Welcome to the web site for the Mangelsdorf/Kliewer laboratory (the Mango Lab) at the University of Texas Southwestern Medical Center in Dallas. Our lab is interested in understanding the molecular and physiologic components of two signal transduction pathways that offer new therapeutic potential for treating diseases such as diabetes, obesity, cancer, and parasitism. The first pathway is governed by nuclear hormone receptors, a class of ligand-dependent transcription factors that affect numerous developmental and metabolic processes. The second pathway is mediated by the endocrine fibroblast growth factors, FGF19 and FGF21, which control energy metabolism in response to nutrient availability.