygenase' Eicosanoid Analog, Inhibits Ionophore- But Not Thrombin-Induced Platelet Aggregation". Molec. Pharm. 39: 114-119, 1991.

118. Westlund, P., Palmblad, J., FALCK, J.R., and S. Lumin, "Synthesis, Structural Identification and Biological Activity of 11,12-Dihydroxyeicosatetraenoic Acids Formed in Human Platelets". Biochim. Biophys. Acta 1081: 301-307, 1991.

119. Campbell, W.B., Brady, M.T., Rosolowsky, L.J., and J.R. FALCK, "Metabolism of Arachidonic Acid by Rat Adrenal Glomerulosa Cells: Synthesis of Hydroxyeicosatetraenoic Acids and Epoxyeicosatrienoic Acids". Endocrinology 128: 2183-2194, 1991.

120. Lumin, S., FALCK, J.R., and M.L. Schwartzman, "A Concise Synthesis of (R)-Hydroxy-E,Z-Diene Fatty Acids: Preparation of 12(R)-HETE, Tetranor-12(R)-HETE, and 13(R)-HODE". Tetrahedron Lett. 32: 2315-2318, 1991.

121. Karara, A., Dishman, E., FALCK, J.R., and J.H. Capdevila, "Endogenous Epoxyeicosatrienoyl-phospholipids. A Novel Class of Cellular Glycerolipids Containing Epoxidized Arachidonate Moieties". J. Biol. Chem. 266: 7561-7569, 1991.

122. Bolitt, V., Mioskowski, C., Bhatt, R.K., and J.R. FALCK, "Synthesis of (S)-(+)-Mevalonolactone and Mevalonate Analogues". J. Org. Chem. 56: 4238-4240, 1991.

123. Masferrer, J.L., Rimarachin, J.A., Gerritsen, M.E., FALCK, J.R., Yadagiri, P., Dunn, M.W., and M. Laniado-Schwartzman, "12(R)-Hydroxyeicosatrienoic Acid, a Potent Chemotactic and Angiogenic Factor Produced by the Cornea". Exp. Eye Res. 52: 417-424, 1991.

124. Bolitt, V., Mioskowski, C., Kollah, R.O., Manna, S., Rajapaksa, D., and J.R. FALCK, "Total Synthesis of Vineomycinone B2 Methyl Ester via Double Bradsher Cyclization". J. Am. Chem. Soc. 113: 6320-6321, 1991.

125. Katoh, T., Takahashi, K., Capdevila, J., Karara, A., FALCK, J.R., Jacobson, H.R., and K.F. Badr, "Glomerular Stereospecific Synthesis and Hemodynamic Actions of 8,9-Epoxyeicosatrienoic Acid in Rat Kidney". Am. J. Physiol. 261: F578-F586, 1991.

126. Pfister, S.L., FALCK, J.R., and W.B. Campbell, "Enhanced Synthesis of Epoxyeicosatrienoic Acids by Cholesterol-Fed Rabbit Aorta". Am. J. Physiol. 261: H843-H852, 1991.

127. Abraham, N.G., Feldman, E., FALCK, J.R., Lutton, J.D., and M.L. Schwartzman, "Modulation of Erythropoiesis by Novel Bone Marrow Cytochrome P450-Dependent Metabolites of Arachidonic Acid". Blood 78: 1461-1466, 1991.

128. Nishimura, M., Schwartzman, M.L., FALCK, J.R., Lumin, S., Zirrolli, J.A., and R.C. Murphy, "Metabolism of 12(R)-Hydroxy-5,8,10,14-eicosatetraenoic Acid (12(R)-HETE) in Corneal Tissues: Formation of Novel Metabolites". Arch. Biochem. Biophys. 290: 326-335, 1991.

129. Schwartzman, M.L., Omata, K., Lin, F., Bhatt, R.K., FALCK, J.R., and N.G. Abraham, "Detection of 20-Hydroxyeicosatetrenoic Acid in Rat Urine". Biochem. Biophys. Res. Comm. 180: 445-449, 1991.

130. Amruthesh, S.C., FALCK, J.R., and E.F. Ellis, "Brain Synthesis and Cerebrovascular Action of Epoxygenase Metabolites of Arachidonic Acid". J. Neurochem. 58: 503-510, 1992.

131. Capdevila, J.H., FALCK, J.R., and R.W. Estabrook, "Cytochrome P450 and the Arachidonate Cascade". FASEB J. 6: 731-736, 1992.

132. Carroll, M.A., Garcia, M.P., FALCK, J.R., and J.C. McGiff, "Cyclooxygenase Dependency of the Renovascular Actions of Cytochrome P450-Derived Arachidonate Metabolites". J. Pharm. Exp. Therap. 260: 104-109, 1992.

133. Jajoo, H.K., Capdevila, J.H., FALCK, J.R., Bhatt, R.K., and I.A. Blair, "Metabolism of 12(R)-Hydroxyeicosatetraenoic Acid by Rat Liver Microsomes". Biochim. Biophys. Acta 1123: 110-116, 1992.

134. Karara, A., Wei, S., Spady, D., Swift, L., Capdevila, J., and J.R. FALCK, "Arachidonic Acid Epoxygenase: Structural Characterization and Quantification of Epoxyeicosatrienoates in Plasma". Biochem. Biophys. Res. Comm. 182: 1320-1325, 1992.

135. Lumin, S., FALCK, J.R., Capdevila, J., and A. Karara, "Palladium Mediated Allylic Mitsunobu Displacement: Stereocontrolled Synthesis of Hepoxilin A3 and Trioxilin A3 Methyl Esters". Tetrahedron Lett. 33: 2091-2094, 1992.

136. Prakash, C., Zhang, J.Y., FALCK, J.R., Chauhan, K. and I.A. Blair, "20-Hydroxyeicosatetraenoic Acid is Excreted as a Glucuronide Conjugate in Human Urine". Biochem. Biophys. Res. Comm. 185: 728-733, 1992.

137. Yu, J., FALCK, J.R. and C. Mioskowski, "Intramolecular Mitsunobu Displacement with Carbon Nucleophiles: Preparation of ?-Nitrocyclopropanes". J. Org. Chem. 57: 3757-3759, 1992.

138. Bhatt, R.K., Shin, D.-S. and J.R. FALCK, "Palladium Catalyzed Cross-Coupling and Tandem Cyclization-Coupling of (-Halo(thio)ethers with Organotins". Tetrahedron Lett. 33: 4885-4888, 1992.

139. FALCK, J.R., Lumin, S., Lee, S.-G., Heckmann, B., Mioskowski, C., Karara, A., and J. Capdevila, "Enantiospecific Synthesis of 17- and 18-Hydroxyeicosatetraenoic Acids, Cytochrome P450 Arachidonate Metabolites". Tetrahedron Lett. 33: 4893-4896, 1992.

140. Heckmann, B., Mioskowski, C., Yu, J., and J.R. FALCK, "Nucleophilic Substitution at the Acetalic Center of Mandelate 1,3-Dioxolan-4-ones using Magnesio-Copper Reagents: Application to the Synthesis of Chiral Secondary Alcohols". Tetrahedron Lett. 33: 5201-5204, 1992.

141. Heckmann, B., Alayrac, C., Mioskowski, C., Chandrasekhar, S., and J.R. FALCK, "Oxidative Decarboxylation of Mandelate Ethers and (-Substituted Phenylacetates via Dioxetanone Generation". Tetrahedron Lett. 33: 5205-5208, 1992.

142. Gebremedhin, D., Ma, Y.-H., FALCK, J.R., Roman, R.J., VanRollins, M., and D.R. Harder, "Mechanism of Action of Cerebral Epoxyeicosatrienoic Acids on Cerebral Arterial Smooth Muscle". Am. J. Physiol. 263: H519-H525, 1992.

143. Henrich, W.L., FALCK, J.R., and W.B. Campbell, "Inhibition of Renin Secretion from Rat Renal Cortical Slices by 12(R)-HETE". Am. J. Physiol. 263: F665-F670, 1992.

144. Capdevila, J.H., Wei, S., Yan, J., Karara, A., Jacobson, H.R., FALCK, J.R., Guengerich, P., and R.N. DuBois, "Cytochrome P-450 Arachidonic Acid Epoxygenase: Regulatory Control of the Renal Epoxygenase by Dietary Salt Loading". J. Biol. Chem. 267: 21720-21726, 1992.

145. FALCK, J.R. and J. Yu, "Synthesis of Alkyl Nitronates via Mitsunobu Condensation" Tetrahedron Lett. 33: 6723-6726, 1992.

146. Capdevila, J.H., Wei, S., Kumar, A., Kobayashi, J., Snapper, J.R., Zeldin, D., Bhatt, R.K., and J.R. FALCK, "Resolution of Dihydroxyeicosanoates and of Dihydroxyeicosatrienoates by Chiral Phase Chromatography". Anal. Biochem. 207: 236-240, 1992.

147. Ma, Y.-H., Gebremedhin, D., Schwartzman, M.L., FALCK, J.R., Clark, J.E., Masters, B.S., Harder, D.R., and R.J. Roman, "20-Hydroxyeicosatetraenoic Acid is an Endogenous Vasoconstrictor of Canine Renal Arcuate Arteries". Circ. Res. 72: 126-136, 1993.

148. Ye, J., Shin, D.-S., Bhatt, R.K., Swain, P.A., and J.R. FALCK, "Reactivity of (-Mesyloxystannanes with Organocopper Reagents: Preparation of Chiral Stannanes". Synlett: 205-206, 1993.

149. Zeldin, D.C., Kobayashi, J., FALCK, J.R., Winder, B.S., Hammock, B.D., Snapper, J.R., and J.H. Capdevila, "Regio- and Enantiofacial Selectivity of Epoxyeicosatrienoic Acid Hydration by Cytosolic Epoxide Hydrolase". J. Biol. Chem. 268: 6402-6407, 1993.

150. Falck, J.R. and A. Abdali, "Total Synthesis of D-myo-inositol 3,4,5-Trisphosphate and 1,3,4,5-Tetrakisphosphate". Bioorg. Med. Chem. Lett. 3: 717-720, 1993.

151. Escalante, B., Omata, K., Sessa, W., Lee, S.-G., FALCK, J.R., and M. L. Schwartzman, "20-Hydroxyeicosatetraenoic acid is an Endothelium-Dependent Vasoconstrictor in Rabbit Arteries". Eur. J. Pharm. 235: 1-7, 1993.

152. Carroll, M.A., Balazy, M., Margiotta, P., FALCK, J.R., and J.C. McGiff, "Renal Vasodilator Activity of 5,6-Epoxyeicosatrienoic Acid Depends upon Conversion by Cyclooxygenase and Release of Prostaglandins". J. Biol. Chem. 268: 12260-12266, 1993.

153. Laethem, R.M., Balazy, M., FALCK, J.R., Laethem, C.L., and D.R. Koop, "Formation of 19(S)-, 19(R)-, and 18(R)-Hydroxyeicosatetraenoic Acids by Alcohol-inducible Cytochrome P450 2E1". J. Biol. Chem. 268: 12912-12918, 1993.

154. Wong, P. Y.-K., Lin, K.T., Iles, J., FALCK, J.R., Yan, Y.T., Shen, S.Y., Ahern, D., and R.K. Bhatt, "14(R),15(S)-Epoxyeicosatrienoic Acid (14(R),(15(S)-EET) Receptor in Guinea-Pig Mononuclear Cell-Membranes". J. Lipid Mediators 6: 199-208, 1993.

155. Van Voorhis, B.J., Dunn, M.S., FALCK, J.R., Bhatt, R.K., VanRollins, M., and G. D. Snyder, "Metabolism of Arachidonic Acid to Epoxyeicosatrienoic Acids by Human Granulosa Cells May Mediate Steroidogenesis". J. Clin. Endocrin. Metabolism 76: 1555-1559, 1993.

156. Karara, A., Makita, E., Jacobson, H.R., FALCK, J.R., Guengerich, F.P., DuBois, R.N., and J.H. Capdevila, "Molecular Cloning, Expression, and Enzymatic Characterization of the Rat Kidney Cytochrome P-450 Arachidonic Acid Epoxygenase", J. Biol. Chem. 268: 13565-13570, 1993.

157. Escalante, B., Erlij, D., FALCK, J. R., and J. C. McGiff, "Cytochrome P450-Dependent Arachidonate Metabolites Affect Renal Transport in the Rabbit." J. Cardiovasc. Pharmacol. 22: S106-S108, 1993.

158. Imig, J.D, FALCK, J. R., Gebremedhin, D., Harder, D. R., and R. J. Roman, "Elevated Renovascular Tone in Young Spontaneously Hypertensive Rats, Role of Cytochrome P-450". Hypertension 22: 357-364, 1993.

159. Yu, J., Cho, H.-S., and J.R. FALCK, "Stereospecific Dehydrative Alkylation of Bis-Sulfones: Synthesis of a Lesser Tea Tortrix Pheromone". J. Org. Chem. 58: 5892-5894, 1993.

160. Macica, C., Balazy, M., FALCK, J.R., Mioskowski, C., and M.A. Carroll, "Characterization of Cytochrome P-450-Dependent Arachidonic Acid Metabolism in Rabbit Intestine". Am. J. Physiol. 265: G735-G741, 1993.

161. FALCK, J.R., Chandrasekhar, S., Manna, S., Chiu, C.-C.S., Mioskowski, C., and I. Wetzel, "Total Synthesis of the Spiro-o-Benzoquinonefuran (-)-Stypoldione". J. Am. Chem. Soc. 115: 11606-11607, 1993.

162. Reddy, K.K., FALCK, J.R., and J. Capdevila, "Insulin Second Messengers: Synthesis of 6-O-(2-Amino-2-Deoxy-??D-Glucopyranosyl)-D-Chiro-Inositol-1-Phosphate". Tetrahedron Lett. 34: 7869- 7872, 1993.

163. Ye, J., Bhatt, R.K., and J.R. FALCK, "Stereospecific (-Alkoxystannane Couplings With Acyl Chlorides: Total Synthesis of (+)-Goniofufurone". Tetrahedron Lett. 34: 8007-8010, 1993.

164. Wong, P.Y.-K., Yan, Y.T., Lin, K.-T., Shen S.Y., and J.R. FALCK, "14(R),15(S)-Epoxyeicosatrienoic Acid Receptor Binding During Monocyte and Endothelial Cell Interactions". Atheroscler. Rev. 25:101-109, 1993.

165. Ye, J., Bhatt, R.K., and J.R. FALCK, "Stereospecific Palladium/Copper Co-Catalyzed Cross-Coupling of (-Alkoxy- and (-Aminostannanes with Acyl Chlorides". J. Am. Chem. Soc. 116: 1-5, 1994.

166. Yamamoto, S., Nishimura, M., Conners, M.S., Stoltz, R.A., FALCK, J.R., Chauhan, K., and M. Laniado-Schwartzman, "Oxidation and Keto Reduction of 12-hydroxy-5,8,10,14-eicosatetraenoic Acids in Bovine Corneal Epithelial Microsomes". Biochim. Biophys. Acta 1210: 217-225, 1994.

