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Jef De Brabander

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  1. Studies toward the Unique Pederin Family Member Psymberin: Full Structure Elucidation, Two Alternative Total Syntheses, and Analogs

Feng, Y.; Jiang, X.; De Brabander, J. K. J. Am. Chem. Soc., 2012, 134, 17083. DOI

2.   Inhibition of Pyrimidine Synthesis Reverses Viral Virulence Factor-mediated Block of mRNA Nuclear Export

Zhang, L.; Das, P., Schmolke; M., Manicassamy, B.; Wang, Y.; Deng, X.; Cai, L.; Tu, B. P; Forst, C. V.; Roth, M. G.; Levy, D. E.; García-Sastre, A.; De Brabander, J. K.; Phillips, M. A.; Fontoura, B. M.A. J. Cell. Biol. 2012, 196, 315. DOI 

  1. Lessons and Revelations from Biomimetic Syntheses
    Razzak, M.; De Brabander, J. K. Nature Chemical Biology, 2011, 7, 865. DOI
  2. Platinum-Catalyzed Synthesis of β-Keto Tetrahydropyrans and Cyclic Dienolethers
    Liang, Q.; Qian, M.; Razzak, M.; De Brabander, J. K. Chem. Asian J., 2011, 6, 1958. DOI
  3. Heterocycles via Intramolecular Platinum-Catalyzed Propargylic Substitution
    Liang, Q.; De Brabander, J. K. Tetrahdron, 2011, 67, 5046. DOI
  4. Gold-Catalysed Synthesis of Amino Acid-Derived 2,5-Disubstituted Oxazoles
    Paradise, C. L.; Sarkar, P. R.; Razzak, M.; De Brabander, J. K. Org. Biomol. Chem., 2011, 9, 4017. DOI
  5. Development of Proneurogenic, Neuroprotective Small Molecules
    MacMillan, K. S.; Naidoo, J.; Liang, J.; Melito, L.; Williams, N. S.; Morlock, L.; Huntington, P. J.; Estill, S. J.; Longgood, J.; Becker, G. L.; McKnight, S. L.; Pieper, A. A.; De Brabander, J. K.; Ready, J. M. J. Am. Chem. Soc. 2011, 133, 1428. DOI
  6. Discovery of a Neuroprotective Chemical
    Pieper, A. A.; Xie, S.; Capota, E.; Estill, S. J.; Zhong, J.; Long, J. M.; Becker, G. L.; Huntington, P.; Goldman, S. E.; Shen, C.-H.; Capota, M.; Britt, J. K.; Kotti, T.; Ure, K.; Brat, D. J.; Williams, N. S.; MacMillan, K.S.; Naidoo, J.; Melito, L.; Hsieh, J.; De Brabander, J. K.; Ready, J. M.; McKnight, S. L. Cell, 2010, 142, 39. DOI
  7. Inhibition of Iron Uptake Is Responsible for Differential Sensitivity to V-ATPase Inhibitors in Several Cancer Cell Lines
    Straud, S.; Zubovych, I.; De Brabander, J. K.; Roth, M. G.; PloS one 2010, 5, e11629. DOI
  8. Expanded Utility of the β-Glucuronide Linker: ADCs That Deliver Phenolic Cytotoxic Agents
    Jeffrey, S. C.; De Brabander, J. K.; Miyamoto, J.; Senter, P. D. ACS Med. Chem. Lett. 2010, 1, 277-280. DOI
  9. A Concise Total Synthesis of Saliniketal B
    Jun, L.; De Brabander, J. K. J. Am. Chem. Soc. 2009, 131, 12562-12563. DOI
  10. A Concise Synthesis of Berkelic Acid Inspired by Combining the Natural Products Spicifernin and Pulvilloric Acid
    Bender, C. F.; Yoshimoto, F. K.; Paradise, C. L.; De Brabander, J. K. J. Am. Chem. Soc. 2009, 131, 11350-11352. DOI
  11. Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide
    Lebreton, S.; Jaunbergs, J.; Roth, M. G.; Ferguson, D. A.; De Brabander, J. K. Bioorg. Med. Chem. Lett. 2008, 18, 5879-5883. DOI
  12. Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters
    De Brabander, J. K.; Liu, B.; Qian, M. Org. Lett. 2008, 10, 2533-2536. DOI
  13. Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A
    Jiang, X.; Liu, B.; Lebreton, S.; De Brabander, J. K. J. Am. Chem. Soc. 2007, 129, 6386-6387. DOI
  14. Synthesis of Psymberin Analogues: Probing a Functional Correlation with the Pederin/Mycalamide Family of Natural Products
