Ilya Bezprozvanny's Lab Homepage

News Release about our Neuron-2003 paper on Huntington's disease

News Release about our PNAS-2005 paper on Huntington's disease

News Release about our Cell-2006 paper on Alzheimer's disease

News Release about our NSL-2006 paper on Huntington's disease

News Release about our JCI-2007 paper on Alzheimer's disease

News Release about our JN-2007 paper on Huntington's disease

News Release about our JN-2008 paper on SCA3 ataxia

Postdoctoral Positions are Available

Preface

Ilya Bezprozvanny received M.Sci in Physics (1989) from the Leningrad Polytechnic Institute and PhD in Cell Biology (1992) from the Institute of Cytology Russian Academy of Sciences (scientific advisors - Alex P. Naumov and Galina N. Mozhayeva). As a part of his training, Ilya worked with Barbara E. Ehrlich (1990-1994) in the University of Connecticut Health Center at Farmington, Connecticut and then with Richard W. Tsien (1994-1996) in the Department of Molecular and Cellular Physiology at the Stanford University Medical Center, Stanford, California. In 1996 Ilya joined the UT Southwestern Medical Center faculty as an Assistant Professor. This is how our lab started.

Our address and contact info:

Dept of Physiology
ND12.200AA
UT Southwestern Medical Center at Dallas
5323 Harry Hines Blvd.
(for FedEx: 6001 Forest Park)
Dallas, TX 75390-9040

Telephones:

(214) 645-6017 (Ilya's office, ND12.200AA)
(214) 645-6016 (Main Lab, ND12.200A)

Fax: (214) 645-6018 (Lab office, ND12.200A)

Our administrative associate is Leah Benson
Leah is at ND12.120; tel: 214-645-5920; fax: (214) 645-6019, e-mail: Leah.Benson@UTSouthwestern.edu

Who we are

Members of the lab:

Ilya Bezprozvanny, Ph.D.
Ilya.Bezprozvanny@UTSouthwestern.edu

Ilya is from St. Petersburg, Russia.
Ilya is a Professor (2007) in the Department of Physiology at the UT Southwestern Medical Center. Ilya is a member of Neuroscience and Integrative Biology graduate programs. Since 2006 Ilya holds the Carla Cocke Francis Professorship in Alzheimer's Research.

Jun Wu, Ph.D.
Jun.Wu@UTSouthwestern.edu

Jun is from Wuhan, Hubei province, China.
She received her Ph.D. (1999) in Synthetic Organic Chemistry from Wuhan University, Wuhan (scientific advisor Prof. Hansheng Xu). She was trained as a postdoctoral research fellow at Friedrich-Schiller-Universität Jena, Germany (2001) and at New Mexico State University, Las Cruces, New Mexico (2002-2004).
Jun joined our lab in July 2005 as a Research Associate.

Suya Sun, Ph.D.
Suya.Sun@UTSouthwestern.edu

Suya is from Zhengzhou, Henan province, China.
Suya received her Ph.D in Pharmaceutical Analysis (2006) from the Shenyang Pharmaceutical University in Shenyang, China. She worked as a group leader in Shanghai Institute of Pharmaceutical Industry, Shanghai, China (1998 - 2006) and then contunued her training in Retina Foundation of the Southwest, Dallas, Texas (2007-2008).
Syua joined our lab in April of 2008 as a postdoctoral research fellow.

Volodymyr Rybalchenko, Ph.D.
Volodymyr.Rybalchenko@UTSouthwestern.edu

Volodya is from Uman, Ukraine.
He received his Ph.D. (1994) in Biological Sciences (scientific advisor - Dr. Roman Skryma) from the Institute of Bioorganic Chemistry, Kiev, Ukraine. He continue his training as a postdoctoral fellow in Louis Pasteur University, Strasbourg, France (1994 - 1999), University of Science and Technology in Lille, France (1999-2000), and Yale University (2000 - 2004). He was a faculty member in University of North Texas Health Science Centre (2004 - 2008). Volodya joined our lab in January 2009 as an Instructor.

