Abstracts

Deshpande D, Srivastava S, Gumbo T. Pharmacokinetic-pharmacodynamic model of intracellular Mycobacterium avium infection and moxifloxacin dose selection. 49th Interscience Conference of Antimicrobial Agents and Chemotherapy, San Francisco, CA. September 13, 2009.

Deshpande D, Srivastava S, Gumbo T. Thioridazine As Chemotherapy Against Extracellular and Intracellular Mycobacterium avium 49th Interscience Conference of Antimicrobial Agents and Chemotherapy, San Francisco, CA. September 13, 2009.

Pasipanodya J, Gumbo T. Is high dose pyrazinamide really that toxic? 49th Interscience Conference of Antimicrobial Agents and Chemotherapy, San Francisco, CA. September 14, 2009.

Pasipanodya J, Gumbo T. Fat, fractals and failure of antituberculosis therapy. 49th Interscience Conference of Antimicrobial Agents and Chemotherapy, San Francisco, CA. September 14, 2009.

Srivastava S, Sherman C, Gumbo T. Pharmacokinetic mismatch hypothesis and emergence of antituberculosis drug resistance. Falsified! 49th Interscience Conference of Antimicrobial Agents and Chemotherapy, San Francisco, CA. September 13, 2009.

Srivastava S, Sherman C, Gumbo T. Is 100% Compliance Necessary to Prevent Anti-tuberculosis Drug Resistance? Give me a Break! 49th Interscience Conference of Antimicrobial Agents and Chemotherapy, San Francisco, CA. September 13, 2009.

Musuka S, Siyambalapitiyage Dona C, Gumbo T. Bad Drugs, Not Bad Bugs: Efflux Pump Inhibition Abolishes The Selectivity Of Standard Drugs Against Tuberculosis (TB). 49th Interscience Conference of Antimicrobial Agents and Chemotherapy, San Francisco, CA. September 13, 2009.

Musuka S, Siyambalapitiyage Dona C, Gumbo T. Efflux Pump Inhibition of Tubercle Bacillus Is A Double Edged Sword for Streptomycin. 49th Interscience Conference of Antimicrobial Agents and Chemotherapy, San Francisco, CA. September 13, 2009.

Gumbo T. Optimization of anti-tuberculosis therapy by use of pharmacokinetics-pharmacodynamics and pharmacogenetic data: the mathematical interface between basic science and the clinic. 11th RCMI symposium. Honolulu, Hawai'i, December 3, 2008

Gumbo T. PK/PD- New microbial diseases and model systems. Symposium title: William A. Craig Symposium. International Society of Antimicrobial Pharmacology Research Meeting. Madison, WI. October 29, 2008.

Gumbo T, W.C. Siyambalapitiyage Dona, C. Meek, R. Leff. PK/PD of Pyrazinamide Sterilizing Effect and Resistance Suppression. (Oral presentation) (Abstract # A-1823) 48th Interscience Conference of Antimicrobial Agents and Chemotherapy and 46th Infectious Diseases Society of America, Washington, DC. October, 2008.

Siyambalapitiyage Dona WC, S. Srivastava, S. Musuka, T. Gumbo. Efflux Pumps Limit The Role of Ethambutol Anti-TB Therapy: A PK/PD Approach. (Oral presentation) (Abstract # A-1822) 48th Interscience Conference of Antimicrobial Agents and Chemotherapy and 46th Infectious Diseases Society of America, Washington, DC. October, 2008.

Musuka S, W.C. Siyambalapitiyage Dona, S. Srivastava, T. Gumbo. Thioridazine Has Dramatic Sterilizing Effect Against Extracellular Tubercle Bacilli. (Oral presentation) (Abstract # A-1821) 48th Interscience Conference of Antimicrobial Agents and Chemotherapy and 46th Infectious Diseases Society of America, Washington, DC. October, 2008.

Gumbo T. Pharmacokinetics-pharmacodynamics of drugs used against M. tuberculosis. (Invited Lecture). Symposium title: Pharmacokinetic/Pharmacodynamic Factors in Treating Infection in Special Sites and/or Special Pathogens. 48th Interscience Conference of Antimicrobial Agents and Chemotherapy and 46th Infectious Diseases Society of America, Washington, DC. October, 2008.