    Jiang, X.; Williams, N.; De Brabander, J. K. Org. Lett. 2007, 9, 227-230. DOI
  15. Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals
    Liu, B.; De Brabander, J. K. Org. Lett. 2006, 8, 4907-4910. DOI
  16. Synthesis of spirastrellolide A fragments for structure elucidation
    Pan, Y.; De Brabander, J. K. Synlett. 2006, 853-856. DOI
  17. Synthesis and Complete Stereochemical Assignment of Psymberin/Irciniastatin A
    Jiang, X.; Garcia-Fortanet, J.; De Brabander, J. K. J. Am. Chem. Soc. 2005, 127, 11254-11255. DOI
  18. A Concise Synthesis of (+)-SCH 351448
    Soltani, O.; De Brabander, J. K. Org. Lett. 2005, 7, 2791-2793. DOI
  19. Synthesis of functionalized salicylate esters and amides by photochemical acylation
    Soltani, O.; De Brabander, J. K. Angew. Chemie. Int. Ed. 2005, 44, 1696-1699. DOI
  20. A Photochemical Entry to Depsides: Synthesis of Gustastatin
    Garcia-Fortanet, J.; De Brabander, J. K. Org. Lett. 2005, 7, 685-688. DOI
  21. Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs
    Adams, C. M.; Reitz, J.; De Brabander, J. K.; Feramisco, J. D.; Li, L.; Brown, M. S.; Goldstein, J. L. J. Biol. Chem. 2004, 279, 52772-52780. DOI
  22. Ring-closing metathesis: a powerful tool for the synthesis of simplified salicylihalamide-based V-ATPase inhibitors
    Lebreton, S.; Xie, X.-S.; Ferguson, D.; De Brabander, J. K. Tetrahedron 2004, 60, 9635-9647. DOI
  23. A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death
    Li, L.; Thomas, R. M.; Suzuki, H.; De Brabander, J. K.; Wang, X.; Harran, P. G. Science 2004, 305, 1471-1474. DOI
  24. Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1
    Xie, X.-S.; Padron, D.; Liao, X.; Wang, J.; Roth, M. G.; De Brabander, J. K. J. Biol. Chem. 2004, 279, 19755-19763. DOI
  25. Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A
    Liao, X.; Wu, Y.; De Brabander, J. K. Angew. Chemie. Int. Ed. 2003, 42, 1648-1652. DOI
  26. Total synthesis and initial structure-function analysis of the potent V-ATPase inhibitors salicylihalamide A and related compounds
    Wu, Y.; Liao, X.; Wang, R.; Xie, X.-S.; De Brabander, J. K. J. Am. Chem. Soc. 2002, 124, 3245-3253. DOI
  27. Synthesis of the C1-C21 (C1'-C21') Fragment of the Dimeric Polyketide Natural Product SCH 351448
    Bhattacharjee, A.; Soltani, O.; De Brabander, J. K. Org. Lett. 2002, 4, 481-484. DOI
  28. Total synthesis and biological evaluation of apicularen A and synthetic analogs
    Bhattacharjee, A.; Seguil, O. R.; De Brabander, J. K. Tetrahedron Lett. 2001, 42, 1217-1220. DOI
  29. Revision of the absolute configuration of salicylihalamide A through asymmetric total synthesis
    Wu, Y.; Esser, L.; De Brabander, J. K. Angew. Chemie. Int. Ed. 2000, 39, 4308-4310. DOI
  30. Synthesis and Initial Structure-Activity Relationships of Modified Salicylihalamides
    Wu, Y.; Seguil, O. R.; De Brabander, J. K. Org. Lett. 2000, 2, 4241-4244. DOI
  31. Synthesis of side chain truncated apicularen A
    Bhattacharjee, A.; De Brabander, J. K. Tetrahedron Lett. 2000, 41, 8069-8073. DOI
  32. The chemistry-medicine continuum: synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads
    Wender, P. A.; Martin-Cantalejo, Y.; Carpenter, A. J.; Chiu, A.; De Brabander, J. K.; Harran, P. G.; Jimenez, J.-M.; Koehler, M. F. T.; Lippa, B.; Morrison, J. A.; MŸller, S. G.; MŸller, S. N.; Park, C.-M.; Shiozaki, M.; Siedenbiedel, C.; Skalitzky, D. J.; Tanaka, M.; Irie, K.Pure & Appl. Chem. 1998, 70, 539-546. DOI
  33. The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1
