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Jinming Gao

Dr. Jinming Gao is a Professor of Oncology and Pharmacology at UT Southwestern Medical Center. He also holds a joint appointment in Chemistry and Bioengineering at UT Dallas. He is also the Chair of Gene and Drug Delivery Study Section at NIH. More »


fig1The Gao lab is working at the interface of nanotechnology, cancer biology and clinical oncology. Our primary research interest is to design and develop novel nanomaterials and nanoarchitectures for cancer diagnosis and targeted therapeutic applications. One of our recent inventions is a library of "pH transistor" nanoparticles with binary off/on reporters that are finely tunable in a broad range of physiological pH (4.0-7.4). The ultra pH-sensitive property is a unique nanoscale phenomenon that arises from the cooperative self-assembly of amphiphilic copolymers. These new nanotools uncovered unprecendented biological insights on tumor acidosis, lysosome signaling and metabolism, and cytosolic delivery of biologics. Based on these knowledge, we are implementing the pH transistor technology in several clinically relevant applications, including cancer staging, image-guided surgery, and immunotherapy.


October, 2015 A nanobuffer reporter library was developed for interrogations of endosome/lysosome biology. Unique luminal pH-dependent link between mTOR signaling, lysosome catabolism and cell survival was uncovered. Nature Comm.

September 2015, CPRIT grant to a start-up company launched by Dr. Gao and Dr. Sumer was highlighted in Cancer Center Bulletin, a publication by the Simmons Cancer Center.Link

August 2015, congratulations to Gang on the promotion to Instructor position in the Simmons Comprehensive Cancer Center with secondary appointment in Pharmacology.