Ralf Kittler, Ph.D.
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RESEARCH ARTICLES

Kittler R, Stoneking M, Kayser M. (2002) A whole genome amplification method to generate long fragments from low quantities of genomic DNA. Anal Biochem. 300(2):237-44.

Kittler R, Erler A, Brauer S, Stoneking M, Kayser M. (2003) Apparent intrachromosomal exchange on the human Y chromosome explained by population history. Eur J Hum Genet. 11(4):304-14.

Kittler R, Kayser M, Stoneking M. (2003) Molecular evolution of Pediculus humanus and the origin of clothing. Curr Biol. 13(16):1414-7.

Krönke J, Kittler R, Buchholz F, Windisch MP, Pietschmann T, Bartenschlager R, Frese M. (2004) Alternative approaches for efficient inhibition of Hepatitis C virus RNA replication by small interfering RNAs. 2004. J Virol. 78(7):3436-46.

Kayser M, Kittler R, Erler A, Hedman M, Lee AC, Mohyuddin A, Mehdi SQ, Rosser Z, Stoneking M, Jobling MA, Sajantila A, Tyler-Smith C. (2004). A comprehensive survey of human Y-chromosomal microsatellites. Am J Hum Genet. 74(6):1183-97.

Kittler R, Putz G, Pelletier L, Poser I, Heninger AK, Drechsel D, Fischer S, Konstantinova I, Habermann B, Grabner H, Yaspo ML, Himmelbauer H, Korn B, Neugebauer KM, Pisabarro MT, Buchholz F. (2004) An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature. 432(7020):1036-40.

Kittler R, Pelletier L, Ma C, Poser I, Fischer S, Hyman AA, Buchholz F. (2005) RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells. Proc Natl Acad Sci U S A. 102(7):2396-401.

Quinque D, Kittler R, Kayser M, Stoneking M, Nasidze I. (2006) Evaluation of saliva as a source of human DNA for population and association studies. Anal Biochem. 353(2):272-7.

Kittler R*, Surendranath V*, Heninger AK, Slabicki M, Theis M, Putz G, Franke K, Caldareli A, Grabner H, Kozak K, Wagner J, Rees E, Korn B, Frenzel C, Sachse C, Sönnichsen B, Guo J, Schelter J, Burchard J, Linsley PS, Jackson AL, Habermann B, Buchholz F. (2007) Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies. Nat Methods. 4(4):337-44. * The first two authors contributed equally to this work.

Kittler R*, Pelletier L*, Heninger AK, Slabicki M, Theis M, Miroslaw L, Poser I, Lawo S, Grabner H, Kozak K, Wagner J, Surendranath V, Richter C, Bowen W, Habermann B, Hyman AA, Buchholz B. (2007) Genome-wide RNAi profiling of cell cycle progression in human tissue culture cells. Nat Cell Biol. 9(12): 1401-12. * The first two authors contributed equally to this work.

Zhu F, Lawo S, Bird AW, Pinchev D, Ralph A, Richter C, Müller-Reichert T, Kittler R, Hyman AA, Pelletier L. (2008) Cep192 regulates centrosome biogenesis in mammalian cells. Curr Biol. 18(2):136-41.

Poser I, Sarov M, Hutchins JR, Heriche JK, Toyoda Y, Pozniakovsky A, Weigl D, Nitzsche A, Hegemann B, Bird AW, Pelletier L, Kittler R, Hua S, Naumann R, Augsburg M, Sykora MM, Hofemeister H, Zhang Y, Nasmyth K, White KP, Dietzel S, Mechtler K, Durbin R, Stewart AF, Peters JM, Buchholz F, Hyman AA. (2008) BAC transgeneomics: a high-throughput method for exploration of protein function in mammals. Nat Methods. 5(5):409-15.

Ding L, Paszkowski-Rogacz M, Nitzsche A, Slabicki M, Heninger AK, de Vries I, Kittler R, Junqueira M, Shevchenko A, Schulz H, Huebner N, Doss MX, Sachinidis A, Hescheler J, Iacone R, Anastassiadis K, Stewart AF, Pisabarro MT, Caldarelli A, Poser I, Theis M, Buchholz F. (2009) A Genome-Scale RNAi Screen for Oct4 Modulators Defines a Role of the Paf1 Complex for Embryonic Stem Cell Identity. Cell Stem Cell. 4(5):403-15.

