Publications

2013

36. Rogers, J. L.; Bayeh, L.; Scheuermann, T. H.; Longgood, J.; Key, J.; Naidoo, J.; Melito, L.; Shokri, C.; Frantz, D. E.; Bruick, R. K.; Gardner, K. H.*; MacMillan, J. B.*; Tambar, U. K.* “Development of Inhibitors of the PAS-B Domain of the HIF-2a Transcription Factor” J. Med. Chem.,  2012, submitted.

35. Hu, Y.; Wang, K.; MacMilan, J. B.* “Hunanamycin A, An Antibiotic from a Marine Derived Bacillus hunanensis” Organic Letters, 2013, accepted, DOI: 10.1021/ol303376c (published online 1/10/13).

34. Potts, M. B.; Kim, H.; Fisher, K. W.; Hu, Y.; Carrasco, Y.; Ou, Y-H.; Herrera, M.; Cubillos, F.; Xiao, G.; Hofree, M.; Ideker, T.; Xie, Y.; Lewis, R. E.; MacMillan, J. B.; White, M. A. “Broad-scale mode-of-action annotation of natural product perturbations by functional signature ontology (FUSION)” Science 2012, in revision

33. Pan, E.; Oswald, N.; Life, J. M.; Posner, B. A.; MacMillan, J. B. “Precursor-Directed Generation of Amidine Containing Ammosamide Analogs: Ammosamides E-P” Chem. Sci. 2013, 4, 482-488.

32. Sun, Q.; Carrasco, Y. P.; Hu, Y.; Guo, X.; Mirzaei, H.; MacMillan, J. B.; Chuk, Y-M. “Nuclear export inhibition through covalent conjugation and hydrolysis of leptomycin B by CRM1” Proceedings of the National Academy of Sciences, USA. 2013, accepted, DOI: 10.1073/pnas.1217203110 (published online 1/7/13).  

2012

31. Hu, Y.; Martinez, E. A.; MacMillan, J. B. “Galvaquinones A-E, Anthraquinones from a Marine-Derived Actinomycetospora sp.” J. Nat. Prod. 2012, 75, 1759-1764

30. Rogers, J. L.; MacMillan, J. B. “A Labeled Substrate Approach to Discovery of Biocatalytic Reactions: A Proof of Concept Transformation with N-Methylindole” J. Am. Chem. Soc. 2012, 134, 12378-12380.

29. Pan, E.: Jamison, M.; Yousufuddin, M.; MacMillan, J. B. “Ammosamide D, an oxidatively ring opened ammosamide analog from a marine-derived Streptomyces variabilis.” Org. Lett. 2012, 14, 2390-2393.

28. Hu, Y.; Legako, A. G.; Espindola A. P.; MacMillan J. B. “Erythrolic Acids A-E, Meroterpenoids from a Marine-derived Erythrobacter sp.” J. Org. Chem. 2012.  77, 3301-3307.

27. Hu, Y.; MacMillan, J. B. “A new peptide isolated from a marine derived Streptomyces bacillaris” Nat. Prod. Comm. 2012, 7, 211-214.

2011

26. Hu Y., MacMillan J. B. Erythrazoles A-B, “Cytotoxic Benzothiazoles from a Marine-derived Erythrobacter sp.” Org. Lett. 2011, 13, 6580-6583.

25. Hu Y.; Espindola A. P.; Stewart N. A.; Wei S.; Posner B. A.; MacMillan J. B .“Chromomycin SA analogs from a marine-derived Streptomyces sp.” Bioorg. Med. Chem. 2011, 19, 5183-9.

