Publications

  1. J. Huang, Y. Yamashiro, C. L. Papke, Y. Ikeda, Y. Lin, M. Patel, T. Inagami, V. P. Le, J. E. Wagenseil and H. Yanagisawa: Angiotensin converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4 deficient mice. Science Trans. Med. 5, 183ra58 (2013). [Abstract] [Full text] [Reprint]
  2. M. Budatha, S. Silva, T. I.Montoya, A. Suzuki, S. Shah-Simpson, C. K. Wieslander, M.Yanagisawa, R. A. Word* and H. Yanagisawa*: Dysregulation of protease and protease inhibitors in a mouse mode; of human pelvic organ prolapse. PloS One 8(2): e56376 (2013).
  3. N. Funato, M. Nakamura, J. A. Richardson, D. Srivastava and H. Yanagisawa: Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet 21 (11):2524-2537 (2012).
  4. Kapustin A, Stepanova V, Aniol N, Cines DB, Poliakov A, Yarovoi S, Lebedeva T, Wait R, Ryzhakov G, Parfyonova Y, Gursky Y, Yanagisawa H, Minashkin M, Beabealashvilli R, Vorotnikov A, Bobik A, Tkachuk V: Fibulin-5 binds urokinase type plasminogen activator and mediates urokinase-stimulated beta1 integrin-dependent cell migration. Biochemical J: 443 (2):491-502 (2012).
  5. M. Budatha, S. Roshanravan, Q. Zheng, C. Weislander, S. L. Chapman, E. C. Davis, B.C. Starcher, R. A. Word and H. Yanagisawa: Extracelular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans. J Clin Invst doi:10.1172/JCI45636 (2011). (Featured in commentary in the same issue of JCI and June 21 issue of NEJM).
  6. W. Wan, H. Yanagisawa, and R. L. Gleason Jr.: Biomechanical and microstructural properties of common carotid arteries from fibulin-5 null mice. Ann Biomed Eng. 38 (12):3605-17 (2010).
  7. Y. Y. Kisanuki, N. Emoto, T. Ohuchi, B. Widyantoro, Yagi, K., R. M. Kedzuerski, R. E. Hammer, H. Yanagisawa, S. C. Williams, J. A. Richardson, T. Suzuki, and M. Yanagisawa: Low blood pressure in endothelial cell-specific endothelin-1 knockout mice. Hypertension. 56(1):121-128 (2010).
  8. H. Yanagisawa and E.C. Davis. Unraveling the mechanism of elastic fiber assembly: The role of short elastogenic fibulins. Int. J. Biochem & Cell Biol. (Review) 2010 March 14 [Epub ahead of print].
  9. M. K. Schluterman, S. L. Chapman, G. Korpanty, K. Ozumi, T. Fukai, H. Yanagisawa and R. A. Brekken. Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS. Disease Models and Mechanisms 2010 Mar 2 [Epub ahead of print].
  10. J. Huang, E. C. Davis, S. L. Chapman, M. Budatha, L. Y. Marmorstein, R. A. Word, and H. Yanagisawa. Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ. Res. 106 (3): 583-592 (2010).
  11. S. L. Chapman, F-X Sicot, E. C. Davis, T. Sasaki, J. Huang, M-L. Chu and H. Yanagisawa. Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury. Arteriosclerosis Thrombosis and Vascular Biology, 30 (1):68-74 (2010).
  12. H. Yanagisawa, M.K. Schluterman, R.A. Brekken. Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. J. Cell Com. Signaling. (Review). 2009 Oct. 2 [Epub ahead of print] DOI 10.1007/s12079-009-0065-3.
  13. J. Choi, R. Bissonnette, L Rouleau, R. L. Leask, B. Starcher, H. Yanagisawa and E. C. Davis. Organization and Function of Fibulin-5 in Skin. Matrix Biology 28(4):211-20 (2009).
  14. Liu, N., A. C. Barbosa, S. L. Chapman, S. Bezprozvannaya, X. Qi, J. A. Richardson, H. Yanagisawa, and E. N. Olson. DNA binding-dependent and –independent functions of the Hand2 transcription factor during mouse embryogenesis. Development, 136:933-942 (2009).
  15. N. Funato, S. L. Chapman, Marc D. McKee, H. Funato, J. A. Morris, J. M. Shelton, J. A. Richardson, and H. Yanagisawa. Hand proteins control osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development, 136, 615-625 (2009) (Featured in “In this Issue”).