167. Chauhan, K., Bhatt, R.K., FALCK, J.R., and J.H. Capdevila, "Total Synthesis of the Ethanol Inducible, Pro-Inflammatory Autacoid 3(S)-Hydroxy-Leukotriene B4 (3-OH-LTB4) and Analogues". Tetrahedron Lett. 35: 1825-1828, 1994.

168. Harnett, J.J., Alcaraz, L., Mioskowski, C., Martel, J.P., Le Gall, T., Shin, D.-S., and J.R. FALCK, "A Novel Synthesis of Homologated Allylic Alcohols Using Dimethylsulphonium Methylide". Tetrahedron Lett. 35: 2009-2012, 1994.

169. FALCK, J.R., Manna, S., Chandrasehkar, S., Mioskowski, C., and I. Wetzel, "Terpenoid Chirons: Preparation and Transformations of 2-Hydroxy-1,1,4a(R),6-Tetramethyl-trans- (5,6-Octalin". Tetrahedron Lett. 35: 2013-2016, 1994.

170. Ribeiro, C.M.P., Dubay, G.R., FALCK, J.R., and L.J. Mandel, "Parathyroid Hormone Inhibits Na+,K+-ATPase Through a Cytochrome P450 Pathway". Am. J. Physiol. 266: F497-F505, 1994.

171. Bhatt, R.K., Chauhan, K., Wheelan, P., Murphy, R.C., and J.R. FALCK, "3-Hydroxy-Leukotriene B4(3-OH-LTB4): Total Synthesis and Stereochemical Assignment". J. Am. Chem. Soc. 116: 5050-5056, 1994.

172. Bhatt, R.K., Ye, J., and J.R. FALCK, "Convenient Preparation of (-Trimethylsilyloxy and (-Hydroxystannanes from Aldehydes". Tetrahedron Lett. 35: 4081-4084, 1994.

173. Harder, D. R., Gebremedhin, D., Narayanan, J., Jefcoat, C., FALCK, J.R., Campbell, W. B., and R. Roman, "Formation and Action of a P-450 4A Metabolite of Arachidonic Acid in Cat Cerebral Microvessels". Am. J. Physiol. 266: H2098-H2107, 1994.

174. Chandrasekhar, S., Yu, J., FALCK, J.R., and C. Mioskowski, "SmI2 Mediated Reductive Addition of Bis-Phenylsulfones to Ketones". Tetrahedron Lett. 35: 5441-5444, 1994.

175. Yu, J., Cho, H.-S., Chandrasekhar, S., FALCK, J.R., and C. Mioskowski, "Reductive Lithiation of Bis-Phenylsulfones". Tetrahedron Lett. 35: 5437-5440, 1994.

176. Alcaraz, L., Harnett, J.J., Mioskowski, C., Martel, J.P., Le Gall, T., Shin, D.-S. and J.R. FALCK, "Novel Conversion of Epoxides to One Carbon Homologated Allylic Alcohols by Dimethylsulfonium Methylide". Tetrahedron Lett. 35: 5449-5452, 1994.

177. Belosludtsev, Y. Y., Kollah, R. O., FALCK, J.R., and J. H. Capdevila, "Hepoxilins B3: Synthesis of All Four Stereoisomers and a Glutathione Adduct". Tetrahedron Lett. 35: 5327-5330, 1994.

178. Alcaraz, L., Harnett, J.J., Mioskowski, C., Martel, J.P., Le Gall, T., Shin, D.-S. and J.R. FALCK, "Sulfur Ylide Vinylation of Halides and Mesylates". Tetrahedron Lett. 35: 5453-5456, 1994.

179. Escalante, B., Erlij, D., FALCK, J.R., and J.C. McGiff, "Cytochrome P450 Arachidonate Metabolites Affect Ion Fluxes in Rabbit Medullary Thick Ascending Limb". Am. J. Physiol. 266: C1775-C1782, 1994.

180. Zou, A.-P., Imig, J. D., Ortiz De Montellano, P. R., Sui, Z., FALCK, J.R., and R. J. Roman, "Effect of P-450 (-Hydroxylase Metabolites of Arachidonic Acid on Tubuloglomerular Feedback". Am. J. Physiol. 266: F934-F941, 1994.

181. FALCK, J. R., Yu, J., and H.-S. Cho, "A Convenient Synthesis of Unsymmetric Polyfluoroethers". Tetrahedron Lett. 35: 5997-6000, 1994.

182. Cho, H.-S., Yu, J., and J.R. FALCK, "Preparation and Scope of a Remarkably Robust Primary Alcohol Protective Group". J. Am. Chem. Soc. 116: 8354-8355, 1994.

183. Chauhan, K., Aravind, S., Lee, S.-G., FALCK, J.R. and J.H. Capdevila, "vic-Diol Chirons: Enantiospecific Synthesis of 11,12- and 14,15-Dihydroxyeicosatrienoic Acids". Tetrahedron Lett. 35: 6791-6794, 1994.

184. FALCK, J.R., Chauhan, K., Rosolowsky, M., and W.B. Campbell, "Vasoactive Eicosanoids: Synthesis of 12,20-Dihydroxyeicosa-5(Z),8(Z),10(E),14(Z)-Tetraenoic Acid Via a Novel Chiral Bis-Lactol". Bioorg. Med. Chem. Lett. 4: 2113-2116, 1994.

185. Laniado-Schwartzman, M., Lavrovsky, Y., Stoltz, R. A., Conners, M. S., FALCK, J. R., Chauhan, K., and N. G. Abraham, "Activation of Nuclear Factor (B and Oncogene Expression by 12(R)-Hydroxyeicosatrienoic Acid, an Angiogenic Factor in Microvessel Endothelial Cells". J. Biol. Chem. 269: 24321-24327, 1994.

186. Chauhan, K., Ravi, D., Falck, J.R., Stoltz, R.A., and M. Laniado-Schwartzman, "Angiogenic Factors: Syntheses of 12(R)- and 12(S)-Hydroxyeicosa-5(Z),8(Z),14(Z)-Trienoic Acid and Their 14,15-Dehydro Analogs". Bioorg. Med. Chem. Lett. 4: 2689-2692, 1994.

187. Makita, K., Takahashi, K., Karara, A., Jacobson, H.R., FALCK, J.R., and J.H. Capdevila, "Experimental and/or Genetically Controlled Alterations of the Renal Microsomal Cytochrome P450 Epoxygenase Induce Hypertension in Rats Fed a High Salt Diet". J. Clin. Invest. 94: 2414-2420, 1994.

188. Toker, A., Meyer, M., Reddy, K.K, FALCK, J.R., Aneja, R., Aneja, S., Parra, A., Burns, D.J., Ballas, L.M., and L.C. Cantley, "Activation of Protein Kinase C Family Members by the Novel Polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3." J. Biol. Chem. 269: 32358-32367, 1994.

189. Wheelan, P., Sala, A., Folco, G., Nicosia, S., FALCK, J.R., Bhatt, R.K., and R.C. Murphy, "Stereochemical Analysis and Biological Activity of 3-Hydroxy-Leukotriene B4: A Metabolite from Ethanol-Treated Rat Hepatocytes". J. Pharm. Exp. Therap. 271: 1514-1519, 1994.

190. Zeldin, D.C., Wei, S., FALCK, J.R., Hammock, B.D., Snapper, J.R, and J.H. Capdevila, "Metabolism of Epoxyeicosatrienoic Acids by Cytosolic Epoxide Hydrolase: Substrate Structural Determinants of Asymmetric Catalysis". Arch. Biochem. Biophys. 316: 443-451, 1995.

191. Conners, M.S., Laniado-Schwartzman, M., Quan, X., Heilman, E., Chauhan, K., FALCK, J.R., Godfrey, H.P., "Enhancement of Delayed Hypersensitivity Inflammatory Reactions in Guinea Pig Skin by 12(R)-Hydroxy-5,8,14-Eicosatrienoic Acid". J. Invest. Dermatol. 104: 47-51, 1995.

192. Powell, W.S., Hashefi, M., FALCK, J.R., Chauhan, K., Rokach, J., Wang, S.S., Mills, E., and R. J. MacLeod, "Effects of Oxo and Dihydro Metabolites of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid on Chemotaxis and Cytosolic Calcium Levels in Human Neutrophils". J. Leukocyte Biol. 57: 257-263, 1995.

193. Capdevila, J.H., Morrow, J.D., Belosludtsev, Y.Y., Beauchamp, D.R., DuBois, R.N., and J.R. FALCK, "The Catalytic Outcomes of the Constitutive and the Mitogen Inducible Isoforms of Prostaglandin H2 Synthase Are Markedly Affected by Glutathione and Glutathione Peroxidase(s)". Biochemistry 34: 3325-3337, 1995.

194. Sakairi, Y., Jacobson, H.R., Noland, T.D., Capdevila, J.H., FALCK, J.R., and M.D. Breyer, "5,6-EET Inhibits Ion Transport in Collecting Duct by Stimulating Endogenous Prostaglandin Synthesis". Am. J. Physiol. 268: F931-F939, 1995.

195. Zeldin, D.C., Plitman, J.D., Kobayashi, J., Miller, R.F., Snapper, J.R., FALCK, J.R., Szarek, J.L., Philpot, R.M., and J.H. Capdevila, "The Rabbit Pulmonary Cytochrome P450 Arachidonic Acid Metabolic pathway: Characterization and Significance". J. Clin. Invest. 95: 2150-2160, 1995.

196. Reddy, K.K., Saady, M., FALCK, J.R., and G. Whited, "Intracellular Mediators: Synthesis of L-( -Phosphatidyl-D-myo-inositol 3,4,5-Trisphosphate and Glyceryl Ether Analogs". J. Org. Chem. 60: 3385-3390, 1995.

197. FALCK, J.R., Bhatt, R.K., and J. Ye, "Tin-Copper Transmetalation: Cross-Coupling of (-Heteroatom-Substituted Alkytributylstannanes with Organohalides". J. Am. Chem. Soc. 117: 5973-5982, 1995.

198. Zou, A.P., Muirhead, E.E., Cowley, A.W., Mattson, D.L., FALCK, J.R., Jiang, J., and R.J. Roman, "Role of Changes in Renal Hemodynamics and P-450 Metabolites of Arachidonic Acid in the Reversal of One-Kidney, One Clip Hypertension". J. Hypertension 13: 557-566, 1995.

199. Lai, J.Y., Yu, J. Hawkins, R.D., and J.R. FALCK, "Two-Carbon Elongation/Annulation of Alcohols to Nitriles". Tetrahedron Lett. 36: 5691-5694, 1995.

200. Belosludtsev, Y.Y., Bhatt, R.K., and J.R. FALCK, "C-Glycosides: Pd/Cu Co-Catalyzed Thiocarboxylation of Stannyl Glucopyranosides". Tetrahedron Lett. 36: 5881-5882, 1995.

201. Fretland, D., Anglin, C., Baron, D., Widomski, D., Chauhan, K., Bhatt, R., and J.R. FALCK, "3(S)-Hydroxy-Leukotriene B4 is a Potent Granulocyte Chemotaxin in the Guinea Pig Dermis". Inflamm. Res. 44 (Supplement 2): S137-S138, 1995.

202. Zeldin, D., DuBois, R.N., FALCK, J.R., and J.H. Capdevila, "Molecular Cloning, Expression and Characterization of an Endogenous Human Cytochrome P450 Arachidonic Acid Epoxygenase Isoform". Arch. Biochem. Biophys.: 322: 76-86, 1995.

203. Zhang, J., FALCK, J.R., Reddy, K.K., Abrams, C.S., Zhao, W., and S.E. Rittenhouse, "Phosphatidylinositol (3,4,5)-Trisphosphate Stimulates Phosphorylation of Pleckstrin in Human Platelets". J. Biol. Chem. 270: 22807-22810, 1995.

204. Alcaraz, L., Harnett, J.J., Mioskowski, C., Le Gall, T., Shin, D.-S., and J.R. FALCK, "Taxol Total Synthesis: Preparation of a Chiral Ring A Moiety via Biomimetic Cyclization and Evaluation of a Tandem Nitrile Oxide Strategy for Rings B/C". J. Org. Chem. 60: 7209-7214, 1995.

205. Yu, J., Cho, H.-S., and J.R. FALCK, "Synthesis of Bicyclic Fused Carbocycles via Intramolecular Dehydrative Alkylation". Tetrahedron Lett. 36: 8577-8580, 1995.

206. Yu, J., Lai, J.-Y., and J.R. FALCK, "Methyl Carboxymethylenation of Alcohols via Dehydrative Alkylation". Synlett 11: 1127-1128, 1995.

207. FALCK, J., Reddy, K.K., Ye, J., Saady, M., Mioskowski, C., Shears, S.B., Tan, Z., and S. Safrany, "Synthesis and Structure of Cellular Mediators: Inositol Polyphosphate Diphosphates". J. Am. Chem. Soc. 117: 12172-12175, 1995.

208. Toker, A., Bachelot, C., Chen, C.-S., FALCK, J.R., Hartwig, J.H., Cantley, L.C., and T. J. Kovacsovics, "Phosphorylation of the Platelet p47 Phosphoprotein is Mediated by the Lipid Products of Phosphoinositide 3-Kinase". J. Biol. Chem. 270: 29525-29531, 1995.

209. Hildebrandt, E., Albanesi, J.P., FALCK, J.R., and W. B. Campbell, "Regulation of Calcium Influx and Catecholamine Secretion in Chromaffin Cells by a Cytochrome P450 Metabolite of Arachidonic Acid". J. Lipid Res. 36: 2599-2608, 1995.

210. Lin, F., Rios, A., FALCK, J.R., Belosludtsev, Y., and M.L. Schwartzman, "20-Hydroxyeicosatetraenoic Acid is Formed in Response to EGF and is a Mitogen in Rat Proximal Tubule". Am. J. Physiol. 269: F806-F816, 1995.

211. Smith, L.K., Vlahos, C.J., Reddy, K.K., FALCK, J.R., and C.W. Garner, "Wortmannin and LY294002 Inhibit the Insulin-Induced Down-Regulation of IRS-1 in 3T3-L1 Adipocytes". Mol. Cell. Endo. 113: 73-81, 1995.

212. Powell, W.S., Rokach, J., Khanapure, S.P., Manna, S., Hashefi, M., Gravel, S., Macleod, R.J., FALCK, J.R., and R.K. Bhatt, "Effects of Metabolites of Leukotriene B4 on Human Neutrophil Migration and Cytosolic Calcium Levels". J. Pharm. Exp. Therap. 276: 728-736, 1996.

213. Wu, S., Moomaw, C.R., Tomer, K.B., FALCK, J.R., and D.C. Zeldin, "Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450 Arachidonic Acid Epoxygenase Highly Expressed in Heart". J. Biol. Chem. 271: 3460-3468, 1996.

214. Heckman, B., Mioskowski, C., Bhatt, R., and J.R FALCK, "Grignard additions to, (,(-Unsaturated Dioxolanones: Preparation of Chiral Allylic Alcohols and Protected (-Hydroxy Aldehydes". Tetrahedron Lett. 37: 1421-1424, 1996.

