Ilya Bezprozvanny Laboratory

The University of Texas Southwestern Medical Center

Our publications:

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Research Papers:

    1998-2000

  1. Lupu VD, E Kaznacheyeva, RJ Falck, MU Krishna, and I Bezprozvanny (1998) Functional coupling of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate receptor. J Biol Chem (Communication) v 273, pp. 14067-14070
  2. Kaznacheyeva E, VD Lupu and I Bezprozvanny (1998) Single-channel properties of inositol (1,4,5)-trisphosphate receptor heterologously expressed in HEK-293 cells. J Gen Physiol v 111, pp. 847-856
  3. Maximov A, TC Südhof and I Bezprozvanny (1999) Association of neuronal calcium channels with modular adaptor proteins. J Biol Chem Communication) v 274, pp. 24453-24456
  4. Kaznacheeva E, A Zubov, A Nikolaev A, V Alexeenko, I Bezprozvanny , GN Mozhayeva (2000) Plasma membrane calcium channels in human carcinoma A431 cells are functionally coupled to inositol 1,4,5-trisphosphate receptor-phosphatidylinositol 4,5-bisphosphate complexes. J Biol Chem, v 275, pp. 4561-4564
  5. Gao B, Y Sekido, A Maximov, M Saad, E Forgacs, F Latif, M Lerman, J-H Lee, E Perez-Reyes, I Bezprozvanny , JD Minna (2000) Functional properties of a new voltage-dependent calcium channel a2d auxiliary subunit gene (CACNA2D2).J Biol Chem, v 275, pp 12237-12242
  6. Glouchankova L, MU Krishna, BVL Potter, JR Falck and I Bezprozvanny (2000) Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and Adenophostin A. Mol Cell Biol Res Com, v 3, pp 153-158

    2001-2003

  7. Kaznacheyeva E, A Zubov, K Gusev, I Bezprozvanny , GN Mozhayeva (2001) Activation of calcium entry in human carcinoma A431 cells by store depletion and phospholipase C- dependent mechanisms converge on Icrac-like calcium channels. PNAS, v 98, pp 148-153
  8. Miyakawa T, A Mizushima, K Hirose, T Yamazawa, I Bezprozvanny , T Kurosaki, M Iino (2001) Ca2+- sensor region of IP3 receptor controls intracellular Ca2+ signaling. EMBO J, v 20, pp 1674-1680
  9. I Bezprozvanny and A Maximov (2001) Classification of PDZ domains. FEBS Lett, v 509, pp 457-562
  10. Tu H, T Miyakawa, Z Wang, L Glouchankova, M Iino and I Bezprozvanny (2002) Functional characterization of the type 1 inositol 1,4,5-trisphosphate receptor coupling domain splice variants and opisthotonos mutant form. Biophys J, v 82, pp 1995 - 2004
  11. Nosyreva E, T Miyakawa, Z Wang, L Glouchankova, A Mizushima, M Iino and I Bezprozvanny (2002) The high affinity calcium-calmodulin-binding site does not play a role in modulation of type 1 inositol (1,4,5)-trisphosphate receptor function by calcium and calmodulin. Biochemical J, v 365, pp 659-667
  12. Maximov A and I Bezprozvanny (2002) Synaptic targeting of N-type calcium channels in hippocampal neurons. J Neuroscience v 22, pp 6939-6952
  13. Tang T-S, H Tu, Z Wang and I Bezprozvanny (2003) Modulation of the type 1 inositol (1,4,5)-trisphosphate receptor function by PKA and PP1alpha. J Neuroscience , v 23, pp 403-415
  14. Maximov A, T-S Tang, I Bezprozvanny (2003) Association of the type 1 inositol (1,4,5)-trisphosphate receptors with 4.1N protein in neurons. Mol Cell Neuroscience, v 22, pp 271-283
  15. Tu H, E Nosyreva, T Miyakawa, Z Wang, A Mizushima, M Iino and I Bezprozvanny (2003) Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor. Biophys J, v 85, pp 290 - 299
  16. Tang T-S, H Tu, EYW Chan, A Maximov, Z Wang, CL Wellington, MR Hayden and I Bezprozvanny (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron, v 39, pp 227-239
  17. Gusev K, L Glouchankova, A Zubov, E Kaznacheyeva, Z Wang, I Bezprozvanny and GN Mozhayeva (2003) The store-operated calcium entry pathways in human carcinoma A431 cells: functional properties and activation mechanisms. J Gen Physiol, v 122, pp 81-94

