|PROF. JINMING GAO|
Dr. Jinming Gao is a Professor of Oncology and Pharmacology at UT Southwestern Medical Center. He also holds a joint appointment in Chemistry and Bioengineering at UT Dallas. He is also the Chair of Gene and Drug Delivery Study Section at NIH. More »
|WELCOME TO THE GAO LAB|
Our main research focus is to design, develop and evaluate novel nanomaterials and nanoarchitectures for cancer molecular imaging and targeted therapeutic applications. Two design principles are emphasized throughout research: (1) understand tumor pathophysiology and identify key cancer targets to improve biological specificity, and (2) build innovative nanomedicine platforms with non-linear bioresponsive properties to achieve diagnostic and therapeutic efficacy.
Each project involves multifaceted scientific inquiries in nanomaterial synthesis and supramolecular self-assembly, fluorescent and MR molecular imaging, cancer biology and others. Design of new nanomaterials with unique physical properties arising from nanoscale (but absent in the molecular or bulk states) and can interact with biological systems in non-linear dynamics are particularly seeked to amplify biological signals to improve imaging and therapeutic outcomes. More »
Our lab members are from diverse scientific disciplines in polymer science, physico-organic chemistry, bioengineering, molecular and cell biology, diagnostic imaging, and others. Each lab member develops a focal area of expertise and our successes capitalize on synergistic collaborations among team members. The broad spectrum of scientific expertise and collaborative spirits enable the rapid development of new ideas and devices from bench to bed, and lab to the clinics. Meet the Team »
January 2015, Esterase activatable β-lapachone prodrug micelles have been developed with high drug loading and improved safety and antitumor efficacy for NQO1-targeted lung cancer therapy. (J. Controlled Release) PDF
July 2014, an article titled with "Ultra-pH Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions" was published in the Journal of the American Chemical Society and featured in ACS Editors' Choice. PDF
June 2014, Chensu Wang, a graduate student in the lab was awarded 2014 Howard Hughes Medical Institute International Student Research Fellowship.
June 2014, a surprising micelle self-assembly process enabled by chaotropic anions with block copolymers containing hydrophobic, cationic ammonium groups has been reported. (Angew. Chem. Inter. Ed.) PDF