215. Heckman, B., Mioskowski, C., Lumin, S., FALCK, J.R., Wei, S., and J.H. Capdevila, "Chiral Acetals: Stereocontrolled Syntheses of 16-, 17-, and 18-Hydroxyeicosatetraenoic Acids, Cytochrome P450 Arachidonate Metabolites". Tetrahedron Lett. 37: 1425-1428, 1996.

216. Imig, J.D., Zou, A.-P., Stec, D.E., Harder, D.R., FALCK, J.R., and R.J. Roman, "Formation and Actions of 20-hydroxyeicosatetraenoic Acid in Rat Renal Arterioles". Am. J. Physiol. 270: R217-R227, 1996.

217. Zou, A.-P., Fleming, J.T., FALCK, J.R., Jacobs, E.R., Gebremedhin, D., Harder, D.R., and R.J. Roman, "20-HETE is an Endogenous Inhibitor of the Large-Conductance Ca2+-activated K+ Channel in Renal Arterioles". Am. J. Physiol. 270: R228-R237, 1996.

218. Zou, A.-P., Fleming, J.T., FALCK, J.R., Jacobs, E.R., Gebremedhin, D., Harder, D.R., and R.J. Roman, "Stereospecific Effects of Epoxyeicosatrienoic Acids on Renal Vascular Tone and K+-channel Activity". Am. J. Physiol. 270: F822-F832, 1996.

219. Rosolowsky, M., FALCK, J.R., and W. B. Campbell, "Metabolism of Arachidonic Acid by Canine Polymorphonuclear Leukocytes Synthesis of Lipoxygenase and Omega-Oxidized Metabolites". Biochim. Biophys. Acta 1300: 143-150, 1996.

220. Bhatt, R.K., Ye, J., and J.R. FALCK, "Conjugate Addition of (-Alkoxystannanes via in situ Transmetalation Using Catalytic CuCN". Tetrahedron Lett. 37: 3811-3814, 1996.

221. FALCK, J.R., Mekonnen, B., Yu, J., and J.-Y. Lai, "Synthesis of the Polycyclopropane Antibiotic FR-900848 via the Horeau Gambit". J. Am. Chem. Soc. 118: 6096-6097, 1996.

222. Ye, J., Doerrler, W.T., Lehrman, M.A., and J.R. FALCK, "GPI Membrane Anchors: Synthesis and Functional Evaluation of Aminoglucosyl Phosphatidylinositol Core Analogs". Bioorg. Med. Chem. Lett. 6: 1715-1718, 1996.

223. Gaidarov, I., Chen, Q., FALCK, J.R., Reddy, K.K., and J.H. Keen, "A Functional Phosphatidylinositol 3,4,5-Triphosphate/Phosphoinositide Binding Domain in the Clathrin Adaptor AP-2 Subunit". J. Biol. Chem. 271: 20922-20929, 1996.

224. Capdevila, J.H., Wei, S., Helvig, C., FALCK, J.R., Belosludtsev, Y., Truan, G., Graham-Lorence, S.E., and J.A Peterson, "The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3". J. Biol. Chem. 271: 22663-22671, 1996.

225. Lai, J.-Y., Yu, J., Mekonnen, B., and J.R. FALCK, "Synthesis of Curacin A, An Antimitotic Cyclopropane-Thiazoline From The Marine Cyanobacterium Lyngbya majuscula". Tetrahedron Lett. 37: 7167-7170, 1996.

226. Doerrler, W.T., Ye, J., FALCK, J.R., and M.A. Lehrman, "Acylation of Glucosaminyl Phosphatidylinositol Revisited". J. Biol. Chem. 271: 27031-27038, 1996.

227. Janowski, B.A., Willy, P.J., Devi, T.R., J.R. FALCK and D.J. Mangelsdorf, "An Oxysterol Signalling Pathway Mediated by the Nuclear Receptor LXRa". Nature 383:.728-731, 1996.

228. Makita, K., FALCK, J.R., and J.H. Capdevila, "Cytochrome P450 the Arachidonic Acid Cascade and Hypertension: New Vistas for an Old Enzyme System". FASEB J. 10: 1456-1463, 1996.

229. Lu, M., Zhu, Y., Balazy, M., Reddy, K.M., FALCK, J.R., and W. Wang, "Effect of Angiotensin II on the Apical K+ Channel in the Thick Ascending Limb of the Rat Kidney". J. Gen. Physiol. 108: 537-547, 1996.

230. Carroll, M.A., Balazy, M., Margiotta, P., Huang, D.-D., FALCK, J.R., and J. C. McGiff, "Cytochrome P-450-dependent HETEs: Profile of Biological Activity and Stimulation by Vasoactive Peptides". Am. J. Physiol. 271: R863-R869, 1996.

231. Imig, J.D., Navar, L.G., Roman, R.J., Reddy, K.K., and J.R. FALCK, "Actions of Epoxygenase Metabolites on the Preglomerular Vasculature". J. Am. Soc. Nephrol. 7: 2364-2370, 1996.

232. Graham-Lorence, S., Truan, G., Peterson, J.A., FALCK, J.R., Wei, S., Helvin, C., and J.H. Capdevila, "An Active Site Substitution, F87V, Converts Cytochrome P450 BM-3 into a Regio- and Stereoselective (14S,15R)-Arachidonic Acid Epoxygenase". J. Biol. Chem. 272: 1127-1135, 1997.

233. Laussmann, T., Reddy, K.M., Reddy, K.K., FALCK, J.R., and G. Vogel, "Diphospho-myo-inositol Phosphates from Dictyostelium Identified as D-6-diphospho-myo-inositol Pentakisphosphate and D-5,6-bisdiphospho-myo-inositol Tetrakisphosphate". Biochem. J. 322: 31-33, 1997.

234. Hao, W., Zheng, T., Prasad, K., Reddy, K.K., Chen, J., Prestwich, G.D., FALCK, J.R., Shears, S.B., and E. M. Lafer, "Regulation of AP-3 Function by Inositides". J. Biol. Chem. 272: 6393-6398, 1997.

235. Frech, M., Andjelkovic, M., Ingley, E., Reddy, K.K., FALCK, J.R., and B.A. Hemmings, "High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity". J. Biol. Chem. 272: 8474-8481, 1997.

236. Nithipatikom, K., FALCK, J.R., Bhatt, R.K., Hanke, C.J., and W.B. Campbell, "Determination of 14,15-Epoxyeicosatrienoic Acid and 14,15-Dihydroxyeicosatrienoic Acid by Fluoroimmunoassay". Anal. Biochem. 246: 253-259, 1997.

237. Alonso-Galicia, M., Drummond, H.A., Reddy, K.K., FALCK, J.R., and R.J. Roman, "Inhibition of 20-HETE Production Contributes to the Vascular Responses to Nitric Oxide". Hypertension 29: 320-325, 1997.

238. Derman, M.P., Toker, A., Hartwig, J.H., Spokes, K., FALCK, J.R., Chen, C.-S., Cantley, L.C., and L.G. Cantley, "The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility Through Protein Kinase C". J. Biol. Chem. 272: 6465-6470, 1997.

239. Wu, S., Chen, W., Murphy, E., Gabel, S., Tomer, K.B., Foley, J., Steenbergen, C., FALCK, J.R., Moomaw, C.R., and D.C. Zeldin, "Molecular Cloning, Expression, and Functional Significance of a Cytochrome P450 Highly Expressed in Rat Heart Myocytes". J. Biol. Chem. 272: 12551-12559, 1997.

240. FALCK, J.R., Bhatt, R.K., Komandla, M.R., and J. Ye, "Cu2S Mediated Cross-Coupling of (-Stannylepoxides". Synlett 5: 481-482, 1997.

241. Carroll, M.A., Balazy, M., Huang, D.-D., Rybalova, S., FALCK, J.R., and J.C. McGiff, "Cytochrome P450-derived Renal HETEs: Storage and Release". Kidney Internat. 51: 1696-1702, 1997.

242. Reddy, K.K., Rizo, J., and J.R. FALCK, "Concise Synthesis of L-(-Phosphatidyl-D-myo-inositol 3,4-Bisphosphate, An Intracellular Second Messenger". Tetrahedron Lett. 38: 4729-4730, 1997.

243. Reddy, K.M., Reddy, K.K., and J.R. FALCK, "Synthesis of 2- and 5-Diphospho-myo-inositol Pentakisphosphate (2- and 5-PP-InsP5), Intracellular Mediators ". Tetrahedron Lett. 38: 4951-4952, 1997.

244. FALCK, J.R., Reddy, K.K., and S. Chandrasekhar, "Synthesis and Structure Revision of the myo-Inositol Monophosphatase Inhibitor L-671,776". Tetrahedron Lett. 38: 5245-5248, 1997.

245. Wong, P. Y-K, Lai, P.-S., Shen, S.-Y., Belosludtsev, Y.Y., and J.R. FALCK, "Post-Receptor Signal Transduction and Regulation of 14(R),15(S)-Epoxyeicosatrienoic Acid (14,15-EET) Binding in U-937 Cells". J. Lipid Mediators Cell Signal. 16: 155-169, 1997.

246. Reddy, K.K., Ye, J., FALCK, J.R., and J.H. Capdevila, "Intracellular Second Messengers: Synthesis of L-(-Phosphatidyl-D-myo-Inositol 3,4-Bisphosphate and Analogs". Bioorg. Med. Chem. Lett. 7: 2115-2116, 1997.

247. Albert, C., Safrany, S.T., Bembenek, M.E., Reddy, K.M., Reddy, K.K., FALCK, J.R., Brocker, M., Shears, S.B., and G.W. Mayr, "Biological Variability in the Structures of Diphosphoninositol Polyphosphates in Dictyostelium discoideum and Mammalian Cells". Biochem. J. 327: 553-560, 1997.

248. FALCK, J.R., Belosludtsev, Y.Y., Reddy, K.K., Reddy, K.M., Shortt, M.F., Chauhan, K., Capdevila, J., and S. Wei, "Eicosanoid Biosynthesis: Differential Inhibition of Cytochrome P450 Epoxygenase and?(-Hydroxylase". Bioorg. Med. Chem. Lett. 7: 3053-3056, 1997.

249. Bednar, M.M., Gross, C.E., Balazy, M., and J.R. FALCK, "Antineutrophil Strategies". Neurology 49 (Suppl. 4): S20-S22, 1997.

250. Venter, P., Kock, J.L.F., Kumar, G.S., Botha, A., Coetzee, D.J., Botes, P.J., Bhatt, R.K., FALCK, J.R., Schewe, T., and S. Nigam, "Production of 3R-Hydroxy-polyenoic Fatty Acids by the Yeast Dipodascopsis uninucleata". Lipids 32: 1277-1283, 1997.

251. Bhatt, R.K., FALCK, J.R., and S. Nigam, "Enantiospecific Total Synthesis of a Novel Arachidonic Acid Metabolite 3-Hydroxyeicosatetraenoic acid". Tetrahedron Lett. 39: 249-252, 1998.

252. Han, J., Luby-Phelps, K., Das, B., Shu, X., Xia, Y., Mosteller, R.D., Krishna, U. M., FALCK, J.R., White, M.A. and D. Broek, "Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav". Science 279: 558-560, 1998.

253. Pratt, P.F., FALCK, J.R., Reddy, K.M., Kurian, J.B. and W.B. Campbell, "20-HETE Relaxes Bovine Coronary Arteries Through the Release of Prostacyclin". Hypertension 31: 237-241, 1998.

254. Verdier-Pinard, P., Lai, J.Y., Yoo, H.D., Yu, J., Marquez, B., Nagle, D.G., Nambu, M., White, J.D., FALCK, J.R., Gerwick, W.H., Day, B.W., and E. Hamel, "Structure-Activity Analysis of the Interaction of Curacin A, the Potent Colchicine Site Antimititic Agent, with Tubulin and Effects of Analogs on the Growth of MCF- 7 Breast Cancer Cells". Mol. Pharm. 53: 62-76, 1998.

255. Wang, M.H., Brand-Schieber, E., Zand, B.A., Nguyen, X., FALCK, J.R., Balu, N., and M.L. Schwartzman, "Cytochrome P450-Derived Arachidonic Acid Metabolism in the Rat Kidney: Characterization of Selective Inhibitors". J. Pharm. Exp. Therap. 284: 966-973, 1998.

256. Silverstein, D.M., Barac-Nieto, M., FALCK, J.R., and A. Spitzer, "20-HETE Mediates the Effect of Parathyroid Hormone and Protein Kinase C on Renal Phosphate Transport". Prostaglandins, Leukotriene and Essential Fatty Acids 58: 209-213, 1998.

257. Laussmann, T., Hansen, A., Reddy, K.M., Reddy, K.K., FALCK, J.R., and G. Vogel, "Diphospho-myo-inositol Phosphates in Dictyostelium and Polysphondylium: Identification of a New Bisdiphospho-myo-inositol Tetrakisphosphate". FEBS Lett. 426: 145-150, 1998.

258. Lupu, V.D., Kaznacheyeva, E., Krishna, U.M., FALCK, J.R., and I. Bezprozvanny, "Functional Coupling of Phosphatidylinositol 4,5-Bisphosphate to Inositol 1,4,5-Trisphosphate Receptor". J. Biol. Chem. 273: 14067-14070, 1998.

259. Edgemond, W.S., Hillard, C.J., FALCK, J.R., Kearn, C.S., and W.B. Campbell, "Human Platelets and Polymorphonuclear Leukocytes Synthesize Oxygenated Derivatives of Arachidonylethanolamide (Anandamide): Their Affinities for Cannabinoid Receptors and Pathways of Inactivation". Mol. Pharm. 54: 180-188, 1998.

260. Dulin, N.O., Alexander, L.D., Harwalkar, S., FALCK, J.R., and J.G. Douglas, "Phospholipase A2-Mediated Activation of Mitogen-Activated Protein Kinase by Angiotensin II". Proc. Natl. Acad. Sci. 95: 8098-8102, 1998.

261. Schlama, T., Baati, R., Gouverneur, V., Valleix, A., FALCK, J.R., and C. Mioskowski, "Total Synthesis of (±)-Halomon by a Johnson-Claisen Rearrangement". Angew. Chem. Int. Ed. 37: 2085-2087, 1998.

262. Fulton, D., FALCK, J.R., McGiff, J.C., Carroll, M.A., and J. Quilley, "A Method for the Determination of 5,6-EET Using the Lactone as an Intermediate in the Formation of the Diol". J. Lipid Res. 39: 1713-1721, 1998.

263. Pascual, J.M.S., McKenzie, A., Yankaskas, J.R., FALCK, J.R., and D.C. Zeldin, "Epoxygenase Metabolites of Arachidonic Acid Affect Electrophysiologic Properties of Rat Tracheal Epithelial Cells". J. Pharm. Exp. Therap. 286: 772-779, 1998.

264. Chen, J.-K., FALCK, J.R., Reddy, K.M., Capdevila, J., and R.C. Harris, "Epoxyeicosatrienoic Acids and Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation and Induce Mitogenesis in Renal Epithelial Cells". J. Biol. Chem. 273: 29254-29261, 1998.

