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Publications prior to 2007

 

 

  • 1. Haussler, M., Sidell, N., Kelly, M., Donaldson, C. Altman, A., and Mangelsdorf, D. (1983) Specific high-affinity binding and biological action of retinoic acid in human neuroblastoma cell lines. Proc. Natl. Acad. Sci. USA 80: 5525-5529.
  • 2. Haussler, M.R., Dokoh, S., Mangelsdorf, D.J., Donaldson , C.A. and Pike, J.W. (1983) Vitamin D metabolites: New physiologic and clinical insights. In Clinical Disorders of Bone and Mineral Metabolism (B. Frame and J.T. Potts, eds.). Excerpta Medica, Amsterdam , pp. 68-71.
  • 3. Mangelsdorf, D.J., Koeffler, H.P., Donaldson , C.A. , Pike, J.W. and Haussler, M.R. (1984) 1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): Receptor mediated maturation to macrophage-like cells. J. Cell Biol. 98: 391-398.
  • 4. Haussler, M.R., Donaldson, C.A., Kelly, M.A., Mangelsdorf, D.J., Bowden, G.T., Meinke, W.J., Meyskens, F.L. and Sidell, N. (1984) Identification and quantification of intracellular retinol and retinoic acid binding proteins in cultured cells. Biochim. Biophys. Acta 803: 54-62.
  • 5. Haussler, M.R., Mangelsdorf, D.J., Koeffler, H.P., Donaldson, C.A. and Pike, J. W. (1984) 1,25-Dihydroxyvitamin D3 induces differentiation of human leukemia HL-60 cells to monocytes/macrophages via its specific intracellular receptor. In Endocrine Control of Bone and Calcium Metabolism , Vol. 8B (D.V. Cohn, J.T. Potts, Jr. and T. Fujita, eds.) Elsevier Science Publishers BV , Amsterdam , pp. 240-241.
  • 6. Haussler, M.R., Donaldson , C.A. , Allegretto, E.A., Marion , S.L., Mangelsdorf, D.J., Kelly, M.A. and Pike, J.W. (1984) New actions of 1,25-Dihydroxyvitamin D3: Possible clues to the pathogenesis of postmenopausal osteoporosis. In Osteoporosis: Proceedings of the Copenhagen International Symposium on Osteoporosis (C. Christiansen, C.D. Arnaud, B.E.C. Nordin, A.M. Parfitt, W.A. Peck and B.L. Riggs, eds). Aalborg Stiftsbogtrykkeri, Copenhagen , pp. 725-736.
  • 7. Haussler, M.R., Donaldson, C.A., Kelly, M.A., Mangelsdorf, D.J., Marion, S.L. and Pike, J.W. (1985) Functions and mechanisms of action of the 1,25-Dihydroxyvitamin D3 receptor. In Vitamin D: Chemical, Biochemical and Clinical Update (A.W. Norman, K. Schaefer, H.-G. Grigoleit and D.v. Herrath, eds.) Walter de Gruyter , Berlin , pp. 83-92.
  • 8. Mangelsdorf, D.J., Marion , S.L., Pike, J.W. and Haussler, M.R. (1985) 1,25-Dihydroxyvitamin D3 receptors in space flown vs. grounded control rat kidneys. Physiologist 28: S223-S224.
  • 9. Haussler, M.R., Donaldson , C.A. , Marion , S.L., Allegretto, E.A., Kelly, M.A., Mangelsdorf, D.J., and Pike, J.W. (1986) Receptors for the vitamin D hormone: characterization and functional involvement in 1,25-Dihydroxyvitamin D3 regulated events. In The Role of Receptors in Biology and Medicine (A.M. Gotto and B.W. O'Malley, eds.) Raven Press, New York , pp. 91-104.
  • 10. Pike, M.W., Allegretto, E.A., Kelly, M.A., Donaldson , C.A. , Marion , S.L., Mangelsdorf, D.J., and Haussler, M.R. (1986) 1,25-Dihydroxyvitamin D3 receptors: altered functional domains are associated with cellular resistance to vitamin D3. In Steroid Hormone Resistance (G.P. Chrousos, D.L. Loriaux and M.B. Lipsett, eds.) Plenum, New York , pp. 377-390.
  • 11. Haussler, M.R., Mangelsdorf, D.J., Donaldson , C.A. , Marion , S.L., Sleator , N.M. , and Pike, J.W. (1987) Receptor mediated action of the vitamin D hormone. In Gene Regulation by Steroid Hormones III (A.K. Roy and J.H. Clark, eds.) Springer-Verlag , Berlin , pp. 93-110.
  • 12. Pike, J.W., Mangelsdorf, D.J., Allegretto, E.A., and Haussler, M.R. (1987) Receptors for 1,25-Dihydroxyvitamin D3: structural comparisons and recent functional insights. In Sterol/Steroid Hormone Action (T. Spelsberg and R. Kumar, eds.) Martinus Nijhoff, Boston , pp. 339-354.
  • 13. Mangelsdorf, D.J., Pike, J.W., and Haussler, M.R. (1987) Avian and mammalian receptors for 1,25-Dihydroxyvitamin D3: in vitro translation to characterize size and hormone-dependent regulation. Proc. Natl. Acad. Sci. USA 84: 354-358.
  • 14. McDonnell, D.P., Mangelsdorf, D.J., Pike, J.W., Haussler, M.R., and O'Malley, B.W. (1987) Molecular cloning of cDNA encoding the chicken 1,25-Dihydroxyvitamin D3 receptor. Science 235: 1214-1217.