Hua Zhang, Ph.D.
Hua.Zhang@UTSouthwestern.edu

Hua Zhang is from Tajan, Shandong province, China. She received her Ph.D. (2002) in Biochemistry and Molecular Biology (scientific advisor Prof. Cheng-Chao Shou) from Peking University Health Science Center in Beijing. Hua joined our lab in October 2002 and holds an Assistant Instructor position since July 2008.

Tie-Shan Tang, Ph.D.
Tie-Shan.Tang@UTSouthwestern.edu

Tie-Shan is from Dingzhou, Hebei province, China. He received his M.Sci. (1994) from Northwestern Agricultural University in Shanxi, his PhD (1998) in Cell and Developmental Biology (scientific advisor Prof. Fang-Zhen Sun) from the Institute of Developmental Biology, CAS in Beijing, where he then worked until joining our lab in July 2000. Since 2006 Tie-Shan holds an Instructor position.

Xue-Song Chen, Ph.D.
Xuesong.Chen@UTSouthwestern.edu

Xue-Song is from Tianjin city, China.
He received his Ph.D. (2002) in Pharmacognosy from Peking Union Medical College & Chinese Academy of Medical Science, Beijing (scientific advisor Prof. Di-Hua Chen). He then worked as a postdoctoral fellow (2002-2004) in the Institute of Biophysics, Chinese Academy of Sciences, Beijing until joining our lab in November 2004 as a postdoctoral fellow.

Xi ("Tracy") Chen, Ph.D.
Xi.Chen@UTSouthwestern.edu

Tracy is from Tonghua, Jilin province, China.
She received her M.Sci (1999) from Biotechnology Research Center Chinese Academy of Agricultural Sciences and her Ph.D. (2003) in Molecular and Cell Biology (scientific advisor Prof. Zhonghe Zhai) from College of Life Sciences of Peking University in Beijing. Tracy joined our lab in September 2004 as a postdoctoral fellow.

Yuan Luo, PhD
Yuan.Luo@UTSouthwestern.edu

Yuan is from Fengjie, Chongqing, China. She received her Ph.D. in Organic Chemistry (2004) from the Univ. of South Carolina, Columbia, S.C. She then worked as a postdoctoral researcher in the Dept. of Chem. & Biochem., the Univ. of South Carolina (2005-2007, mentor: Dr. Paul Thompson) and in the Dept. of Internal Medicine at UT Southwestern (2007- Feb 2009, mentor: Dr. Tom Kodadek).
Yuan joined our lab in March 2009 as a postdoctoral researcher.

Adebimpe ("Ade") Kasumu, B.Sci.
Adebimpe.Kasumu@UTSouthwestern.edu

Ade is from Lagos, Nigeria. She received her B.Sci in Biology (2007) from Spelman College in Atlanta, Georgia. Ade is working on her PhD in Integrative Biology on the Mechanisms of Disease Training Track (MoD).
Ade joined our lab in March of 2009.

Jing Liu, Ph.D.
Jing5.Liu@UTSouthwestern.edu

Jing is from Kunming, Yunnan province, China.
She received her PhD (2001) in Pathogenic Microbiology from the Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (scientific advisor Prof. Shude JIANG ). She then worked as a postdoctoral research fellow (2001-2004) in the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China (mentor - Prof. Hualiang HUANG.
Jing joined our lab in September of 2006 as a postdoctoral research fellow.

Emin Ozkan, B.Sci.
Emin.Ozkan@UTSouthwestern.edu

Emin is from Istanbul, Turkey.
He received his B.Sci (2004) in Molecular Biology from the Bilkent University in Ankara, Turkey.
Emin is working on his Ph.D. in Neuroscience in our lab since February 2007.

Hongyu Wang, M.D., Ph.D.
Hongyu.Wang@UTSouthwestern.edu

Hongyu is from Jilin, Jilin province, China.
She received her MD (1994) from Bethune Medical University in Changchun and her PhD in Medicine (2003) Univerity of Tsukuba, Tsukuba, Ibaraki, Japan. She then worked as a postdoctoral research fellow (2003-2007) in the National Institute of Animal Health in Tsukuba, Ibaraki, Japan.
Hongyu joined our lab in February of 2008 as a postdoctoral research fellow.

