Welcome to the Mirzaei lab in the Department of Biochemistry at UT Southwestern Medical Center in Dallas, Texas. The lab is headed by Hamid Mirzaei Ph.D. who is also the director of the UTSW Proteomics Core.
Research in the lab is centered around the development of quantitative targeted mass-spectrometry techniques in order to study differential gene and PTM regulations in cancer cells. Take a look at the research page for more details.
Our latest publication in PNAS, which will be highlighted in an upcoming issue of Nature Chemical Biology uses SRM-based targeted proteomics to identify candidate gene regulatory proteins. A broad SRM study of 464 proteins with known or suspected roles in gene regulation in S. cerevisiae identified 15 regulators that interact with the FLO11 promoter. We demonstrate that Mot3 and Azf1 are required for FLO11 expression. See the paper at the link below:
H. Mirzaei, T. A. Knijnenburg, B. Kim, M. Robinson, P. Picotti, G. W. Carter, S. Li, D. J. Dilworth, J. K. Eng, J. D. Aitchison, I. Shmulevich, T. Galitski, R. Aebersold and J. Ranish, PNAS, Early Edition doi: 10.1073/pnas.1216918110, 2013.
Take a look at our full list of publications.
Lead by Dr. Mirzaei, the lab consists of faculty, postdocs and staff with considerable expertise in mass-spectrometry, bioinformatics, biochemistry & cell biology. Visit our people page for photos and bios.