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Publications 2004-present

  1. Shulman, A.I., Larson, C., Mangelsdorf, D.J. and Ranganathan, R. (2004) Molecular basis of allosteric ligand activation in RXR heterodimers. Cell 116:417-429.
  2. Adachi, R., Shulman, A.I., Yamamoto, K., Shimomura, I. , Yamada, S., Mangelsdorf, D.J., Makishima, M. (2004) Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. Molecular Endocrinology 18:43-52.
  3. Volle, D.H., Repa, J.J., Mazur, A., Cummins, C.L., Val, P., Henry-Berger, J., Caira, F., Veyssiere, G., Mangelsdorf, D.J., Lobaccaro, J.-M.A. (2004) Regulation of the Aldo-Keto reductase gene akr1b7 by the nuclear oxysterol receptor LXR-alpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Molecular Endocrinology 18:888-898.
  4. Zhang, Y., Repa, J.J., Inoue, Y., Hayhurst, G.P., Gonzalez, F.J., and Mangelsdorf, D.J. (2004) Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Molecular Endocrinology 18:851-862.
  5. Watanabe, M., Houten, S.M., Wang, L., Moschetta, A., Mangelsdorf, D.J., Heyman, R.A., Moore, D.D., Auwerx, J. (2004) Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J.Clin.Invest. 113:1408-1418.
  6. Cheng, J.B., Levine, M.A., Bell , N.H. , Mangelsdorf, D.J., and Russell, D.W. (2004) Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc. Natl. Acad. Sci. USA., 101:7711-7715 .
  7. Moschetta, A., Bookout, A.L., Mangelsdorf, D.J. (2004) Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. 10: 1352-1358.
  8. Motola, D.L. and Mangelsdorf, D.J. (2005) Vitamin D receptor as a sensor for toxic bile acids. In: Vitamin D, Second Edition (David Feldman, ed), Elsevier Inc Publishers, San Diego, CA, Chapter 53, 863-870.
  9. Frenoux, J-M, Vernet, P., Volle, D.H., Britan, A., Saez, F., Kocer, A., Henry-Berger, J., Mangelsdorf, D.J., Lobaccaro, J-M.A., Drevet, J.R. (2004) Nuclear oxyxterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions. J. Mol. Endoc. 33: 361-375.
  10. Arai, S., Shelton , J.M., Chen, M., Bradley, M.N., Castrillo, A., Bookout, A.L., Mak, P.A., Edwards, P.A., Mangelsdorf, D.J., Tontonoz, P. Miyazaki, T. (2005) A role for the apoptosis inhibitory factor AIM/Sp a /Api6 in atherosclerosis development. Cell Metabolism 1: 201-213.
  11. Yu L., Gupta S., Xu F., Liverman A.D.B., Moschetta A., Mangelsdorf D.J., Repa J.J., Hobbs H.H., Cohen J.C. (2005) Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. J. Biol. Chem. 280: 8742-8747 .
  12. Kalaany , N.Y. , Gauthier, K.C., Zavacki, A.M., Mammen, P.P.A., Kitazume,T., Peterson, J., Horton, J.D., Garry, D.J., Bianco, A.C., Mangelsdorf, D.J. (2005) LXRs Regulate the Balance Between Fat Storage and Oxidation. Cell Metabolism 1: 231-244.
  13. Shulman, A.I. and Mangelsdorf, D.J. (2005) RXR heterodimers in the metabolic syndrome. New England J. Med. 353: 604-615 .
  14. Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C., McDonald, J.G., Luo, G., Jones, S.A., Goodwin, B., Richardson, J.A., Gerard, R.D., Repa, J.J., Mangelsdorf, D.J., and Kliewer, S.A. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metabolism 2: 1-9.
  15. Fu, M., Sun, T., Bookout, A.L., Downes, M. Yu, R.T., Evans, R.M., Mangelsdorf, D.J. (2005) A Nuclear Receptor Atlas: 3T3-L1 Adipogenesis. Mol. Endo. 19: 2437-2450.
  16. Barish, G.D., Downes, M., Alaynick, W.A., Yu, R.T., Ocampo, C.B., Bookout, A.L., Mangelsdorf, D.J., and Evans, R.M. (2005) A Nuclear Receptor Atlas: Macrophage Activation. Mol. Endo. 19: 2466-2477.
  17. Kalaany , N.Y. and Mangelsdorf, D.J. (2006) The yin and yang of cholesterol and fat metabolism. Ann. Rev. of Physiology 68: 159-191 (E Pub doi:10.1146/annurev.physiol.68.033104.152158) .