Xia ("Lisa") Liang, B.Sci.
Xia.Liang@UTSouthwestern.edu

Lisa is from Jiangxi province, China. She received her B.Sci. in computer sciences (1996) from the Agricultural University of Jiangxi. Lisa worked at UT Southwestern Medical Center at Dallas since 2005 and joined our laboratory as a Research Technician I in March of 2009.

Ilya.Bezprozvanny@UTSouthwestern.edu

Interested to join us?

Former members of the lab:

Vitalie Lupu, M.D. (September 1996 - October 1998)
Elena Kaznacheyeva, Ph.D. (April 1997- April 1998)
Lyuba Glouchankova, M.Sci. (March 1998 - June 1999) Ph.D. (2004)
Elena Nosyreva, Ph.D. (September 1999 - March 2002)
Anton Maximov, Ph.D. (May 1997 - June 2002)
Sonal Srikanth (Patel), M.Sci. (September 2002 - July 2003) Ph.D. (2004)
Zhengnan (Nan) Wang, B.Sci. (June 1999 - February 2004)
Huiping Tu, Ph.D. (December 2000 - September 2007)
Qin Li, M.D., Ph.D. (July 2006 - June 2008)
Huarui ("Kelly") Liu, M.D. (September 2007 - June 2009)
Omar Nelson, B.Sci. (January 2005 - June 2009) Ph.D. (2009)

Our Research

Research in our lab is supported by the grants from the Welch Foundation, the McKnight Endowment Fund for Neuroscience, the High Q Foundation, the Alzheimer’s Association, the Alzheimer’s Drug Discovery Foundation, the Department of Defence, and the NINDS at National Institutes of Health.

Our main interest is in calcium signaling. Calcium ion (Ca2+) acts as an intracellular second messenger in living cells. Changes in the cytosolic Ca2+ level influence most fundamental cellular processes. Deranged calcium signaling results in a number of disorders. Local and rapid changes in cytosolic Ca2+ are evoked by activation of plasma membrane voltage-gated Ca2+ channels in response to membrane depolarization. Global changes in cytosolic Ca2+ are supported by intracellular Ca2+ release channels - the inositol (1,4,5)-trisphosphate receptor (InsP3R) and ryanodine receptor (RyanR). The functional properties and modulation of intracellular Ca2+ release channels and voltage-gated Ca2+ channels is the focus of our research.

The main directions of our research are:

1. Structure-function and modulation of InsP3R.
By using molecular, biochemical, imaging, and electrophysiological methods, we study properties of InsP3R. The main emphasis of our work is to understand how activity of these channels is modulated. InsP3R is activated by a second messenger inositol (1,4,5)-trisphosphate (InsP3), generated as a result of PIP2 cleavage by phospholipase C (PLC). In bilayer and biochemical experiments we discovered direct functional coupling of InsP3R to PIP2 [1, 6]. In collaboration with Prof. Galina N. Mozhayeva we study coupling between InsP3R and plasma membrane calcium influx channels [4, 7, 17, 28, 36].Several InsP3R isoforms and splice variants have been isolated, but the functional differences between different InsP3R subtypes are not known. To adress this problem, we set up functional expression of InsP3R in a heterologous expression system and characterize functional properties of recombinant InsP3R1 in planar lipid bilayers [2]. Using this method, we identified key structural determinants of InsP3R function [10, 11, 15, 19, 22, 23, 24]. We collaborate with the laboratories of Prof. Masamitsu Iino [8, 10, 11, 15], Prof. Gaiti Hasan [19, 22] and Prof Humbert De Smedt [23] on this project. Using yeast two-hybrid and biochemical techniques, we identified a number of InsP3R1 neuronal binding partners [13, 14, 18]. Our results provided new insights into InsP3R1 function in the brain and suggested novel connections between InsP3R1 and dopaminergic signaling in the striatum [13, 21].

