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Genes Predicted to be Disrupted in Rats by Sleeping Beauty Gene-Trap Mutagenesis
Mutated Gene (click for more info)	Gene Function	Associated Pathologies in Mammals	Integration	Construct
Abca13	Putative Solute Transporter	Shwachman–Diamond Syndrome; Cancer Metastasis	Intron 53 of 66	ß-Geo Gene Trap
Abcg2	Solute Transporter	Cancer drug resistance, dietary photosensitization, protoporphyria	Intron 6 of 15	ß-Geo Gene Trap (Conditional Potential)
Ankrd28	Ankyrin repeat domain	Unknown	Intron 10 of 27	ß-Geo Gene Trap (Conditional Potential)
Arhgap26	Rho GTPase activating protein 26	Unknown	Intron 17 of 23	ß-Geo Gene Trap
Arl8a	Small GTPase Signaling; microtubule dynamics	Unknown	Intron 1 of 6	ß-Geo Gene Trap
Art3	ADP-ribosylation	Abnormal CNS repair	Intron 1 of 9	ß-Geo Gene Trap (Conditional Potential)
Bmpr1a	BMP receptor	Embryonic lethal; lack of mesoderm; limb malformation; renal failure	Intron 1 of 10	ß-Geo Gene Trap (Conditional Potential)
Btrc	F-box, E3 Ubiquitin Ligase; WD40 Domain	Aberrant Circadian Rhythm; HIV Infection; Cancer	Intron 1 of 14	ß-Geo Gene Trap
Cacna1e	Calcium channel	Impaired glucose tolerance, body weight, motor activity, and behavior	Intron 6 of 46	ß-Geo Gene Trap (Conditional Potential)
*Cadm1*	Cell adhesion	Infertility; decreased body size; impaired T cell development and response	Intron 1 of 11¹	ß-Geo Gene Trap (Conditional Potential)
CDK8	CDK Family Kinase	Colon Cancer Oncogene; HIV Latency	Intron 6 of 11	ß-Geo Gene Trap
Csnk1g1	Casein kinase 1, gamma 1	Unknown	Intron 5 of 11	ß-Geo Gene Trap
Ctnnd1	Catenin, delta 1	Abnormal salivary/lacrimal glands; early postnatal lethal	Intron 1 of 17 or 18	ß-Geo Gene Trap
Dlg1	Signal Transducer	Tumor Suppressor; Anti-Viral Activity	Intron 6 of 28	ß-Geo Gene Trap
Exoc6b	Polarized Exocytosis	Anemia; Hemoglobin Deficiency	Intron 1 of 21	ß-Geo Gene Trap
Fars2	Phenylalanyl-tRNA synthetase	Unknown	Intron 2 of 9	ß-Geo Gene Trap
Fbxo18	F-box, E3 Ubiquitin Ligase; DNA Helicase Domain	Unknown	Intron 19 of 22	ß-Geo Gene Trap
Fstl5	TGF-beta family Signal Transduction	Unknown	Intron 3 of 15	ß-Geo Gene Trap
Grik3	Glutamate Receptor	Obsessive-Compulsive; Alcoholism; Schizophrenia	Exon 11 of 16	ß-Geo Gene Trap
Gsg1l	Claudin Family; Germ Cell-Specific Domain	Unknown	Intron 3 of 6	ß-Geo Gene Trap
Kif18a	Kinesin 8	Infertility	Intron 14 of 15	ß-Geo Gene Trap
Ksr2-like	Signal Transducer	Diabetes; Obesity	Intron 3 of 16²	ß-Geo Gene Trap
Lmx1a	LIM Homeobox transcription factor	Neurological and skeletal defects; inner ear defects; deafness; belly spotting	Intron 2 of 7	ß-Geo Gene Trap
Mei4	Meiotic recombination	Required for meiotic DNA double strand breaks	Intron 2 of 4	ß-Geo Gene Trap
Mrc2	Mannose receptor	Altered muscle mass, fibroblast activity, collagen metabolism	Intron 18 of 29	ß-Geo Gene Trap (Conditional Potential)
Pan3	RNA Metabolism	Unknown	Intron 11 of 25	ß-Geo Gene Trap
Papd4	Polyadenylation; MicroRNA stabilization	Unknown	Intron 7 of 14	ß-Geo Gene Trap
Pclo	Signaling in Pre-Synaptic Vesicles; Exocytosis	Autism; Diabetes	Intron 3 of 25	ß-Geo Gene Trap
Ptpn2	Protein tyrosine phosphatase	Reduced lifespan; abnormal hematopoiesis; enhanced inflammation	Intron 7 of 9	ß-Geo Gene Trap (Conditional Potential)
Ptprh	Protein tyrosine phosphatase	Unknown	Intron 1 or 2 of 14	ß-Geo Gene Trap (Conditional Potential)
Rbpms	RNA binding	Unknown	Intron 6 of 7	ß-Geo Gene Trap
RGD1305225	C3orf19 Homolog	Embryonic lethality	Intron 3 of 10 or 11	ß-Geo Gene Trap
RGD1306353	Zfp198-like	Unknown	Intron 1 of 3	ß-Geo Gene Trap
RGD1559958	Fam73a-like	Unknown	Intron 13 of 21 or 1 of 12	ß-Geo Gene Trap
Rprd1a	Cell Cycle	Unknown	Intron 7 of 7	ß-Geo Gene Trap
Slc1a3	High Affinity Glutamate Transporter	Episodic Ataxia; Hemiplegia; Seizures	Intron 2 of 9	ß-Geo Gene Trap
Slc35a3	Golgi Sugar Transporter	Vertebrate Fusion	Intron 1 of 7	ß-Geo Gene Trap
Smndc1	RNA binding, splicing	Unknown	Intron 4 of 5	ß-Geo Gene Trap (Conditional Potential)
Spaca6	Golgi Transmembrane Protein	Unknown	Intron 2 of 8	ß-Geo Gene Trap
Ssbp2	DNA Metabolism	Prostate Tumor Suppressor/Marker	Intron 3 of 16	ß-Geo Gene Trap
Tbc1d1	Signal Transducer; 2 PTB domains; GAP domain	Diabetes; Leanness; Obesity	Intron 1 of 26	ß-Geo Gene Trap
Tead1	Transcriptional enhancer	Abnormal heart development, embryonic lethal	Intron 1 of 10-12	ß-Geo Gene Trap
Tmem57	Transmembrane Lycopene Cyclase	Coronary Heart Disease; Elevated Cholesterol	Intron 6 of 10	ß-Geo Gene Trap
Tmx4	Cellular Redox Homeostasis	Unknown	Intron 5 of 7	ß-Geo Gene Trap
Ube2k	Ubiquitin-Conjugating Enzyme; E2 Ligase	Huntington Disease; Alzheimer’s disease	Intron 1 of 6	ß-Geo Gene Trap
Ube2q2	Ubiquitin-Conjugating Enzyme; E2 Ligase	Unknown	Intron 1 of 14	ß-Geo Gene Trap
*Zfp948-ps1*	Zinc finger protein	Unknown	Intron 1³	ß-Geo Gene Trap (Conditional Potential)
Zmynd8	Transcription Factor; Zinc finger Domain	T-Cell Lymphoma-Associated Antigen	Intron 4 of 24	ß-Geo Gene Trap

(1) Intron 1 of 11 according to Entrezgene; before exon 1 of 12 according to Ensemble

(2) Currently not confirmed as Ksr2 due to high homology with other genes

(3) Listed as pseudogene with transcription discrepancies