Research in our laboratory is based on the Biology and Applications of Sperm Stem Cells (i.e. spermatogonial stem cells). Spermatogonial stem cells function physiologically as germline stem cells in the testis by continuously renewing developing spermatozoa during reproductive life of males (see figure).

 

 

By nature, this links our investigations in Pharmacology to several general scientific fields including Reproduction, Developmental Biology and Genetics. Understanding the genetic basis of spermatogenesis could lead to strategies to correct male infertility, the discovery of specific gene targets for new male contraceptives, the invention of new technologies to advance animal genetics, novel cancer therapies and even an ability to select against detrimental genetic defects directly in the germline.

Projects