2010

24. Cancer Target Discovery and Development Network, Schreiber, S. L.; Shamji, A. F.; Clemons, P. A.; Hon, C.; Koehler, A. N.; Munoz, B.; Palmer, M.; Stern, A. M.; Wagner, B. K.; Powers, S.; Lowe, S. W.; Guo, X.; Krasnitz, A.; Sawey, E. T.; Sordella, R.; Stein, L.; Trotman, L. C.; Califano, A.; Dalla-Favera, R.; Ferrando, A.; Iavarone, A.; Pasqualucci, L.; Silva, J.; Stockwell, B. R.; Hahn, W. C.; Chin, L.; DePinho, R. A.; Boehm, J. S.; Gopal, S.; Huang, A.; Root, D. E.; Weir, B. A.; Gerhard, D. S.; Zenklusen, J. C.; Roth, M. G.; White, M. A.; Minna, J. D.; MacMillan, J. B.; Posner, B. A. “Towards patient-based cancer therapeutics” Nat Biotechnol.> 2010 9, 904-906.      

2009

23. Espindola A. P, Crouch R, DeBergh J. R, Ready J. M, MacMillan J. B. “Deconvolution of complex NMR spectra in small molecules by multifrequency homonuclear decoupling (MDEC)” J. Am. Chem. Soc. 2009 131, 15994-15995.

22. Chiu Y. H., MacMillan J. B., Chen Z. J. “RNA polymerase III detects cytosolic DNA and induces type I interferon’s through the RIG-I pathway” Cell. 2009, 138, 576-591.

Prior to UTSW

21. Maloney, K.; MacMillan, J.B.; Kauffman, C.; Jensen, P.R.; DiPasquale, A.; Fenical, W. “Lodopyridone, a Structurally-Unprecedented Alkaloid from a Marine Actinomycete” Org. Lett., 2009 11, 5422-5424.

20. Hughes, C.C.; MacMillan, J.B.; Gaudencio, S.P.; Jensen, P.R.; Fenical, W.  “The Ammosamides, Structures of Potent Cytotoxins from a Marine-Derived Streptomyces sp.“ Angew. Chemie Int. Ed., 2009, 48, 725-727.

19. Hughes, C.C.; MacMillan, J.B.; Gaudencio, S.P. Fenical, W.; LaClair, J.J., “Covalent Modification of Myosin by Ammosamides A and B” Angew. Chemie Int. Ed., 2009, 48, 728-732.

18. Newton, G.L.; Jensen, P.R., MacMillan, J.B., Fenical, W. Fahey, R.C. “A homolog of mycothiol can replace mycothiol as the dominant thiol during secondary metabolite production in marine actinomycetes” Archives of Microbiology, 2008, 190, 547-557.

17. MacMillan, J.B.; Zhou, G.Z.; Skepper, C.K. Molinski, T.F. “Phorbasides A-E, Cytotoxic Chlorocyclopropane Macrolide Glycosides from the Marine Sponge Phorbas sp. CD Determination of C-Methyl Sugar Configurations” J. Org. Chem. 2008, 73, 3699-3706.

16. Skepper, C.; MacMillan, J.B.; Zhou, G.Z.; Masuno. M.N.;Molinski, T.F.  “Chlorocyclopropane Macrolides from the Marine Sponge Phorbas sp.: Assignment of Configurations of Phorbasides A and B by Quantitative CD”  JJ. Am. Chem. Soc. 2007, 129, 1450-1451.

15. Linington, R.G.; Robertson, M.; Gauthier, A.; Finlay, B.B.; MacMillan, J.B.; Molinski, T.F.; van Soest, R.; Andersen, R.J. Caminosides B-D, Antimicrobial Glycolipids Isolated from the Marine Sponge Caminus sphaeroconia.  Journal of Natural Products, 2006, 69, 173-177.

14. Cueto, M.; MacMillan. J.B.; Jensen, P.R.; Fenical, W. “Tropolactones A-D, Cytotoxic Terpenes Isolated from a Marine-Derived Fungus” Phytochemistry, 2006, 67,1826-1831.

