Publications

Mohan C, Morel L, Yu Y, Croker B, Tian X-H, Deng A, Wakeland, EK. (1997) Functional dissection of SLE pathogenesis using congenic mouse strains. J Immunol 158:6019-6028.

Mohan C, Morel L, Yang P, Deng A, Wakeland EK. (1997) Genetic dissection of SLE pathogenesis : Sle2 on murine chromosome 4 leads to B-cell hyperactivity. J Immunol 159:454-465.

Mohan C, Alas E, Morel L, Yang P, Wakeland EK. (1998). Genetic dissection of SLE pathogenesis: Sle1 on murine chromosome 1 leads to selective loss of tolerance to chromatin components. J Clin Invest 101:1362-1372.

Mohan C, Morel L, Yang P, Wakeland EK. (1998). Expansion of splenic B1-cells with strong antigen presenting capabilities in the NZM2410 lupus strain. Arthritis Rheum 41:1652-1662.

Sobel ES, Mohan C, Morel L, Schiffenbauer J, Wakeland EK. (1999). Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 on murine Chr 1 by bone marrow. J Immunol 162:2415-2421

Morel L, Mohan C, Schiffenbauer J, Rudofsky UH, Longmate JA, Sobel ES, Tian X-H, Wakeland EK. (1999). Complex inheritance of complex phenotypes in a murine model of lupus. Mam Genome 10:176-181.

Mohan C, Yu Y, Morel L, Yang P, Wakeland E.K. (1999). Genetic dissection of SLE pathogenesis: Sle3 impacts T-cell activation, differentiation and cell death. J Immunol 162:6492-6502.

Mohan C, Morel, L, Yang, P, Watanabe, H, Croker, B, Gilkeson, G, Wakeland EK. (1999). Genetic dissection of SLE pathogenesis: A recipe for nephrophilic autoantibodies. J Clin Invest 103:1685-1695.

Mohan C, Morel L, Wakeland EK. (1999). Genetic insights into murine lupus. In Lupus: Molecular and Cellular Pathogenesis. G.C. Tsokos and G. Kammer (eds.) Humana Press Pages 124-139.

Morel L, Croker BP, Blenman KR, Mohan C, Huang G, Gilkeson G, Wakeland EK. (2000). Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci 97:6670

Mohan C. (2000). Immunogenetic Origins of Lupus. Br Int Med J 2: 1-15

Mohan C, Liu F, Xie C, Williams R. (2001) Antisubnucleosome reactivities in SLE patients and their first degree relatives. Clin Exp Immunol 123:119-126.

Mohan C. (2001). Murine Lupus Genetics: Lessons Learned. Current Opinion in Rheumatology 13:352-360.

Xie S-K, Chang S, Yang P, Jacob C, Kaliyaperumal A, Datta SK, Mohan, C. (2001) Genetic contributions of SWR towards lupus nephritis. J Immunol 167:7150-7156.

Xie S, Chang S, Sedrak P, Kaliyaperumal A, Datta SK, Mohan C. (2002). Dominant NZB contributions to lupus in the (SWR X NZB)F1 model. Genes and Immunity 3: S13-S20.

Chen L, and Mohan C. (2002) Molecular Signatures of anti-ssDNA, anti-dsDNA, and anti-nucleosome autoantibody heavy chains. Mol Immunology 39: 333-347.

Shi X, Xie C, Kreska D, Richardson J, Mohan C. (2002) Genetic Dissection of SLE: Sle1 and Fas impact distinct pathways leading to lymphoproliferative autoimmunity. J Exp Med 196:281-292.

Xie C, Zhou XJ, and Mohan C. (2003) Enhanced susceptibility to nephritis in the lupus facilitating NZW strain. Arthritis Rheum 48:1080-1092.

Xie C, Zhou JX, and Mohan C. (2003) Enhanced susceptibility to nephritis in the lupus facilitating NZW strain. Arthritis Rheum 48:1080-1092.

Raman K, and Mohan C. (2003) Genetic underpinnings of autoimmunity – lessons from studies in arthritis, diabetes, lupus and multiple sclerosis. Curr Opin Immunol (In Press)

Xie, S and Mohan C. (2003) Divide and conquer - the power of congenic strains. Clin Immunol. YCLIM-5443.

Liang Z, Xie C, Chen C, Kreska D, Hsu K, Li L, Zhou X-J, and Mohan C. (2004) Pathogenic profiles and molecular signatures of ANAs derived from NZM2410 lupus mice. J Exp Med 199:381-398.

Patel R and Mohan C. PI3K/AKT signaling and systemic autoimmunity. 2005. Immunol Res 31(1):47-55.

Limaye N, and Mohan C. 2004. Pathogenicity of anti-DNA and anti-glomerular antibodies: weighing the evidence. Drug Discovery Today: Disease Models 1(4):395-403.

Xie C, and Mohan C. 2005. Genetic dissection of SLE pathogenesis. In Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, Springer International (In Press).