  • 15. Haussler, M.R., Mangelsdorf, D.J., Komm, B.S., Allegretto, E.A., Yamaoka, K., McDonnell, D.P., O'Malley, B.W.,and Pike, J.W. (1987) Molecular biology of the vitamin D hormone. In Calcium Regulation and Bone Metabolism, Basic and Clinical Aspects (Vol. 9) (D.V. Cohn, T.J. Martin, and P.J. Meunier, eds.) Elsevier Science Publishers, Amsterdam , pp. 465-474.
  • 16. Mangelsdorf, D.J., Pike, M.W., McDonnell, D.P., O'Malley, B.W., and Haussler, M.R. (1987) Identification of cDNAs to 1,25-Dihydroxyvitamin D3 receptors. In Calcium Regulation and Bone Metabolism, Basic and Clinical Aspects (Vol. 9) (D.V. Cohn, T.J. Martin, and P.J. Meunier, eds.) Elsevier Science Publishers, Amsterdam , pp. 801-804.
  • 17. Haussler, M.R., Mangelsdorf, D.J., Komm, B.S., Allegretto, E.A., Yamaoka, K., Terpening, C.M., Baker, A., McDonnell, D.P., O'Malley, B.W., and Pike, J.W. (1987) The vitamin D hormone: Molecular and cellular biology. In Highlights on Endocrinology (C. Christiansen and B.J. Riis, eds.) Norhaven Bogtrykkeri, Copenhagen , pp. 141-146.
  • 18. Mangelsdorf, D.J., Komm, B.S., McDonnell, D.P., Pike, J.W., and Haussler, M.R. (1987) Immunoselection of cDNAs to avian intestinal calcium binding protein-28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. Biochemistry 26: 8332-8338.
  • 19. Haussler, M.R., Mangelsdorf, D.J., Yamaoka, K., Allegretto, E.A., Komm, B.S., Terpening, C.M., McDonnell, D.P., Pike, J.W., and O'Malley, B.W. (1988) Molecular characterization and actions of the vitamin D hormone receptor. In Steroid Hormone Action (UCLA Symposia on Molecular and Cellular Biology-Vol. 75) (G. Ringold, ed.) Alan Liss, New York , pp. 247-262.
  • 20. Favus, M.J., Mangelsdorf, D.J., Tembe, V., Coe, B.J., and Haussler, M.R. (1988) Evidence for in vivo up-regulation of the intestinal vitamin D receptor during dietary calcium restriction in the rat. J. Clin. Invest. 82: 218-224.
  • 21. Baker, A.R., McDonnell D.P., Hughes, M., Crisp, T.M., Mangelsdorf, D.J., Haussler, M.R., Pike, J.W., Shine, J., and O'Malley, B.W. (1988) Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc. Natl. Acad. Sci. USA 85: 3294-3298.
  • 22. Haussler, M.R., Mangelsdorf, D.J., Komm, B.S., Terpening, C.M., Yamaoka, K., Allegretto, E.A., Baker, A.R., Shine, J., McDonnell, D.P., Hughes, M., Wiegel, N.L., O'Malley, B.W. and Pike, J.W. (1988) Molecular biology of the vitamin D hormone. In Recent Progress in Hormone Research , Vol. 44, pp. 263-305.
  • 23. Merke, J., Milde, P., Lewicka, S., Hügel, U., Klaus, G., Mangelsdorf, D.J., Haussler, M.R., Rauterberg, E.W. and Ritz, E. (1989) Identification and regulation of 1,25-dihydroxyvitamin D 3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D 3 : Studies in cultured bovine aortic endothelial cells and human dermal capillaries. J.Clin.Invest. 83: 1903-1915.
  • 24. Ishikawa, T., Umesono, K., Mangelsdorf, D.J., Aburatani, H., Stanger, B.Z., Shibasaki, Y., Imawari, M., Evans, R.M., and Takaku, F. (1990) A functional retinoic acid receptor encoded by the gene on human chromosome 12. Mol. Endocrinol . 4: 837-844.
  • 25. Schüle, R., Umesono, K., Mangelsdorf, D.J., Bolado, J., Pike, J.W., and Evans, R.M. (1990) JUN/FOS and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene. Cell 61: 497-504.
  • 26. Mangelsdorf, D.J., Ong, E.S., Dyck, J.A., and Evans, R.M. (1990) Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345: 224-229.
  • 27. Yang, N., Schüle, R., Mangelsdorf, D.J., and Evans, R.M. (1991) Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor. Proc. Natl. Acad. Sci. USA 88: 3559-3563.
  • 28. Mangelsdorf, D.J., Umesono, K., Kliewer, S.A., Borgmeyer, U., Ong, E.S., and Evans, R.M. (1991) A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell 66: 555-561.
  • 29. Kliewer , S.A. , Umesono, K., Heyman, R.A., Mangelsdorf, D.J., Dyck, J.A., and Evans, R.M. (1992) RXR/COUP-TF interactions modulate retinoic acid signalling. Proc. Natl. Acad. Sci. USA 89: 1448-1452.
  • 30. Blumberg, B., Mangelsdorf, D.J., Dyck, J.A., Bittner, D.A., Evans, R.M., and De Robertis, E.M. (1992) Multiple retinoidresponsive receptors in a single cell: Families of retinoid "X" receptors in the Xenopus egg. Proc. Natl. Acad. Sci. USA 89: 2321-2325.
  • 31. Kliewer , S.A. , Umesono, K., Mangelsdorf, D.J., and Evans, R.M. (1992) Retinoid X receptor interacts directly with nuclear receptors involved in retinoic acid, thyroid hormone, and vitamin D 3 signalling. Nature 355: 446-449.