  16. C. K. Wieslander, D. Rahn, D. D. Mcintire, J. F. Acevedo, P. G. Drewes, H. Yanagisawa and R. A. Word. Quantification of pelvic organ prolapse in mice: vaginal protease activity precedes increased MOPQ scores in fibulin-5 knockout mice. Biol. Reprod. 2008 Nov. 5 [Epub ahead of print].
  17. A. C. Barbosa, N. Funato, S. Chapman, Marc D. McKee, J.A. Richardson, E. N. Olson and H. Yanagisawa. The Hand transcription factors cooperatively regulate development of the distal midline mesenchyme of the mandibular arch. Developmental Biology. 310:154-168 (2007).
  18. K. M. Sullivan, R. Bissonnette, H. Yanagisawa, S. N. Hussain and E. C. Davis. Fibulin-5 functions as an endogenous angiogenesis inhibitor. Lab. Invest. 87 (8): 818-27 (2007).
  19. P. G. Dewes, H. Yanagisawa, B. Starcher, S. I. Marinis, P. Keller, S. L. Hacker and R. A. Word. Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina. Am. J. Pathol. (170): 578-589 (2007).
  20. Q. Zheng, E. C. Davis, Richardson, J. A., B. Starcher, T. Li, R. D. Gerard, and H. Yanagisawa. Molecular analysis of fibulin-5 function during de novo synthesis of elastic fibers. Mol. Cell. Biol. (27): 1083-1095 (2007).
  21. Q. Zheng, J. Choi, L. Rouleau, R. L. Leask, J. A. Richardson, E. C. Davis, and H. Yanagisawa. Normal Wound healing in mice deficient for fibulin-5, an elastin binding protein essential for dermal elastic fiber assembly. J. Invest. Derm (126): 2707-2714 (2006). (Featured in Commentary).
  22. S. L. Merklinger, R. A. Wagner, A. Hinek, R. H. Knutsen, M. G. Kabir, K. Desai, S. Hacker, L.Wang, G. M. Cann, N. Ambartsumian, E. Lukanidin, D. Burnstein, M. Husain, R. P. Mecham, H. Yanagisawa and M. Rabinovitch. Increased fibulin-5 and elastin in S100A4/Mts 1 Mice with pulmonary hypertension. Circ. Res 16;97(6):596-604 (2005).
  23. Z-P. Liu, Z. Wang, H. Yanagisawa and E. N. Olson. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and Myocardin. Dev. Cell. 9, 261-270 (2005).
  24. J. A. Spencer, S. L. Hacker, E. C. Davis, R. P. Mecham, R. H. Knutsen, D. Y. Li, R. D. Gerard, J. A. Richardson, E. N. Olson and H. Yanagisawa. Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration. Proc. Natl. Acad. Sci. 102, 2946-2951 (2005).
  25. A. D, Nguyen, S. Itoh, V. Jeney, H. Yanagisawa, M. Fujimoto, M. Ushio-Fukai, Fukai T. Fibulin-5 is a novel binding protein for extracellular superoxide dismutase. Circ Res. Nov 26; 95(11):1067-74 (2004).
  26. X. Liu, Y. Zhao, J. Gao, B. Pawlyk, B. Starcher, J.A. Spencer, H. Yanagisawa, J. Zuo and T. Li: Elastic fiber homeostasis requires lysyl oxidase-like 1. Nature Genetics 36, 178-182 (2004).
  27. M. Morishima, H. Yanagisawa, M. Yanagisawa and A. Baldini: Ece-1 and Tbx1 define distinct pathways to aortic arch morphogenesis. Dev. Dyn. 228, 95-104 (2003).
  28. L-B. Ruest, M. Dager, H. Yanagisawa, J. Charite, R. E. Hammer, E. N. Olson, M. Yanagisawa and D. C. Clouthier: dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. Dev. Biol. 257, 263-277 (2003).
  29. H. Yanagisawa, D. E. Clouthier, J. Charite, J. A. Richardson and E. N. Olson: Targeted deletion of a brachial arch-specific enhancer reveals a role of dHAND in craniofacial development. Development 130, 1069-1078 (2003).
  30. H. Yanagisawa*, E. C. Davis, B. C. Starcher, T. Ouchi, M. Yanagisawa, J. A. Richardson and E. N. Olson*: Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature 415, 168-171 (2002) (Previewed in Current Biology, Nature reviews in Molecular Biology). * Co-corresponding author
  31. Z-P. Liu, O. Nakagawa, M. Nakagawa, H. Yanagisawa, R. Passier, J. A. Richardson, D. Srivastava and E. N. Olson: CHAMP, A novel cardiac-specific helicase regulated by MEF2C. Dev. Biol. 234, 497-509 (2001).