Henry T, and Mohan C. 2005. Lesson in lupus from congenic strains. Archivum Immunologiae et Therapiae Experimentalis. 53:207-212.

Xie S., Sharma R., Kaliyaperumal A., Datta SK., and C. Mohan. 2005. Genetics of lupus susceptibility in NZB/SWR hybrids - lessons from an intercross study. Arthritis Rheum 52(2):659-667.

Fu Y, Xie C, Yan M, Li Q, Lu C, and C Mohan. 2005. LPS-induced mesangial transcriptomics – evaluating the role of interferon regulatory factor-1. Kidney Int 67:1350-1361.

Chang S. and Mohan C. 2005. Identification of novel VH1/J558 immunoglobulin germline genes of C57BL/6 (Igh(b)) allotype. Molecular Immunology. 42(11):1293-1301.

Kumar K. R, Zhu J, Bhaskarabhatla M, Yan M, Mohan C. 2005. Enhanced expression of Ly-6A/E correlates with disease severity in various lupus prone mice. J. Autoimmunity 25:215-222.

Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, Wakeland EK, and Mohan C. 2005. Genetic dissection of lupus: T-cell hyperactivity as a consequence of hyperstimulatory antigen presenting cells. J Clin Invest 115(7):1869-1878.

Q Li, C Xie, C Putterman, C Mohan. 2005. Glomerular proteome arrays – a novel approach to study glomerular-reactive autoantibodies in lupus. J Clin Invest 115:3428-3439.

Li J, Liu Y, Xie C, Zhu J, Zhou XJ, C Mohan. 2005. Deficiency of Type I interferon contributes to Sle2-associated component lupus phenotypes. Arthritis Rheum 52:3063-3072.

Fu Y, Xie C, Chen J, Zhu J, Zhou H, Thomas J, Zhou XJ, Mohan C. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol. 2006 Jan 1;176(1):632-9.

Mehrad B, Park SJ, Akangire G, Standiford TJ, Wu T, Zhu J, Mohan C. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol. 2006 Mar 1;176(5):3233-9.

Kumar KR, Li L, Yan M, Bhaskarabhatla M, Mobley AB, Nguyen C, Mooney JM, Schatzle JD, Wakeland EK, Mohan C. Regulation of B cell tolerance by the lupus susceptibility gene ly108. Science. 2006 Jun 16;312(5780):1665-9.

Chun Xie, Rahul Patel, Tianfu Wu, Jiankun Zhu, Tamika Henry, Madhavi Bhaskarabhatla, Renuka Samudrala, Katalin Tus, Yimei Gong, Hui Zhou, Edward K. Wakeland, Xin J. Zhou, and Chandra Mohan. PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr . International Immunol. 2007; 19: 509-522.
Liu Y, L Li, C Xie, S Lightfoot, X J. Zhou, M Weigert and C Mohan. 2007. Lupus susceptibility loci breach B-cell tolerance to DNA by impairing receptor revision of nuclear antigen reactive B-cells. J Immunol 179: 1340 - 1352

Xiaoyan Shi, Chun Xie, Sooghee Chang, Xin J Zhou, Thomas Tedder and Chandra Mohan. 2007. CD19 hyper-expression augments Sle1-induced humoral autoimmunity but not clinical nephritis. Arthritis Rheum 56(9):3057-69
Xie C, Qin X, Jonnala G, Zhou XJ, and Mohan C. 2007. Enhanced immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Clin Immunol 124(1):49-56
Fu Y, Yong D and Mohan C. 2007. The experimental anti-GBM model as a tool for studying spontaneous lupus nephritis. Clin Immunol 124: 109-118
Zhu J. Mohan C. SLE 1, 2, 3...genetic dissection of lupus. Adv Exp Med Biol. 601:85-95, 2007

Xie C, Qin X, Xie S, Zhu J, Zhou XJ, and Mohan C. 2007. Strain distribution pattern of mice to anti-GBM nephritis - a follow up study. International Immunol (Acceptance pending revision).

Wu T, C Xie, HW Wang, XJ Zhou, N Schwartz, M Mackay, C Aranow, C Putterman, and C Mohan. 2007. Elevated urinary VCAM-1, P-selectin, sTNFR-1 and CXCL16 in multiple murine lupus strains and human lupus nephritis. J Immunol 179(10):7166-75

Li L. Mohan C. Genetic basis of murine lupus nephritis. Seminars in Nephrology. 27(1):12-21, 2007

Wu T. Xie C. Bhaskarabhatla M. Yan M. Leone A. Chen SS. Zhou XJ. Putterman C. Mohan C. Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significance. Arthritis Rheum. 56(3):949-59, 2007

Li QZ. Zhou J. Wandstrat AE. Carr-Johnson F. Branch V. Karp DR. Mohan C. Wakeland EK. Olsen NJ. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes. Clin Exp Immunol. 147(1):60-70, 2007