265. Pfister, S.L., Spitzbarth, N., Nithipatikom, K., Edgemond, W.S., FALCK, J.R., and W.B. Campbell, "Identification of the 11,14,15- and 11,12,15-Trihydroxyeicosatrienoic Acids as Endothelium-derived Relaxing Factors of Rabbit Aorta". J. Biol. Chem. 273: 30879-30887, 1998.

266. Sun, C.-W., Alonso-Galicia, M., Taheri, M.R., FALCK, J.R., Harder, D.R., and R.J. Roman, "Nitric Oxide-20-Hydroxyeicosatetraenoic Acid Interaction in the Regulation of K+ Channel Activity and Vascular Tone in Renal Arterioles". Circ. Res. 83: 1069-1079, 1998.

267. Vafeas, C., Mieyal, P.A., Urbano, F., FALCK, J.R., Chauhan, K., Berman, M., and M.L. Schwartzman, "Hypoxia Stimulates the Synthesis of Cytochrome P450-Derived Inflammatory Eicosanoids in Rabbit Corneal Epithelium". J. Pharm. Exp. Therap. 287: 903-910, 1998.

268. Alonso-Galicia, M., Sun, C.-W., FALCK, J.R., Harder, D.R., and R.J. Roman, "Contribution of 20-HETE to the Vasodilator Actions of Nitric Oxide in Renal Arteries". Am. J. Physiol. 275: F370-F378, 1998.

269. Rzigalinski, B.A., Willoughby, K.A., Hoffman, S.W., FALCK, J.R., and E.F. Ellis, "Calcium Influx Factor, Further Evidence it is 5,6-Epoxyeicosatrienoic Acid". J. Biol. Chem. 274: 175-182, 1999.

270. Imig, J.D., Inscho, E.W., Deichmann, P.C., Reddy, K.M., and J.R. FALCK, "Afferent Arteriolar Vasodilation to the Sulfonimide Analog of 11,12-Epoxyeicosatrienoic Acid Involves Protein Kinase A". Hypertension 33: 408-413, 1999.

271. Sun, C.-W., FALCK, J.R., Harder, D.R., and R.J. Roman, "Role of Tyrosine Kinase and PKC in the Vasoconstrictor Response to 20-HETE in Renal Arterioles". Hypertension 33: 414-418, 1999.

272. Lombard, J.H., Kunert, M.P., Roman, R.J., FALCK, J.R., Harder, D.R., and W.F. Jackson, "Cytochrome P-450 (-Hydroxylase Senses O2 in Hamster Muscle, But Not Cheek Pouch Epithelium, Microcirculation". Am. J. Physiol. 276: H503-H508, 1999.

273. Jacobs, E.R., Effros, R.M., FALCK, J.R., Reddy, K.M., Campbell, W.B., and D. Zhu, "Airway Synthesis of 20-Hydroxyeicosatetraenoic Acid: Metabolism by Cyclooxygenase to a Bronchodilator". Am. J. Physiol. 276: L280-L288, 1999.

274. FALCK, J.R., Barma, D.K., Mioskowski, C., and T. Schlama, "(-Chlorovinylation: Synthesis of 2-Chloropropenyl and Propargyl Alcohols". Tetrahedron Lett. 40: 2091-2094, 1999.

275. FALCK, J.R., Lai, J.-Y., Venkata, R., and S-G Lee, "Synthesis of Alcohols via Mild Oxidation of Perfluoroethylstannanes". Tetrahedron Lett. 40: 2715-2718, 1999.

276. Chen, J.-K., Wang, D.-W., FALCK, J.R., Capdevila, J., and R.C. Harris, "Transfection of an Active Cytochrome P450 Arachidonic Acid Epoxygenase Indicates That 14,15-Epoxyeicosatrienoic Acid Functions as an Intracellular Second Messenger in Response to Epidermal Growth Factor". J. Biol. Chem. 274: 4764-4769, 1999.

277. Gaidarov, I., Krupnick, J.G., FALCK, J.R., Benovic, J.L., and J.H. Keen, "Arrestin Function in G Protein-Coupled Receptor Endocytosis Requires Phosphoinositide Binding". EMBO J. 18: 871-881, 1999.

278. FALCK, J.R., Lai, J.-Y., Cho, S.-D., and J. Yu, "Alkylthioether Synthesis via Imidazole Mediated Mitsunobu Condensation". Tetrahedron Lett. 40: 2903-2906, 1999.

279. Hanck, T., Stricker, R., Krishna, U.M., FALCK, J.R., Chang, Y.-T., Chung, S.-K., and G. Reiser, "Recombinant p42IP4, a Brain-Specific 42-kDa High-Affinity Ins(1,3,4,5)P4 Receptor Protein, Specifically Interacts with Lipid Membranes Containing Ptd-Ins(3,4,5)P3". Eur. J. Biochem. 261: 577-584 , 1999.

280. Truan, G., Komandla, M.R., FALCK, J.R., and J.A. Peterson, "P450BM-3: Absolute Configuration of the Primary Metabolites of Palmitic Acid". Arch. Biochem. Biophys. 366: 192-198, 1999.

281. Nguyen, X., Wang, M.-H., Reddy, K.M., FALCK, J.R., and M.L. Schwartzman, "Kinetic Profile of the Rat CYP4A Isoforms: Arachidonic Acid Metabolism and Isoform-Specific Inhibitors". Am. J. Physiol. 276: R1691-R1700, 1999.

282. FALCK, J.R., Bondlela, M., Ye, J., and S.-D. Cho, "A Preparation of Benzylic and Allylic Boronates: Cross-Coupling of Aryl- and Alkenylstannanes with Bromomethylboronates". Tetrahedron Lett. 40: 5647-5650, 1999.

283. Safrany, S.T., Ingram, S.W., Cartwright, J.L., FALCK, J.R., McLennan, A.G., Barnes, L.D., and S.B. Shears, "The Diadenosine Hexaphosphate Hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are Homologues of the Human Diphosphoinositol Polyphosphate Phosphohydrolase". J. Biol. Chem. 274: 21735-21740, 1999.

284. Imig, J.D., FALCK, J.R., and E.W. Inscho, "Contribution of Cytochrome P450 Epoxygenase and Hydroxylase Pathways to Afferent Arteriolar Autoregulatory Responsiveness". Brit. J. Pharm. 127: 1399-1405, 1999.

285. Cho, S.-D., Kim, H.-J., Ahn, C., FALCK, J.R., and D.-S. Shin, "The First Preparation of (-Functionalized Benzylamine". Tetrahedron Lett. 40: 8215-8217, 1999.

286. FALCK, J.R., Krishna, U.M., and J.H. Capdevila, "A Synthesis of L-(-Phosphatidyl-D-myo-inositol 4,5-Bisphosphate (4,5-PIP2) and Glyceryl Lipid Analogs". Tetrahedron Lett. 40: 8771-8774, 1999.

287. Alonso-Galicia, M., FALCK, J.R., Reddy, K.M., and R.J. Roman, "20-HETE Agonists and Antagonists in the Renal Circulation". Am. J. Physiol. 277: F790-F796, 1999.

288. Hasler, J.A., Estabrook, R.W., Murray, M., Pikuleva, I., Waterman, M., Capdevila, J., Holla, V., Helvig, C., FALCK, J.R., Farrel, G., Kaminsky, L.S., Spivack, S.D., Boitier, E., and P. Beaune, "Human Cytochromes P450". Mol. Aspect Med. 20: 1-137, 1999.

289. Capdevila, J.H., FALCK, J.R., and R.C. Harris, "Cytochrome P450 and Arachidonic Acid Bioactivation: Molecular and Functional Properties of the Arachidonate Monooxygenase". J. Lipid Res. 41: 163-181, 2000.

290. Imig, J.D., Pham, B.T., LeBlanc, E.A., Reddy, K.M., FALCK, J.R., and E.W. Inscho, "Cytochrome P450 and Cyclooxygenase Metabolites Contribute to the Endothelin-1 Afferent Arteriolar Vasoconstrictor and Calcium Responses". Hypertension 35: 307-312, 2000.

291. Baati, R., Valleix, A., Mioskowski, C., Barma, D.K., and J.R. FALCK, "A Convenient Synthesis of 2-Tetrahydrofuranyl Ethers". Org. Lett. 2: 485-487, 2000.

292. Zhu, D., Bousamra, M., Zeldin, D.C., FALCK, J.R., Townsley, M., Harder, D.R., Roman, R.J., and E.R. Jacobs, "Epoxyeicosatrienoic Acids Constrict Isolated Pressurized Rabbit Pulmonary Arteries". Am. J. Physiol. 278: L335-L343, 2000.

293. Harrison, K.A., Davies, S.S., Marathe, G.K., McIntyre, T., Prescott, S., Reddy, K.M., FALCK, J.R., and R.C. Murphy, "Analysis of Oxidized Glycerophosphocholine Lipids Using Electrospray Ionization Mass Spectrometry and Microderivatization Techniques". J. Mass Spectrom. 35: 224-236, 2000.

294. Chu, Z.M., Croft, K.D., Kingsbury, D.A., FALCK, J.R., Reddy, K.M., and L.J. Beilin, "Cytochrome P450 Metabolites of Arachidonic Acid May Be Important Mediators in Angiotensin II-Induced Vasoconstriction in the Rat Mesentery In Vivo". Clin. Sci. 98: 277-282, 2000.

295. Popov, S., Krishna, U.M., FALCK, J.R., and T.M. Wilkie, "Ca2+/Calmodulin Reverses Phosphatidylinositol 3,4,5-Trisphosphate-dependent Inhibition of Regulators of G Protein-signaling GTPase-activating Protein Activity". J. Biol. Chem. 275: 18962-18968, 2000.

296. Bednar, M.M., Gross, C.E., Balazy, M.K., Belosludtsev, Y., Colella, D.T., FALCK, J.R., and M. Balazy, "16(R)-Hydroxy-5,8,11,14-eicosatetraenoic Acid, a New Arachidonate Metabolite in Human Polymorphonuclear Leukocytes". Biochem. Pharm. 60: 447-455, 2000.

297. Das, B., Shu, X., Day, G.-J., Han, J., Krishna, U.M., FALCK, J.R., and D. Broek, "Control of Intramolecular Interactions Between the Pleckstrin Homology and Dbl Homology Domains of Vav and Sos1 Regulates Rac Binding". J. Bio. Chem. 275: 15074-15081, 2000.

298. FALCK, J.R., Krishna, U.M., Katipally, K.R., Capdevila, J.H., and E.T. Ulug, "Concise Syntheses of L-(-Phosphatidyl-D-myo-Inositol 3-Phosphate (3-PIP), 5-Phosphate (5-PIP), and 3,5-Bisphosphate (3,5-PIP2)." Tetrahedron Lett. 41: 4271-4275, 2000.

299. Glouchankova, L., Krishna, U.M., Potter, B.V.L., FALCK, J.R., and I. Bezprozvanny, "Association of the Inositol (1,4,5)-Trisphosphate Receptor Ligand Binding Site with Phosphatidylinositol (4,5)-Bisphosphate and Adenophostin A". Mol. Cell Biol. Res. Comm. 3: 153-158, 2000.

300. Quigley, R., Baum, M., Reddy, K.M., Griener, J.C., and J.R. FALCK, "Effects of 20-HETE and 19(S)-HETE on Rabbit Proximal Straight Tubule Volume Transport". Am. J. Physiol. 278: F949-F953, 2000.

301. FALCK, J.R., Krishna, U.M., and J.H. Capdevila, "Preparation of L-(-Phosphatidyl-D-myo-inositol 3-Phosphate (3-PIP) and 3,5-Bisphosphate (3,5-PIP2)". Bioorg. Med. Chem. Lett. 10: 1711-1713, 2000.

302. Sun, C-W., FALCK, J.R., Okamoto, H., Harder, D.R., and R.J. Roman, "Role of cGMP versus 20-HETE in the Vasodilator Response to Nitric Oxide in Rat Cerebral Arteries". Am. J. Physiol. 279: H339-H350, 2000.

303. Maier, K.G., Henderson, L., Narayanan, J., Alonso-Galicia, M., FALCK, J.R., and R.J. Roman, "Fluorescent HPLC Assay for 20-HETE and Other P-450 Metabolites of Arachidonic Acid". Am. J. Physiol. 279: H863-H871, 2000.

304. Frisbee, J.C., FALCK, J.R., and J.H. Lombard, "Contribution of Cytochrome P-450 (-Hydroxylase to Altered Arteriolar Reactivity with High-Salt Diet and Hypertension". Am. J. Physiol. 278: H1517-H1526, 2000.

305. Capdevila, J.H., and J.R. FALCK, "Biochemical and Molecular Characteristics of the Cytochrome P450 Arachidonic Acid Monooxygenase". Prostaglandins& Other Lipid Med. 62: 271-292, 2000.

306. Hoch, U., FALCK, J.R., and P. R. Ortiz de Montellano, "Molecular Basis for the (-Regiospecificity of the CYP4A2 and CYP4A3 Fatty Acid Hydroxylases". J. Biol. Chem. 275: 26952-26958, 2000.

307. Gebremedhin, D., Lange, A.R., Lowry, T.F., Taheri, M.R., Birks, E.K., Hudetz, A.G., Narayanan, J., FALCK, J.R., Okamoto, H., Roman, R.J., Nithipatikom, K., Campbell, W.B., and D.R. Harder, "Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow". Circ. Res. 87: 60-65, 2000.

308. Frisbee, J.C., Roman, R.J., FALCK, J.R., Linderman, J.R., and J.H. Lombard, "Impairment of Flow-Induced Dilation of Skeletal Muscle Arterioles with Elevated Oxygen in Normotensive and Hypertensive Rats". Microvasc. Res. 60: 37-48, 2000.

309. Bhardwaj, A., Northington, F.J., Carhuapoma, J.R., FALCK, J.R., Harder, D.R., Traystman, R.J., and R.C. Koehler, "P-450 Epoxygenase and NO Synthase Inhibitors Reduce Cerebral Blood Flow Response to N-Methyl-D-Aspartate". Am. J. Physiol. 279: H1616-H1624, 2000.

310. Zhu, D., Birks, E.K., Dawson, C.A., Patel, M., FALCK, J.R., Presberg, K., Roman, R.J., and E.R. Jacobs, "Hypoxic Pulmonary Vasoconstriction is Modified by P-450 Metabolites". Am. J. Physiol. 279: H1526-H1533, 2000.

311. Wong, P. Y.-K., Lai, P.-S., and J.R. FALCK, "Mechanism and Signal Transduction of 14(R),15(S)-Epoxyeicosatrienoic Acid (14,15-EET) Binding in Guinea Pig Monocytes". Prostaglandins & Other Lipid Med. 62: 321-333, 2000.

312. Bednar, M.M., Gross, C.E., Russell, S.R., Fuller, S.P., Ahern, T.P., Howard D.B., Falck, J.R., Reddy, K.M., and M. Balazy, "16(R)-Hydroxyeicosatetraenoic Acid, a Novel Cytochrome P450 Product of Arachidonic Acid, Suppresses Activation of Human Polymorphonuclear Leukocytes and Reduces Intracranial Pressure in a Rabbit Model of Thromboembolic Stroke". Neurosurg. 47: 1410-1419, 2000.

