Genes Predicted to be Disrupted in Rats by Sleeping Beauty Gene-Trap Mutagenesis

Mutated Gene

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Gene Function
Associated Pathologies in Mammals
Integration
Construct

Abca13

Putative Solute Transporter

Shwachman–Diamond Syndrome; Cancer Metastasis

Intron 53 of 66

ß-Geo Gene Trap
Abcg2
Solute Transporter

Cancer drug resistance, dietary photosensitization, protoporphyria

Intron 6 of 15
ß-Geo Gene Trap (Conditional Potential)
Ankrd28
Ankyrin repeat domain

Unknown

Intron 10 of 27
ß-Geo Gene Trap (Conditional Potential)

Arhgap26

Rho GTPase activating protein 26

Unknown

Intron 17 of 23

ß-Geo Gene Trap

Arl8a

Small GTPase Signaling; microtubule  dynamics

Unknown

Intron 1 of 6

ß-Geo Gene Trap
ADP-ribosylation
Abnormal CNS repair
Intron 1 of 9
ß-Geo Gene Trap (Conditional Potential)
BMP receptor
Embryonic lethal; lack of mesoderm; limb malformation; renal failure
Intron 1 of 10
ß-Geo Gene Trap (Conditional Potential)

Btrc

F-box, E3 Ubiquitin Ligase; WD40 Domain

Aberrant Circadian Rhythm; HIV Infection; Cancer

Intron 1 of 14

ß-Geo Gene Trap
Calcium channel
Impaired glucose tolerance, body weight, motor activity, and behavior
Intron 6 of 46
ß-Geo Gene Trap (Conditional Potential)
Cadm1
Cell adhesion
Infertility; decreased body size; impaired T cell development and response
Intron 1 of 111
ß-Geo Gene Trap (Conditional Potential)

CDK8

CDK Family Kinase

Colon Cancer Oncogene; HIV Latency

Intron 6 of 11

ß-Geo Gene Trap
Csnk1g1
Casein kinase 1, gamma 1
Unknown
Intron 5 of 11
ß-Geo Gene Trap
Catenin, delta 1
Abnormal salivary/lacrimal glands; early postnatal lethal
Intron 1 of 17 or 18
ß-Geo Gene Trap

Dlg1

Signal Transducer

Tumor Suppressor; Anti-Viral Activity

Intron 6 of 28

ß-Geo Gene Trap

Exoc6b

Polarized Exocytosis

Anemia; Hemoglobin Deficiency

Intron 1 of 21

ß-Geo Gene Trap

Fars2

Phenylalanyl-tRNA synthetase

Unknown

Intron 2 of 9

ß-Geo Gene Trap

Fbxo18

F-box, E3 Ubiquitin Ligase; DNA Helicase Domain

Unknown

Intron 19 of 22

ß-Geo Gene Trap

Fstl5

TGF-beta family Signal Transduction

Unknown

Intron 3 of 15

ß-Geo Gene Trap

Grik3

Glutamate Receptor

Obsessive-Compulsive;  Alcoholism; Schizophrenia

Exon 11 of 16

ß-Geo Gene Trap

Gsg1l

Claudin Family;  Germ Cell-Specific Domain

Unknown

Intron 3 of 6

ß-Geo Gene Trap
Kinesin 8
Infertility
Intron 14 of 15
ß-Geo Gene Trap

Ksr2-like

Signal Transducer

Diabetes; Obesity

Intron 3 of 162

ß-Geo Gene Trap
LIM Homeobox transcription factor
Neurological and skeletal defects; inner ear defects; deafness; belly spotting
Intron 2 of 7
ß-Geo Gene Trap
Meiotic recombination
Required for meiotic DNA double strand breaks
Intron 2 of 4
ß-Geo Gene Trap
Mannose receptor
Altered muscle mass, fibroblast activity, collagen metabolism
Intron 18 of 29
ß-Geo Gene Trap (Conditional Potential)

Pan3

RNA Metabolism

Unknown

Intron 11 of 25

ß-Geo Gene Trap
Papd4
Polyadenylation; MicroRNA stabilization
Unknown
Intron 7 of 14
ß-Geo Gene Trap

Pclo

Signaling in Pre-Synaptic Vesicles; Exocytosis

Autism; Diabetes

Intron 3 of 25

ß-Geo Gene Trap
Protein tyrosine phosphatase
Reduced lifespan; abnormal hematopoiesis; enhanced inflammation
Intron 7 of 9
ß-Geo Gene Trap (Conditional Potential)
Ptprh
Protein tyrosine phosphatase
Unknown
Intron 1 or 2 of 14
ß-Geo Gene Trap (Conditional Potential)
RNA binding
Unknown
Intron 6 of 7
ß-Geo Gene Trap
C3orf19 Homolog
Embryonic lethality
Intron 3 of 10 or 11
ß-Geo Gene Trap
RGD1306353
Zfp198-like
Unknown
Intron 1 of 3
ß-Geo Gene Trap
RGD1559958
Fam73a-like
Unknown
Intron 13 of 21 or 1 of 12
ß-Geo Gene Trap

Rprd1a

Cell Cycle

Unknown

Intron 7 of 7

ß-Geo Gene Trap

Slc1a3

High Affinity Glutamate Transporter

Episodic Ataxia; Hemiplegia; Seizures

Intron 2 of 9

ß-Geo Gene Trap

Slc35a3

Golgi Sugar Transporter

Vertebrate Fusion

Intron 1 of 7

ß-Geo Gene Trap
RNA binding, splicing
Unknown
Intron 4 of 5
ß-Geo Gene Trap (Conditional Potential)

Spaca6

Golgi Transmembrane Protein

Unknown

Intron 2 of 8

ß-Geo Gene Trap

Ssbp2

DNA Metabolism

Prostate Tumor Suppressor/Marker

Intron 3 of 16

ß-Geo Gene Trap

Tbc1d1

Signal Transducer; 2 PTB domains; GAP domain

Diabetes; Leanness; Obesity

Intron 1 of 26

ß-Geo Gene Trap
Transcriptional enhancer
Abnormal heart development, embryonic lethal
Intron 1 of 10-12
ß-Geo Gene Trap

Tmem57

Transmembrane Lycopene Cyclase

Coronary Heart Disease; Elevated Cholesterol

Intron 6 of 10

ß-Geo Gene Trap

Tmx4

Cellular Redox Homeostasis

Unknown

Intron 5 of  7

ß-Geo Gene Trap

Ube2k

Ubiquitin-Conjugating Enzyme; E2 Ligase

Huntington Disease; Alzheimer’s  disease

Intron 1 of 6

ß-Geo Gene Trap

Ube2q2

Ubiquitin-Conjugating Enzyme; E2 Ligase

Unknown

Intron 1 of 14

ß-Geo Gene Trap
Zinc finger protein
Unknown
Intron 13
ß-Geo Gene Trap (Conditional Potential)

Zmynd8

Transcription Factor;  Zinc finger Domain

T-Cell Lymphoma-Associated Antigen

Intron 4 of 24

ß-Geo Gene Trap

 

(1) Intron 1 of 11 according to Entrezgene; before exon 1 of 12 according to Ensemble

(2) Currently not confirmed as Ksr2 due to high homology with other genes

(3) Listed as pseudogene with transcription discrepancies