  • 32. *Heyman, R.A., *Mangelsdorf, D.J., Dyck, J.A., Stein, R.B., Eichele, G., Evans, R.M., and Thaller, C.T. (1992) 9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68: 397-406.
  • 33. Mangelsdorf, D.J., Borgmeyer, U., Heyman, R.A., Zhou, J., Ong, E.S., Oro, A.E., Kakizuka, A., and Evans, R.M. (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 6: 329-344.
  • 34. Mangelsdorf, D.J. and Evans, R.M. (1992) Retinoid receptors as transcription factors. In Transcriptional Regulation (K. Yamamoto and S.L. McKnight, eds.), Cold Spring Harbor Press, pp. 1137-1167.
  • 35. Mangelsdorf, D.J. and Evans, R.M. (1992) Vitamin A receptors: new insights on retinoid control of transcription. In Retinoids in Normal Development and Teratogenesis (G. Morriss-Kay, ed.), Oxford University Press, pp. 27-50.
  • 36. Mangelsdorf, D.J., Kliewer , S.A. , Kakizuka, A., Umesono, K., and Evans, R.M. (1993) Retinoid receptors. In Recent Progress in Hormone Research, Vol. 48. New York , Academic Press, pp. 99-121.
  • 37. Mangelsdorf, D.J., Umesono, K., and Evans, R.M. (1994) The retinoid receptors. In The Retinoids: Biology, Chemistry, and Medicine, 2nd Edition. (M. B. Sporn, A. B. Roberts, and D. S. Goodman, eds.). New York , Raven Press, pp. 319-349.
  • 38. Kliewer , S.A. , Umesono, K., Evans, R.M, and Mangelsdorf, D.J. (1994) The retinoid X receptors: modulators of multiple hormonal signaling pathways. In Vitamin A in Health and Disease (R. Blomhoff, ed.), New York , Marcel Dekker, pp. 239-256.
  • 39. Boehm, M.F., McClurg, M.R., Pathirana, C., Mangelsdorf, D.J., White, S.K., Hebert, J., Winn, D., Goldman, M.E., and Heyman, R.A. (1994) Synthesis of high specific activity [ 3 H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. J. Med. Chem. 37: 408-414.
  • 40. Mangelsdorf, D.J. (1994) Vitamin A receptors. Nutr. Rev. 52: S32-S44.
  • 41. Almasan, A., Mangelsdorf, D.J., Ong, E.S., Wahl, G.M., and Evans, R.M. (1994) Chromosomal localization of the human retinoid X receptors. Genomics 20: 397-403.
  • 42. Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., and Evans, R. M. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91: 7355-7359.
  • 43. Willy, P.J., Umesono, K., Ong, E.S., Evans, R.M., Heyman, R.A., and Mangelsdorf, D.J. (1995) LXR, a nuclear receptor that defines a distinct retinoid-response pathway. Genes Dev. 9: 1033-1045.
  • 44. Harmon, M.A., Boehm, M.F., Heyman, R.A., and Mangelsdorf, D.J. (1995) Activation of mammalian retinoid X receptors by the insect growth regulator, methoprene. Proc. Natl. Acad. Sci. USA 92: 6157-6160.
  • 45. Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R.M. (1995) The nuclear receptor superfamily: the second decade. Cell 83: 835-839.
  • 46. Mangelsdorf, D.J. and Evans, R.M. (1995) The RXR heterodimers and orphan receptors. Cell 83: 841-850.
  • 47. Janowski, B.A., Willy, P.J., Rama Devi, T., Falck, J.R., and Mangelsdorf, D.J. (1996) Identification of an oxysterol signaling pathway mediated by the nuclear receptor, LXR a . Nature 383: 728-731.
  • 48. Willy, P.J. and Mangelsdorf, D.J. (1997) Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR. Genes Dev. 11: 289-298.
  • 49. Lala, D.S., Syka, P.M., Lazarchik, S.B., Mangelsdorf, D.J., Parker, K.L., and Heyman, R.A. (1997) Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. Proc. Natl. Acad. Sci. USA 94: 4895-4900.
  • 50. Minna, J.D. and Mangelsdorf, D.J. (1997) Retinoic acid receptor expression abnormalities in lung cancer: important clues or major obstacles? J. Natl. Cancer Inst . 89: 602-604.
  • 51. Robertson, D.W., Willy, P.J., Heyman, R.A., and Mangelsdorf, D.J. (1997) Chapter 25. Nuclear orphan receptors: Scientific progress and therapeutic opportunities. In Annual Reports in Medicinal Chemistry , Vol. 32 (J.A. Bristol, ed.), San Diego, Academic Press, Inc., pp.251-260.
  • 52. Harmon, M.A., Scott, T.C., Li, Y., Boehm, M.F., Phillips, M.A., and Mangelsdorf, D.J. (1997) Trypanosoma brucei : Effects of methoprene and other isoprenoid compounds on procyclic and bloodstream forms in vitro and in mice. Experimental Parasitology 87: 229-236.
  • 53. Guo, X., Harmon, M.A., Laudet, V., Mangelsdorf, D.J., and Palmer, M.J. (1997) Isolation of a functional ecdysteroid receptor homologue from the ixodid tick Amblyomma americanum (L.). J. Insect Biochem. Mol. Biol. 27: 945-962.
  • 54. Willy, P.J. and Mangelsdorf, D.J. (1998) Nuclear orphan receptors: the search for novel ligands and signaling pathways. In Hormones and Signaling , Vol. 1 (B.W. O'Malley, ed.), San Diego, Academic Press, Inc., pp.307-358.
  • 55. Peet, D.J., Doyle, D.F., Corey, D.R., and Mangelsdorf, D.J. (1998) Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR. Chemistry & Biology 5: 13-21.