Shaw J, Gumbo T. TB meningitis has poor long term outcome despite standard therapy. (Abstract # L-642)48th Interscience Conference of Antimicrobial Agents and Chemotherapy and 46th Infectious Diseases Society of America, Washington, DC. October, 2008.

Srivastava S, A. Ayyagari, T. N. Dhole, S. K. Dwivedi, K. K. Nyati, T. Gumbo. emb gene nucleotide polymorphism and role of embB306 mutation in resistance to ethambutol in Mycobacterium tuberculosis. (Abstract # C2-1986)48th Interscience Conference of Antimicrobial Agents and Chemotherapy and 46th Infectious Diseases Society of America, Washington, DC. October, 2008.

Musuka S, Srivastava S, Gumbo T. Centrality of efflux pump inhibitors in accelerating anti-TB therapy. 4th Annual NIH Director's Pioneer Award Symposium. NIH, Bethesda, MD, September 23, 2008.

Gumbo T, Drusano GL, Liu W, Fregeau C, Hsu V, Louie A. Once A Week Micafungin Therapy Is As Effective As Daily Therapy For Disseminated Candidiasis During Persistent Neutropenia. (Late Breaker) (Abstract # M-0310a). 46th Interscience Conference of Antimicrobial Agents and Chemotherapy, San Francisco, CA. September, 2006
Gumbo T, Louie A, Liu W, Fregeau C, Hsu V, Drusano G. Differential Microbial Response to Intermittent Micafungin by Candida glabrata in Three Different Organs. Abstract#93. Focus on Fungal Infections, Las Vegas, NV, March 2006.

Gumbo T, Louie A, Deziel MR, Liu W, Brown D, Fregeau C, Drusano GL. Isoniazid (INH) Pharmacodynamics (PD) in Hollow Fiber System (HFS): Correlation with Early Bactericidal Activity (EBA) in Patients and Failure to Suppress Resistance (Abstract # A-459). 45th Interscience Conference of Antimicrobial Agents and Chemotherapy, Washington, DC. December, 2005.

Gumbo T, Louie A, Liu W, Deziel MR, Drusano M, Turner L, Fregeau C, Brown D, Drusano GL. Pharmacokinetics and Pharmacodynamics (PK/PD) of Micafungin in neutropenic mice with disseminated Candida glabrata demonstrate prolonged antifungal effects. 44th Interscience Conference of Antimicrobial Agents and Chemotherapy, Washington, DC. November, 2004.

Gumbo T, Louie A, Liu W, Deziel MR, Drusano M, Drusano GL. Pharmacokinetics/Pharmacodynamics (PK/PD) of Anidulafungin in Candida glabrata-Infected Neutropenic Mice. 44th Interscience Conference of Antimicrobial Agents and Chemotherapy, Washington, DC, November, 2004.

Louie A, Liu W, Deziel MR, Drusano M, Turner L, Gumbo T, Drusano GL. Pharmacodynamics of rifalazil in a thigh model of Staphylococcus Infection. 44th Interscience Conference of Antimicrobial Agents and Chemotherapy, Washington, DC, November, 2004.

Louie A, Deziel MR, Brown D, Turner L, Fregeau C, Gumbo T, Drusano GL. Efficacy of moxifloxacin for treatment of wild-type and isogenic efflux pump mutant of Streptococcus pneumoniae in a hollow fiber infection model. 44th Interscience Conference of Antimicrobial Agents and Chemotherapy, Washington, DC, November, 2004.

Gumbo T, Louie A, Deziel MR, Drusano GL. Pharmacodynamic driven dosing of Rifampin in a hollow fiber system model of tuberculosis. (Abstract # A-1156). 43rd Interscience Conference of Antimicrobial Agents and Chemotherapy, Chicago, Ill, September, 2003.

Gumbo T, Louie A, Lui W, Drusano MF, Deziel MR, Drusano GL. Relative efficacies of anidulafungin, fluconazole, and amphotericin B for treatment of disseminated Candida glabrata in neutropenic mice. (Abstract # A-1577). 43rd Interscience Conference of Antimicrobial Agents and Chemotherapy, Chicago, Ill, September, 2003.

Louie A, Deziel MR, Lui W, Drusano MF, Gumbo T, Drusano GL. Kidney concentrations are critical in understanding the pharmacodynamics of caspofungin. (Abstract # A-1573). 43rd Interscience Conference of Antimicrobial Agents and Chemotherapy, Chicago, Ill, September, 2003.