2. Deranged calcium signaling and neurodegenerative disorders.
In the course of our studies of InsP3R we recently discovered a connection between deranged neuronal calcium signaling and Huntington's disease (HD) [16, 20, 27, 33, 35, 38, 39, 41, 43, 44]. Currently we expanding this area of reasearch to other neurodegenerative diseases, such as spinocerebellar ataxia type 3 (SCA3) [42], spinocerebellar ataxia type 2 (SCA2) [46] and Alzheimer's disease (AD) [31, 34]. We collaborate with the laboratory of Prof. Michael R Hayden on studies of HD [16, 20, 27, 39], with the laboratory of Prof. Nobuyuki Nukina on studies of SCA3/MJD1 [42], with the laboratory of Prof. Stefan Pulst on studies of SCA2 [46] and with laboratories of Dr Gang Yu and Prof. Bart De Strooper on AD project [31, 34].

3. Synaptic voltage-gated calcium channels.

In the nervous system secretion of neurotransmitter is triggered by Ca2+ influx via presynaptic voltage-gated Ca2+ channels. Synaptic transmission is strongly affected by changes in behavior of these channels. In collaboration with the laboratory of Prof. Thomas C. Südhof we discovered that carboxy-terminal region of Ca2+ channels binds to the Mint1-1 PDZ domain and CASK-SH3 domain in yeast 2-hybrid and biochemical experiments [3]. Discovered interactions create a potential for formation of Ca2+ channel/mint1/CASK ternary complex and recruitment of N-type and Q-type Ca2+ channels to a marcomolecular signaling complex assembled at synaptic junction. We use biochemical, imaging, electriophysiological and genetic methods to test proposed model experimentally [12]. This work also prompted us to examine general rules that govern PDZ domain ligand specificty using the bioinformatics approach [9] and develop a high-throughput screen for small molecule PDZ domain inhibitors [37]. We extended the same approach to postsynaptic L-type calcium channels. In a collaborative study with the laboratory of Prof. D. James Surmeier we discovered that CaV1.3 L-type calcium channels bind to Shank postsynaptic modular adaptor protein and demonstrated that CaV1.3-Shank association is important for targeting of L-type channels to PSD, signaling to pCREB nuclear transription factor and modulation of L-type channels by G-protein coupled receptors [25, 26, 30].



Our publications:

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    1998 - 2000

  1. Lupu VD, E Kaznacheyeva, RJ Falck, MU Krishna, and I Bezprozvanny (1998) Functional coupling of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate receptor. J Biol Chem (Communication) v 273, pp. 14067-14070
  2. Kaznacheyeva E, VD Lupu and I Bezprozvanny (1998) Single-channel properties of inositol (1,4,5)-trisphosphate receptor heterologously expressed in HEK-293 cells. J Gen Physiol v 111, pp. 847-856
  3. Maximov A, TC Südhof and I Bezprozvanny (1999) Association of neuronal calcium channels with modular adaptor proteins. J Biol Chem (Communication) v 274, pp. 24453-24456
  4. Kaznacheeva E, A Zubov, A Nikolaev A, V Alexeenko, I Bezprozvanny , GN Mozhayeva (2000) Plasma membrane calcium channels in human carcinoma A431 cells are functionally coupled to inositol 1,4,5-trisphosphate receptor-phosphatidylinositol 4,5-bisphosphate complexes. J Biol Chem, v 275, pp. 4561-4564
  5. Gao B, Y Sekido, A Maximov, M Saad, E Forgacs, F Latif, M Lerman, J-H Lee, E Perez-Reyes, I Bezprozvanny , JD Minna (2000) Functional properties of a new voltage-dependent calcium channel a2d auxiliary subunit gene (CACNA2D2). J Biol Chem, v 275, pp 12237-12242
  6. Glouchankova L, MU Krishna, BVL Potter, JR Falck and I Bezprozvanny (2000) Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and Adenophostin A. Mol Cell Biol Res Com, v 3, pp 153-158

