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Publications 2007-present



1.  Chen, W., Chen, G., Head, D.L., Mangelsdorf, D.J., Russell, D.W. (2007) Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metabolism 5: 73-79.   PMID: 17189208

2.  Uppal, H., Saini, S.P.S., Moschetta, A., Mu, Y., Zhou, J., Gong, H., Zhai, Y., Ren, S., Michalopoulos, G.K., Mangelsdorf, D.J., Xie, W. (2007) Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology 45: 422-432.  PMID: 17256725

3.  Baker, K.D., Beckstead, R.B., Mangelsdorf, D.J., Thummel, C.S. (2007) Functional interactions between the moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. Genes Dev. 21: 450-64.  PMID: 17322404. PMCID: 1804333

4.  Gerisch, B., Rottiers, V., Li, D., Motola, D.L., Cummins, C.L., Lehrach, H., Mangelsdorf, D.J., Antebi, A. (2007) A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 104: 5014-5019.  PMID: 17360327. PMCID: 1821127.

5.  Wang, Z., Cummins, C.L., Motola, D.L., Mangelsdorf, D.J. (2007) Bile acid-like hormones function as ligands for the nematode orphan nuclear receptor DAF-12 and govern dauer formation, reproduction and lifespan. In: Bile Acids: Biological Actions and Clinical Relevance—Falk Symposium 155, 14: 99-108.

6.  Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J.K.,  Gerard, R.D., Burgess, S.C., Hammer, R.E., Mangelsdorf, D.J., Kliewer, S.A. (2007) Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metabolism 5: 415-425.  PMID: 17550777

7.  Houten, S.M., Volle, D.H., Cummins, C.L., Mangelsdorf, D.J., Auwerx, J. (2007) In vivo imaging of FXR activity reveals the ileum as the primary bile acid signaling tissue. Molec. Endocr. 21: 1312-1323.  PMID: 17426284

8.  Umetani, M., Domoto, H., Gormley, A., Yuhanna, I.S., Cummins, C.L., Javitt, N.B., Korach, K.S., Shaul, P.W., Mangelsdorf, D.J. (2007) 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nature Medicine 13: 1185-1192.  PMID: 17873880

9.  Jung, D., Inagaki, T., Dawson, P.A., Kliewer, S.A., Mangelsdorf, D.J., Moschetta, A.M. (2007) FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.  J. Lipid Res. 48: 2693-2700.  PMID: 17823457

10.  Katona, B.W, Cummins, C.L., Ferguson, A.D., Li, T., Schmidt, D.R., Mangelsdorf, D.J., and Covey, D.F. (2007) Synthesis, Characterization, and Receptor Interaction Profiles of Enantiomeric Bile Acids. J. Med. Chem. 50: 6048-6058.  PMID: 17963371

11.  Lefterov, I., Bookout, A., Wang, Z., Staufenbiel, M., Mangelsdorf, D.J., and Koldamova, R. (2007) Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment. Molecular Neurodegeneration 2: 20. PMID: 17953774. PMCID: PMC2214725.

12.  DuSell, C., Umetani, M., Shaul, P., Mangelsdorf, D.J., McDonnell, D.P. (2008) 27-Hydroxycholesterol is an endogenous Selective Estrogen Receptor Modulator (SERM). Molec. Endocr. 22: 65-77.  PMID: 17872378. PMCID: PMC2194632.

13.  Lee, YK, Schmidt, D.R., Cummins, C.L., Choi, M., Peng, L., Zhang, Y., Goodwin, B., Hammer, R.E., Mangelsdorf, D.J., Kliewer, S.A. (2008) Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Molec. Endocr. 22:1345-1356.  PMID: 18323469. PMCID: PMC2409274.

14.  Satapati, S., He, T., Inagaki, T., Potthoff, M., Merritt, M.E., Esser, V., Mangelsdorf, D.J., Kliewer, S.A., Browning, J.D., Burgess, S.C. (2008) Partial resistance to PPAR-alpha agonists in Zucker diabetic fatty (ZDF) rats is associated with defective hepatic mitochondrial metabolism. Diabetes 57:2012-2021.  PMID: 18469201. PMCID: 2494699.

15.  Inagaki, T., Lin, V.Y., Goetz, R., Mohammadi, M., Mangelsdorf, D.J., Kliewer, S.A. (2008) Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metabolism 8:77-83. PMID: 18585098. PMCID: PMC2575072.

