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PROF. JINMING GAO

Jinming Gao

Dr. Jinming Gao is a Professor of Oncology, Pharmacology and Otolaryngology at UT Southwestern Medical Center. He also holds a joint appointment in Chemistry and Bioengineering at UT Dallas. More »

WELCOME TO THE GAO LAB

fig1The Gao lab is working at the interface of nanotechnology, cancer biology and clinical oncology. Our primary research interest is to design and develop novel nanomaterials and nanoarchitectures for cancer diagnosis and targeted therapeutic applications. One of our recent inventions is a library of "pH transistor" nanoparticles with binary off/on reporters that are finely tunable in a broad range of physiological pH (4.0-7.4). The ultra pH-sensitive property is a unique nanoscale phenomenon that arises from the cooperative self-assembly of amphiphilic copolymers. These new nanotools uncovered unprecendented biological insights on tumor acidosis, lysosome signaling and metabolism, and cytosolic delivery of biologics. Based on these knowledge, we are implementing the pH transistor technology in several clinically relevant applications, including cancer staging, image-guided surgery, and immunotherapy.

NEWS

A multi-colored nanobarcode is developed as a 'chemical transistor' to digitize endocytic pH, enabling discovery of mutated KRAS in accelerating organelle maturation(Adv. Mater.). PDF

A unique all-or-nothing protonation distribution was discovered for ultra-pH sensitive nanoprobes, which explained the molecular basis of pH cooperativity and binary on/off switch of fluorescence (Nature Comm.). PDF

A review paper titled "Investigation of Endosome and Lysosome Biology by Ultra pH Sensitive Nanoprobes" was published on Advanced Drug Delivery Reviews. PDF