Selected Publications

Levine B, Hardwick JM, Trapp BD, Crawford TO, Bollinger RC, and Griffin DE. Antibody-mediated clearance of alphavirus infection from neurons. Science. 1991; 254:856-860.

Levine B, Huang X, Isaacs JT, Reed JC, Griffin DE, and Hardwick JM. Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature. 1993; 361:739-742.

Levine B, Goldman JE, Jiang HH, Griffin DE, and Hardwick JM. Bcl-2 protects mice against fatal alphavirus encephalitis. Proc Natl Acad Sci USA. 1996; 93:4810-4815.

Liang XH, Kleeman LK, Jiang HH, Gordon GW, Goldman JE, Berry G, Herman B, and Levine B. Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein. J Virol. 1998; 72:8586-8596.

Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, and Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999; 402:672-676.

Talloczy Z, Jiang W, Virgin HW, Lieb DA, Scheuner D, Kaufman RJ, Eskelinen E-L, and Levine B. Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway. Proc Natl Acad Sci USA. 2002; 99:190-195.

Melendez A, Talloczy Z, Seaman M, Eskelinen E-L, Hall DH, and Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science. 2003; 301:1387-1391. PMID: 12958363

Qu X, Yu J, Bhaghat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen E-L, Mizushima N, Ohsumi Y, Cattoretti G, and Levine B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003; 112:1809-1820.

Pattingre S, Tassa A, Qu X, Liang XH, Packer M, Schneider MD, and Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005; 122:927-939. PMID: 16179260

Jia K, Hart A, and Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabitis elegans. Autophagy. 2007; 3:21-25.

Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, and Levine B. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell. 2007; 128:931-946.

Orvedahl A, Alexander D, Talloczy Z, Leib DA, and Levine B. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host & Microbe. 2007; 1:23-35.

Jia K and Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy. 2007; 3:597-599.

Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, and Wyss-Coray T. The autophagy-related proten Beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice. J Clin Invest. 2008; 118:2190-2199. PMCID: PMC2391284

Wei Y, Pattingre S, Sinha S, Bassik M, and Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008; 30:678-688. PMCID: PMC2478643

Jia K, Thomas C, Akbar M, Sun Q, Adams-Huet B, and Levine B. Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci USA. 2009; 106:14564-14569. PMCID: PMC2731839

Orvedahl A, MacPherson S, Sumpter R, Talloczy Z, Zou Z, and Levine B. Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host & Microbe. 2010; 18:115-127. PMCID: PMC2860265

Orvedahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier R, Xie Y, and Levine B. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature. 2011; 480:113-117. PMCID: PMC3229641

He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, and Levine B. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012; 481;511-515. PMCID: PMC3518436

Huang S, Jia K, Wang Y, Zhou Z, and Levine B. Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development. Autophagy. 2013; 9:138-49. PMCID: PMC3552879

Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, and Levine B. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science. 2012; 338:956-959. PMCID: PMC3507442

Shoji-Kawata S, Sumpter Jr R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW IV, Helms B, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, and Levine B. Identification of a candidate therapeutic autophagy-inducing peptide. Nature. 2013; 494:201-206. PMCID: PMC23364696

He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, and Levine B. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 2013; 154:1085-99. PMCID: PMC23954414

Wei Y, Zou Z, Becker N, Anderson M, Sumpter R, Xiao G, Kinch L, Koduru P, Christudass CS, Veltri RW, Grishin NV, Peyton M, Minna J, Bhagat G, Levine B. EGFR-mediated phosphorylation of Beclin 1 in autophagy suppression, tumor progression and tumor chemoresistance. Cell. 2013; 154:1269-1284.

Liu Y, Shoji-Kawata S, Sumpter R, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier R, Shaw S, Clarke PGH, Puyal J, Levine B. Autosis is a Na+,K+-ATPase-regulated form of autophagic cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. PNAS. 2013; 110:20364-20371. PMCID: PMC24277826