  • 56. Sun, T., Zhao, Y., Mangelsdorf, D.J., and Simpson, E.R. (1998) Characterization of a Region Upstream of Exon I.1 of the Human CYP19 (Aromatase) Gene That Mediates Regulation by Retinoids in Human Choriocarcinoma Cells. Endocrinology 139: 1684-1691.
  • 57. Peet, D.J., Turley , S.D. , Ma, W., Janowski, B.A., Lobaccaro, J.A., Hammer, R.E., and Mangelsdorf, D.J. (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor, LXR a . Cell 93: 693-704.
  • 58. Guo, X., Xu, Q., Harmon, M.A., Jin, X., Laudet, V., Mangelsdorf, D.J. and Palmer, M.J. (1998) Isolation of two functional retinoid X receptor subtypes from the ixodid tick, Amblyomma americanum (L.). Mol. Cell. Endocrinol. 139: 45-60.
  • 59. Peet, D.J., Janowski, B.A. and Mangelsdorf, D.J. (1998) The LXRs: a new class of oxysterol receptors. Current Opinion in Genetics & Development 8: 571-575.
  • 60. Hu, X., White, K.M., Jacobsen, N.E., Mangelsdorf, D.J., and Canfield, L.M. (1998) Inhibition of growth and cholesterol synthesis in breast cancer cells by oxidation products of gamma-carotene. J. Nutr. Biochem 9: 567-574.
  • 61. Wang, M., Koyama, K., Shimabukuro, M., Mangelsdorf, D.J., Newgard, C.B., and Unger, R.H. (1999) Overexpression of Leptin Receptors (OB-Rb) in Pancreatic Islets of Zucker Diabetic Fatty Rats Restores GLUT-2, Glucokinase and Glucose-Stimulated Insulin Secretion. Proc. Natl. Acad. Sci USA 95: 11921-11926.
  • 62. Janowski, B.A., Grogan, M.J., Jones, S.A., Wisely, G.B., Kliewer, S.A., Corey, E.J., and Mangelsdorf, D.J. (1999) Structural requirements of ligands for the oxysterol receptors LXR a and LXR b . Proc. Natl. Acad. Sci USA 96: 266-271.
  • 63. Lee, H., Sueoka, N., Hong, W., Mangelsdorf, D.J., Claret, F.X., and Kurie, J.M. (1999) All-trans-Retinoic Acid Inhibits Jun N-Terminal Kinase by Increasing Dual-Specificity Phosphatase Activity. Mol. Cell. Bio. 19: 1973-1980.
  • 64. Suh, N., Wang, Y., Honda, T., Gribble, G.W., Dmitrovsky, E., Hickey, W.F., Maue, R.A., Place, A.E., Porter, D.M., Spinella, M.J., Williams, C.R., Wu, G., Dannenberg, A.J., Flanders, K.C., Letterio, J.J., Mangelsdorf, D.J., Nathan, C.F., Nguyen, L., Porter, W.W., Ren, R.F., Roberts, A.B., Roche, N.S., Subbaramaiah, K., and Sporn, M.B. (1999) A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-Dioxoolean-1,9-Dien-28-Oic Acid (CDDO), With Potent Differentiating, Anti-Proliferative, and Anti-Inflammatory Activity. Cancer Res. 59: 336-341.
  • 65. Makishima, M., Okamoto, A.Y., Repa, J.J., Tu, H., Learned, R.M., Luk, A., Hull, M.V., Lustig, K.D., Mangelsdorf, D.J., and Shan, B. (1999) Identification of a nuclear receptor for bile acids. Science 284: 1362-1365.
  • 66. Makishima, M. and Mangelsdorf, D.J. (1999) A new function of bile acids as ligands for nuclear hormone receptors. Experimental Medicine 17: 1333-1335.
  • 67. Repa, J.J. and Mangelsdorf, D.J. (1999) Nuclear receptor regulation of cholesterol and bile acid metabolism. Curr. Opin. in Biotech. 10: 557-563.
  • 68. Alberts, D.S., Colvin, O.M., Conney, A.H., Ernster, V.L., Garber, J.E., Greenwald, P., Gudas, L.J., Ki Hong, W., Kelloff, G.J., Kramer, R.A., Lerman, C.E., Mangelsdorf, D.J., Matter, A., Minna, J.D., Nelson, V, W.G., Pezzuto, J.M.,Prendergast, F., Rusch, V.W., Sporn, M.B., Wattenberg, L.W., and Weinstein, I.B. (1999) Prevention of Cancer in the Next Millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research. Cancer Research 59: 4743-4758.
  • 69. Doyle, D.F., Mangelsdorf, D.J., and Corey, D.R. (2000) Modifying ligand specificity of gene regulatory proteins. Curr. Opin. in Chemical Biology 4: 60-63.
  • 70. Denson, L.A. , Auld, K.L., Schiek, D.S., McClure, M.H., Mangelsdorf, D.J., and Karpen, S.J. (2000) "Interleukin-1 b suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation." J. Biol. Chem. 275: 8835-8843.
  • 71. Venkateswaran, A., Repa, J.J., Lobaccaro, J.A., Bronson, A., Mangelsdorf, D.J., and Edwards, P.A. (2000) Human White/Murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages: a transcriptional role for specific oxysterols. J. Biol. Chem. 275:14700-14707.
  • 72. Wan, Y.-J., An, D., Cai, Y., Repa, J.J., Chen, T.H.-P., Flores , M., Postic, K., Mangnuson, M.A., Chen, J., Chien, K.R., French, S., Mangelsdorf, D.J., and Sucov, H.M. (2000) Hepatocyte-specific mutation establishes RXR as a heterodimeric integrator of multiple physiological processes in the liver. Mol. Cell. Biol. 20: 4436-4444.