16.  Schmidt, D.R., Mangelsdorf, D.J. (2008) Nuclear Receptors of the enteric tract: guarding the frontier. Nutrition Reviews 66 (Suppl. 2):S88-S97. PMID: 18844851. PMCID: PMC2741173

17.  Wang, H., Zhang, Y., Yehuda-Shnaidman, E., Medvedev, A.V., Kumar, N., Daniel, K.W. Robidoux, J., Czech, M.P.,  Mangelsdorf, D.J., Collins, S. (2008) Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype Mol. Cell. Biol. 28: 2187-2200. PMID: 18195045. PMCID: PMC2268430.

18.  Bethke, A., Fielenbach, N., Wang, Z., Mangelsdorf, D.J., Antebi, A. (2009) Nuclear hormone receptor regulation of microRNAs controls developmental progression. Science 324:95-98. PMID: 19342589. PMCID: PMC2757405

19.  Sharma, K.K., Wang, Z., Motola, D.L., Cummins, C.L., Mangelsdorf, D.J., Auchus, R.J. (2009) Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Molec. Endocr. 23:640-648. PMID: 19196833. PMCID: PMC2675950

20.  Xie, C., Jeong, Y., Fu, M., Bookout, A.L., Garcia-Barrio, M.T., Sun, T., Kim, B., Xie, Y., Root, S., Zhang, J., Xu, R., Chen, Y.E., Mangelsdorf, D.J. (2009) Expression profiling of nuclear receptors in human and mouse embryonic stem cells. Molec. Endocr. 23:724-733. PMID: 19196830. PMCID: PMC2675959

21.  Sun, T., Fu, M., Bookout, A.L., Kliewer, S.A., Mangelsdorf, D.J. MicroRNA let-7 regulates 3T3-L1 adipogenesis. (2009) Molec. Endocr. 23:925-931. PMID: 19324969. PMCID: PMC2691679

22.  Wang, Z., Zhou, X.E., Motola, D.L., Gao, X., Suino-Powell, K., Conneely, A., Ogata, C., Sharma, K.K., Auchus, R.J., Lok, J.B., Hawdon, J.M., Kliewer, S.A., Xu, H.E., Mangelsdorf, D.J. (2009) Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc. Natl. Acad. Sci. USA 106:9138-9143. PMID: 19497877. PMCID: PMC2695123

23.  Potthoff, M.J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B.N., Mangelsdorf, D.J., Kliewer, S.A., Burgess, S.C. (2009) FGF21 induces PGC-1a and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.  Proc. Natl. Acad. Sci. USA 106:10853-10858. PMID: 19541642. PMCID: PMC2705613

24.  Hofmann, A.F., Mangelsdorf, D.J., and Kliewer, S.A. (2009) Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release. Clin. Gastroenterol. Hepatol. 7:1189-1194. PMID: 19665580. PMCID: PMC2850200

25.  Jeong, Y. and Mangelsdorf, D.J. (2009) Nuclear receptor regulation of stemness and stem cell differentiation.  Exp. Mol. Med. 41:525-537. PMID: 19696553. PMCID: PMC2739892

26.  Kliewer, S.A. and Mangelsdorf, D.J. (2010) Fibroblast growth factor 21: from pharmacology to physiology. Am. J. Clin. Nutr. 91:254S-257S. PMID: 19906798. PMCID: PMC2793111

27.  Holbeck, S., Chang, J., Best, A.M., Bookout, A.L., Mangelsdorf, D.J., and Martinez, E.D. (2010) Expression profiling of nuclear receptors in the NC160 cancer cell panel reveals receptor-drug and receptor-gene interactions. Molec. Endocr. 24:1287-1296. PMID: 20375240. PMCID: PMC2875807

28.  Schmidt, D.R., Holmstrom, S.R., Fon Tacer, K., Bookout, A.L., Kliewer, S.A., and Mangelsdorf, D.J. (2010) Regulation of bile acid synthesis by fat-soluble vitamins A and D. J. Biol. Chem. 285:14486-14494. PMID: 20233723. PMCID: PMC2863217