313. Brand-Schieber, E., FALCK, J.R., and M. Schwartzman, "Selective Inhibition of Arachidonic Acid Epoxidation In Vivo". J. Physiol. Pharm. 51: 655-672, 2000.

314. Frisbee, J.C., Roman, R.J., Krishna, U.M., FALCK, J.R., and J.H. Lombard, "20-HETE Modulates Myogenic Response of Skeletal Muscle Resistance Arteries from Hypertensive Dahl-SS Rats". Am. J. Physiol. 280: H1066-H1074, 2001.

315. Frisbee, J.C., Roman, R.J., FALCK, J.R., Krishna, M., and J.H. Lombard, "20-HETE Contributes to Myogenic Activation of Skeletal Muscle Resistance Arteries in Brown Norway and Sprague-Dawley Rats". Microcir. 8: 45-55, 2001.

316. FALCK, J.R., Barma, D.K., Baati, R., and C. Mioskowski, "Differential Cleavage of Arylmethyl Ethers: Reactivity of 2,6-Dimethoxybenzyl Ethers". Angew. Chem. Int. Ed 40: 1281-1283, 2001.

317. Cowart, L.A., FALCK, J.R., and J.H. Capdevila, "Structural Determinants of Active Site Bidning Affinity and Metabolism by Cytochrome P450 BM-3". Arch. Biochem. Biophys. 387: 117-124, 2001.

318. Pomposiello, S.I., Carroll, M.A., FALCK, J.R., and J.C. McGiff, "Epoxyeicosatrienoic Acid-Mediated Renal Vasodilation to Arachidonic Acid is Enhanced in SHR". Hypertension 37: 887-893, 2001.

319. Kunert, M.P., Roman, R.J., Alonso-Galicia, M., FALCK, J.R., and J.H. Lombard, "Cytochrome P-450 (-Hydroxylase: A Potential O2 Sensor in Rat Arterioles and Skeletal Muscle Cells". Am. J. Physiol. 280: H1840-H1845, 2001.

320. Hilton, J.M., Plomann, M., Ritter, B., Modregger, J., Freeman, H.N., FALCK, J.R., Krishna, U.M., and A.B. Tobin, "Phosphorylation of a Synaptic Vesicle-Associated Protein by an Inositol Hexakisphosphate-Regulated Protein Kinase". J. Biol. Chem. 276: 16341-16347, 2001.

321. Holla, V.R., Adas, F., Imig, J.D., Zhao, X., Price, E., Jr., Olsen, N., Kovacs, W.J., Magnuson, M.A., Keeney, D.S., Breyer, M.D., FALCK, J.R., and M.R. Waterman, "Alterations in the Regulation of Androgen-Sensitive Cyp 4a Monooxygenases Cause Hypertension". Proc. Natl. Acad. Sci. USA 98: 5211-5216, 2001.

322. Nithipatikom, K., DiCamelli, R.F., Kohler, S., Gumina, R.J., FALCK, J.R., Campbell, W.B., and G.J. Gross, "Determination of Cytochrome P450 Metabolites of Arachidonic Acid in Coronary Venous Plasma During Ischemia and Reperfusion in Dogs". Anal. Biochem. 292: 115-124, 2001.

323. FALCK, J.R., Reddy, Y.K., Haines, D.C., Reddy, K.M., Krishna, U.M., Graham, S., Murry, B., and J.A. Peterson, "Practical, Enantiospecific Syntheses of 14,15-EET and Leukotoxin B (Vernolic Acid)". Tetrahedron Lett. 42: 4131-4133, 2001.

324. Mohapatra, S., Capdevila, J.H., Murphy, R.C., Hevko, J.M., and J.R. FALCK, "Efficient Total Synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-Eicosatetraenoic Acid (5-oxo-ETE), a Potent Proinflammatory Autacoid". Tetrahedron Lett. 42: 4109-4110, 2001.

325. Alexander, L.D., Cui, X.-L., FALCK, J.R., and J.G. Douglas, "Arachidonic Acid Directly Activates Members of the Mitogen-Activated Protein Kinase Superfamily in Rabbit Proximal Tubule Cells". Kid. Internat. 59: 2039-2053, 2001.

326. Wu, Y., Huang, A., Sun, D., FALCK, J.R., Koller, A., and G. Kaley, "Gender-Specific Compensation for the Lack of NO in the Mediation of Flow-Induced Arteriolar Dilation". Am. J. Physiol. 280: H2456-H2461, 2001.

327. Huang, A., Sun, D., Carroll, M.A., Jiang, H., Smith, C.J., Connetta, J.A., FALCK, J.R., Shesely, E.G., Koller, A., and G. Kaley, "EDHF Mediates Flow-Induced Dilation in Skeletal Muscle Arterioles of Female eNOS-KO Mice". Am. J. Physiol. 280: H2462-H2469, 2001.

328. Imig, J.D., Zhao, X., FALCK, J.R., Shouzou, W., and J.H. Capdevila, "Enhanced Renal Microvascular Reactivity to Angiotensin II in Hypertension is Ameliorated by the Sulfonimide Analog of 11,12-Epoxyeicosatrienoic Acid". J. Hypertension 19: 983-992, 2001.

329. Frisbee, J.C., Roman, R.J., Krishna, U.M., FALCK, J.R., and J.H. Lombard, "Altered Mechanisms Underlying Hypoxic Dilation of Skeletal Muscle Resistance Arteries of Hypertensive Versus Normotensive Dahl Rats". Microcir. 8: 115-127, 2001.

330. Campbell, W.B., FALCK, J.R., and K. Gauthier, "Role of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factor in Bovine Coronary Arteries". Med. Sci. Monit. 7: 578-584, 2001.

331. Imig, J.D., FALCK, J.R., Wei, S., and J.H. Capdevila, "Epoxygenase Metabolites Contribute to Nitric Oxide-Independent Afferent Arteriolar Vasodilation in Response to Bradykinin". J. Vasc. Res. 38: 247-255, 2001.

332. Frisbee, J.C., Roman, R.J., Krishna, U.M., FALCK, J.R., and J.H. Lombard, "Relative Contributions of Cyclooxygenase-and Cytochrome P450 (-Hydroxylase-Dependent Pathways to Hypoxic Dilation of Skeletal Muscle Resistance Arteries". J. Vasc. Res. 38: 305-314, 2001.

333. Yang, B., Graham, L., Dikalov, S., Mason, R.P., FALCK, J.R., Liao, J.K., and D.C. Zeldin, "Overexpression of Cytochrome P450 CYP2J2 Protects Against Hypoxia-Reoxygenation Injury in Cultured Bovine Aortic Endothelial Cells". Mol. Pharm. 60: 310-320, 2001.

334. Qu, W., Bradbury, J.A., Tsao, C.-C., Maronpot, R., Harry, G.J., Parker, C.E., Davis, L.S., Breyer, M.D., Waalkes, M.P., FALCK, J.R., Chen, J., Rosenberg, R.L., and D.C. Zeldin, "Cytochrome P450 CYP2J9, a New Mouse Arachidonic Acid (-1 Hydroxylase Predominantly Expressed in Brain". J. Biol. Chem. 276: 25467-25479, 2001.

335. Zou, G., and J. R. FALCK, "Suzuki-Miyaura Cross-Coupling of Lithium n-Alkylborates". Tetrahedron Lett. 42: 5817-5819, 2001.

336. Baati, R., Barma, D.K., FALCK, J.R., and C. Mioskowski, "Chromium Vinylidene Carbenoids: Generation, Characterization, and Reactivity. First Evidence for an Internal Proton Return Phenomenon with Vinylidene Carbenoids". J. Am. Chem. Soc. 123: 9196-9197, 2001.

337. Krishna, U.M., Reddy, M.M., Xia, J., FALCK, J.R., and M. Balazy, "Stereospecific Synthesis of trans-Arachidonic Acids". Bioorg. Med. Chem. Lett. 11: 2415-2418, 2001.

338. Cho, S.-D., Song, S.-Y., Hur, E.-J., Chen, M., Joo, W.-H., FALCK, J.R., Yoon, Y.-J., and D.-S. Shin, "Regioselectivity of Pictet-Spengler Cyclization: Synthesis of Halotetrahydroisoquinolines". Tetrahedron Lett. 42: 6251-6253, 2001.

339. Zou, G., Reddy, Y.K., and J.R., FALCK, "Ag(I)-Promoted Suzuki-Miyaura Cross-Couplings of n-Alkylboronic Acids". Tetrahedron Lett. 42: 7213-7215, 2001.

340. FALCK, J.R., Kumar, P.S., Reddy, Y.K., Zou, G., and J.H. Capdevila, "Stereospecific Synthesis of EET Metabolites via Suzuki-Miyaura Coupling". Tetrahedron Lett. 42: 7211-7212, 2001.

341. FALCK, J.R., Bondlela, M., Venkataraman, S.K., and D. Srinivas, "Bromo-Boronolactonization of Olefins". J. Org. Chem. 66: 7148-7150, 2001.

342. Capdevila, J.H. and J.R. FALCK, "The CYP P450 Arachidonic Acid Monooxygenases: From Cell Signaling to Blood Pressure Regulation". Biochem. Biophys. Res. Comm. 285: 571-576, 2001.

343. Gu, R.-M., Wei, Y., FALCK, J.R., Krishna, U.M., and W.-H. Wang, "Effects of Protein Tyrosine Kinase and Protein Tyrosine Phosphatase on Apical K+ Channels in the TAL". Am. J. Physiol. 281: C1188-C1195, 2001.

344. Frisbee, J.C., Krishna, U.M., FALCK, J.R., and J.H. Lombard, "Role of Prostanoids and 20-HETE in Mediating Oxygen-Induced Constriction of Skeletal Muscle Resistance Arteries". Microvasc. Res. 62: 271-283, 2001.

345. Zhao, X., Inscho, E.W., Bondlela, M., FALCK, J.R., and J.D. Imig, "The CYP450 Hydroxylase pathway Contributes to P2X Receptor-Mediated Afferent arteriolar vasoconstriction". Am. J. Physiol. 281: H2089-H2096, 2001.

346. Nithipatikom, K., Grall, A.J., Holmes, B.B., Harder, D.R., FALCK, J.R., and W.B. Campbell, "Liquid Chromatographic-Electrospray Ionization-Mass Spectrometric Analysis of Cytochrome P450 Metabolites of Arachidonic Acid". Anal. Biochem. 298: 327-336, 2001.

347. Zhang, F., Wang, M.-H., Krishna, U.M., FALCK, J.R., Laniado-Schwartzman, M., and A. Nasjletti, "Modulation by 20-HETE of Phenylephrine-Induced Mesenteric Artery Contraction in Spontaneously Hypertensive and Wistar-Kyoto Rats". Hypertension 38: 1311-1315, 2001.

348. Barma, D.K., Baati, R., Valleix, A., Mioskowski, C., and J.R. FALCK, "Chromium Vinylidene Carbenoids: Stereospecific Synthesis of (Z)-2-Chloroalk-2-en-1-ols". Org. Lett. 3: 4237-4238, 2001.

349. Kunert, M.P., Roman, R.J., FALCK, J.R., and J.H. Lombard, "Differential Effect of Cytochrome P-450 (-Hydroxylase Inhibition on O2-Induced Constriction of Arterioles in SHR with Early and Established Hypertension". Microcirc. 8: 435-443, 2001.

350. Baati, R., Barma, D.K., Krishna, U.M., Mioskowski, C., and J.R. FALCK, "A Convenient Synthesis of (Z)-1-Chloro-1-Alkenes and (Z)-1-Chloro-2-Alkoxy-1-Alkenes". Tetrahedron Lett. 43: 959-961, 2002.

351. FALCK, J.R., Barma, D.K., Venkataraman, S.K., Baati, R., and C. Mioskowski, "Regioselective de-O-Benzylation of Monosaccharides". Tetrahedron Lett. 43: 963-966, 2002.

352. Baati, R., Barma, D.K., FALCK, J.R., and C. Mioskowski, "Three-Component Synthesis of 2-Haloalk-2(Z)-en-1-ols via Tandem Haloalkylidenation-Aldehyde addition". Tetrahedron Lett. 43: 2179-2181, 2002.

353. Baati, R., Barma, D.K., FALCK, J.R., and C. Mioskowski, "A Versatile Synthesis of 2-Haloalk-2(Z)-en-1-ols and 1-Chloro-1 (Z)-Alkenes from Trichloromethylcarbinols". Tetrahedron Lett. 43: 2183-2185, 2002.

354. Reddy, Y. K. and J. R. FALCK, "Asymmetric Synthesis of (+)-Fostriecin". Org. Lett. 4: 969-971, 2002.

355. Barma, D. K., Kundu, A., Baati, R., Mioskowski, C., and J.R. FALCK, "A Convenient Preparation of 3-Substituted Furans: Synthesis of Perillene and Dendrolasin". Org. Lett. 4: 1387-1389, 2002.

356. Yu, J., Lai, J.-Y., Ye, J., Balu, N., Reddy, M., Duan, D., Fogel, E.R., Capdevila, J.H., and J.R. FALCK, "Chiral Cyclopropanes: Asymmetric Synthesis of Constanolactones A and B". Tetrahedron Lett. 43: 3939-3941, 2002.

357. Zeng, W.-Z., Liou, H.-H., Krishna, U.M., FALCK, J.R., and C-L. Huang, "Structural Determinants and Specificities for ROMK1-Phosphoinositide Interaction". Am. J. Physiol. 282: F826-F834, 2002.

358. Campbell, W.B., Deeter, C., Gauthier, K.M., Ingraham, R.H., FALCK, J.R., and P.-L. Li, "14,15-Dihydroxyeicosatrienoic Acid Relaxes Bovine Coronary Arteries by Activation of KCa Channels". Am. J. Physiol. 282: H1656-H1664, 2002.

359. Gauthier, K.M., Deeter, C., Krishna, U.M., Reddy, Y.K., Bondlela, M., FALCK, J.R., and W.B. Campbell, "14,15-Epoxyeicosa-5(Z)-Enoic Acid: A Selective Epoxyeicosatrienoic Acid Antagonist That Inhibits Endothelium-Dependent Hyperpolarization and Relaxation in Coronary Arteries". Circ. Res. 90: 1028-1036, 2002.

360. Mezentsev, A., Seta, F., Dunn, M.W., Ono, N., FALCK, J.R., and M. Laniado-Schwartzman, "Eicosanoid Regulation of Vascular Endothelial Growth Factor Expression and Angiogenesis in Microvessel Endothelial Cells". J. Biol. Chem. 277: 18670-18676, 2002.

361. Capdevila, J.H., Harris, R.C., and J.R. FALCK, "Microsomal Cytochrome P450 and Eicosanoid Metabolism". Cell. Mol. Life Sci. 59: 780-789, 2002.