  • 73. Repa, J.J., Turley, S.D., Lobaccaro, J.A., Medina, J., Li, L., Lustig, K., Shan , B., Heyman, R.A., Dietschy, J.M., and Mangelsdorf, D.J. (2000) Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289: 1524-1529.
  • 74. Baker, K.D., Warren , J.T., Thummel, C.S., Gilbert, L.I., and Mangelsdorf, D.J. (2000) Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids. Insect Biochem. & Mol. Biol . 30: 1037-1043.
  • 75. Lu, T.T., Makishima, M., Repa, J.J., Schoonjans, K., Kerr, T.A., Auwerx, J., and Mangelsdorf, D.J. (2000) Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Molecular Cell 6: 507-515.
  • 76. Repa, J.J. and Mangelsdorf, D.J. (2000) The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Ann. Rev. Cell & Develop. Biol. 16: 459-481.
  • 77. Lee, H.-Y., Suh, Y., Robinson, M.J., Clifford, J.L., Hong, W.K., Woodgett, J.R., Cobb, M.H., Mangelsdorf, D.J., and Kurie, J. M. (2000) Stress pathway activation induces phosphorylation of retinoid X receptor. J. Biol. Chem. 275: 32193-32199.
  • 78. Repa, J.J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J-M.A., Shimomura, I., Shan, B., Brown, M.S., Goldstein, J.L., and Mangelsdorf, D.J. (2000) Regulation of mouse sterol regulatory element binding protein-1c (SREBP-1c) by oxysterol receptors, LXR a and LXR b . Genes & Dev. 14:2819-2830.
  • 79. Schultz, J.R., Tu, H. Luk, A., Repa, J.J., Medina, J.C., Li, L., Schwender, S., Wang, S., Thoolen, M., Mangelsdorf, D. J., Lustig, K.D., Shan, B. (2000) Role of LXRs in control of lipogenesis. Genes & Dev. 14: 2831-2838.
  • 80. Auwerx, J., and Mangelsdorf, D. (2000) X-ceptors, nuclear receptors for metabolism. In Atherosclerosis XII , ( S. Stemme and A.G. Olsson, ed.), Amsterdam , Elsevier Science, pp. 21-39.
  • 81. Schoonjans, K., Brendel, C., Mangelsdorf, D., and Auwerx, J. (2000) Sterols and gene expression: control of affluence. Biochimica Et Biophysica Acta 1529: 114-125.
  • 82. Wang, Y., Porter, W.W., Suh, N., Honda, T., Gribble, G.W., Lessnitzer, L.M., Plunket, K.D., Mangelsdorf, D.J., Blanchard, S.G., Willson, T.M., and Sporn, M.B. (2000) A Synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid ( CDDO), is a ligand for the peroxisome proliferator-activated receptor g . Mol. Endoc . 14: 1550-1556.
  • 83. Hanley, K., Ng, D.C., He, S.S., Lau, P., Min, K., Elias, P.M., Bikle, D.D., Mangelsdorf, D.J., Williams, M.L., Feingold, K.R. (2000) Oxysterols induce differentiation in human keratinocytes and increase AP-1-depdendent involucrin transcription. J. Invest. Derm. 114:545-553.
  • 84. Laffitte, B.A., Repa, J.J, Joseph, S.B., Wilpitz , D.C. , Kast, H.R., Mangelsdorf, D.J., and Tontonoz, P. (2001) LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc. Natl. Acad. Sci. USA 98: 507-512.
  • 85. Claudel, T., Leibowitz, Fievet, C., Tailleux, A., Wagner, B., Repa, J.J., Torpier, G., Lobaccaro, J-M., Paterniti, J.R., Mangelsdorf, D.J., Heyman, R.A., and Auwerx, J. (2001) Reduction of atherosclerosis in apolipoprotein E knock-out mice by activation of the retinoid X receptor. Proc. Natl. Acad. Sci. USA , 98:2610-2615.
  • 86. Denson, L.A. , Sturm, E., Echevarria, W., Zimmerman, T.L., Makishima, M., Mangelsdorf, D.J., and Karpen, S.J. (2001) The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology 121: 140-147.
  • 87. Lobaccaro, J.-M.A., Repa, J.J., Lu, T.T., Caira, F., Henry-Berger,J., Volle, D.H., and Mangelsdorf, D.J. (2001) Regulation of lipid metabolism by the orphan receptors. Ann.Endocrinol. 62(3): 239-247.
  • 88. Lu, T.T., Makishima, M., Repa, J.J. and Mangelsdorf, D.J. (2001) Adolf Windaus Prize lecture: Nuclear orphan receptor regulation of cholesterol and bile acid homeostasis. In Biology of Bile Acids in Health and Disease-Falk Symposium 120 (van Berge Henegouwen et al, ed.), Kluwer Academic Publishers, Lancaster , UK , pp. 28-36.
  • 89. Sporn, M., Suh, N., and Mangelsdorf, D.J. (2001) Prospects for prevention and treatment of cancer with SPARMs (selective PPAR g modulators). Trends in Molecular Medicine 7: 395-400.
  • 90. Repa, J., Makishima, M., Lu, T.T., and Mangelsdorf, D.J. (2001) Orphan nuclear receptors and the regulation of cholesterol and bile acid metabolism. In The Liver: Biology and Pathobiology, Fourth Edition (Arias et al, ed.) Lippincott Williams & Wilkins, New York , NY , pp. 1029-1040.