  18. Inagaki, T., Moschetta, A., Lee, Y.K., Peng, Li, Zhao, G., Downes, M., Yu, R.T., Shelton, J.M., Richardson, J.A., Repa, J.J., Mangelsdorf, D.J., Kliewer, S.A. (2006) Regulation of antibacterial defense in small intestine by the nuclear bile acid receptor. Proc. Natl. Acad. Sci. USA, 103: 3920-3925 .
  19. Rottiers, V., Motola, D.L., Gerisch, B., Cummins, C.L., Nishiwaki, K., Mangelsdorf, D.J., Antebi, A. (2006) Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Dev. Cell 10:473-482.
  20. Motola, D.L., Cummins, C.L., Rottiers, V., Sharma, K.K., Li, T., Li, Y., Suino-Powell, K., Xu, H.E., Auchus, R.J., Antebi, A., Mangelsdorf, D.J. (2006) Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell 124: 1209-1223 .
  21. Cummins, C.L., Volle, D.H., Zhang, Y., McDonald, J.G., Sion, B., Lefrancois-Martinez, A-M., Caira, F., Veyssiere, G., Mangelsdorf, D.M., Lobaccaro, J-M. (2006) Liver X receptors regulate adrenal cholesterol balance. J Clin. Invest. 116: 1902-1912.
  22. Jung, D., Mangelsdorf, D.J., Meyer, U.A. (2006) PXR is a target of FXR. J. Biol. Chem. 281: 19081-19091.
  23. Bookout, A.L., Jeong, Y., Downes, M., Yu, R.T., Evans, R.M., Mangelsdorf, D.M. (2006) Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell . 126: 789-799.
  24. Yang, X., Downes M., Yu, R.T., Bookout, A.L., He, W., Straume, M., Mangelsdorf, D.J., Evans, R.M. (2006) Nuclear receptor expression links the circadian clock to metabolism. Cell 126: 801-810.
  25. Yang, C., McDonald, J.G., Patel, A., Zhang, Y., Umetani, M., Xu, F., Mangelsdorf, D.J., Westover, E.J., Covey, D.F., Cohen, J.C., Hobbs , H.H. (2006) Sterol intermediates from cholesterol biosynthetic pathway as LXR ligands. J. Biol. Chem. 281: 27816-27826.
  26. Choi, M., Moschetta, A., Bookout, A.L., Umetani, M., Holmstrom, S., Peng, L., Suino-Powell, K., Xu, H.E., Richardson, J.A., Gerard, R.D., Mangelsdorf, D.J., Kliewer, S.A. (2006) Identification of a hormonal basis for gallbladder filling. Nature Medicine 12 : 1253-1255.
  27. Germain, P., Chambon P., Eichele G., Evans, R.M., Lazar, M.A., Leid M., De Lera, A.R., Lotan, R., Mangelsdorf D.J., Gronemeyer, H. (2006) International Union of Pharmacology, LX. Retinoic acid receptors. Pharmacol. Rev. 58: 712-725.
  28. Moore, DD, Kato S., Xie, W., Mangelsdorf, D.J., Schmidt, D.R., Xiao, R., Kliewer, S.A. (2006) International Union of Pharmacology, LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacol. Rev. 58: 742-759.
  29. Germain, P., Chambon P., Eichele G., Evans, R.M., Lazar, M.A., Leid M., De Lera, A.R., Lotan, R., Mangelsdorf D.J., Gronemeyer, H. (2006) International Union of Pharmacology, LXIII. Retinoid X receptors. Pharmacol. Rev. 58: 760-772.
  30. Cummins, C.L., Mangelsdorf, D.J. (2006) Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland. Biochem. Soc. Trans. 34: 1110-1113.
  31. Chen, W., Chen, G., Head, D.L., Mangelsdorf, D.J., Russell, D.W. (2007) Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metabolism 5, 73-79.
  32. Wang, Z., Cummins, C.L., Motola, D.L., Mangelsdorf, D.J. (2007) Bile acid-like hormones function as ligands for the nematode orphan nuclear receptor DAF-12 and govern dauer formation, reproduction and lifespan. In: Bile Acids: Biological Actions and Clinical Relevance—Falk Symposium 155, in press.
  33. Uppal, H., Saini, S.P.S., Moschetta, A., Mu, Y., Zhou, J., Gong, H., Zhai, Y., Ren, S., Michalopoulos, G.K., Mangelsdorf, D.J., Xie, W. (2007) Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology, in press.
  34. Baker, K.D., Beckstead, R.B., Mangelsdorf, D.J., Thummel, C.S. (2007) Functional Interactions between the Moses Corepressor and DHR78 Nuclear Receptor Regulate Growth in Drosophila. Genes and Dev., in press.
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