LPS Detoxification

M. Lu, M. Zhang, R.L. Kitchens, S. Fosmire, A. Takashima, R.S. Munford.  2003.  Stimulus-dependent deacylation of bacterial lipopolysaccharides by dendritic cells. J. Exp. Med. 197:1745-1754.

M. Lu, M. Zhang, A. Takashima, J. Weiss, M. A. Apicella, X. H. Li, D. Yuan, and R. S. Munford. Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria. Nat. Immunol., 6:989-984, 2005.

Munford, R.S. and A.W. Varley, 2006. Shield as signal: Lipopolysaccharides and the evolution of immunity to Gram-Negative bacteria. PLoS Pathogens 2:e67.

B. Shao, M. Lu, S. C. Katz, A. W. Varley, J. Hardwick, T. E. Rogers, N. Ojogun, D.C. Rockey, R. P. DeMatteo, and R. S. Munford. A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen. J. Biol. Chem. 282 (18):13726-13735, 2007.

R. S. Munford. Sensing gram-negative bacterial lipopolysaccharides; a human disease determinant? Infect. Immun. 76 (2):454-465, 2008.

Innate Immunity, Sepsis

Munford, R. S., and J. Pugin.  2001.  Normal systemic responses to injury or anti-inflammatory and can be immunosuppresive.  Am. J. Respir. Crit. Care Med.  163: 316-321

R. S. Munford. Sepsis, Severe Sepsis and Septic Shock. In: Principles and Practice of Infectious Diseases, edited by G. L. Mandell, J. E. Bennett, and R. Dolin. Elsevier Churchill-Livingstone, 2005, p. 906-926.

F.A. Rivera-Chavez, D.L. Hybki, R. Barber, G. Lindberg, R.S. Munford, G.E. O’Keefe.  2004. Innate immunity genes and the severity of acute appendicitis.  Ann. Surg. 240:269-277.

F.A. Rivera-Chavez, H. Wheeler, G. Lindberg, R. S. Munford, G. E. O’Keefe. 2003. Regional and systemic cytokine responses to acute inflammation of the vermiform appendix.  Ann. Surg. 237:408-416.

R.S. Munford.  Severe sepsis and septic shock: the role of Gram-negative bacteremia. 2006.  Annu. Rev. Patholol. Mech. Dis. 1:467-496

Munford, R. S., A.W. Varley.  2006.  Shield as signal: lipopolysaccharides and the evolution of immunity to Gram-negative bacteria.  PLoS Pathogens.  2:e67.