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Recent Publications of the Brown/Goldstein Laboratory in  the Molecular Genetics 
			 Department at the University of Texas Southwestern
Brown/Goldstein's Recent Publications
Das, A., Goldstein, J.L., Anderson, D.D., Brown, M.S. and Radhakrishnan, A.: Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells. Proc. Natl. Acad. Sci. USA, 110: 10580-10585, 2013.
Zhang, Y., Motamed, M., Seemann, J., Brown, M.S., and Goldstein, J.L.: Point mutation in luminal Loop 7 of Scap blocks interaction with Loop 1 and abolishes movement to Golgi. J. Biol. Chem. 288: 14059-14067, 2013.
Goldstein, J.L., and Brown, M.S.: A golden era of Nobel Laureates. Science, 338: 1033-1034, 2012.
Owen, J.L., Zhang, Y., Bae, S.-H., Farooqi, M.S., Liang, G., Hammer, R.E., Goldstein, J.L., and Brown, M.S.: Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proc. Natl. Acad. Sci. USA, 109: 16184-16189, 2012.
Brown, M.S. and Goldstein, J.L.: Reflections: Scientific side trips: six excursions from the beaten path. J. Biol. Chem., 287: 22418-22435, 2012.
Li, R.L, Sherbet, D. P., Elsbernd, B.L, Goldstein, J.L, Brown, M.S. and Zhao, T.-J.: Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. J. Biol. Chem., 287: 17942-17950, 2012.
Xie, X., Brown, M.S., Shelton, J.M., Richardson, J.A., Goldstein, J.L. and Liang, G.: Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice. Proc. Natl. Acad. Sci. USA 108: 15330-15335, 2011.
Goldstein, J.L., Zhao, T.-J., Li, R.L., Sherbet, D.P., Liang, G., and Brown, M.S.: Surviving starvation: essential role of the ghrelin-growth hormone axis. Cold Spring Harbor Symp. Quant. Biol. 76: doi: 10.1101/sqb.2011.76.010447, 2011.
Brown, M.S. and Goldstein, J.L.: Richard G.W. Anderson (1940-2011) and the birth of receptor-mediated endocytosis. J. Cell Biol., 193: 601-603, 2011.
Motamed, M., Zhang, Y., Wang, M.L., Seemann, J., Kwon, H.J., Goldstein, J.L. and Brown, M.S.: Identification of luminal loop of Scap as the sterol sensor that maintains cholesterol homeostasis. J. Biol. Chem., 286: 18002-18012, 2011.
Zhao, T.-J., Sakata, I., Li, R.L., Liang, G., Richardson, J.A., Brown, M.S., Goldstein, J.L., and Zigman, J.M.: Ghrelin secretion stimulated by -adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc. Natl. Acad. Sci. USA, 107: 15868-15873, 2010.
Brown, M.S., Ye, J., and Goldstein, J.L.: HDL miR-d down by SREBP introns. Science, 328: 1495-1496, 2010.
Zhao, T.-J., Liang, G., Li, R.L., Xie, X., Sleeman, M.W., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Goldstein, J.L., and Brown, M.D.: Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc. Natl. Acad. Sci. USA. 107: 7467-7472, 2010.
Li, S., Brown, M.S., Goldstein, J.L.: Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc. Natl. Acad. Sci. USA, 107: 3441-3446, 2010.
Evers, B.M., Farooqi, M.S., Shelton, J.M., Richardson, J.A., Goldstein, J.L., Brown, M.S., Liang, G.: Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin. J. Invest. Dermatol. 130: 1237-1248, 2010.
Okazaki, H., Goldstein, J.L., Brown, M.S., Liang, G.: LXR - SREBP-1c - phospholipid transfer protein axis controls VLDL particle size., J. Biol. Chem. 285: 6801-6810, 2010.
Ikeda, Y., DeMartino, G.N., Brown, M.S., Lee, J.N., Goldstein, J.L. and Ye, J.: Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. J. Biol. Chem. 284: 34889-34900, 2009.
Abi-Mosleh, L., Infante, R.E., Radhakrishnan, A., Goldstein, J.L., and Brown, M.S.: Cyclodextrin overcomes deficient lysosome-to-ER reticulum transport of cholesterol in Niemann-Pick type C cells. Proc. Natl. Acad. Sci. USA 106: 19316-19321, 2009.
Guan, H.-P., Goldstein, J.L., M.S. Brown, and Liang, G.: Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice. J. Biol. Chem. 284: 24644-24652, 2009.
Kwon, H.J., Abi-Mosleh, L., Wang, M.L., Deisenhofer, J., Goldstein, J.L., Brown, M.S., and Infante, R.E.: Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell, 137: 1213-1224, 2009.
Goldstein, J.L. and Brown, M.S.: History of discovery: The LDL receptor. Arterioscler. Thromb. Vasc. Biol. 29: 431-438, 2009.