  • 91. Lu, T.T., Repa, J.J., and Mangelsdorf, D.J. (2001) Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J.Biol.Chem., 276:37735-37738.
  • 92. Chawla, A., Repa, J.J., Evans, R.M. and Mangelsdorf, D.J. (2001) Nuclear receptors and lipid physiology: opening the X-files. Science 294: 1866-1870.
  • 93. Ananthanarayanan, M., Balasubramanian, N., Makishima, M., Mangelsdorf, D.J., and Suchy, F.J. (2001) Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J.Biol.Chem., 276:28857-28865.
  • 94. Zhang, Y., Repa, J.J., Gauthier, K., Mangelsdorf, D.J. (2001) Regulation of lipoprotein lipase by the oxysterol receptors, LXR a and LXR b . J.Biol.Chem. 276:43018-43024.
  • 95. Doyle, D.F., Braasch, D.A., Jackson , L.K., Weiss, H.E., Boehm, M.F., Mangelsdorf, D.J., and Corey, D. R. (2001) Engineering orthogonal ligand-receptor pairs from “near drugs”. J. Am. Chem. Soc., 123:11367-11371.
  • 96. Kömüves, L., Schumuth, M., Fowler, A.J. Elias, P.M., Hanley, K., Man, M-Q., Moser, A.H., Lobaccaro, J-M. A., Williams, M.L., Mangelsdorf, D.J., and Feingold, K.R. (2002) Oxysterol stimulation of epidermal differentiation is mediated by LXR- b in murine epidermis. J. Invest. Derm., 118:25-34.
  • 97. Makishima, M., Lu, T.T., Xie, W., Whitfield, G.K., Domoto, H., Evans, R.M., Haussler, M.R., and Mangelsdorf, D.J. (2002) Vitamin D receptor as an intestinal bile acid sensor. Science 296:1313-1316.
  • 98. Jung, D., Podvinec, M., Meyer, U.A., Mangelsdorf, D.J., Fried, M., Meier, P.J., and Kullak-Ublick, G.A. (2002) Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Gastroenterology 122:1954-1966.
  • 99. Zhang, Y. and Mangelsdorf, D. (2002) LuXuRies of lipid homeostasis: The unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing. Molecular Interventions 2:78-87.
  • 100. Urizar, N.L., Liverman, A.B., Dodds, D.T., Silva, F. V., Ordentlich, P., Yingzhuo, Y., Gonzalez, F.J., Heyman, R.A., Mangelsdorf, D.J. and Moore, D.D. (2002) A natural product that lowers cholesterol targets the farnesoid X receptor. Science 296 : 1703-1706 .
  • 101. Repa, J.J., Berge, K.E., Pomajzl, C., Richardson, J.A., Hobbs, H., and Mangelsdorf, D.J. (2002) Regulation of ATP-binding cassette sterol transporters, ABCG5 and ABCG8, by the liver X receptors a and b . J.Biol.Chem. 277:18793-18800 .
  • 102. Mak, P.A., Laffitte, B.A., Desrumaux, C., Joseph, S.B., Curtiss, L.K., Mangelsdorf, D.J., Tontonoz, P., and Edwards, P.A. (2002) Regulated expression of the ApoE/C-I/C-IV/C-II gene cluster in murine and human macrophages; a critical role for the nuclear receptors LXR a and LXR b . J.Biol.Chem. 277:31900-31908 .
  • 103. Lee, Y., Yu, X. Gonazles, F., Mangelsdorf, D.J., Wang, M-Y., Richarson, C., Witters, L.A., and Unger, R.H. (2002) PPAR a is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc. Natl. Acad. Sci. USA 99:11848-11853 .
  • 104. Tangirala, R.K, Bischoff, E.D., Joseph, S.B., Wagner, B.L, Walczak, R., Laffitte, B.A., Daige, C.L., Thomas, D., Heyman, R.A., Mangelsdorf, D.J., Wang, X., Lusis, A.J., Tontonoz, P., and Schulman, I.G. (2002) Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc. Natl. Acad. Sci. USA 99:11896-11901.
  • 105. Tanaka, T., Takeno, T., Watanabe, Y., Uchiyama, Y., Murakami, T., Yamashita, H., Suzuki, A., Aoi, R., Iwanari, H., Jiany, S-Y., Naito, M., Tachibana, K., Doi, T., Shulman, A.I., Mangelsdorf, D.J., Reiter, R., Auwerx, J., Hamakubo, T., and Kodama, T., (2002) The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs). J. Atherosclerosis and Thrombosis 9:233-242.
  • 106. Repa, J.J. and Mangelsdorf, D.J. (2002) The liver X receptor gene team: potential new players in atherosclerosis. Nature Medicine 8:1243-1248.
  • 107. Goodwin, B.J., Gauthier, K.C., Umetani, M., Watson, M.A., Lochansky, M.I., Collins, J.L., Leitersdorf, E., Mangelsdorf, D.J., Kliewer, S.A., and Repa, J.J. (2003) Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic receptor PXR. Proc. Natl. Acad. Sci. USA 100:223-228 .
  • 108. Lu, T.T., Makishima, M., and Mangelsdorf, D.J. (2003) Vitamin D receptor as a bile acid sensor. In: Falk Sympsium 129 – Bile Acids: From Genomics to Disease and Therapy (G. Paumgartner, ed.) Kluwer Academic Publishers, London , UK , pp.39-45.
  • 109. Fowler, A.J., Sheu, M.Y., Schmuth, M., Kao, J., Fluhr, J.W., Rhein, L., Collins, J.L., Willson, T.M., Mangelsdorf, D.J., Elias, P.M., and Feingold, K.R. (2003) LXR activatators display anti-inflammatory activity in irritant and allergic contact dermatitis models: LXR-specific inhibition of inflammation and primary cytokine production. J. Invest. Dermatol. 120 :246 -255 .