Theis M, Slabicki M, Junqueira M, Paszkowski-Rogacz M, Sontheimer J, Kittler R, Heninger AK, Glatter T, Kruusmaa K, Poser I, Hyman AA, Pisabarro MT, Gstaiger M, Aebersold R, Shevchenko A, Buchholz F. (2009) Comparative Profiling Identifies C13orf3 as a Component of the Ska Complex Required for Mammalian Cell Division. EMBO J. 28(10):1453-65.

Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R,  Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, Pinchev D, Buchholz F, Peters JM, Hyman AA, Gingras AC, Pelletier L. (2009) HAUS, the 8-subunit human Augmin complex regulates centrosome and spindle integrity. Curr Biol.19(10):816-26.

Hua S*, Kittler R*, White KP. (2009) Genomic Antagonism between Retinoic Acid and Estrogen Signaling in Breast Cancer. Cell. 137(7):1259-71. * The first two authors contributed equally to this work.

Sun C, Southard C, Witonsky DB, Kittler R, Di Rienzo A (2010)  Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations. PLoS Genet. 2010 Oct 6 10

Ludwig MZ, Manu null, Kittler R, White KP, Kreitman M (2011)  Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness.  PLoS Genet. 2011 Nov 7 (11)

Park J, Sarode VR, Euhus D, Kittler R, Scherer PE (2012) Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer.  Proc. Natl. Acad. Sci. U.S.A. Dec 109 51

Kittler R, Zhou J, Hua S, Ma L, Liu Y, Pendleton E, Cheng C, Gerstein M, White KP (2013)  A comprehensive nuclear receptor network for breast cancer cells.  Cell Rep Feb 3 2 538-51

Kappei D, Butter F, Benda C, Scheibe M, Draškovic I, Stevense M, Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R, Jessberger R, Londoño-Vallejo JA, Mann M, Buchholz F (2013)  HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.  EMBO J. Jun 12;32(12):1681-701

Wang S, Kollipara RK, Srivastava N, Li R, Ravindranathan P, Hernandez E, Freeman E, Humphries CG, Kapur P, Lotan Y, Fazli L, Gleave ME, Plymate SR, Raj GV, Hsieh JT, Kittler R. (2014) Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer. Proc Natl Acad Sci U S A. Mar 18;111

Eliazer S, Palacios V, Wang Z, Kollipara RK, Kittler R, Buszczak M. (2014) Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells. PLoS Genet. Mar 13;10(3)

 

INVITED ARTICLES

Kittler R, Buchholz F. (2003) RNA interference: Gene silencing in the fast lane. Semin Cancer Biol. 13(4):259-65.

Calegari F, Marzesco AM, Kittler R, Buchholz F, Huttner WB. (2004) Tissue-specific RNA interference in post-implantation mouse embryos using directional electroporation and whole embryo culture. Differentiation. 72(2‑3):92-102.

Kittler R, Buchholz F. (2005) Functional genomic analysis of cell division by endoribonuclease-prepared siRNAs. Cell Cycle. 4(4):564-7.

Kittler R, Heninger AK, Franke K, Habermann B, Buchholz F. (2005) Synthesis of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells. Nat Methods. 2(10):779-84.

Buchholz F, Kittler R, Slabicki M, Theis M. (2006) Enzymatically prepared RNAi libraries. Nat Methods. 3(9):696-700.

Kittler R, Pelletier L, Buchholz F. (2008) Systems biology of mammalian cell division. Cell Cycle. 7(14):2123-8.

 

BOOK CHAPTERS

Buchholz F, Drechsel D, Ruer M, Kittler R. (2004) Production of siRNA in vitro by enzymatic digestion of double-stranded RNA. In: Gene Silencing by RNA interference: Technology and Application; M. sohail, ed.; CRC press.

Buchholz F, Calegari F, Kittler R, Huttner WB. (2005) RNA interference in post-implantation mouse embryos. In: RNA interference Technology: From Basic Biology to Drug Development; K. Appasani, ed.; Cambridge University Press.

Miroslaw L, Chorazyczewski A, Buchholz F, Kittler R. (2005) Correlation-based method for automatic mitotic cell detection in phase contrast microscopy. In: Series : Advances in Soft Computing, Computer Recognition Systems; Kurzynski M, Puchala E, Wozniak M, Zolnierek A, eds. Springer.