    18. 2004 - 2005

  18. Huiping Tu, Tie-Shan Tang, Zhengnan Wang, and Ilya Bezprozvanny (2004) Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A. J Biol Chem, v 279, pp 19375-19382
  19. Sonal Srikanth, Zhengnan Wang, Dhananjay Wagh, Huiping Tu, Mathew K Mathew, Gaiti Hasan, and Ilya Bezprozvanny (2004) Functional properties of Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutants. Biophysical J, v 86, pp 3634-3646.
  20. Tie-Shan Tang, Huiping Tu, Paul C. Orban, Edmond Y.W. Chan, Michael R. Hayden and Ilya Bezprozvanny (2004) HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca2+ release in primary culture of striatal medium spiny neurons. European Journal of Neuroscience, v 20, pp 1779-17876
  21. Tie-Shan Tang and Ilya Bezprozvanny (2004) Dopamine receptor-mediated Ca2+ signaling in striatal medium spiny neurons. J Biol Chem, v 279, pp 42082-42094
  22. Sonal Srikanth, Zhengnan Wang, Gaiti Hasan and Ilya Bezprozvanny (2004) Functional properties of a pore mutant in the Drosophila Melanogaster inositol 1,4,5-trisphosphate receptor. FEBS Lett, v 575, pp 95-98
  23. Huiping Tu, Zhengnan Wang, Elena Nosyreva, Humbert De Smedt and Ilya Bezprozvanny (2005) Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Biophysical J, v 88, pp 1046-1055
  24. Huiping Tu, Zhengnan Wang and Ilya Bezprozvanny (2005) Modulation of mammalian inositol 1,4,5-trisphosphate receptor isoforms by calcium: a role of calcium sensor region. Biophysical J, v 88, pp 1056-1069
  25. Hua Zhang, Anton Maximov, Yu Fu, Fang Xu, Tie-Shan Tang, Tatiana Tkatch, D. James Surmeier and Ilya Bezprozvanny (2005) Association of CaV1.3 L-type calcium channels with Shank. J Neuroscience, v 25, pp 1037-1049
  26. Patricia A. Olson, Tatiana Tkatch, Salvador Hernandez-Lopez, Sasha Ulrich, Ema Ilijic, Enrico Mugnaini, Hua Zhang, Ilya Bezprozvanny and D. James Surmeier (2005) G-protein-coupled receptor modulation of striatal CaV1.3 L-type Ca2+ channels is dependent on a Shank-binding domain. J Neuroscience, v 25, pp 1050-1062.
  27. Tie-Shan Tang, Elizabeth Slow, Vitalie Lupu, Irina G. Stavrovskaya, Mutsuyuki Sugimori, Rodolfo Llinás, Bruce S. Kristal, Michael R. Hayden and Ilya Bezprozvanny (2005) Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease. PNAS, v 102, pp 2602-2607
  28. Vladislav Bugaj, Vadim Alexeenko, Alexander Zubov, Lyuba Glushankova, Anton Nikolaev, Zhengnan Wang, Elena Kaznacheyeva, Ilya Bezprozvanny , and Galina N. Mozhayeva (2005) Functional properties of endogenous receptor- and store-operated calcium influx channels in HEK293 cells. J Biol Chem, v 280, pp 16790-16797
  29. Ying Chen, Uwe Beffert, Mert Ertunc, Tie-Shan Tang, Ege T. Kavalali, Ilya Bezprozvanny , Joachim Herz (2005) Reelin modulates NMDA receptor activity in cortical neurons. J Neuroscience, v 25, pp 8209-8216