    Wender, P. A.; De Brabander, J. K.; Harran, P. G.; Jimenez, J.-M.; Koehler, M. F. T.; Lippa, B.; Park, C.-M.; Siedenbiedel, C.; Pettit, G. R. Proc. Nat. Acad. Sci. 1998, 95, 6624-6629. DOI
  34. Synthesis of the First Members of a New Class of Biologically Active Bryostatin Analogs
    Wender, P. A.; De Brabander, J. K.; Harran, P. G.; Jimenez, J.-M.; Koehler, M. F. T.; Lippa, B.; Park, C.-M.; Shiozaki, M. J. Am. Chem. Soc. 1998, 120, 4534-4535. DOI
  35. (R)-Carvone as chiral template for the synthesis of some polyols
    De Brabander, J. K.; Kulkarni, B. A.; Garcia-Lopez, R.; Vandewalle, M. Bulletin des Societes Chimiques Belges 1997, 106, 665-669.
  36. Non-destructive removal of the bornanesultam auxiliary in α-substituted N-acylbornane-10,2-sultams under mild conditions. An efficient synthesis of enantiomerically pure ketones and aldehydes
    Oppolzer, W.; Darcel, C.; Rochet, P.; Rosset, S.; De Brabander, J. K. Helv. Chim. Act. 1997, 80, 1319-1337. DOI
  37. Towards a synthesis of epothilone A. Rapid assembly of the C(1)-C(6) and C(7)-C(12) fragments
    De Brabander, J. K.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824-826. DOI
  38. Enantioselective total synthesis of (-)-denticulatins A and B using a novel group-selective aldolization of a meso dialdehyde as a key step
    De Brabander, J. K.; Oppolzer, W. Tetrahedron 1997, 53, 9169-9202. DOI
  39. Bryostatin: a novel asymmetric synthesis of the C27-C34 fragment starting from (R)-carvone as chiral template
    De Brabander, J. K.; Kulkarni, B. A.; Garcia-Lopez, R.; Vandewalle, M. Tetrahedron: Asymmetry 1997, 8, 1721-1724. DOI
  40. Asymmetric synthesis of ibuprofen via diastereoselective alkylation of a homochiral N-acylbornanesultam
    Oppolzer, W.; Rosset, S.; De Brabander, J. K. Tetrahedron Lett. 1997, 38, 1539-1540. DOI
  41. Enantioselective synthesis of the Prelog-Djerassi lactonic acid via group-selective aldolization/desymmetrization of a meso dialdehyde with a chiral N-propionylsultam
    Oppolzer, W.; Walther, E.; Balado, C. P.; De Brabander, J. K. Tetrahedron Lett. 1997, 38, 809-812. DOI
  42. Towards the asymmetric synthesis of bryostatin 1
    De Brabander, J. K.; Vandewalle, M. Pure & Appl. Chem. 1996, 68, 715-718. DOI
  43. Asymmetric synthesis of (-)-denticulatins A and B via group-selective aldolization of a meso dialdehyde with a chiral N- propionylsultam
    Oppolzer, W.; De Brabander, J. K.; Walther, E.; Bernardinelli, G. Tetrahedron Lett. 1995, 36, 4413-4416. DOI
  44. Total synthesis of the macrolide (+)-aspicilin by an asymmetrically catalyzed macrocyclization of an ω-alkynal ester
    Oppolzer, W.; Radinov, R. N.; De Brabander, J. K. Tetrahedron Lett. 1995, 36, 2607-2610. DOI
  45. Bryostatins: the asymmetric synthesis of the C1-C9 and C17-C27 fragments
    De Brabander, J. K.; Vandewalle, M. Synthesis 1994, 855-865. DOI
  46. Bryostatins: the asymmetric synthesis of C1-C9 and C11-C16 fragments
    De Brabander, J. K.; Vanhessche, K.; Vandewalle, M. Tetrahedron Lett. 1991, 32, 2821-2824. DOI
  47. Chemistry of the transition metals: application to organic synthesis
    De Brabander, J. K. Chemie Magazine 1989, 15, 23-26.
  48. The Protective Effect of Behavioral Activation on the Growth of a Syngeneic Tumor and Mortality in Socially Stressed Mice
    De Brabander, B.; D'haeseleer, F.; De Brabander, M.; Distelmans, W.; Van Ginckel, R.; De Brabander, J. K. Eur. J. Psychiat., 1989, 3, 238.
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