29.  Fon Tacer, K., Bookout, A.L., Kurosu, H., John, G., Wang, L., Kuro-o, M., Mangelsdorf, D.J., and Kliewer, S.A. (2010) Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Molec. Endocr. 24:2050-2064. PMID: 20667984. PMCID: PMC2954642

30.  Jeong, Y., Xie, Y.,  Xiao, G., Behrens, C., Girard, L.,Wistuba, I.I., Minna, J.D.,  and Mangelsdorf, D.J. (2010) Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer. PLoS Medicine 7: e1000378. doi:10.1371/journal.pmed.1000378. PMID: 21179495. PMCID: PMC3001894

31.  Mangelsdorf, D.J. (2010) Commentary: the year in nuclear receptor control of metabolism. Molec. Endocr. 2010 24:2075-80. PMID: 20880985

32.  Schmidt, D.R., Schmidt, S., Holmstrom, S.R., Makishima, M., Yu, R.T., Cummins, C.L., Mangelsdorf, D.J., and Kliewer, S.A. (2011) AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids. J. Biol. Chem. 286:2425-32. PMID: 21081494. PMCID: PMC3024736

33.  Patel, R., Patel, M., Tsai, R., Lin, V., Bookout, A.L., Zhang, Y., Magomedova, L., Li, T., Chan, J.F., Budd, C., Mangelsdorf, D.J., and Cummins, C.L. (2011) LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. J. Clin. Invest. 121:431-41. PMID: 21123945. PMCID: PMC3007136

34.  Kir,  S., Beddow, S.A., Samuel, V.T., Miller, P., Previs, S.F., Suino-Powell, K., Xu, H.E., Shulman, G.I., Kliewer, S.A., and Mangelsdorf, D.J. (2011) FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 331:1621-24. PMID: 21436455. PMCID: PMC3076083.

35.  Li, T., Holmstrom, S., Kir, S., Umetani, U., Schmidt, D.R., Kliewer, S.A., and Mangelsdorf, D.J. (2011) The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Molec. Endocr.  25:1066-71. PMID: 21454404. PMCID: PMC3100601.

36.  Potthoff, M.J., Boney-Montoya, J., Choi, M., He, T., Sunny, N.E., Satapati, S., Suino-Powell, K., Xu, H.E., Gerard, R.D., Finck, B.N., Burgess, S.C., Mangelsdorf, D.J., and Kliewer, S.A. (2011) FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC1a pathway. Cell Metabolism 8:729-38. PMID: 21641554.  PMCID: PMC3131185.

37.  Holmstrom, S.R., Deering, T., Swift, G.H., Poelwijk, F.J., Mangelsdorf, D.J., Kliewer, S.A., and MacDonald, R.J. (2011) LRH-1 and PTF1-L Co-regulate an Exocrine Pancreas-specific Transcriptional Network for Digestive Function. Genes Dev. 25:1674-1679. PMID: 21852532. PMCID: PMC3165932.

38.  Wollam J., Magomedova L., Magner D.B., Shen Y., Rottiers V., Motola D.L., Mangelsdorf D.J., Cummins C.L., and Antebi A. (2011) The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell 10:879-884. PMID: 21749634. PMCID in process.

39.  Kir, S., Kliewer, S.A., and Mangelsdorf, D.J. (2011) Roles of FGF19 in liver metabolism. Cold Spring Harb. Symp. Quant. Biol. In press. PMID: 21813638. PMCID in process.

40.  Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, and Xu HE. (2011) Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes. J. Biol. Chem. In press. PMID: 22170062. PMCID in process.

41.  Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, and Kliewer SA. (2012) Fibroblast growth factor-21 Regulates PPARg activity and the antidiabetic actions of thiazolidinediones. Cell 148(3):556-567. PMID: 22304921. PMCID in process.

42.  Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, Goetz R, Mohammadi M, Gerard RD, Dechow PC, Mangelsdorf DJ, Kliewer SA, and Wan Y. (2012) Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc. Natl. Acad. Sci. USA 109(8):3143-3148. PMID: 22315431. PMCID in process.

43.  Potthoff MJ, Kliewer SA, and Mangelsdorf DJ. (2012) Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev. 26(4):312-324. PMID: 22302876. PMCID in process.

44.  Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom SR,  Kliewer SA, Mangelsdorf DJ, and Schulman IG. (2012) Liver LXRa expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J. Clin. Invest. 122 (in press).


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