News
2011
June 2011, a tunable series of ultra-sensitive pH-responsive nanoparticles are established with >50-fold fluorescence ON/OFF activation in <0.25 pH unit. These nanoparticles provide a useful platform for imaging and therapeutic applications (Angew Chem). PDF
April 2011, Dr. Jinming Gao received a Distinguished Scientist Award from the Society of Experimental Biology and Medicine.
April 2011, Chase's paper titled "In Vivo Angiogenesis Imaging of Solid Tumors by alphavbeta3-Targeted, Dual-Modality Micellar Nanoprobes" received the Best Paper Award in 2010 (Alan MacDiarmid Award in the Interdisciplinary Research Category) from the Society of Experimental Biology and Medicine. PDF
April 2011, a time-resolved MRI method was used to investigate the kinetics of nanoparticle targeting to the angiogenic endothelium in the tumor vasculature. Data show for the first time that specific targeting can be achieved in as early as the first 5 mins after i.v. injection in three preclinical tumor models. These results provide mechanistic insights for the development of molecular imaging probes. PDF
2010
August 2010
Congratulations to Li Tao, a joint Ph.D. student between Dr. Walter Hu (UTD EE) and Dr. Gao's lab, who successfully defended his thesis titled "Lithographically Defined Shape-Specific Polymeric Particulates for Nanomedicine Applications". Dr. Tao will pursue his postdoctoral training in the EE department at UT Austin in August.
Congratulations to Chase Kessinger, a Ph.D. student in the Cancer Biology track, who successfully defended his thesis titled "Alpha(v)Beta(3)-Targeted Nanoprobes for In Vivo Imaging of Tumor Angiogenesis ". Dr. Kessinger will pursue his postdoctoral training in Cardiovascular Research Center at Massachusetts General Hospital (Boston MA) in August .
July 2010, A dual-modality fluorescent-MRI nanoprobe is developed for angiogenesis imaging in tumor-bearing mice (Kessinger et al. Exp. Biol. Med. 2010). A 3D high resolution method was used to connect the isolated 'hot spots' in 2D slices into 3D network structures, which improves the accuracy of vessel identification and quantification. This article was selected as the Feature article in the August issue of EBM, and was alerted by EurekAlert.
July 2010
A dual-modality fluorescent-MRI nanoprobe is developed for angiogenesis imaging in tumor-bearing mice (Kessinger et al. Exp. Biol. Med. 2010). A 3D high resolution method was used to connect the isolated 'hot spots' in 2D slices into 3D network structures, which improves the accuracy of vessel identification and quantification. This article was selected as the Feature article in the August issue of EBM, and was alerted by EurekAlert.
Congratulations to Li Tao, a joint Ph.D. student between Dr. Walter Hu (UTD EE) and Dr. Gao's lab, who successfully defended his thesis titled "Lithographically Defined Shape-Specific Polymeric Particulates for Nanomedicine Applications". Dr. Tao will pursue his postdoctoral training in the EE department at UT Austin in August.
Congratulations to Chase Kessinger, a Ph.D. student in the Cancer Biology track, who successfully defended his thesis titled "Alpha(v)Beta(3)-Targeted Nanoprobes for In Vivo Imaging of Tumor Angiogenesis ". Dr. Kessinger will pursue his postdoctoral training in Cardiovascular Research Center at Massachusetts General Hospital (Boston MA) in August.
June 2010
Polymeric micelles for the delivery of beta-lapachone are established and shown to provide efficacious treatment of lung cancer in animal tumor models (Cancer Res. . 2010).