    2001 - 2003

  7. Kaznacheyeva E, A Zubov, K Gusev, I Bezprozvanny , GN Mozhayeva (2001) Activation of calcium entry in human carcinoma A431 cells by store depletion and phospholipase C- dependent mechanisms converge on Icrac-like calcium channels. PNAS, v 98, pp 148-153
  8. Miyakawa T, A Mizushima, K Hirose, T Yamazawa, I Bezprozvanny , T Kurosaki, M Iino (2001) Ca2+- sensor region of IP3 receptor controls intracellular Ca2+ signaling. EMBO J, v 20, pp 1674-1680
  9. I Bezprozvanny and A Maximov (2001) Classification of PDZ domains. FEBS Lett, v 509, pp 457-562
  10. Tu H, T Miyakawa, Z Wang, L Glouchankova, M Iino and I Bezprozvanny (2002) Functional characterization of the type 1 inositol 1,4,5-trisphosphate receptor coupling domain splice variants and opisthotonos mutant form. Biophys J, v 82, pp 1995 - 2004
  11. Nosyreva E, T Miyakawa, Z Wang, L Glouchankova, A Mizushima, M Iino and I Bezprozvanny (2002) The high affinity calcium-calmodulin-binding site does not play a role in modulation of type 1 inositol (1,4,5)-trisphosphate receptor function by calcium and calmodulin. Biochemical J, v 365, pp 659-667
  12. Maximov A and I Bezprozvanny (2002) Synaptic targeting of N-type calcium channels in hippocampal neurons. J Neuroscience v 22, pp 6939-6952
  13. Tang T-S, H Tu, Z Wang and I Bezprozvanny (2003) Modulation of the type 1 inositol (1,4,5)-trisphosphate receptor function by PKA and PP1alpha. J Neuroscience , v 23, pp 403-415
  14. Maximov A, T-S Tang, I Bezprozvanny (2003) Association of the type 1 inositol (1,4,5)-trisphosphate receptors with 4.1N protein in neurons. Mol Cell Neuroscience, v 22, pp 271-283
  15. Tu H, E Nosyreva, T Miyakawa, Z Wang, A Mizushima, M Iino and I Bezprozvanny (2003) Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor. Biophys J, v 85, pp 290 - 299
  16. Tang T-S, H Tu, EYW Chan, A Maximov, Z Wang, CL Wellington, MR Hayden and I Bezprozvanny (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron, v 39, pp 227-239
  17. Gusev K, L Glouchankova, A Zubov, E Kaznacheyeva, Z Wang, I Bezprozvanny and GN Mozhayeva (2003) The store-operated calcium entry pathways in human carcinoma A431 cells: functional properties and activation mechanisms. J Gen Physiol, v 122, pp 81-94

