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Publications 2007-present



1.  Chen, W., Chen, G., Head, D.L., Mangelsdorf, D.J., Russell, D.W. (2007) Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metabolism 5: 73-79.   PMID: 17189208

2.  Uppal, H., Saini, S.P.S., Moschetta, A., Mu, Y., Zhou, J., Gong, H., Zhai, Y., Ren, S., Michalopoulos, G.K., Mangelsdorf, D.J., Xie, W. (2007) Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology 45: 422-432.  PMID: 17256725

3.  Baker, K.D., Beckstead, R.B., Mangelsdorf, D.J., Thummel, C.S. (2007) Functional interactions between the moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Genes Dev. 21: 450-64.  PMID: 17322404. PMCID: 1804333

4.  Gerisch, B., Rottiers, V., Li, D., Motola, D.L., Cummins, C.L., Lehrach, H., Mangelsdorf, D.J., Antebi, A. (2007) A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 104: 5014-5019.  PMID: 17360327. PMCID: 1821127.

5.  Wang, Z., Cummins, C.L., Motola, D.L., Mangelsdorf, D.J. (2007) Bile acid-like hormones function as ligands for the nematode orphan nuclear receptor DAF-12 and govern dauer formation, reproduction and lifespan. In: Bile Acids: Biological Actions and Clinical Relevance—Falk Symposium 155, 14: 99-108.

6.  Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J.K.,  Gerard, R.D., Burgess, S.C., Hammer, R.E., Mangelsdorf, D.J., Kliewer, S.A. (2007) Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metabolism 5: 415-425.  PMID: 17550777

7.  Houten, S.M., Volle, D.H., Cummins, C.L., Mangelsdorf, D.J., Auwerx, J. (2007) In vivo imaging of FXR activity reveals the ileum as the primary bile acid signaling tissue. Molec. Endocr. 21: 1312-1323.  PMID: 17426284

8.  Umetani, M., Domoto, H., Gormley, A., Yuhanna, I.S., Cummins, C.L., Javitt, N.B., Korach, K.S., Shaul, P.W., Mangelsdorf, D.J. (2007) 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nature Medicine 13: 1185-1192.  PMID: 17873880

9.  Jung, D., Inagaki, T., Dawson, P.A., Kliewer, S.A., Mangelsdorf, D.J., Moschetta, A.M. (2007) FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.  J. Lipid Res. 48: 2693-2700.  PMID: 17823457

10.  Katona, B.W, Cummins, C.L., Ferguson, A.D., Li, T., Schmidt, D.R., Mangelsdorf, D.J., and Covey, D.F. (2007) Synthesis, Characterization, and Receptor Interaction Profiles of Enantiomeric Bile Acids. J. Med. Chem. 50: 6048-6058.  PMID: 17963371

11.  Lefterov, I., Bookout, A., Wang, Z., Staufenbiel, M., Mangelsdorf, D.J., and Koldamova, R. (2007) Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment. Molecular Neurodegeneration 2: 20. PMID: 17953774. PMCID: PMC2214725.

12.  DuSell, C., Umetani, M., Shaul, P., Mangelsdorf, D.J., McDonnell, D.P. (2008) 27-Hydroxycholesterol is an endogenous Selective Estrogen Receptor Modulator (SERM). Molec. Endocr. 22: 65-77.  PMID: 17872378. PMCID: PMC2194632.

13.  Lee, YK, Schmidt, D.R., Cummins, C.L., Choi, M., Peng, L., Zhang, Y., Goodwin, B., Hammer, R.E., Mangelsdorf, D.J., Kliewer, S.A. (2008) Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Molec. Endocr. 22:1345-1356.  PMID: 18323469. PMCID: PMC2409274.

14.  Satapati, S., He, T., Inagaki, T., Potthoff, M., Merritt, M.E., Esser, V., Mangelsdorf, D.J., Kliewer, S.A., Browning, J.D., Burgess, S.C. (2008) Partial resistance to PPAR-alpha agonists in Zucker diabetic fatty (ZDF) rats is associated with defective hepatic mitochondrial metabolism. Diabetes 57:2012-2021.  PMID: 18469201. PMCID: 2494699.