13. Makarieva, T.N.; Denisenko, V.A.; Dmitrenok, P.S.; Guzii, A.G.; Santalova, E.A.; Stonik, V.A. MacMillan, J.B.; Molinski, T.F., “Oceanalin A, a Hybrid Bifunctionalized Sphingoid Tetrahydroisoquinoline Glycoside from the Marine Sponge Oceanapia sp.” Org. Lett. 2005, 7, 2897-2900.

12. MacMillan, J.B.; Molinski T.F. “ Majusculoic acid, a Brominated Cyclopropyl Fatty Acid from a Marine Cyanobacterial Mat Assemblage”J. Nat. Prod, 2005, 68, 604-606.

11.  Kossuga, M.H.; MacMillan, J.B.; Rogers, E.W.; Molinski, T.F.; Nascimento, G.G.F.; Rocha, R.M.; Berlinck, R.G.S. “(2S,3R)-2-Aminododecan-3-ol, a New Antifungal Agent the Ascidian Clavelina oblonga”  J. Nat. Prod. 2004, 67, 1879-1881.

10. MacMillan, J.B.; Linington, R.G.; Andersen, R.J.;  Molinski, T.F. “ Stereochemical Assignment in Acyclic Lipids Across Long Distance by Circular Dichroism: Absolute Stereochemistry of the Aglycone of Caminoside A”   Angew. Chemie. Int. Ed. 2004, 43, 5946-5951.

9. Liu, C.; Masuno, M.N.; MacMillan, J.B.; Molinski, T.F. “Enantioselective Total Synthesis of (+)-Milnamide A and Evidence of Its Autoxidation to (+)-Milnamide D.”  Angew. Chemie. Int. Ed. 2004, 43, 5951-5954.

8. MacMillan, J.B.; Molinski, T.F. “Long-Range Stereo-Relay: Relative and Absolute Configuration of 1,n-Glycols from Circular Dichroism of Liposomal Porphyrin Esters” J. Am. Chem. Soc. 2004, 126, 9944-9945.

7. MacMillan, J.B.; Ernst-Russell, M.A.; deRopp, J.S.; Molinski, T.F. “Lobocyclamides A-C, Lipopeptides from a Cryptic Cyanobacterial Mat Containing Lyngbya confervoides” J. Org. Chem. 2002, 67, 8210-8215.

6. Nicholas, G.M.; Li, R.H.; MacMillan, J.B.; Molinski, T.F. “Antifungal Activity of Bifunctional Sphingolipids. Intramolecular Synergism within Long-Chain a,w-Bis Aminoalcohols” Biorg. Med. Chem Lett. 2002, 12, 2159-2162.

5. MacMillan, J.B.; Molinski, T.F. “Lobocyclamide B from Lyngbya confervoides. Configuration and Asymmetric Synthesis of b-Hydroxy-a-Amino Acids by (-)-Sparteine-Mediated Aldol Addition” Org. Lett. 2002, 4, 1883-1886.

4. MacMillan, J.B.; Molinski, T.F. “Caylobolide A, a Unique 36-Membered Macrolactone from a Bahamian Lyngbya majuscule” Org. Lett. 2002, 2, 1535-1538.

3. Moon, S.S.; MacMillan, J.B.; Olmstead, M..M.; Ta. T.A.; Pessah, I.N.; Molinski, T.F. “(+)-7S-Hydroxyxestospongin A from the Marine Sponge Xestospongia sp. and Absolute Configuration of (+)-Xestospongin D”  J. Nat Prod. 2002, 65, 249-254.

2. MacMillan, J.B.; Trousdale, E.K.; Molinski, T.F. “Structure of (-)-Neodysidenin from Dysidea herbacea. Implications for Biosynthesis of 5,5,5-Trichloroleucine Peptides” Org. Lett, 2000, 2, 272-273.

1. MacMillan, J.B.; Molinski, T.F. “Herbacic Acid, a Simple Prototype of 5,5,5-Trichloroleucine Metabolites from the Sponge Dysidea herbacea” J. Nat. Prod.1999, 63, 155-157.