It has been said that the basis of science is measurement. It is also agreed that the universal language of science is mathematics. It is also true that all matter in the universe, including microbes, humans and antibiotics, obey the same fundamental laws of physics and chemistry. In our laboratory we measure how antimicrobial drugs behave (pharmacokinetics), how microbes react to these drug concentrations (pharmacokinetics-pharmacodynamics), mathematically model the drug concentrations and the reaction of microbes to the drugs, and then translate from microbe and rodents to the human being since all three species obey the same universal laws. The challenge to us has been to apply these simple principles to that great nemesis of mankind-tuberculosis. Currently, 2 of 6 billion people have been infected by Mycobacterium tuberculosis, and tuberculosis is responsible for 3% of all disease related death. We are applying the lessons of pharmacokinetics-pharmacodynamics to rapidly kill this organisms, and also prevent emergence of resistance. Our goal is to develop tools to deal a quick death to this ancient enemy of humanity, and cure patients within two months. We are also applying these accumulated lessons to another foe- Candida. Candida infections kill many patients, especially those undergoing chemotherapy for cancer. Our laboratory measures how the Candida responds to drug concentrations, and then mathematically translate this information to give physicians and patients a chance to fight this infection. The goal of our laboratory is to develop therapies that would only need to be administered once or twice, and cure patients.

The In Vitro Pharmacodynamic Model of Tuberculosis