15.  Inagaki, T., Lin, V.Y., Goetz, R., Mohammadi, M., Mangelsdorf, D.J., Kliewer, S.A. (2008) Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metabolism 8:77-83. PMID: 18585098. PMCID: PMC2575072.

16.  Schmidt, D.R., Mangelsdorf, D.J. (2008) Nuclear Receptors of the enteric tract: guarding the frontier. Nutrition Reviews 66 (Suppl. 2):S88-S97. PMID: 18844851. PMCID: PMC2741173

17.  Wang, H., Zhang, Y., Yehuda-Shnaidman, E., Medvedev, A.V., Kumar, N., Daniel, K.W. Robidoux, J., Czech, M.P.,  Mangelsdorf, D.J., Collins, S. (2008) Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype Mol. Cell. Biol. 28: 2187-2200. PMID: 18195045. PMCID: PMC2268430.

18.  Bethke, A., Fielenbach, N., Wang, Z., Mangelsdorf, D.J., Antebi, A. (2009) Nuclear hormone receptor regulation of microRNAs controls developmental progression. Science 324:95-98. PMID: 19342589. PMCID: PMC2757405

19.  Sharma, K.K., Wang, Z., Motola, D.L., Cummins, C.L., Mangelsdorf, D.J., Auchus, R.J. (2009) Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Molec. Endocr. 23:640-648. PMID: 19196833. PMCID: PMC2675950

20.  Xie, C., Jeong, Y., Fu, M., Bookout, A.L., Garcia-Barrio, M.T., Sun, T., Kim, B., Xie, Y., Root, S., Zhang, J., Xu, R., Chen, Y.E., Mangelsdorf, D.J. (2009) Expression profiling of nuclear receptors in human and mouse embryonic stem cells. Molec. Endocr. 23:724-733. PMID: 19196830. PMCID: PMC2675959

21.  Sun, T., Fu, M., Bookout, A.L., Kliewer, S.A., Mangelsdorf, D.J. MicroRNA let-7 regulates 3T3-L1 adipogenesis. (2009) Molec. Endocr. 23:925-931. PMID: 19324969. PMCID: PMC2691679

22.  Wang, Z., Zhou, X.E., Motola, D.L., Gao, X., Suino-Powell, K., Conneely, A., Ogata, C., Sharma, K.K., Auchus, R.J., Lok, J.B., Hawdon, J.M., Kliewer, S.A., Xu, H.E., Mangelsdorf, D.J. (2009) Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc. Natl. Acad. Sci. USA 106:9138-9143. PMID: 19497877. PMCID: PMC2695123

23.  Potthoff, M.J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B.N., Mangelsdorf, D.J., Kliewer, S.A., Burgess, S.C. (2009) FGF21 induces PGC-1a and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.  Proc. Natl. Acad. Sci. USA 106:10853-10858. PMID: 19541642. PMCID: PMC2705613

24.  Hofmann, A.F., Mangelsdorf, D.J., and Kliewer, S.A. (2009) Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release. Clin. Gastroenterol. Hepatol. 7:1189-1194. PMID: 19665580. PMCID: PMC2850200

25.  Jeong, Y. and Mangelsdorf, D.J. (2009) Nuclear receptor regulation of stemness and stem cell differentiation.  Exp. Mol. Med. 41:525-537. PMID: 19696553. PMCID: PMC2739892

26.  Kliewer, S.A. and Mangelsdorf, D.J. (2010) Fibroblast growth factor 21: from pharmacology to physiology. Am. J. Clin. Nutr. 91:254S-257S. PMID: 19906798. PMCID: PMC2793111

27.  Holbeck, S., Chang, J., Best, A.M., Bookout, A.L., Mangelsdorf, D.J., and Martinez, E.D. (2010) Expression profiling of nuclear receptors in the NC160 cancer cell panel reveals receptor-drug and receptor-gene interactions. Molec. Endocr. 24:1287-1296. PMID: 20375240. PMCID: PMC2875807

28.  Schmidt, D.R., Holmstrom, S.R., Fon Tacer, K., Bookout, A.L., Kliewer, S.A., and Mangelsdorf, D.J. (2010) Regulation of bile acid synthesis by fat-soluble vitamins A and D. J. Biol. Chem. 285:14486-14494. PMID: 20233723. PMCID: PMC2863217