    30. 2006-2007

  30. Hua Zhang, Yu Fu, Christophe Altier, Josef Platzer, D. James Surmeier and Ilya Bezprozvanny (2006) CaV1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB. European Journal of Neuroscience, v 23, pp 2297-2310 .
  31. Huiping Tu, Omar Nelson, Arseny Bezprozvanny, Zhengnan Wang, Sheu-Fen Lee, Yi-Heng Hao, Lutgarde Serneels, Bart De Strooper, Gang Yu, and Ilya Bezprozvanny (2006) Presenilins form ER calcium leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell, v 126, pp 981-993.
  32. Mengliang Zhang, Natalya Sukiasyan, Morten Møller, Ilya Bezprozvanny , Hua Zhang, Jacob Wienecke, Hans Hultborn (2006) Localization of L-type calcium channel CaV1.3 in cat lumbar spinal cord – with emphasis on motoneurons. Neuroscience Letters, v 407, pp 42-47.
  33. Jun Wu, Tie-Shan Tang, and Ilya Bezprozvanny (2006) Evaluation of clinically-relevant glutamate pathway inhibitors in in vitro model of Huntington's disease. Neuroscience Letters, v 407, pp 219-223.
  34. Omar Nelson, Huiping Tu, Tianhua Lei, Mostafa Bentahir, Bart de Strooper, and Ilya Bezprozvanny (2007) Familial Alzheimer's disease-linked mutations specifically disrupt calcium leak function of presenilin 1. Journal of Clinical Investigation, v 117, pp 1230-1239
  35. Tie-Shan Tang, Xi Chen, Jing Liu, and Ilya Bezprozvanny (2007) Dopaminergic signaling and striatal neurodegeneration in Huntington's disease. J Neuroscience, vol 27, pp. 7899-7910
  36. Elena Kaznacheyeva, Lyuba Glushankova, Vladislav Bugaj, Olga Zimina, Anton Skopin, Vadim Alexeenko, Leonidas Tsiokas, Ilya Bezprozvanny , and Galina N. Mozhayeva (2007) Suppression of TRPC3 leads to disappearance of store-operated channels and formation of a new type of store-independent channels in A431 cells. Journal of Biological Chemistry, vol 282, pp. 23655-23662
  37. Xuesong Chen, Carolyn Michnoff, Shuguang Wei, Doug Franz and Ilya Bezprozvanny (2007) High-throughput screen for small molecule inhibitors of Mint1-PDZ domains. Assay and Drug Development Technologies, vol 5, pp. 769-783

    38. 2008-2009

  38. Hua Zhang, Sudipto Das, Quan-Zhen Li, Ioannis Dragatsis, Joyce J. Repa, Scott Zeitlin, György Hajnóczky, and Ilya Bezprozvanny (2008) Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts. BMC Neuroscience, vol 9:38
  39. Hua Zhang, Qin Li, Rona K Graham, Elizabeth Slow, Michael R. Hayden, and Ilya Bezprozvanny (2008) Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease. Neurobiology of Disease, v 31, pp. 80-88
  40. Jay W Schneider, Zhengliang Gao, Shijie Li, Midhat Farooqi, Tie-Shan Tang, Ilya Bezprozvanny , Doug E Frantz and Jenny Hsieh (2008) Small-molecule activation of neuronal cell fate. Nature Chemical Biology, v 4, pp 408-410
  41. Jun Wu, Qin Li, and Ilya Bezprozvanny (2008) Evaluation of Dimebon in cellular model of Huntington's disease. Molecular Neurodegeneration, 3:15
  42. Xi Chen, Tie-Shan Tang, Huiping Tu, Omar Nelson, Mark Pook, Robert Hammer, Nobuyuki Nukina, and Ilya Bezprozvanny (2008) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. Journal of Neuroscience,v 28, pp 12713-12724
  43. Jun Wu, Hye Kyoung Jeong, Sarah Bulin, Sung Won Kwon, Jeong Hill Park, and Ilya Bezprozvanny (2009) Ginsenosides protect striatal neurons in cellular model of Huntington's disease. J. Neuroscience Research, v 87, pp 1904-1912
  44. Tie-Shan Tang, Caixia Guo, Hongyu Wang, Xi Chen, and Ilya Bezprozvanny (2009) Neuroprotective effects of inositol 1,4,5-trisphosphate receptor carboxy-terminal fragment in Huntington's disease mouse model. Journal of Neuroscience, v 29, pp 1257-1266
  45. Jiaxin Hu, Masayuki Matsui, Keith T. Gagnon, Jacob C. Schwartz, Sylvie Gabillet, Khalil Arar, Jun Wu, Ilya Bezprozvanny , and David R. Corey (2009) Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nature Biotechnology, v 27, pp 478-484
  46. Jing Liu, Tie-Shan Tang, Huiping Tu, Omar Nelson, Emily Herndon, Duong P. Huynh, Stefan-M. Pulst, and Ilya Bezprozvanny (2009) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. Journal of Neuroscience, v 29, pp 9148-9162
  47. Meewhi Kim , Yogarany Chelliah, Sang Woo Kim, Zbyszek Otwinowski, and Ilya Bezprozvanny (2009) Secondary structure of Huntingtin amino-terminal region. Structure, v 17, pp 1205-1212
  48. John W. Steele, Soong Ho Kim, John R. Cirrito, Deborah K. Verges, Jessica L. Restivo, David Westaway, Paul Fraser, Peter St George Hyslop, Mary Sano, Ilya Bezprozvanny , Michelle E. Ehrlich, David M. Holtzman, and Sam Gandy (2009) Acute dosing of latrepirdine (Dimebon-TM), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Molecular Neurodegeneration, 4:51

