Selected Publications

1. Wei Y, Zou Z, Becker N, Anderson M, Sumpter R, Xiao G, Peyton M, Minna J, Bhagat G, Levine B. EGFR-mediated phosphorylation of Beclin 1 in autophagy suppression, tumor progression and tumor chemoresistance. 2013; In revision

2. He C, Wei Y, Sun K, Li B, Zou Z, Liu Y, Kinch LN, Khan S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, and Levine B. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. 2013; In revision

3. Shoji-Kawata S, Sumpter Jr R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW IV, Helms B, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, and Levine B. A. Identification of a candidate therapeutic autophagy-inducing peptide. Nature. 2013; 494:201-206.

4. Choi AMK, Ryter SW, Levine B. Autophagy in human health and disease. New Engl J Med. 2013; 368:651-662.

5. Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, and Levine B. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science. 2012; 338:956-959.

6. He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, and Levine B. Exercise induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012; 481;511-515.

7. Rubinsztein DC, Codogno P, and Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discovery. 2012; 11:709-730.

8. Orvedahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier R, Xie Y, and Levine B. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature. 2011; 480:113-117.

9. Levine B, Mizushima N, and Virgin HW. Autophagy in immunity and inflammation. Nature. 2011; 469:323-335.

10. Orvedahl A, MacPherson S, Sumpter R, Talloczy Z, Zou Z, and Levine B. Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host & Microbe. 2010; 18:115-127.

11. Mizushima N, Yoshimori T, and Levine B. Methods in mammalian autophagy research. Cell. 2010; 140:312-326.

12. Jia K, Thomas C, Akbar M, Sun Q, Adams-Huet B, and Levine B. Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci USA. 2009; 106:14564-14569.

13. Wei Y, Pattingre S, Sinha S, Bassik M, and Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008; 30:678-688.

14. Levine B and Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008; 132:27-42.

15. Jia K and Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy. 2007; 3:597-599.

16. Orvedahl A, Alexander D, Talloczy Z, Leib DA, and Levine B. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host & Microbe. 2007; 1:23-35.

17. Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, and Levine B. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell. 2007; 128:931-946.

18. Jia K, Hart A, and Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabitis elegans. Autophagy. 2007; 3:21-25.

19. Pattingre S, Tassa A, Qu X, Liang XH, Packer M, Schneider MD, and Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005; 122:927-939.

20. Levine B and Klionsky D. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004; 6:463-477.

21. Qu X, Yu J, Bhaghat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen E-L, Mizushima N, Ohsumi Y, Cattoretti G, and Levine B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003; 112:1809-1820.

22. Melendez A, Talloczy Z, Seaman M, Eskelinen E-L, Hall DH, and Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science. 2003; 301:1387-1391.

23. Talloczy Z, Jiang W, Virgin HW, Lieb DA, Scheuner D, Kaufman RJ, Eskelinen E-L, and Levine B. Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway. Proc Natl Acad Sci USA. 2002; 99:190-195.

24. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, and Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999; 402:672-676.

25. Liang XH, Kleeman LK, Jiang HH, Gordon GW, Goldman JE, Berry G, Herman B, and Levine B. Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein. J Virol. 1998; 72:8586-8596.

26. Levine B, Goldman JE, Jiang HH, Griffin DE, and Hardwick JM. Bcl-2 protects mice against fatal alphavirus encephalitis. Proc Natl Acad Sci USA. 1996; 93:4810-4815.

27. Levine B, Huang X, Isaacs JT, Reed JC, Griffin DE, and Hardwick JM. Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature. 1993; 361:739-742.

28. Levine B, Hardwick JM, Trapp BD, Crawford TO, Bollinger RC, and Griffin DE. Antibody-mediated clearance of alphavirus infection from neurons. Science. 1991; 254:856-860.