29.  Fon Tacer, K., Bookout, A.L., Kurosu, H., John, G., Wang, L., Kuro-o, M., Mangelsdorf, D.J., and Kliewer, S.A. (2010) Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Molec. Endocr. 24:2050-2064. PMID: 20667984. PMCID: PMC2954642

30.  Jeong, Y., Xie, Y.,  Xiao, G., Behrens, C., Girard, L.,Wistuba, I.I., Minna, J.D.,  and Mangelsdorf, D.J. (2010) Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer. PLoS Medicine 7: e1000378. doi:10.1371/journal.pmed.1000378. PMID: 21179495. PMCID: PMC3001894

31.  Mangelsdorf, D.J. (2010) Commentary: the year in nuclear receptor control of metabolism. Molec. Endocr. 2010 24:2075-80. PMID: 20880985

32.  Schmidt, D.R., Schmidt, S., Holmstrom, S.R., Makishima, M., Yu, R.T., Cummins, C.L., Mangelsdorf, D.J., and Kliewer, S.A. (2011) AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids. J. Biol. Chem. 286:2425-32. PMID: 21081494. PMCID: PMC3024736

33.  Patel, R., Patel, M., Tsai, R., Lin, V., Bookout, A.L., Zhang, Y., Magomedova, L., Li, T., Chan, J.F., Budd, C., Mangelsdorf, D.J., and Cummins, C.L. (2011) LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. J. Clin. Invest. 121:431-41. PMID: 21123945. PMCID: PMC3007136

34.  Kir,  S., Beddow, S.A., Samuel, V.T., Miller, P., Previs, S.F., Suino-Powell, K., Xu, H.E., Shulman, G.I., Kliewer, S.A., and Mangelsdorf, D.J. (2011) FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 331:1621-24. PMID: 21436455. PMCID: PMC3076083.

35.  Li, T., Holmstrom, S., Kir, S., Umetani, U., Schmidt, D.R., Kliewer, S.A., and Mangelsdorf, D.J. (2011) The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Molec. Endocr.  25:1066-71. PMID: 21454404. PMCID: PMC3100601.

36.  Potthoff, M.J., Boney-Montoya, J., Choi, M., He, T., Sunny, N.E., Satapati, S., Suino-Powell, K., Xu, H.E., Gerard, R.D., Finck, B.N., Burgess, S.C., Mangelsdorf, D.J., and Kliewer, S.A. (2011) FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC1a pathway. Cell Metabolism 8:729-38. PMID: 21641554.  PMCID: PMC3131185.

37.  Holmstrom, S.R., Deering, T., Swift, G.H., Poelwijk, F.J., Mangelsdorf, D.J., Kliewer, S.A., and MacDonald, R.J. (2011) LRH-1 and PTF1-L Co-regulate an Exocrine Pancreas-specific Transcriptional Network for Digestive Function. Genes Dev. 25:1674-1679. PMID: 21852532. PMCID: PMC3165932.

38.  Wollam J., Magomedova L., Magner D.B., Shen Y., Rottiers V., Motola D.L., Mangelsdorf D.J., Cummins C.L., and Antebi A. (2011) The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell 10:879-884. PMID: 21749634. PMCID: PMC3909771.

39.  Kir, S., Kliewer, S.A., and Mangelsdorf, D.J. (2011) Roles of FGF19 in liver metabolism. Cold Spring Harb. Symp. Quant. Biol. In press. PMID: 21813638.

40.  Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, and Xu HE. (2011) Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes. J. Biol. Chem. In press. PMID: 22170062. PMCID: PMC3281614.

41.  Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, and Kliewer SA. (2012) Fibroblast growth factor-21 Regulates PPARg activity and the antidiabetic actions of thiazolidinediones. Cell 148(3):556-567. PMID: 22304921. PMCID: PMC3273727.

42.  Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA, and Wan Y. (2012) Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc. Natl. Acad. Sci. USA 109(8):3143-3148. PMID: 22315431. PMCID: PMC3286969.

43.  Potthoff MJ, Kliewer SA, and Mangelsdorf DJ. (2012) Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev. 26(4):312-324. PMID: 22302876. PMCID: PMC3289879.