    49. 2010-present

  49. Hongyu Wang, Xi Chen, Yuemei Li, Tie-Shan Tang and Ilya Bezprozvanny (2010) Tetrabenazine is neuroprotective in Huntington's disease mice. Molecular Neurodegeneration,5:18
  50. Omar Nelson, Charlene Supnet, Huarui Liu and Ilya Bezprozvanny (2010) Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes. Journal of Alzheimer's Disease, vol 21, pp 781-793
  51. Hua Zhang, Suya Sun, An Herreman, Bart De Strooper and Ilya Bezprozvanny (2010) Role of presenilins in neuronal calcium homeostasis. Journal of Neuroscience, v 30, pp 8566-8580
  52. Alexey Shalygin, Ryazantseva, M., Glushankova, L., Mozhayeva, G.N., Bezprozvanny, I. and Kaznacheyeva, E. (2010) Homer regulation of native plasma membrane calcium channels in A431 cells. Cell Calcium, v 48, pp 209 - 214
  53. Jun Wu, Hsin-Pei Shih, Vladimir Vigont, Lori Hrdlicka, Len Diggins, Carol Singh, Matt Mahoney, Richard Chesworth, Gideon Shapiro, Olga Zimina, Xuesong Chen, Qingqing Wu, Lyubov Glushankova, Michael Ahlijanian, Gerhard Koenig, Galina N. Mozhayeva, Elena Kaznacheyeva, and Ilya Bezprozvanny (2011) Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment. Chemistry and Biology, v 18, pp 777-793
  54. Omar Nelson, Charlene Supnet, Alexandria Tolia, Katrien Horré, Bart De Strooper and Ilya Bezprozvanny (2011) Mutagenesis mapping of presenilin 1 calcium leak conductance pore. J Biol Chem, v 286, pp 22339-22347
  55. Xuesong Chen, Jun Wu, Yuan Luo, Xia Liang, Charlene Supnet, Meewhi Kim, Gregor P. Lotz, Guocheng Yang, Paul J. Muchowski, Thomas Kodadek and Ilya Bezprozvanny (2011) Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease. Chemistry and Biology, v 18, pp 1113-1125
  56. Xi Chen, Jun Wu, Svetlana Lvovskaya, Emily Herndon, Charlene Supnet and Ilya Bezprozvanny (2011) Dantrolene is neuroprotective in Huntingtons disease transgenic mouse model. Molecular Neurodegeneration, 6:81
  57. Geert Bultynck, Santeri Kiviluoto, Nadine Henke, Hristina Ivanova, Lars Schneider, Volodymyr Rybalchenko, Tomas Luyten, Koen Nuyts, Wim Deborggraeve, Ilya Bezprozvanny, Jan B. Parys, Humbert De Smedt, Ludwig Missiaen, and Axel Methner (2011) The C-terminus of bax inhibitor-1 forms a Ca2+-permeable channel pore. J Biol Chem, v 287, pp 2544-2557
  58. Adebimpe Kasumu, Xia Liang, Polina Egorova, Daria Vorontsova, and Ilya Bezprozvanny (2012) Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar Purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice. Journal of Neuroscience, v 32, pp 12786-12796
  59. Adebimpe W. Kasumu, Charlotte Hougaard, Frederik Rode, Thomas A. Jacobsen, Jean Marc Sabatier, Birgitte L. Eriksen, Dorte Strøbæk, Xia Liang, Polina Egorova, Dasha Vorontsova, Palle Christophersen, Lars Christian B. Rønn, and Ilya Bezprozvanny (2012) Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chemistry and Biology, v 19, pp 1340-1353
  60. Yuan Luo, Sheetal Vali, Suya Sun, Xuesong Chen, Xia Liang, Tatiana Drozhzhina, Elena Popugaeva, and Ilya Bezprozvanny (2013) Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands. ACS Chem. Neurosci., in press
  61. Meewhi Kim (2013) Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues. Prion, in press