    2004 - 2005

  18. Huiping Tu, Tie-Shan Tang, Zhengnan Wang, and Ilya Bezprozvanny (2004) Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A. J Biol Chem, v 279, pp 19375-19382
  19. Sonal Srikanth, Zhengnan Wang, Dhananjay Wagh, Huiping Tu, Mathew K Mathew, Gaiti Hasan, and Ilya Bezprozvanny (2004) Functional properties of Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants. Biophysical J, v 86, pp 3634-3646.
  20. Tie-Shan Tang, Huiping Tu, Paul C. Orban, Edmond Y.W. Chan, Michael R. Hayden and Ilya Bezprozvanny (2004) HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca2+ release in primary culture of striatal medium spiny neurons. European Journal of Neuroscience, v 20, pp 1779-17876
  21. Tie-Shan Tang and Ilya Bezprozvanny (2004) Dopamine receptor-mediated Ca2+ signaling in striatal medium spiny neurons. J Biol Chem, v 279, pp 42082-42094
  22. Sonal Srikanth, Zhengnan Wang, Gaiti Hasan and Ilya Bezprozvanny (2004) Functional properties of a pore mutant in the Drosophila Melanogaster inositol 1,4,5-trisphosphate receptor. FEBS Lett, v 575, pp 95-98
  23. Huiping Tu, Zhengnan Wang, Elena Nosyreva, Humbert De Smedt and Ilya Bezprozvanny (2005) Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Biophysical J, v 88, pp 1046-1055
  24. Huiping Tu, Zhengnan Wang and Ilya Bezprozvanny (2005) Modulation of mammalian inositol 1,4,5-trisphosphate receptor isoforms by calcium: a role of calcium sensor region. Biophysical J, v 88, pp 1056-1069
  25. Hua Zhang, Anton Maximov, Yu Fu, Fang Xu, Tie-Shan Tang, Tatiana Tkatch, D. James Surmeier and Ilya Bezprozvanny (2005) Association of CaV1.3 L-type calcium channels with Shank. J Neuroscience, v 25, pp 1037-1049
  26. Patricia A. Olson, Tatiana Tkatch, Salvador Hernandez-Lopez, Sasha Ulrich, Ema Ilijic, Enrico Mugnaini, Hua Zhang, Ilya Bezprozvanny and D. James Surmeier (2005) G-protein-coupled receptor modulation of striatal CaV1.3 L-type Ca2+ channels is dependent on a Shank-binding domain. J Neuroscience, v 25, pp 1050-1062.
  27. Tie-Shan Tang, Elizabeth Slow, Vitalie Lupu, Irina G. Stavrovskaya, Mutsuyuki Sugimori, Rodolfo Llinás, Bruce S. Kristal, Michael R. Hayden and Ilya Bezprozvanny (2005) Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease. PNAS, v 102, pp 2602-2607
  28. Vladislav Bugaj, Vadim Alexeenko, Alexander Zubov, Lyuba Glushankova, Anton Nikolaev, Zhengnan Wang, Elena Kaznacheyeva, Ilya Bezprozvanny , and Galina N. Mozhayeva (2005) Functional properties of endogenous receptor- and store-operated calcium influx channels in HEK293 cells. J Biol Chem, v 280, pp 16790-16797
  29. Ying Chen, Uwe Beffert, Mert Ertunc, Tie-Shan Tang, Ege T. Kavalali, Ilya Bezprozvanny , Joachim Herz (2005) Reelin modulates NMDA receptor activity in cortical neurons. J Neuroscience, v 25, pp 8209-8216

    2006-2007

  30. Hua Zhang, Yu Fu, Christophe Altier, Josef Platzer, D. James Surmeier and Ilya Bezprozvanny (2006) CaV1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB. European Journal of Neuroscience, v 23, pp 2297-2310 .
  31. Huiping Tu, Omar Nelson, Arseny Bezprozvanny, Zhengnan Wang, Sheu-Fen Lee, Yi-Heng Hao, Lutgarde Serneels, Bart De Strooper, Gang Yu, and Ilya Bezprozvanny (2006) Presenilins form ER calcium leak channels, a function disrupted by familial Alzheimer’s disease-linked mutations. Cell, v 126, pp 981-993.
  32. Mengliang Zhang, Natalya Sukiasyan, Morten Møller, Ilya Bezprozvanny , Hua Zhang, Jacob Wienecke, Hans Hultborn (2006) Localization of L-type calcium channel CaV1.3 in cat lumbar spinal cord – with emphasis on motoneurons. Neuroscience Letters, v 407, pp 42-47.
  33. Jun Wu, Tie-Shan Tang, and Ilya Bezprozvanny (2006) Evaluation of clinically-relevant glutamate pathway inhibitors in in vitro model of Huntington’s disease. Neuroscience Letters, v 407, pp 219-223.
  34. Omar Nelson, Huiping Tu, Tianhua Lei, Mostafa Bentahir, Bart de Strooper, and Ilya Bezprozvanny (2007) Familial Alzheimer’s disease-linked mutations specifically disrupt calcium leak function of presenilin 1. Journal of Clinical Investigation, v 117, pp 1230-1239
  35. Tie-Shan Tang, Xi Chen, Jing Liu, and Ilya Bezprozvanny (2007) Dopaminergic signaling and striatal neurodegeneration in Huntington’s disease. J Neuroscience, vol 27, pp. 7899-7910
  36. Elena Kaznacheyeva, Lyuba Glushankova, Vladislav Bugaj, Olga Zimina, Anton Skopin, Vadim Alexeenko, Leonidas Tsiokas, Ilya Bezprozvanny , and Galina N. Mozhayeva (2007) Suppression of TRPC3 leads to disappearance of store-operated channels and formation of a new type of store-independent channels in A431 cells. Journal of Biological Chemistry, vol 282, pp. 23655-23662
  37. Xuesong Chen, Carolyn Michnoff, Shuguang Wei, Doug Franz and Ilya Bezprozvanny (2007) High-throughput screen for small molecule inhibitors of Mint1-PDZ domains. Assay and Drug Development Technologies, vol 5, pp. 769-783