362. Frisbee, J.C., Maier, K.G., FALCK, J.R., Roman, R.J., and J.H. Lombard, "Integration of Hypoxic Dilation Signaling Pathways for Skeletal Muscle Resistance Arteries". Am. J. Physiol. 283: R309-R319, 2002.

363. Hidaka, K., Caffrey, J.J., Hua, L., Zhang, T., FALCK, J.R., Nickel, G.C., Carrel, L., Barnes, L.D., and S.B. Shears, "An Adjacent Pair of Human NUDT Genes on Chromosome X are Preferentially Expressed in Testis and Encode Two New Isoforms of Diphosphoinositol Polyphosphate Phosphohydrolase". J. Biol. Chem. 277: 32730-32738, 2002.

364. Cowart, L.A., Wei, S., Hsu, M.-H., Johnson, E.F., Krishna, M.U., FALCK, J.R., and J.H. Capdevila, "The CYP4A Isoforms Hydroxylate Epoxyeicosatrienoic Acids to Form High Affinity Peroxisome Proliferator-activated Receptor Ligands". J. Biol. Chem. 277: 35105-35112, 2002.

365. Looft-Wilson, R.C., FALCK, J.R., Krishna, U.M., and C.V. Gisolfi, "20-HETE Pathway Antagonists Inhibit Rat Small Mesenteric Artery Tone". Microvasc Res. 64: 349-352, 2002.

366. FALCK, J.R., Mohapatra, S., Bondlela, M., and S.K. Venkataraman, "Homocoupling of Alkyl-, Alkenyl-, and Arylboronic Acids". Tetrahedron Lett. 43: 8149-8151, 2002.

367. Snyder, G.D., Krishna, U.M., FALCK, J.R., and A.A. Spector, "Evidence for a Membrane Site of Action for 14,15-EET on Expression of Aromatase in Vascular Smooth Muscle". Am. J. Physiol. 283: H1936-H1942, 2002.

368. Peng, X., Carhuapoma, J.R., Bhardwag, A., Alkayed, N.J., FALCK, J.R., Harder, D.R., Traystman, R.J., and R.C. Koehler, "Suppression of Cortical Functional Hyperemia to Vibrissal Stimulation in the Rat by Epoxygenase Inhibitors". Am. J. Physiol. 283: H2029-H2037, 2002.

369. Capdevila, J.H. and J.R. FALCK, "Biochemical and Molecular Properties of the Cytochrome P450 Arachidonic Acid Monooxygenases". Prostaglandins& Other Lipid Med. 68-69: 325-344, 2002.

370. FALCK, J.R., Krishna, U.M., Reddy, Y.K., Kumar, P.S., Reddy, K.M., Hittner, S.B., Deeter, C., Sharma, K.K., Gauthier, K.M., and W.B. Campbell, "Comparison of Vasodilatory Properties of 14,15-EET Analogs: Structural Requirements for Dilation". Am. J. Physiol. 284: H337-H349, 2003.

371. Kaide, J.-I., Wang, M.-H., Wang, J.-S., Zhang, F., Gopal, V.R., FALCK, J.R., Nasjletti, A., and M. Laniado-Schwartzman, "Transfection of CYP4A1 cDNA Increases Vascular Reactivity in Renal Interlobar Arteries". Am. J. Physiol. 284: F51-F56, 2003.

372. Innocenti, M., Frittoli, E., Ponzanelli, I., FALCK, J.R., Brachmann, S.M., DiFiore, P.P., and G. Scita, "Phosphoinositide 3-Kinase Activates Rac by Entering in a Complex with Eps8, Abi1, and Sos-1". J. Cell Biol. 160: 17-23, 2003.

373. Barma, D.K., Kundu, A., Zhang, H., Mioskowski, C., and J.R. FALCK, "(Z)-(-Haloacrylates: An Exceptionally Stereoselective Preparation via Cr(II)-Mediated Olefination of Aldehydes with Trihaloacetates". J. Am. Chem. Soc. 125: 3218-3219, 2003.

374. Ren, Y., Garvin, J.L., FALCK, J.R., Renduchintala, K.V., and O.A. Carretero, "Glomerular Autacoids Stimulated by Bradykinin Regulate Efferent Arteriole Tone". Kid. Internat. 63: 987-993, 2003.

375. Archer, S.L., Gragasin, F.S., Wu, X., Wang, S., McMurtry, S., Kim, D.H., Platonov, M., Koshal, A., Hashimoto, K., Campbell, W.B., FALCK, J.R., and E.D. Michelakis, "Endothelium-Derived Hyperpolarizing Factor in Human Internal Mammary Artery is 11,12-Epoxyeicosatrienoic Acid and Causes Relaxation by Activating Smooth Muscle BKCa Channels". Circ. 107: 769-776, 2003.

376. Barma, D.K., Elayadi, A., FALCK, J.R., and D.R. Corey, "Inhibition of Telomerase by BIBR 1532 and Related Analogues". Bioorg. Med. Chem. Lett 13: 1333-1336, 2003.

377. Grates, H.E., McGowen, R.M., Gupta, S.V., FALCK, J.R., Brown, T.R., Callewaert, D.M., and D.M. Sasaki, "Quantification of 20-Hydroxyeicosatetraenoic Acid by Colorimetric Competitive Enzyme Linked Immunosorbent Assay". J. Biosci. 28: 109-113, 2003.

378. Wang, D., Borrego-Conde, L.J., FALCK, J.R., Sharma, K.K., Wilcox, C.S., and J.G. Umans, "Contributions of Nitric Oxide, EDHF, and EETs to Endothelium-Dependent Relaxation in Renal Afferent Arterioles". Kid. Internat. 63: 2187-2193, 2003.

379. Yu, M., Alonso-Galicia, M., Sun, C.-W., Roman, R.J., Ono, N., Hirano, H., Ishimoto, T., Reddy, Y.K., Katipally, K.R., Reddy, K.M., Gopal, V.R., Yu, J., Takhi, M., and J.R. FALCK, "20-Hydroxyeicosatetraenoic Acid (20-HETE): Structural Determinants for Renal Vasoconstriction". Bioorg. Med. Chem. 11: 2803-2821, 2003.

380. Pfister, S.L., Spitzbarth, N., Nithipatikom, K., FALCK, J.R., and W.B. Campbell, "Metabolism of 12-Hydroperoxyeicosatetraenoic Acid to Vasodilatory Trioxilin C3 by Rabbit Aorta." Biochim. Biophys. Acta 1622: 6-13, 2003.

381. Kwon, S.W., Kim, S.C., Jaunbergs, J., FALCK, J.R., and Y. Zhao. "Selective Enrichment of Thiophosphorylated Polypeptides as a Tool for the Analysis of Protein Phosphorylation". Mol. Cell. Proteomics 2: 242-247, 2003.

382. Patel, S., Wohlfeil, E.R., Rademacher, D.J., Carrier, E.J., Perry, L.J., Kundu, A., FALCK, J.R., Nithipatikom, K., Campbell, W.B., and C.J. Hillard, "The General Anesthetic Propofol Increases Brain N-Arachidonylethanolamine (Anandamide) Content and Inhibits Fatty Acid Amide Hydrolase". Brit. J. Pharm. 139: 1005-1013, 2003.

383. Ciprés, A., Carrasco, S., Merino, E., Díaz, E., Krishna, U.M., FALCK, J.R., Martínez-A.C., and I. Mérida, "Regulation of Diacylglycerol Kinase ( by Phosphoinositide 3-Kinase Lipid Products". J. Biol. Chem. 278: 35629-35635, 2003.

384. Stricker, R., Vandekerckhove, J., Krishna, M.U., FALCK, J.R., Hanck, T., and G. Reiser, "Oligomerization Controls in Tissue-Specific Manner Ligand Binding of Native, Affinity-Purified p42IP4/Centaurin ( 1 and Cytohesins-Proteins with High Affinity for the Messengers D-Inositol 1,3,4,5-Tetrakisphosphate/Phosphatidylinositol 3,4,5-Trisphosphate". Biochim. Biophys. Acta 1651: 102-115, 2003.

385. Reddy, Y.K., Reddy, L.M., Capdevila, J.H., and J.R. FALCK, "Practical, Asymmetric Synthesis of 16-Hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic Acid (16-HETE), an Endogenous Inhibitor of Neutrophil Activity". Bioorg. Med. Chem. Lett. 13: 3719-3720, 2003.

386. Pomposiello, S.I., Quilley, J., Carroll, M.A., FALCK, J.R., and J.C. McGiff, "5,6-Epoxyeicosatrienoic Acid Mediates the Enhanced Renal Vasodilation to Arachidonic Acid in the SHR". Hypertension 42: 548-554, 2003.

387. Gauthier, K.M., Jagadeesh, S.G., FALCK, J.R., and W.B. Campbell, "14,15-Epoxyeicosa-5(Z)-enoic-mSI: A 14,15- and 5,6-EET Antagonist in Bovine Coronary Arteries". Hypertension 42: 555-561, 2003.

388. FALCK, J.R., Reddy, L.M., Reddy, Y.K., Bondlela, M., Krishna, U.M., Ji, Y., Sun, J., and J.K. Liao, "11,12-Epoxyeicosatrienoic Acid (11,12-EET): Structural Determinants for Inhibition of TNF-(-Induced VCAM-1 Expression". Bioorg. Med. Chem. Lett. 13: 4011-4014, 2003.

389. Cho, S-D., Park, Y-D., Kim, J-J., Lee, S-G., Ma, C., Song, S-Y., Joo, W-H., FALCK, J.R., Shiro, M., Shin, D-S., and Y-J. Yoon, "A One-Pot Synthesis of Pyrido[2,3-b][1,4]oxazin-2-ones". J. Org. Chem 68: 7918-7920, 2003.

390. Barma, D.K., Bandyopadhyay, A., Capdevilla, J.H., and J.R. FALCK, "Dimethylthiocarbamate (DMTC): An Alcohol Protecting Group". Org. Lett 5: 4755-4757, 2003.

391. Mohapatra, S., Bandyopadhyay, A., Barma, D.K., Capdevila, J.H., and J.R. FALCK, "Chiral(,(-Dialkoxy- and (-Alkoxy-(-aminostannanes: Preparation and Copper-Mediated Cross-Coupling". Org. Lett 5: 4759-4762, 2003.

392. Cho, S-D., Song, S-Y., Park, Y-D., Kim, J-J., Joo, W-H., Shiro, M., FALCK, J.R., Shin, D-S., and Y-J. Yoon, "Novel Synthesis of Pyridazino[4,5-b][1,4]oxazin-3,8-diones". Tetrahedron Lett. 44: 8995-8998, 2003.

393. Rivera, J., Ward, N., Hodgson, J., Puddey, I.B., FALCK, J.R., and K.D. Croft, "Measurement of 20-Hydroxyeicosatetraenoic Acid in Human Urine by Gas Chromatgoraphy-Mass Spectrometry". Clin. Chem. 50: 224-226, 2004.

394. Kaduce, T.L., Fang, X., Harmon, S.D., Oltman, C.L., Dellsperger, K.C., Teesch, L.M., Gopal, V.R., FALCK, J.R., Campbell, W.B., Weintraub, N.L., and A.A. Spector, "20-Hydroxyeicosatetraenoic Acid (20-HETE) Metabolism in Coronary Endothelial Cells". J. Biol. Chem. 279: 2648-2656, 2004.

395. Ma, C., Cho, S-D., FALCK, J.R., and D-S. Shin, "Synthetic Studies on Isoquinoline Derivatives with Multidrug Resistance (MDR) Modulating Activity". Heterocycles 63: 75-85, 2004.

396. Jiang, M., Mezentsev, A., Kemp, R., Byun, K., FALCK, J.R., Miano, J.M., Nasjletti, A., Abraham, N.G., and M. Laniado-Schwartzman, "Smooth Muscle-Specific Expression of CYP4A1 Induces Endothelial Sprouting in Renal Arterial Microvessels". Circ. Res. 94: 167-174, 2004.

397. Huang, A., Sun, D., Wu, Z., Yan, C., Carroll, M.A., Jiang, H., FALCK, J.R., and G. Kaley, "Estrogen Elicits Cytochrome P450-Mediated Flow-Induced Dilation of Arterioles in NO Deficiency, Role of P13K-Akt Phosphorylation in Genomic Regulation". Circ. Res. 94: 245-252, 2004.

398. Yu, M., Cambj-Sapunar, L., Kehl, F., Maier, G.K., Takeuchi, K., Miyata, N., Ishimoto , T., Reddy, L.M., FALCK, J.R., Gebremedhin, D., Harder, D. R., and R.J. Roman, "Effects of a 20-HETE Antagonist and Agonist on Cerebral Vascular Tone". Eur. J. Pharm. 486: 297-306, 2004.

399. Cheng, M.K., Doumad, A.B., Jiang, H., FALCK, J.R., McGiff, J.C., and M.A. Carroll, "Epoxyeicosatrienoic Acids Mediate Adenosine-Induced Vasodilation in Rat Preglomerular Microvessels (PGMV) via A2A Receptors". Brit. J. Pharm. 141: 441-448, 2004.

400. Gauthier, K.M., FALCK, J.R., Reddy, L.M., and W.B. Campbell, "14,15-EET Analogs: Characterization of Structural Requirements for Agonist and Antagonist Activity in Bovine Coronary Arteries". Pharm. Res. 49: 515-524, 2004.

401. Xu, F., FALCK, J.R., Ortiz de Montellano, P.R., and D.L. Kroetz, "Catalytic Activity and Isoform-Specific Inhibition of Rat Cytochrome P450 4F Enzymes". J. Pharm. Exp. Ther. 308: 887-895, 2004.

402. Gopal, V.R., Jagadeesh, S.G., Reddy, Y.K., Bandyopadhyay, A., Capdevila, J.H., and J.R. FALCK, "A Practical, Stereospecific Route to 18-, 19-, and 20-Hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic Acids (18-, 19-, and 20-HETEs)". Tetrahedron Lett. 45: 2563-2565, 2004.

403. FALCK, J.R., Bandyopadhyay, A., Barma, D.K., Shin, D.-S., Kundu, A., and R.V.K. Kishore, "Stereoselective CrCl2-Mediated Condensation of Aldehydes with Functionalized 1,1,1-Trichlorides: Synthesis of Trisubstituted (Z)-Chloroolefins". Tetrahedron Lett. 45: 3039-3042, 2004.

404. Cho, S.-D., Park, Y.-D., Kim, J.-J., Joo, W.-H., Shiro, M., Esser, L., FALCK, J.R., Ahn, C., Shin, D.-S., and Y.-J. Yoon, "An Efficient Synthesis of [1,4]Pyridazinooxazine[3,4-a]tetrahydroisoquinolines". Tetrahedron 60: 3763-3773, 2004.

405. Cho, S.-D., Park, Y.-D., Kim, J.-J., FALCK, J.R., and Y.-J. Yoon, "Facile Reduction of Carboxylic Acids, Esters, Acid Chlorides, Amides and Nitriles to Alcohols or Amines Using NaBH4/BF3(Et2O". Bull. Korean Chem. Soc. 25: 407-409, 2004.

