Welcome to the Mirzaei lab in the Department of Biochemistry at UT Southwestern Medical Center in Dallas, Texas. We develop and use state-of-the-art mass-spectrometry proteomics techniques to address important biological questions.
Research in the lab is centred around developing proteomics methods that can be applied to a wide range of important biological research. We have interests including: the in-depth study of protein ubiquitination; comprehensive identification of protein complexes; identification of drug and pathogen targets; development of methods and software to improve proteomics data analysis.
Take a look at the research page for more details.
In 2013 we published extensively with collaborators in PNAS and Cell.
Our largest work, published in PNAS and highlighted in Nature Chemical Biology uses SRM-based targeted proteomics to identify candidate gene regulatory proteins. A broad SRM study of 464 proteins with known or suspected roles in gene regulation in S. cerevisiae identified 15 regulators that interact with the FLO11 promoter. We demonstrate that Mot3 and Azf1 are required for FLO11 expression. See the paper at the link below:
H. Mirzaei, T. A. Knijnenburg, B. Kim, M. Robinson, P. Picotti, G. W. Carter, S. Li, D. J. Dilworth, J. K. Eng, J. D. Aitchison, I. Shmulevich, T. Galitski, R. Aebersold and J. Ranish, PNAS, Early Edition doi: 10.1073/pnas.1216918110, 2013.
Take a look at our full list of publications.
Lead by Dr. Mirzaei, the lab consists of faculty, postdocs and staff with considerable expertise in mass-spectrometry, bioinformatics, biochemistry & cell biology. Visit our people page for photos, bios and contact info.