    62. Reviews:

    1. I Bezprozvanny and A Maximov (2001) PDZ domains: more than just a glue. PNAS, v 98, pp 787-789
    2. Davis GW and I Bezprozvanny (2001) Maintaining the stability of neural function: a homeostatic hypothesis. Ann Rev of Physiol, v 63, pp. 847-869
    3. I Bezprozvanny and MR Hayden (2004) Deranged neuronal calcium signaling and Huntington disease. Biochemical and Biophysical Research Communications, v 322, pp. 1310-1317
    4. I Bezprozvanny (2005) The Inositol 1,4,5-trisphosphate receptors. Cell Calcium, vol 38, pp 261-272
    5. I Bezprozvanny and MP Mattson (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease Trends in Neuroscience, v. 31, pp 454-463
    6. I Bezprozvanny (2009) Calcium signaling and neurodegenerative diseases. Trends in Molecular Medicine, v. 15, pp 89-100
    7. I Bezprozvanny (2009) Amyloid goes global. Sci Signal, vol 2, pe16 Free Content
    8. I Bezprozvanny and T. Klockgether (2010) Therapeutic prospects for spinocerebellar ataxia type 2 and 3. Drugs of the Future, v. 34, pp 991-999
    9. C. Supnet and I Bezprozvanny (2010) The dysregulation of intracellular calcium in Alzheimer's disease. Cell Calcium, v. 47, pp 183-189
    10. C. Supnet and I Bezprozvanny (2010) Neuronal calcium signaling and Alzheimer's disease. Journal of Alzheimer's Disease, v. 20 Suppl 2, pp S487-498
    11. A. Kasumu and I Bezprozvanny (2012) Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias. Cerebellum, v 11, pp 630-639
    12. I Bezprozvanny (2010) The rise and fall of Dimebon. Drug News & Perspectives, v. 23, pp 518-523
    13. B Miller and I Bezprozvanny (2010) Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine, and calcium. Future of Neurology, v. 5, pp 735-756 Free Content
    14. I Bezprozvanny (2011) Role of inositol 1,4,5-trishosphate receptors in pathogenesis of Huntington's disease and spinocerebellar ataxias. Neurochemical Research, v. 36, pp 1186–1197
    15. C. Supnet and I Bezprozvanny (2011) Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis. Cell Calcium, v. 50, pp 303-309
    16. I. Bezprozvanny , C. Supnet, S. Sun, H. Zhang, Bart De Strooper, B. (2012) Response to Shilling et al, jbc.M111.300491. J Biol Chem, v 287, p 20469
    17. I Bezprozvanny (2012) Presenilins: A novel link between intracellular calcium signaling and lysosomal function? J Cell Biology, v/. 198, pp 7 – 10
    18. E. Popugaeva, C. Supnet, and I Bezprozvanny (2012) Presenilins, Deranged Calcium Homeostasis, Synaptic Loss and Dysfunction in Alzheimer’s Disease. Messenger v 1, pp 53–62 Free Content
    19. I Bezprozvanny (2012) Bilayer measurement of endoplasmic reticulum calcium channels. CSHL Press. PROTOCOLS/2011/066225. In press.

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