    2008-present

  38. Hua Zhang, Sudipto Das, Quan-Zhen Li, Ioannis Dragatsis, Joyce J. Repa, Scott Zeitlin, György Hajnóczky, and Ilya Bezprozvanny (2008) Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts. BMC Neuroscience, vol 9:38
  39. Hua Zhang, Qin Li, Rona K Graham, Elizabeth Slow, Michael R. Hayden, and Ilya Bezprozvanny (2008) Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington’s disease. Neurobiology of Disease, v 31, pp. 80-88
  40. Jay W Schneider, Zhengliang Gao, Shijie Li, Midhat Farooqi, Tie-Shan Tang, Ilya Bezprozvanny , Doug E Frantz and Jenny Hsieh (2008) Small-molecule activation of neuronal cell fate. Nature Chemical Biology, v 4, pp 408-410
  41. Jun Wu, Qin Li, and Ilya Bezprozvanny (2008) Evaluation of Dimebon in cellular model of Huntington's disease. Molecular Neurodegeneration, 3:15
  42. Xi Chen, Tie-Shan Tang, Huiping Tu, Omar Nelson, Mark Pook, Robert Hammer, Nobuyuki Nukina, and Ilya Bezprozvanny (2008) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. Journal of Neuroscience,v 28, pp 12713-12724
  43. Jun Wu, Hye Kyoung Jeong, Sarah Bulin, Sung Won Kwon, Jeong Hill Park, and Ilya Bezprozvanny (2009) Ginsenosides protect striatal neurons in cellular model of Huntington’s disease. J. Neuroscience Research, v 87, pp 1904-1912
  44. Tie-Shan Tang, Caixia Guo, Hongyu Wang, Xi Chen, and Ilya Bezprozvanny (2009) Neuroprotective effects of inositol 1,4,5-trisphosphate receptor carboxy-terminal fragment in Huntington's disease mouse model. Journal of Neuroscience, v 29, pp 1257-1266
  45. Jiaxin Hu, Masayuki Matsui, Keith T. Gagnon, Jacob C. Schwartz, Sylvie Gabillet, Khalil Arar, Jun Wu, Ilya Bezprozvanny , and David R. Corey (2009) Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nature Biotechnology, v 27, pp 478-484
  46. Jing Liu, Tie-Shan Tang, Huiping Tu, Omar Nelson, Emily Herndon, Duong P. Huynh, Stefan-M. Pulst, and Ilya Bezprozvanny (2009) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. Journal of Neuroscience,in press

Reviews:

  1. I Bezprozvanny and A Maximov (2001) PDZ domains: more than just a glue. PNAS, v 98, pp 787-789
  2. Davis GW and I Bezprozvanny (2001) Maintaining the stability of neural function: a homeostatic hypothesis. Ann Rev of Physiol, v 63, pp. 847-869
  3. I Bezprozvanny and MR Hayden (2004) Deranged neuronal calcium signaling and Huntington disease. Biochemical and Biophysical Research Communications, v 322, pp. 1310-1317
  4. I Bezprozvanny (2005) The Inositol 1,4,5-trisphosphate receptors. Cell Calcium, vol 38, pp 261-272
  5. I Bezprozvanny and MP Mattson (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer’s disease Trends in Neuroscience, v. 31, pp 454-463
  6. I Bezprozvanny (2009) Calcium signaling and neurodegenerative diseases. Trends in Molecular Medicine, v. 15, pp 89-100
  7. I Bezprozvanny (2009) Amyloid goes global. Sci Signal, vol 2, pe16

    For the list of publications prior to 1998 please look at Ilya's CV at COS profile

    This page was last updated on June 09, 2009
    This site is maintained by Ilya Bezprozvanny who would very much appreciate you questions, comments, and suggestions.