44.  Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom SR,  Kliewer SA, Mangelsdorf DJ, and Schulman IG. (2012) Liver LXRa expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J. Clin. Invest. 122(5):1688-99. PMID: 22484817.  PMCID: PMC3336978.

45. Jeong Y, Xie Y, Lee W, Bookout AL, Girard L, Raso G, Behrens C, Wistuba II, Gadzar AF, Minna JD, Mangelsdorf DJ. (2012) Research resource:  Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer. Mol. Endocrinology. 26(8):1443-54. PMID: 22700587.  PMCID: PMC3404298.

46. Lee S, Wang PY, Jeong Y, Mangelsdorf DJ, Anderson RG, Michaely P. (2012) Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE.  Exp. Cell Res.  318(16):2128-42.  PMID: 22728266.  PMCID: PMC3867128.

47. Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, Mangelsdorf DJ, Kliewer SA. (2012) βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.  Cell Metab. 16(3):387-93.  PMID: 22958921.  PMCID: PMC3447537.

48. Kir S, Zhang Y, Gerard RD, Kliewer SA, Mangelsdorf DJ. (2012) Nuclear receptors HNF4a and LRH-1 cooperate in regulating Cyp7a1 in vivo.  J. Biol. Chem.  287(49):41334-41.  PMID: 23038264.  PMCID: PMC3510831.

49. Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ.  (2012) The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.  Elife.  1:e00065.  PMID: 23066506.  PMCID: PMC3466599.

50. Potthoff MJ, Potts A, He T, Duarte JA, Taussig R, Mangelsdorf DJ, Kliewer SA, Burgess SC. (2013) Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.  Am. J. Physiol. Gastrointest. Liver Physiol.  304(4):G371-80.  PMID: 23257920.  PMCID: PMC3566618.

51. Nelson BT, Ding X, Boney-Montoya J, Gerard RD, Kliewer SA, Andrews MT. (2013) Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor.  PLoS One.  8(1):e53574.  PMID: 23301087.

52. Atkin SD, Owen BM, Bookout AL, Cravo RM, Lee C, Elias CF, Elmquist JK, Kliewer SA, Mangelsdorf DJ. (2013) Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.  Mol. Endocrinol.  27(4):598-605.  PMID: 23504956.  PMCID: PMC3607696.

53. Owen BM, Bookout AL, Ding X, Lin VY, Atkin SD, Gautron L, Kliewer SA, Mangelsdorf DJ. (2013) FGF21 contributes to neuroendocrine control of female reproduction.  Nat. Med. 19(9):1153-6.  PMID: 23933983.  PMCID: PMC3769455.

54. Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA. (2013) FGF21 regulates metabolism and circadian behavior by acting on the nervous system.  Nat. Med.  19(9):1147-52.  PMID: 23933984.  PMCID: PMC3769420.

55. Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE.  (2013) Structural insights into gene repression by the orphan nuclear receptor SHP.  Proc. Natl. Acad. Sci. USA.  111(2): 839-44.  111(10):3895.  PMID: 24379397.  PMCID: PMC3896210.

56. Evans RM, Mangelsdorf DJ. (2014) Nuclear Receptors, RXR and the Big Bang.  Cell.  157(1):255-66.  PMID: 24679540.

57. Liu C, Bookout AL, Lee S, Sun K, Jia L, Lee C, Udit S, Deng Y, Scherer PE, Mangelsdorf DJ, Gautron L, Elmquist JK. (2014) PPARγ in vagal neurons regulates high-fat diet induced thermogenesis.  Cell Metab.  PMID: 24703703.

58. Markan KR, Naber MC, Ameka MK, Anderegg MD, Mangelsdorf DJ, Kliewer SA, Mohammadi M, Potthoff MJ. (2014) Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.  Diabetes.  pii: DB_140595.  PMID: 25008183.

59. Owen BM, Ding X, Morgan DA, Coate KC, Bookout AL, Rahmouni K, Kliewer SA, Mangelsdorf DJ. (2014) FGF21 acts centrally to induce sympathethic nerve activity, energy expenditure, and weight loss.  Cell Metab.  pii: S1550-4131(14)00320-9.  PMID: 25130400.




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