Welcome to the Mirzaei lab in the Department of Biochemistry at UT Southwestern Medical Center in Dallas, Texas. We develop and use state-of-the-art mass-spectrometry proteomics techniques to address important biological questions.
Research in the lab is centred around developing proteomics methods that can be applied to a wide range of important biological research. We have interests including: the in-depth study of protein ubiquitination; comprehensive identification of protein complexes; identification of drug and pathogen targets; development of methods and software to improve proteomics data analysis.
Take a look at the research page for more details.
Our newest work, published in Nature communications is Hydralazine, induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signaling pathway. We demonstrate that hydralazine extends healthy lifespan (~25%) in wild type and tauopathy model C. elegans at least as effectively as other anti-aging compounds, such as curcumin and metformin. We show that hydralazine-mediated lifespan extension is SKN-1 dependent, with a mechanism most likely mimicking calorie restriction. Using both in vitro and in vivo models, we demonstrate that hydralazine has neuroprotective properties against endogenous and exogenous stressors.
See the paper at the link below:
Take a look at our full list of publications.
Lead by Dr. Mirzaei, the lab consists of faculty, postdocs and staff with considerable expertise in mass-spectrometry, bioinformatics, biochemistry & cell biology. Visit our people page for photos, bios and contact info.