KR Kumar and C. Mohan. 2007. B-cell tolerance checkpoint violations in systemic lupus erythematosus. Future Rheumatology 2(4): 415-422.
Wu T, Mohan C. Three pathogenic determinants in immune nephritis - anti-glomerular antibody specificity, innate triggers and host genetics. Frontiers in Bioscience 12: 2207-2211, 2007

Wu T. Mohan C. Proteomics on the diagnostic horizon: Lessons from rheumatology. Am J Med Sci. 333(1):16-25, 2007

Wu T, X Qin, Liu K, Z Kurepa, M Bhaskarabhatla, XJ Zhou, Satterthwaite AB, LS Davis and C Mohan. 2007. Shared signaling networks that fire up in lupus B cells from genetically distinct mouse models - implications for disease pathogenesis and therapy. J Clin Invest 117: 2186 - 2196.

Liu K. Li QZ. Yu Y. Liang C. Subramanian S. Zeng Z. Wang HW. Xie C. Zhou XJ. Mohan C. Wakeland EK. Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Genes & Immunity. 8(8):634-45, 2007

Y Liu, L Li and C. Mohan. 2008. The role of rearrangement at the second immunoglobulin heavy chain locus in maintaining B-cell tolerance to DNA. J Immunol 180(11):7721-7.

Y Du, Y Fu and C Mohan. 2008. Experimental anti-GBM nephritis as an analytical tool for studying spontaneous lupus nephritis. Archivum Immunologiae et Therapiae Experimentalis. 56:1-10.

Kumar KR. Mohan C. Understanding B-cell tolerance through the use of immunoglobulin transgenic models. Immunol Res. 40(3):208-23, 2008.

C Xie, ZSM Rahman, S Xie, J Zhu, Y Du, X Qin, H Zhou, XJ Zhou, and C Mohan. 2008. Strain distribution pattern of immune nephritis - a follow-up study. International Immunol 20(6):719-728.

Y Liu, L Li and C Mohan. 2008. The role of rearrangement at the second immunoglobulin heavy chain locus in maintaining B-cell tolerance to DNA J Immunol 180(11):7721-7.

Jack Hutcheson, John C. Scatizzi, Akbar M. Siddiqui, G. Kenneth Haines, Tianfu Wu, Quan-Zhen Li, Laurie S. Davis, Chandra Mohan, and Harris Perlman. Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity. Immunity 2008 28: 206-217.

Kui Liu and Chandra Mohan. 2009. Altered B Cell Signaling in Lupus. Autoimmunity reviews 8(3):214-8.

Andrew Wang, Anna-Marie Fairhurst, Katalin Tus, Srividya Subramanian, Yang Liu, Fangming Lin, Peter Igarashi1, Xin J. Zhou, Frederic Batteux, Donald Wong, Edward K.Wakeland, and Chandra Mohan. 2009. CXCR4/CXCL12 hyperexpression plays a pivotal role in lupus pathogenesis. J Immunol 182(7):4448-58.

Wu T and Mohan C. 2009. The AKT axis as a therapeutic target in autoimmune diseases. Endocrine, Metabolic & ImmuneDisorders - Drug Targets. Jun;9(2):145-50.

Kui Liu, Quan-Zhen Li, Anna-Karin Abelson, Elena S¨¢nchez, Jennifer A. Kelly, et al, and Mohan C. 2009. Kallikreins as disease genes in lupus and anti-glomerular antibody-induced nephritis. J Clin Invest 119(4):911-23.

Zhiyan Liang, Sooghee Chang, Min So Youn, and Chandra Mohan. 2009. Molecular Hallmarks of Anti-chromatin Antibodies Associated with the Lupus Susceptibility Locus, Sle1. Mol Immunol (In Press).

Quan-Zhen Li, Jinchun Zhou, Ru Yang, Mei Yan, Qiu Ye, Kui Liu, Nancy Liu, Xinli Shao, Li Li, Ward Wakeland, and Chandra Mohan. 2009. The lupus susceptibility gene kallikrein down-modulates antibody-mediated glomerulonephritis. Genes Immunity (In Press)

Hasna Kanta and Chandra Mohan. 2009. Murine Lupus genes target 3 checkpoints in disease development-central tolerance in the adaptive immune system, peripheral amplification by innate immunity, and end-organ inflammation. Genes Immunity (In Press)

Chandra Mohan and Anil K. Agarwal. 2009. Melanocortin-4-receptor autoantibodies: a new player in obesity. J Clin Endocrin Metab 94(3):757-9.

Chaim O Jacob, Jiankun Zhu, et al., and Mohan C. 2009. Identification of IRAK1 as a disease gene in systemic lupus erythematosus through combined forward genetic and reverse genetic approaches. Proc Natl Acad Sci USA 106(15):6256-61.

Wu T, Mohan C. Proteomic toolbox for autoimmunity research. Autoimmun Rev. 2009 Jun;8(7):595-8

This page is maintained by the UTSW rheumatology department.
Email questions to: mohanlab@utsouthwestern.edu
This page was last modified 2/20/2006.

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