Brown, M.S. and Goldstein, J.L.: Cholesterol feedback: from Schoenheimer’s bottle to Scap’s MELADL. J. Lipid. Res., S15-S27, 2009.
Radhakrishnan, A., Goldstein, J.L., McDonald, J.G., Brown, M.S.: Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance. Cell Metabolism 8: 512-521, 2008.
Infante, R.E., Wang, M.L., Radhakrishnan, A., Kwon, H.J., Brown, M.S. and Goldstein, J.L.: NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proc. Natl. Acad. Sci. USA, 105: 15287-15292, 2008.
Yang, J., Zhao, T.-J., Goldstein, J.L., and Brown, M.S.: Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc. Natl. Acad. Sci. USA, 105: 10750-10755, 2008.
Goldstein, J.L. and Brown, M.S.: From fatty streak to fatty liver: 33 years of joint publications in the JCI. J. Clin. Invest., 118: 1220-1222, 2008.
Yang, J., Brown, M.S., Liang, G., Grishin, N.V., and Goldstein, J.L.: Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell, 132: 387-396, 2008.
Brown, M.S. and Goldstein, J.L.: Selective vs. total insulin resistance: A pathogenic paradox. Cell Metabolism, 7: 95-96, 2008.
Infante, R.E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J.D., Brown, M.S., and Goldstein, J.L.: Purified NPC1 protein: I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J. Biol. Chem. 283: 1052-1063, 2008.
Infante, R.E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L.N., Wang, M.L., Grishin, N.V., Goldstein, J.L., and Brown, M.S.: Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J. Biol. Chem. 283: 1064-1075, 2008.
CLASSIC PAPERS
Brown, M.S., and Goldstein, J.L.: A receptor-mediated pathway for cholesterol homeostasis. Science 232: 34-47, 1986.
Reiss, Y., Goldstein, J.L., Seabra, M.C., Casey, P.J., and Brown, M.S. Inhibition of purified p21ras farnesyl:protein transferase by
Cys-AAX tetrapeptides. Cell 62: 81-88, 1990.
Seabra, M.C., Brown, M.S., and Goldstein, J.L. Retinal Degeneration in
Choroideremia: Deficiency of Rab Geranylgeranyl Transferase. Science 259:377-381, 1993.
Briggs, M.R., Yokoyama, C., Wang, X., Brown, M.S., and Goldstein, J.L. Nuclear Protein That Binds Sterol Regulatory Element of Low Density Lipoprotein Receptor Promoter, I. Identification of the Protein and Delineation of Its Target Nucleotide Sequence. J. Biol. Chem. 268:14490-14496, 1993.
Wang, X., Briggs, M.R., Hua, X., Yokoyama, C., Goldstein, J.L., and Brown, M.S., Nuclear Protein That Binds Sterol Regulatory Element of Low Density Lipoprotein Receptor Promoter, II. Purification and Characterization. J. Biol. Chem. 268: 14497-14504, 1993.
Brown, M.S. and Goldstein, J.L. Heart Attacks: Gone with the Century? Science 272: 629 (editorial), 1996.
Brown, M.S. and Goldstein, J.L.: The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor. Cell 89: 331-340, 1997
Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S., and Goldstein, J.L.: Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401: 73-76, 1999.
Brown, M.S., Ye, J., Rawson, R.B., and Goldstein, J.L.: Regulated Intramembrane Proteolysis: A Control Mechanism Conserved from Bacteria to Humans. Cell, 100: 391-398, 2000.
Nohturfft, A., Yabe, D., Goldstein, J.L., Brown, M.S., and Espenshade,P.J.: Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell, 102: 315-323, 2000.
Matsuda, M., Korn, B.S., Hammer, R.E., Moon, Y.-A., Komuro, R., Horton, J.D., Goldstein, J.L., Brown, M.S. and Shimomura, I.: SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev., 15: 1206-1216, 2001.
Goldstein, J.L., Rawson, R.B., and Brown, M.S.: Mutant mammalian cells as tools to delineate the sterol regulatory element-binding pathway forfeedback regulation of lipid synthesis. Arch. Biochem. Biophys., 397: 139-148, 2002.
Horton, J.D., Goldstein, J.L., and Brown, M.S.: SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in liver. J. Clin. Invest., 109: 1125-1131, 2002.
Yang, T., Espenshade, P.J., Wright, M.E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J.L., and Brown, M.S.: Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, amembrane protein that facilitates retention of SREBPs in the ER. Cell, 110: 489-500, 2002.
Sun, L.-P., Seemann, J., Goldstein, J.L., and Brown, M.S., Sterol-regulated transport of SREBPS from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc. Natl. Acad. Sci. USA, 104: 6519-6526, 2007.
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