  • 110. Joseph, S.B., Castrillo, A., Laffitte, B.A., Mangelsdorf, D.J., and Tontonoz, P. (2003) Reciprocal regulation of inflammation and lipid metabolism by LXRs. Nature Medicine 9:213-219.
  • 111. Laffitte, B.A., Joseph, S.B., Chen, M-Y., Repa, J., Wilpitz, D., Mangelsdorf, D., and Tontonoz, P. (2003) The phospholipid transfer protein gene is an LXR target gene expressed by macrophages in atherosclerotic lesions. Molecular and Cellular Biology 23:2182-2191 .
  • 112. Choi, M., Yamamoto, K., Itoh, T., Makishima, M., Mangelsdorf, D., Moras, D., DeLuca, H.F., Yamada, S. (2003) Interaction between vitamin D receptor and vitamin D Ligands: Two-dimensional alanine scanning mutational analysis. Chemistry & Biology 10:1-20.
  • 113. Baker, K.D., Shewchuk, L.M., Kozlova, T., Makishima, M., Hassell, A., Wisely, B., Caravella, J.A., Lambert, M.H., Reinking, J.L., Krause, H., Thummel, C.S., Willson, T.M., Mangelsdorf, D.J. (2003) The Drosophia orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell 113:731-742.
  • 114. Castrillo, A., Joseph, S.B., Marathe, C., Mangelsdorf, D.J., Tontonoz, P. (2003) Liver X receptor dependent repression of Matrix metalloproteinase-9 expression in macrophages. J.Biol.Chem. 278:10443-10449 .
  • 115. Tontonoz, P., Mangelsdorf, D.J. (2003) Liver X receptor signaling pathways in cardiovascular disease. Molecular Endocrinology 17:985-993.
  • 116. Cheng, J.B., Motola, D.L., Mangelsdorf, D.J., and Russell, D.W. (2003) De-orphanization of cytochrome P450 2R1: A microsomal vitamin D 25-hydroxylase. J.Biol.Chem . 278:38084-38093 .
  • 117. Russell, D.W., and Mangelsdorf, D.J. (2003) Methods in Enzymology, Volume 364:Nuclear Receptors . (D. Russell and D. Mangelsdorf, ed) Elsevier Inc Publishers, San Diego , CA .
  • 118. Bookout, A.L., and Mangelsdorf, D.J. (2003) A quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. NURSA e-Journal 1, 6 ID#1.11082003.1.
  • 119. Hinshelwood, M.M., Repa, J.J., Shelton , J.M., Richardson , J.A., Mangelsdorf, D.J., and Mendelson, C.R. (2003) Expression of LRH-1 and SF-1 in the mouse ovary: Localization in different cell types correlates with differing function. Molecular and Cellular Endocrinology 207:39-45.
  • 120. Shulman, A.I., Larson, C., Mangelsdorf, D.J. and Ranganathan, R. (2004) Molecular basis of allosteric ligand activation in RXR heterodimers. Cell 116:417-429.
  • 121. Adachi, R., Shulman, A.I., Yamamoto, K., Shimomura, I. , Yamada, S., Mangelsdorf, D.J., Makishima, M. (2004) Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. Molecular Endocrinology 18:43-52.
  • 122. Volle, D.H., Repa, J.J., Mazur, A., Cummins, C.L., Val, P., Henry-Berger, J., Caira, F., Veyssiere, G., Mangelsdorf, D.J., Lobaccaro, J.-M.A. (2004) Regulation of the Aldo-Keto reductase gene akr1b7 by the nuclear oxysterol receptor LXR-alpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Molecular Endocrinology 18:888-898.
  • 123. Zhang, Y., Repa, J.J., Inoue, Y., Hayhurst, G.P., Gonzalez, F.J., and Mangelsdorf, D.J. (2004) Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Molecular Endocrinology18:851-862.
  • 124. Watanabe, M., Houten, S.M., Wang, L., Moschetta, A., Mangelsdorf, D.J., Heyman, R.A., Moore, D.D., Auwerx, J. (2004) Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J.Clin.Invest. 113:1408-1418.
  • 125. Cheng, J.B., Levine, M.A., Bell , N.H. , Mangelsdorf, D.J., and Russell, D.W. (2004) Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc. Natl. Acad. Sci. USA., 101:7711-7715 .
  • 126. Moschetta, A., Bookout, A.L., Mangelsdorf, D.J. (2004) Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. 10: 1352-1358.
  • 127. Motola, D.L. and Mangelsdorf, D.J. (2005) Vitamin D receptor as a sensor for toxic bile acids. In: Vitamin D, Second Edition (David Feldman, ed), Elsevier Inc Publishers, San Diego, CA, Chapter 53, 863-870.
  • 128. Frenoux, J-M, Vernet, P., Volle, D.H., Britan, A., Saez, F., Kocer, A., Henry-Berger, J., Mangelsdorf, D.J., Lobaccaro, J-M.A., Drevet, J.R. (2004) Nuclear oxyxterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions. J. Mol. Endoc. 33: 361-375.
  • 129. Arai, S., Shelton , J.M., Chen, M., Bradley, M.N., Castrillo, A., Bookout, A.L., Mak, P.A., Edwards, P.A., Mangelsdorf, D.J., Tontonoz, P. Miyazaki, T. (2005) A role for the apoptosis inhibitory factor AIM/Sp a /Api6 in atherosclerosis development. Cell Metabolism1: 201-213.
