Publications

Levine, B., Hardwick, J.M., Trapp, B.D., Crawford, T.O., Bollinger, R.C., and Griffin, D.E. Antibody-mediated clearance of alphavirus infection from neurons. Science. 1991; 254:856-860.

Levine, B., Huang, X., Isaacs, J.T., Reed, J.C., Griffin, D.E., and Hardwick, J.M. Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature. 1993; 361:739-742.

Levine, B., Goldman, J.E., Jiang, H.H., Griffin, D.E., and Hardwick, J.M. Bcl-2 protects mice against fatal alphavirus encephalitis. Proc Natl Acad Sci USA. 1996; 93:4810-4815.

Liu, Y., Schiff, M., Czymmek, K., Talloczy, Z., Levine, B., and Dinesh-Kumar, S.P. Autophagy regulates programmed cell death during the plant innate immune response. Cell. 2005; 121:567-577.

Pattingre, S., Tassa, A., Qu, X., Liang, X.H., Packer, M., Schneider, M.D., and Levine, B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005; 122:927-939.

Qu, X., Zou, Z., Sun, Q., Luby-Phelps, K., Cheng, P., Hogan, R.N., Gilpin, C., and Levine, B. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell. 2007; 128:931-946.

Orvedahl, A., Alexander, D., Talloczy, Z, Leib, D.A., and Levine, B. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host & Microbe. 2007; 1:23-35.

Jia, K. and Levine, B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy. 2007; 3:597-599.

Wei, Y., Pattingre, S., Sinha, S., Bassik, M., and Levine, B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008; 30:678-688.

Sinha, S., Colbert, C., Becker, N., Wei, Y., and Levine, B. Molecular basis of the regulation of Beclin 1-dependent autophagy by the γ-herpesvirus 68 Bcl-2 homolog M11. Autophagy. 2008; 4(8):989-997.

Jia, K., Thomas, C., Akbar, M., Sun, Q., Adams-Huet, B., and Levine, B. Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci USA. 2009; 106:14564-14569.

Orvedahl, A., MacPherson, S., Sumpter, R., Talloczy, Z, Zou, Z, and Levine, B. Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host & Microbe. 2010; 18:115-127.

Levine, B. and Klionsky, D. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004; 6:463-477.

Levine, B. Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell. 2005; 120:159-162.

Levine, B. and Yuan, J. Autophagy in cell death: an innocent convict? J Clin Invest. 2005; 115:2679-2688.

Levine, B. Cell biology: autophagy and cancer. Nature. 2007; 446:745-747.

Levine, B. and Deretic, V. Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol. 2007; 7:767-777.

Liang, X.H., Kleeman, L.K., Jiang, H.H., Gordon, G.W. Goldman, J.E., Berry, G., Herman, B., and Levine, B. Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein. J Virol. 1998; 72:8586-8596.

Liang, X.H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H. and Levine, B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999; 402:672-676.

Talloczy, Z, Jiang, W., Virgin IV, H.W., Lieb, DA., Scheuner, D., Kaufman, RJ., Eskelinen, E.-L., and Levine, B. Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway. Proc Natl Acad Sci USA. 2002; 99:190-195.

Melendez, A., Talloczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D.H., and Levine, B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science. 2003; 301:1387-1391.

Qu, X., Yu, J., Bhaghat, G, Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., Cattoretti, G., and Levine, B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003; 112:1809-1820.

Furuya, N., Yu, J., Byfield, M., Pattingre, S., and Levine, B. The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy. 2005; 1:46-52.

Levine, B. and Kroemer, G. Autophagy in the pathogenesis of disease. Cell. 2008; 132:27-42.

Mizushima, N., Levine, B., Cuervo, A.M., and Klionsky, D. Autophagy fights disease through cellular self-digestion. Nature. 2008; 451:1069-1075.

Cecconi, F., and Levine, B. The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell. 2008; 15:344-357.

Virgin, H.W. IV, and Levine, B. Autophagy genes in immunity. Nat Immunol. 2009; 10:461-470.

Deretic, V., and Levine B. Autophagy, immunity, and microbial adaptations. Cell Host & Microbe. 2009; 5:527-549.

He, C., and Levine, B. The Beclin 1 interactome. Curr Opin Cell Biol. 2010; 22:140-149.

Wang, R.C., and Levine, B. Autophagy in cellular growth control. FEBS Lett. 2010; 584:1417-1426.

Mizushima, N., Yoshimori, T., and Levine, B. Methods in mammalian autophagy research. Cell 2010; 140:312-326.