406. Ma, C., Cho, S.-D., FALCK, J.R., and D.-S. Shin, "One-Pot Synthesis of Pyridazino [1,4]oxazin-3-ones". Syn. Commun. 34: 1399-1405, 2004.

407. Cho, S.-D., Song, S.-Y., Kim, K.-H., Zhao, B.-X., Ahn, C., Joo, W.-H., Yoon, Y.-J., FALCK, J.R., and D.-S. Shin, "One-Pot Synthesis of Symmetrical 1,4-Disubstituted Piperazine-2,5-diones". Bull. Korean Chem. Soc. 25: 415-416, 2004.

408. Barma, D.K., Kundu, A., Bandyopadhyay, A., Kundu, A., Sangras, B., Briot, A., Mioskowski, C., and J.R. FALCK, "A Highly Stereospecific Synthesis of (E)-(,(-unsaturated Esters". Tetrahedron Lett. 45: 5917-5920, 2004.

409. Rajapakse, N.W., Roman, R.J., FALCK, J.R., Oliver, J.J., and R.G. Evans, "Modulation of V1-Receptor-Mediated Renal Vasoconstriction by Expoxeicosatrienoic Acids". Am. J. Physiol. 287: R181-R187, 2004.

410. Ward, N.C., Rivera, J., Hodgson, J., Puddey, I.B., Beilin, L.J., FALCK, J.R., and K.D. Croft, "Urinary 20-Hydroxyeicosatetraenoic Acid is Associated with Endothelial Dysfunction in Humans". Circ. 110: 438-443, 2004.

411. Kaide, J-I., Zhang, F., Wei, Y., Wang, W.H., Gopal, V.R., FALCK, J.R., Schwartzman, M.L., and A. Nasjletti, "Vascular CO Counterbalances the Sensitizing Influence of 20-HETE on Agonist-Induced Vasoconstriction". Hypertension 44: 210-216, 2004.

412. Zghibeh, C.M., Gopal, V.R., Poff, C.D., FALCK, J.R., and M. Balazy, "Determination of Trans-Arachidonic Acid Isomers In Human Blood Plasma". Anal. Biochem. 332: 137-144, 2004.

413. Jagadeesh, S.G., Reddy, L.M., Nasjletti, A., and J.R. FALCK, "A Concise Synthesis of 12(S),20-Dihydroxyeicosa-5(Z ),8(Z),10(E),14(Z)-Tetraenoic Acid, an Endogenous Vasoconstrictor". Tetrahedron Lett. 45: 7111-7113, 2004.

414. FALCK, J.R., Barma, D.K., Mohapatra, S., Bandyopadhyay, A., Reddy, K.M., Qi, J., and W.B. Campbell, "Asymmetric Synthesis of the Stereoisomers of 11,12,15(S)-Trihydroxyeicosa-5(Z),8(Z),13(E)-Trienoic Acid, A Potent Endothelium-Derived Vasodilator". Bioorg. Med. Chem. Lett. 14: 4987-4990, 2004.

415. Jiang, H., McGiff, J.C., Quilley, J., Sacerdoti, D., Reddy, M.L., FALCK, J.R., Zhang, F., Lerea, K.M., and P. Y-K. Wong, "Identification of 5,6-trans-Epoxyeicosatrienoic Acid in the Phospholipids of Red Blood Cells". J. Biol. Chem. 279: 36412-36418, 2004.

416. Zhang, F., Wang, M-H., Wang, J-S., Zand, B., Gopal, V.R., FALCK, J.R., Schwartzman, M.L., and A. Nasjletti, "Transfection of CYP4A1 cDNA Decreases Diameter and Increases Responsiveness of Gracilis Muscle Arterioles to Constrictor Stimuli". Am. J. Physiol. 287: H1089-H1095, 2004.

417. Kho, Y., Kim, S.C., Jiang, C., Barma, D., Kwon, S.W., Cheng, J., Jaunbergs, J., Weinbaum, C., Tamanoi, F., FALCK, J., and Y. Zhao, "A Tagging-via-substrate Technology for Detection and Proteomics of Farnesylated Proteins". Proc. Natl. Acad. Sci. USA 101: 12479-12484, 2004.

418. Kim, J-J., Park, Y-D., Cho, S-D., Kim, H-K., Kang, Y.-J., Lee, S-G., FALCK, J.R., Shiro, M., and Y-J. Yoon, "Preparation of O-Alkylhydroxamic Acids Using 2-Acylpyridazin-3(2H)-ones in Water". Bull. Korean Chem. Soc. 25: 1273-1276, 2004.

419. Nithipatikom, K., Gross, E.R., Endsley, M.P., Moore, J.M., Isbell, M.A., FALCK, J.R., Campbell, W.B., and G.J. Gross, "Inhibition of Cytochrome P450(-Hydroxylase A Novel Endogenous Cardioprotective Pathway". Cir. Res. 95: e65-e71, 2004.

420. Kim, J-J., Park, Y-D., Cho, S-D., Kim, H-K., Chung, H.A., Lee, S-G., FALCK, J.R., and Y-J. Yoon, "Efficient N-arylation of Pyridazin-3(2H)-ones". Tetrahedron Lett. 45: 8781-8784, 2004.

421. Gross, E.R., Nithipatikom, K., Hsu, A.K., Peart, J.N., FALCK, J.R., Campbell, W.B., and G.J. Gross, "Cytochrome P450 ??hydroxylase Inhibition Reduces Infarct Size During Reperfusion via the Sarcolemmal KATP Channel". J. Mol. Cell. Cardio. 37: 1245-1249, 2004.

422. Harrington, L.S., FALCK, J.R., and J.A. Mitchell, "Not so EEZE: The 'EDHF' Antagonist 14,15 Epoxyeicosa-5(Z)-Enoic Acid has Vasodilator Properties in Mesenteric Arteries". Eur. J. Pharm. 506: 165-168, 2004.

423. Caron, N., El Hajjam, A., Declèves, A-E., Joly, E., FALCK, J.R., and R. Kramp, "Changes in Renal Haemodynamics Induced by Indomethacin in the Rat Involve Cytochrome P450 Arachidonic Acid-Dependent Epoxygenases". Clin. Exp. Pharm. Physiol. 31: 683-690, 2004.

424. Zhao, X., FALCK, J.R., Gopal, V.R., Inscho, E.W., and J.D. Imig, "P2X Receptor-Stimulated Calcium Responses in Preglomerular Vascular Smooth Muscle Cells Involves 20-Hydroxyeicosatetraenoic Acid". J. Pharm. Exp. Ther. 311: 1211-1217, 2004.

425. Xiao, Y-F., Ke, Q., Seubert, J.M., Bradbury, J.A., Graves, J., DeGraff, L.M., FALCK, J.R., Krausz, K., Gelboin, H.V., Morgan, J.P., and D.C. Zeldin, "Enhancement of Cardiac L-Type Ca2+ Currents in Transgenic Mice with Cardiac-Specific Overexpression of CYP2J2". Mol. Pharm. 66: 1607-1616, 2004.

426. Nithipatikom, K., Endsley, M.P., Isbell, M.A., FALCK, J.R., Iwamoto, Y., Hillard, C.J., and W.B. Campbell, "2-Arachidonoylglycerol: A Novel Inhibitor of Androgen-Independent Prostate Cancer Cell Invasion". Can. Res. 64: 8826-8830, 2004.

427. Wei, Yuan, Lin, D-H., Kemp, R., Yaddanapudi, G., Nasjletti, A., FALCK, J.R., and W-H Wang, "Arachidonic Acid Inhibits Epithelial Na Channel via Cytochrome P450 (CYP) Epoxygenase-Dependent Metabolic Pathways". J. Gen. Physiol. 124: 719-727, 2004.

428. Zhang, F., Deng, H., Kemp, R., Singh, H., Gopal, V.R., FALCK, J.R., Schwartzman, M.L., and A. Nasjletti, "Decreased Levels of Cytochrome P450 2E1-Derived Eicosanoids Sensitize Renal Arteries to Constrictor Agonists in Sponteneously Hypertensive Rats". Hypertension 45: 103-108, 2005.

429. Randriamboavonjy, V., Kiss, L., FALCK, J.R., Busse, R., and I. Fleming, "The Synthesis of 20-HETE in Small Porcine Coronary Arteries Antagonizes EDHF-Mediated Relaxtion". Cardiovas. Res. 65: 487-494, 2005.

430. Michaelis, U.R., FALCK, J.R., Schmidt, R., Busse, R., and I. Fleming, "Cytochrome P4502C9-Derived Epoxyeicosatrienoic Acids Induce the Expression of Cyclooxygenase-2 in Endothelial Cells". Arter. Thromb. Vasc. Biol. 25: 321-326, 2005.

431. Patel, S., Carrier, E.J., Ho, W-S., Rademacher, D.J., Cunningham, S., Reddy, D.S., FALCK, J.R., Cravatt, B.F., and C.J. Hillard, "The Postmortal Accumulation of Brain N-Arachidonylethanolamine (Anandamide) is Dependent Upon Fatty Acid Amide Hydrolase Activity". J. Lipid. Res. 46: 342-349, 2005.

432. Chen, P., Guo, M., Wygle, D., Edwards, P.A., FALCK, J.R., Roman, R.J., and A.G. Scicli, "Inhibitors of Cytochrome P450 Suppress Angiogenic Responses". Am. J. Pathol. 166: 615-624, 2005.

433. Gauthier, K.M., Baewer, D.V., Hittner, S., Hillard, C.J., Nithipatikom, K., Reddy, D.S., FALCK, J.R., and W.B. Campbell, "Endothelium-Derived 2-Arachidonylglycerol: An Intermediate in Vasodilatory Eicosanoid Release in Bovine Coronary Arteries". Am. J. Physiol. 288: H1344-H1351, 2005.

434. Huang, A., Sun, D., Jacobson, A., Carroll, M.A., FALCK, J.R., and G. Kaley, "Epoxyeicosatrienoic Acids are Released to Mediate Shear Stress-Dependent Hyperpolarization of Arteriolar Smooth Muscle". Circ. Res. 96: 376-383, 2005.

435. Gluais, P., Edwards, G., Weston, A.H., FALCK, J.R., Vanhoutte, P.M., and M. Fèlètou, "Role of SKCa and IKCa in Endothelium-Dependent Hyperpolarizations of the Guinea-Pig Isolated Carotid Artery". Brit. J. Pharm. 144: 477-485, 2005.

436. Jiang, H., Quilley, J., Reddy, M.L., FALCK, J.R., Wong, P., and J.C. McGiff, "Red Blood Cells: Reservoirs of cis- and trans-Epoxyeicosatrienoic Acids". Prost. Lipid Med. 75: 65-78, 2005.

437. Bejot, R., Tisserand, S., Reddy, L.M., Barma, D.K., Baati, R., FALCK, J.R., and C. Mioskowski, "Stereoselective Transformations of Trihalomethylcarbinols Induced by Chromous Chloride". Angew. Chem. Int. Ed. 44: 2008-2011, 2005.

438. Yang, W., Gauthier, K.M., Reddy, L.M., Sangras, B., Sharma, K.K., Nithipatikom, K., FALCK, J.R., and W. B. Campbell, "Stable 5,6-Epoxyeicosatrienoic Acid Analog Relaxes Coronary Arteries through Potassium Channel Activation". Hypertension 45: 681-686, 2005.

439. Zhao, B., Guengerich, F.P., Bellamine, A., Lamb, D.C., Izumikawa, M., Lei, L., Podust, L.M., Sundaramoorthy, M., Kalaitzis, J.A., Reddy, L.M., Kelly, S.L., Moore, B.S., Stec, D., Voehler, M., FALCK, J.R., Shimada, T., and M.R. Waterman, "Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces Coelicolor A3(2) Cytochrome P450 158A2". Biol.Chem. 280: 11599-11607, 2005.

440. Gauthier, K.M., Edwards, E.M., FALCK, J.R., Reddy, D.S., and W.B. Campbell, "14, 15-Epoxyeicosatrienoic Acid Represents a Transferable Endothelium-Dependent Relaxing Factor in Bovine Coronary Arteries". Hypertension 45: 666-671, 2005.

441. Just, A., Olson, A.J.M., FALCK, J.R., and W. J. Arendshorst, "No and No-Independent Mechanisms Mediate ETB Receptor Buffering of ET-1-Induced Renal Vasoconstriction in the Rat". Am. J. Physiol. 288: R1168-R1177, 2005.

442. Sellers, K.W., Sun, C., Diez-Freire, C., Waki, H., Morisseau, C., FALCK, J.R., Hammock, B.D., Paton, J.F., and M.K. Raizada, "Novel Mechanism of Brain Soluble Epoxide Hydrolase-Mediated Blood Pressure Regulation in the Spontaneously Hypertensive Rat". FASEB J. 19: 626-628, 2005.

443. Wang, J., Roman, R.J., FALCK, J.R., de la Cruz, L., and J.H. Lombard, "Effects of High-Salt Diet on CYP450-4A w-Hydroxylase Expression and Active Tone in Mesenteric Resistance Arteries". Am. J. Physiol. 288: H1557-H1565, 2005.

444. Volti, G.L., Sacerdoti, D., Sangras, B., Vanella, A., Mezentsev, A., Scapagnini, G., FALCK, J.R., and N. G. Abraham, "Carbon Monoxide Signaling in Promoting Angiogenesis in Human Microvessel Endothelial Cells". Antioxid. Redox Signal. 7: 707-710, 2005.

445. Park, Y-D., Kim, J-J., Cho, S-D., Lee, S-G., FALCK, J.R., and Y-J Yoon, "2-Chloropyridazin-3(2H)-ones as Electrophilic Chlorinating Agents: Effective a-Chlorination of Active Methylene/Methine Compounds". Synthesis 7: 1136-1140, 2005.

446. Krummen, S., FALCK, J.R., and E. Thorin, "Two Distinct Pathways Account for EDHF-Dependent Dilatation in the Gracilis Artery of Dyslipidaemic hApoB+/+ Mice". Brit. J. Pharm. 145: 264-270, 2005.

447. Drenjancevic-Peric, I., Phillips, S.A., FALCK, J.R., and J. H. Lombard, "Restoration of Normal Vascular Relaxation Mechanisms in Cerebral Arteries by Chromosomal Substitution in Consomic SS.13BN Rats". Am. J. Physiol. 289: H188-H195, 2005.

448. Kim, J-J., Kweon, D-H., Cho, S-D., Kim, H-K., Jung, E-Y., Lee, S-G., FALCK, J.R., and Y-J. Yoon, "2-Cyanopyridazin-3(2H)-ones: Effective and Chemoselective Electrophilic Cyanating Agents". Tetrahedron 61: 5889-5894, 2005.

449. Sprung, R., Nandi, A., Chen, Y., Kim, S.C., Barma, D., FALCK, J.R., and Y. Zhao, "Tagging-via-Substrate Strategy for Probing O-GlcNAc Modified Proteins". J. Prot. Res. 4: 950-957, 2005.

450. Parmentier, J-H., Lavrentyev, E.N., FALCK, J.R., Capdevila, J.H., and K.U. Malik, "Evaluation of Cytochrome P450 4 Family as Mediator of Phospholipase D Activiation in Aortic Vascular Smooth Muscle Cells". Life Sciences 77: 1015-1029, 2005.