  32. O. Nakagawa, D. G. McFadden, M. Nakagawa, H. Yanagisawa, T. Hu, D. Srivastava and E. N. Olson: Members of the HRT family of bHLH proteins act as transcriptional repressors downstream of Notch signaling. Proc. Natl. Aca. Sci. 97 (25), 13655-13660 (2000).
  33. J. Rice, B. Doggett, D. A. Sweetser, H. Yanagisawa, M. Yanagisawa, R. P. Kapur: Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice. Dev. Dyn. 217(1), 120-132 (2000).
  34. D. E. Clouthier, S. C. Williams, H. Yanagisawa, M. Wieduwilt, J. A. Richardson, and M. Yanagisawa: Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice. Dev. Biol. 217(1), 10-24 (2000).
  35. H. Yanagisawa, R. E. Hammer, J. A. Richardson, S. C. Williams, N. Emoto, S. Takeda and M. Yanagisawa: Disruption of ECE-1 and ECE-2 reveals a role for endothelin converting enzyme-2 in murine cardiac development. J. Clin. Invst. 105, 1373-1382 (2000).
  36. J. D. Taurog, S. D. Maika, N. Satimtura, M. L. Dorris, W. A. Simmons, I. L. McLean, H. Yanagisawa, A. Sayad, A. J. Stagg, G. M. Fox, A. L. O’Brien, M. Rehman, M. Zhou, A. L. Weiner, J. B. Splawski, J. A. Richardson and R, E, Hammer: Inflammatory disease in HLA-B27 transgenic rats. Immunological Reviews, 169, 209-223 (1999).
  37. Q. Lin, JR. Lu, H. Yanagisawa, R. Webb, G. E. Lyons, J. A. Richardson and E. N. Olson: Requirement of the MADS-box transcription factor MEF2C for vascular development. Development 125, 4565-4574 (1998).
  38. N. Berthiaume, M. Yanagisawa, H. Yanagisawa, D. deWit and P. D'Orleans-Juste. Pharmacology of endothelins in vascular circuits of normal or heterozygous endothelin-A or endothelin-B knockout transgenic mice. J Cardiovasc Pharmacol 31, Suppl (1998).
  39. D. E. Clouthier, K. Hosoda, J. A. Richardson, H. Yanagisawa, R. E. Hammer and M. Yanagisawa: Cranial and cardiac neural crest defects in endothelin-A receptor- deficient mice. Development 125, 813-824 (1998).
  40. H. Yanagisawa, R. E. Hammer, J. A. Richardson, S. C. Williams, D. E. Clouthier and M. Yanagisawa: Role of endothelin-1/ endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J. Clin. Invst. 102, 22-33 (1998).
  41. H. Yanagisawa, M. Yanagisawa, R. P. Kapur, D. E. Clouthier, S. C. Williams, N. Emoto, J. A. Richardson and R. E. Hammer: Dual genetic pathways of endothelin-mediated signaling defined by targeted disruption of endothelin converting enzyme-1 gene. Development 125, 825-836 (1998).
  42. H. Yanagisawa, J. A. Richardson, J. D. Taurog and R. E. Hammer: Characterization of psoriasiform and alopecic skin lesions in HLA-B27 transgenic rats. Am. J. Pathol., 147, 955-964 (1995).
  43. H. Watanabe, M. Kuraya, R. Kasukawa, H. Yanagisawa, M. Yanagisawa and T. Fujita: Analysis of C5a receptor by monoclonal antibody. J. Immunol. Method., 185, 19-29 (1995).
  44. T. Nagasawa, H. Yanagisawa, Y. Hasegawa, H. Kanma and T. Abe: Polycythemia associated with primary systemic amyloidosis: elevated levels of hematopoietic factors and cytokines. Am. J. Hematol., 43, 57-60 (1993).
  45. Sakamoto, M. Yanagisawa, T. Sakurai, Y. Takuwa, H. Yanagisawa and T. Masaski: Cloning and functional expression of human cDNA for the ETB endothelin receptor. Biochem. Biophys. Res. Commun., 178, 656-663 (1991).
  46. H. Yanagisawa, T. Nagasawa, T. Abe, S. Kuramochi, Y. Ikawa and K. Todokoro: Constitutive expression of exogenous c-myb gene causes maturation block in monocyte-macrophage differentiation. Biochim. Biophys. Acta., 1088, 380-384 (1991).
  47. K. Todokoro, R. J. Watson, H. Higo, H. Amanuma, S. Kuramochi, H. Yanagisawa and Y. Ikawa: Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation. Proc. Natl. Acad. Sci. USA, 85, 8900-8904 (1988).