  • 130. Yu L., Gupta S., Xu F., Liverman A.D.B., Moschetta A., Mangelsdorf D.J., Repa J.J., Hobbs H.H., Cohen J.C. (2005) Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. J. Biol. Chem. 280: 8742-8747
  • 131. Kalaany , N.Y. , Gauthier, K.C., Zavacki, A.M., Mammen, P.P.A., Kitazume,T., Peterson, J., Horton, J.D., Garry, D.J., Bianco, A.C., Mangelsdorf, D.J. (2005) LXRs Regulate the Balance Between Fat Storage and Oxidation. Cell Metabolism 1: 231-244.
  • 132. Shulman, A.I. and Mangelsdorf, D.J. (2005) RXR heterodimers in the metabolic syndrome. New England J. Med. 353: 604-615 .
  • 133. Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C., McDonald, J.G., Luo, G., Jones, S.A., Goodwin, B., Richardson, J.A., Gerard, R.D., Repa, J.J., Mangelsdorf, D.J., and Kliewer, S.A. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metabolism 2: 1-9.
  • 134. Fu, M., Sun, T., Bookout, A.L., Downes, M. Yu, R.T., Evans, R.M., Mangelsdorf, D.J. (2005) A Nuclear Receptor Atlas: 3T3-L1 Adipogenesis. Mol. Endo. 19: 2437-2450.
  • 135. Barish, G.D., Downes, M., Alaynick, W.A., Yu, R.T., Ocampo, C.B., Bookout, A.L., Mangelsdorf, D.J., and Evans, R.M. (2005) A Nuclear Receptor Atlas: Macrophage Activation. Mol. Endo.19: 2466-2477.
  • 136. Kalaany , N.Y. and Mangelsdorf, D.J. (2006) The yin and yang of cholesterol and fat metabolism. Ann. Rev. of Physiology 68: 159-191 (E Pub doi:10.1146/annurev.physiol.68.033104.152158) .
  • 137. Inagaki, T., Moschetta, A., Lee, Y.K., Peng, Li, Zhao, G., Downes, M., Yu, R.T., Shelton, J.M., Richardson, J.A., Repa, J.J., Mangelsdorf, D.J., Kliewer, S.A. (2006) Regulation of antibacterial defense in small intestine by the nuclear bile acid receptor. Proc. Natl. Acad. Sci. USA, 103: 3920-3925 .
  • 138. Rottiers, V., Motola, D.L., Gerisch, B., Cummins, C.L., Nishiwaki, K., Mangelsdorf, D.J., Antebi, A. (2006) Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Dev. Cell 10:473-482.
  • 139. Motola, D.L., Cummins, C.L., Rottiers, V., Sharma, K.K., Li, T., Li, Y., Suino-Powell, K., Xu, H.E., Auchus, R.J., Antebi, A., Mangelsdorf, D.J. (2006) Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell 124: 1209-1223 .
  • 140. Cummins, C.L., Volle, D.H., Zhang, Y., McDonald, J.G., Sion, B., Lefrancois-Martinez, A-M., Caira, F., Veyssiere, G., Mangelsdorf, D.M., Lobaccaro, J-M. (2006) Liver X receptors regulate adrenal cholesterol balance. J Clin. Invest. 116: 1902-1912.
  • 141. Jung, D., Mangelsdorf, D.J., Meyer, U.A. (2006) PXR is a target of FXR. J. Biol. Chem. 281: 19081-19091.
  • 142. Bookout, A.L., Jeong, Y., Downes, M., Yu, R.T., Evans, R.M., Mangelsdorf, D.M. (2006) Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell. 126: 789-799.
  • 143. Yang, X., Downes M., Yu, R.T., Bookout, A.L., He, W., Straume, M., Mangelsdorf, D.J., Evans, R.M. (2006) Nuclear receptor expression links the circadian clock to metabolism. Cell126: 801-810.
  • 144. Yang, C., McDonald, J.G., Patel, A., Zhang, Y., Umetani, M., Xu, F., Mangelsdorf, D.J., Westover, E.J., Covey, D.F., Cohen, J.C., Hobbs , H.H. (2006) Sterol intermediates from cholesterol biosynthetic pathway as LXR ligands. J. Biol. Chem. 281: 27816-27826.
  • 145. Choi, M., Moschetta, A., Bookout, A.L., Umetani, M., Holmstrom, S., Peng, L., Suino-Powell, K., Xu, H.E., Richardson, J.A., Gerard, R.D., Mangelsdorf, D.J., Kliewer, S.A. (2006) Identification of a hormonal basis for gallbladder filling. Nature Medicine12 : 1253-1255.
  • 146. Germain, P., Chambon P., Eichele G., Evans, R.M., Lazar, M.A., Leid M., De Lera, A.R., Lotan, R., Mangelsdorf D.J., Gronemeyer, H. (2006) International Union of Pharmacology, LX. Retinoic acid receptors. Pharmacol. Rev. 58: 712-725.
  • 147. Moore, DD, Kato S., Xie, W., Mangelsdorf, D.J., Schmidt, D.R., Xiao, R., Kliewer, S.A. (2006) International Union of Pharmacology, LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacol. Rev. 58: 742-759.
  • 148. Germain, P., Chambon P., Eichele G., Evans, R.M., Lazar, M.A., Leid M., De Lera, A.R., Lotan, R., Mangelsdorf D.J., Gronemeyer, H. (2006) International Union of Pharmacology, LXIII. Retinoid X receptors. Pharmacol. Rev. 58: 760-772.
  • 149. Cummins, C.L., Mangelsdorf, D.J. (2006) Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland. Biochem. Soc. Trans. 34: 1110-1113.
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