451. Weston, A.H., M. Fèlètou., Vanhoutte, P.M., FALCK, J.R., Campbell, W.B., and G. Edwards, "Bradykinin-Induced, Entothelium-Dependent Responses in Porcine Coronary Arteries: Involvement of Potassium Channel Activation and Epoxyeicosatrienoic Acids". Brit. J. Pharm. 145: 775-784, 2005.

452. Pozzi, A., Macias-Perez, I., Abair, T., Wei, S., Su, Y., Zent, R., FALCK, J.R., and J. H. Capdevila, "Characterization of 5,6- and 8,9-Epoxyeicosatrienoic Acids (5,6- and 8,9-EET) as Potent in Vivo Angiogenic Lipids". J. Biol. Chem. 280: 27138-27146, 2005.

453. Liclican, E.L., McGiff, J.C., Pedraza, P.L., Ferreri, N.R., FALCK, J.R., and M. A. Carroll, "Exaggerated Response to Adenosine in Kidneys from High Salt-Fed Rats: Role of Epoxyeicosatrienoic Acids". Am. J. Physiol. 289: F386-F392, 2005.

454. Parker, T.A., Grover, T.R., Kinsella, J.P., FALCK, J.R. and S. H. Abman, "Inhibition of 20-HETE Abolishes the Myogenic Response During NOS Antagonism in the Ovine Fetal Pulmonary Circulation". Am. J. Physiol. 289: L261-L267, 2005.

455. Huang, A., Sun, D., Yan, C., FALCK, J.R., and G. Kaley, "Contribution of 20-HETE to Augmented Myogenic Constriction in Coronary Arteries of Endothelial NO Synthase Knockout Mice". Hypertension 46: 607-613, 2005.

456. Dunn, L.K., Gruenloh, S.K., Dunn, B.E., Reddy, D.S., FALCK, J.R., Jacobs, E.R., and M. Medhora, "Chick Chorioallantoic Membrane as an in Vivo Model to Study Vasoreactivity: Characterization of Development-Dependent Hyperemia Induced by Epoxeicosatrienoic Acids (EETs)". Anatom. Rec. 285A: 771-780, 2005.

457. Gross, G.J., FALCK, J.R., Gross, E.R., Isbell, M., Moore, J., and K. Nithipatikom, "Cytochrome P450 and Arachidonic Acid Metabolites: Role in Myocardial Ischemia/Reperfusion Injury Revisited". Cardiovas.Res. 68: 18-25, 2005.

458. Collins, X.H., Harmon, S.D., Kaduce, T.L., Berst, K.B., Fang, X., Moore, S.A., Raju, T.V., FALCK, J.R., Weintraub, N.L., Duester, G., Plapp, B.V., and A.A. Spector, "w-Oxidation of 20-Hydroxyeicosatetraenoic Acid (20-HETE) in Cerebral Microvascular Smooth Muscle and Endothelium by Alcohol Dehydrogenase 4". J. Biol. Chem. 280: 33157-33164, 2005.

BIBLIOGRAPHY - BOOK CHAPTERS

1. Cohen, T., Ruffner, R.J., Shull, D.W., Fogel, E.R., and J.R. FALCK, "Vinyl Sulfides from Thioacetals with Copper(I) Trifluoromethanesulfonate: (Z)-2-Methoxy-1-phenylthio-1,3-butadiene". Org. Synth. 59: 202-212, 1980.

2. Corey, E.J., Niwa, H., FALCK, J.R., Mioskowski, C., Arai, Y., and A. Marfat, "Recent Studies on the Chemical Synthesis of Eicosanoids". Adv. Prostaglandin Thromboxane Res. 6: l9-25, l980.

3. Jacobson, H.R., Corona, S., Capdevila, J., Chacos, N., Manna, S., Womack, A., and J.R. FALCK, "Effects of Epoxyicosatrienoic Acids on Ion Transport in the Rabbit Cortical Collecting Tubule". In Prostaglandins and Membrane Ion Transport, Volume 1. Edited by P. Braquet, J.C. Frolich, S. Nicosia, and R. Garay. Raven Press, New York, 1984, pp. 311-318.

4. Capdevila, J., Snyder, G., and J.R. FALCK, "Arachidonic Acid Epoxygenase: A New Member of the Arachidonate Cascade". In Microsomes and Drug Oxidations. Edited by A.R. Boobis, J. Caldwell, F. DeMatteis, and C.R. Elcombe. Taylor and Francis, Ltd, Philadelphia, 1985, pp. 84-94.

5. Ojeda, S.R., Capdevila, J., Snyder, G., McCann, S.M., Negro-Vilar, A., and J.R. FALCK, "Involvement of Arachidonic Acid Metabolites in the Control of Hypothalamic-Pituitary Function". Adv. Prost. Throm. Leuk. Res. 15: 559-560, 1985.

6. Proctor, K.G., Shatkin, Jr., S., FALCK, J.R., and J. Capdevila, "A Novel Class of Arachidonic Acid Metabolites with Vasodilator Properties". In Microcirculation - An Update, Vol. 1. Edited by M. Tsuchiya, M. Asano, Y. Mishima, and M. Oda. Elsevier, New York, 1987, pp. 739-742.

7. Marcus, A.J., Safier, L.B., Ullman, H.L., Islam, N., Broekman, M.J., FALCK, J.R., Fischer, S., and C. von Schacky, "Cell-Cell Interactions in the Eicosanoid Pathways". In Prog. Clin. Biol. Res. 283: 559-67, 1988.

8. Marcus, A.J., Safier, L.B., Ullman, H.L., Islam, N., Broekman, M.J., FALCK, J.R., Fischer, S., and C. von Schacky, "Platelet-Neutrophil Interactions in the Eicosanoid Pathway". In Adv. Exp. Med. Biol. (Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis). Edited by C.L. Malmendier and P. Alaupovic. Plenun Press, New York, 1988, Vol. 243, pp. 31-36.

9. FALCK, J.R., Lumin, S., Yadagiri, P., and D.-S. Shin, "Chemical Syntheses of Trioxilins". Adv. Prost. Throm. Leuk. Res. 19: 635-638, 1989.

10. Malcolm, K., FALCK, J.R., and F.A. Fitzpatrick, "Novel Eicosanoids Generated by Cytochrome P-450: Effects on Platelet Aggregation and Protein Phosphorylation". Adv. Prost. Throm. Leuk. Res. 20: 87-94, 1990.

11. Marcus, A.J., Safier, L.B., Ullman, H.L., Islam, N., Broekman, M.J., FALCK, J.R., Fischer, S., Santos, M.T., Valles, J., and C. von Schacky, "Interactions Between Platelets and Neutrophils in the Eicosanoid Pathway". Adv. Prost. Throm. Leuk. Res. 19: 263-266, 1988.

12. FALCK, J.R., Yadagiri, P., and J. Capdevila, "Synthesis of Epoxyeicosatrienoic Acids and Heteroatom Analogs". In Methods in Enzymology 187: Arachidonate Related Lipid Mediators. Edited by R.C. Murphy and F.A. Fitzpatrick. Academic Press, Inc., San Diego, 1990, pp. 357-364.

13. Capdevila, J.H., FALCK, J.R., Dishman, E., and A. Karara, "Cytochrome P-450 Arachidonate Oxygenase". In Methods in Enzymology 187: Arachidonate Related Lipid Mediators. Edited by R.C. Murphy and F.A. Fitzpatrick. Academic Press, Inc., San Diego, 1990, pp. 385-394.

14. Escalante, B., Erlij, D., FALCK, J.R., and J.C. McGiff, "Ion Transport Inhibition in the Medullary Thick Ascending Limb of Henle's Loop by Cytochrome P450-Arachidonic Acid Metabolites". Adv. Prost. Throm. Leuk. Res. 21: 209-212, 1990.

15. Rosolowsky, M., FALCK, J.R., and W.B. Campbell, "Synthesis and Biological Activity of Epoxyeicosatrienoic Acids (EETs) by Cultured Bovine Coronary Artery Endothelial Cells". Adv. Prost. Throm. Leuk. Res. 21: 213-216, 1990.

16. Laniado-Schwartzman, M., Lutton, J.D., Moqattash, S., Ahmed, T., FALCK, J.R., and N.G. Abraham, "A Novel Cytochrome P450 Human Bone Marrow Arachidonate Metabolism with Powerful Erythroid Potentiating Activity". In Molecular Biology of Haematopoiesis. Edited by L. Sachs, N.G. Abraham, C.J. Wiedermann, A.S. Levine, and G. Konwalinka. Intercept Ltd., Andover, NH, 1990, pp. 139-148.

17. FALCK, J.R. and A. Abdali, "Enantiospecific Synthesis of Inositol Polyphosphates, Phosphatidylinositides, and Analogues from (-)-Quinic Acid". In Inositol Phosphates and Derivatives: Synthesis, Biochemistry, and Therapeutic Potential. Edited by A.B. Reitz. Amican Chemical Society, 1991, pp. 145-154.

18. Capdevila, J.H., Dishman, E., Karara, A., and J.R. FALCK, "Cytochrome P-450 Arachidonic Acid Epoxygenase: Stereochemical Characterization of the Epoxyeicosatrienoic Acids". In Methods in Enzymology 206: Cytochrome P-450. Edited by M.R. Waterman and E.F. Johnson. Academic Press, Inc., San Diego, 1991, pp. 441-453.

19. Capdevila, J.H., Jin, Y., Karara, A., and J.R. FALCK, "Cytochrome P-450 Epoxygenase Dependent Formation of Novel Endogenous Epoxyeicosatrienoyl-Phospholipids". In Dev. Oncol. (Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury). Edited by S. Nigam, K.V. Honn, L.J. Marnett, and T.L. Walden, Jr. Kluwer Academic Publishers, 1993, pp. 11-15.

20. Capdevila, J.H., Zeldin, D., Makita, K., Karara, A., and J.R. FALCK, "Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids". In Cytochrome P450: Structure, Mechanism, and Biochemistry (Second Edition). Edited by P.R. Ortiz de Montellano. Plenum Press, New York, 1995, pp. 443-471.

21. Capdevila, J.H., Zeldin, D., Karara, A., and J.R. FALCK, "Eicosanoid Metabolism and Bioactivation by Microsomal Cytochrome P450". In Advances in Molecular and Cell Biology. Edited by E.E. Bittar and C.R. Jefcoate. JAI Press Inc., 1996, Vol. 14, pp. 317-339.

22. Mao, K., Reddy, K.K., FALCK, J.R., McGiff, J.C., and M. Balazy, "New Group of Lipid Mediators Containing ??Hydroxyarachidonic acid (20-HETE)". In Adv. Exp. Med. Biol. (Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Res.). Edited by Sinzinger et al., Plenum Press, New York, 1997, Vol. 433, pp. 55-59.

23. Sasaki, D.M., Yuan, Y., Gikas, K., Reddy, M., FALCK, J.R., Nithipatikom, K., Campbell, W.B., and D.M.Callewaert, "Development of Enzyme Immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETS and the Corresponding DHETs". In Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Edited by Honn et al. Kluwer Academic/Plenum Publishers, 2002, pp. 531-536.

24. Lombard, J.H., Frisbee, J.C., Roman, R.J., and J.R. FALCK, "Evaluation of Cytochrome P450-4A ?-Hydroxylase and 20-HETE as an 02 Sensing Mechanism in the Microcirculation. In: Oxygen Sensing-Methods in Enzymology. Edited by C.K. Sen and G.L. Semenza. New York; Academic Press, Inc., 2004, Vol. 381, pp. 140-165.

PATENTS

1. FALCK, J.R., Miller, L.L., and F.R. Stermitz, "Angular Alkylated Polycyclides by Electrochemical Annelation," U.S. Patent No. 491610; July 24, 1974. Chem. Abst. 82: 117,889.

2. Sun, L. and J.R. FALCK, "Process for Functionalizing Carbohydrate Derivatives by Base-Induced (- Elimination and Olefination Forming Arachidonic Acid Metabolites and Derivatives," U.S. Patent No. 5,334,736, August 2, 1994. Chem. Abst. 122: 187,243j.

3. FALCK, J.R., Bednar, M.M., Gross, C.E. and M. Balazy, "Preparation of Novel Analogs of 16- Hydroxyeicosatetraenoic Acid as Leukotriene Production Inhibitors," PCT Int. Appl. WO 9959964 A1; Nov. 25, 1999. Chem. Abst. 132: 3283.

4. Roman, R.J., FALCK, J.R., Alonso-Galicia, M., Jacobs, E.R. and D.R. Harder, "Synthesis and Biological Activity of 20-HETE Antagonists and Agonists," PCT Int. App. WO 9943310 A2; Sept. 2, 1999, Chem. Abst. 131: 184809.

5. Gerwick, W.H., FALCK, J.R., and B.L. Marquez, "Preparation of Curacin A Analogs with Antiproliferative Activity for use as Anticancer Agents ," U.S. Patent No. 6,057,348; May 2, 2000. CAN 132:308191 AN 2000:289075.

6. Bednar, M.M., Gross, C.E, Balazy, M. and J.R. FALCK, "Arachidonic Acid Metabolite, 16- Hydroxyeicosatetraenoic Acid (16-HETE), and Methods and Products for Inhibiting Neutrophil Adhesion and Neutrophil Aggregation," PCT Int. Appl. (1997), WO 9744024 A1; CAN 128:43848 , AN 1997:772632.

7. Klimko, P.G.; Hellberg, M.R.; Falck, J.R.; Conrow, R.E., "Preparation of Hydroxyeicosatetraenoic Acid Analogs and Methods of their use in Treating Dry Eye Disorders, " U.S. Pat. Appl. Publ. (2002), Cont.-in- part of U. S. Ser. No. 694,537, abandoned. US 20020035095 A1 20020321; CAN 136:263024 , AN 2002:221213.

8. FALCK, J.R., Bednar, M.M., Gross, C.E., and M. Balazy, "Methods and Products Related to 16-HETE Analogs," U.S. Patent No. 6,562,988; May 13, 2003.

9. Klimko, P.G., Hellberg, M.R., FALCK, J.R., and R.E. Conrow, "Hydroxyeicosatetraenoic Acid Analogs and Methods of Their Use in Treating Dry Eye Disorders," U.S. Patent No. 6,803,385 B2; Oct. 12, 2004.

10. FALCK, J. R., Miyata, N., Ono, N., Naganami, T., Hirano, H., Toda, Y., Tanami, T., and S. Okuyama, "Elastase Release Inhibitors Containing Hydroxyeicosenoic Acid Analogs and Their Use for Treatment of Cerebral Infarction," Jpn. Kokai Tokkyo Koho (2005), JP 2005097236 A2 20050414; CAN 142:367674; AN 2005:322807.

11. Zhao, Y., and FALCK, J.R. "Methods and Compositions for Tagging via Azido Substrates", U.S. Pat. Appl. Publ. (2005), US 20050106627 A1 20050519; US 2003-715329, 20031117; AN 2005:429309.