Welcome to the De Brabander Lab-Publications

Publications

Li, L.; Thomas, R.M.; Suzuki, H.; De Brabander, J.K.; Wang, X.; Harran, P.G., "A small molecule Smac mimic potentiates TRAIL- and TNFa-mediated cell death" Science, 305: 1471-1474, 2004

Lebreton, S., Xie, X.-S., Ferguson, D., De Brabander, J.K., "Ring-closing metathesis: A powerful tool for the synthesis of simplified salicylihalamide-based V-ATPase inhibitors" Tetrahedron, in press.

Xie, X.-S., Padron-Perez, D., Liao, X., Wang, J., Roth, M.G., and De Brabander, J.K., "Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1" Journal of Biological Chemistry, 279:19755-19763, 2004

Liao, X, Wu, Y., and De Brabander, J.K., "Total Synthesis and Absolute Configuration of the Novel Microtubule Stabilizing Agent Peloruside A" Angew. Chem. Int. Ed. Engl, 42:1648-1652, 2003

Wu, Y., Liao, X., Wang, R., Xie, X-S., and De Brabander, J.K., "Total Synthesis and Initial Structure-Function Analysis of the potent V-ATPase Inhibitors Salcylihalamide A and Related Compounds." J. Am. Chem. Soc., 124:3245-3253, 2002

Bhattacharjee, A., Soltani, O., De Brabander, J.K., "Synthesis of the C1-C21 (C1'-C21') Fragment of the Dimeric Polyketide Natural Product SCH 351448." Org. Lett., 4:481-484, 2002

Bhattacharjee, A., Seguil, O.R., and De Brabander, J.K., "Total synthesis and biological evaluationn of apicularen A and synthetic analogs." Tetrahedron Lett., 41:1217-1220, 2001

Wu, Y., Esser, L., De Brabander, J.K., "Revision of the Absolute Configuration of Salicylihalamide A through Asymmetric Total Synthesis." Angew. Chem. Int. Ed. Engl., 39:4308-4310, 2000

Wu, Y., Seguil, O.R., De Brabander, J.K., "Synthesis and Initial Structure-Activity Relationships of Modified Salicylihalamides." Org. Lett., 2:4241-4244, 2000

Bhattacharjee, A., and De Brabander, J.K., "Synthesis of Side Chain Truncated Apicularen A" Tetrahedron Lett., 41:8069-8073, 2000

Esser, L., and De Brabander, J.K., "2-[(7R,9S,10R,12E)-4,9-Dihydroxy-10-methyl-5-oxo-7,8,9,10,11,14-hexahydro-5H-6-oxa-benzocyclododecen-7-yl]ethyl octanoate" Acta Cryst., E58:o142-o144, 2002

Randle, D.E., Wu, Y., De Brabander, J., and Minna, J., "In vitro characterization of salicylihalamides: A new class of anticancer drugs" Clinical Cancer Research, 7 (11),:473 Suppl. S, 2001