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Recent Publications of Dr. Russell DeBose-BoydLab in the Molecular Genetics 
			 Department at the University of Texas Southwestern
Dr. Russell DeBose-Boyd's Recent Publications
Elsabrouty, R., Jo, Y., Dinh, T.T., Debose-Boyd, R.A. Sterol-Induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Membranes of Permeabilized Cells. Mol Biol Cell. 2013 Sep 11. [Epub ahead of print] PMID:24025715
DeBose-Boyd, R.A. and Horton, J.D. (2013) Opening up new fronts in the fight against cholesterol. Elife 2: e00663.
Faulkner, R.A., Nguyen, A.D., Jo, Y., DeBose-Boyd, R.A. (2013) Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells. J. Lipid Res. 54: 1011-1022.
Jo, Y., Hartman, I.Z., DeBose-Boyd, R.A. (2013) Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes. Mol. Biol. Cell. 24:169-183.
Jo, Y., Lee, P.C., Sguigna, P.V., DeBose-Boyd, R.A. (2011) Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8. Proc. Natl. Acad. Sci. USA 108: 20503-20508.
Ye, J., DeBose-Boyd, R.A. (2011) Regulation of cholesterol and fatty acid synthesis. Cold Spring Harb. Perspect. Biol. 3: a004754.
Jo, Y., Sguigna, P.V., DeBose-Boyd, R.A. (2011) Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem. 286: 15022-15031.
Jo, Y., Debose-Boyd, R.A. (2010) Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. Crit. Rev. Biochem. Mol. Biol. 45: 185-98.
Hartman, I.Z., Liu, P., Zehmer, J.K., Luby-Phelps, K., Jo, Y., Anderson, R.G., Debose-Boyd, R.A. (2010) Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets. J. Biol. Chem. 285: 19288-98.
Lee, P.C., Debose-Boyd, R.A. (2010) Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells. J. Lipid Res. 51: 192-201.
Nguyen, A.D., Lee, S.H., DeBose-Boyd, R.A. (2009) Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells. J. Biol. Chem. 284: 26778-88.
Debose-Boyd, R.A. (2008) Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. Cell Res. 18: 609-621.
Cao, J., Wang, J., Qi, W., Miao, H.H., Wang, J., Ge, L., Debose-Boyd, R.A., Tang, J.J., Li, B.L., and Song, B.L. (2007) Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase. Cell Metab. 6: 115-128.
Nguyen, A.D., McDonald, J.G., Bruick, R.K., and Debose-Boyd, R.A. (2007) Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase through accumulation of lanosterol and hypoxia-inducible
factor-mediated induction of insigs. J. Biol. Chem. 282: 27436-27446.
Lee, P.C., Liu, P., and Debose-Boyd, R.A. (2007) Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells. J. Lipid. Res. 48, 1944-1954.
Debose-Boyd, R.A. (2007) A helping hand for cytochrome p450 enzymes. Cell Metab. 5: 81-83.
Lee, P.C., Nguyen, A.D., and DeBose-Boyd, R.A. (2007) Mutations within membrane domains of HMG CoA reductase confer resistance to sterol-accelerated degradation. J. Lipid Res. 48, 318-327.
Lee, J.N., Song, B., and Debose-Boyd, R.A. (2006) Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase, gp78. J. Biol. Chem. 281, 39308-39315.
Song, B.L., and DeBose-Boyd, R.A. (2006) Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols. J. Biol. Chem. 281, 25054-25061.
Goldstein, J.L, DeBose-Boyd, R.A., and Brown, M.S. (2006) Protein sensors for membrane sterols. Cell, 124, 35-46.
Song, B.L., Sever, N., and DeBose-Boyd, R.A. (2005) Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. Mol. Cell 19, 829-840.
Song, B.L., Javitt, N.B., and DeBose-Boyd, R.A. (2005) Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metab 1, 179-189.
Lee, P.C., Sever, N., and DeBose-Boyd, R.A. (2005) Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2. J. Biol. Chem. 280, 25242-25249.
DeBose-Boyd, R.A. (2004) Knowing when to let go: endosomal release of LDL from the LDL-receptor. Mol. Cell 16, 160-162
Sever, N., Lee, P.C.W, Song, B.-L., Rawson, R.B., and DeBose-Boyd, R.A. (2004) Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Biol. Chem. 279, 43136-43147.
Sever, N., Song, B.-L., Yabe, D., Goldstein, J.L., Brown, M.S., and DeBose-Boyd, R.A. (2003) Insig-Dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl CoA Reductase Stimulated by Sterols and Geranylgeraniol. J. Biol. Chem. 278, 52479-52490.
SIGNIFICANT PUBLICATIONS
Song, B.-L. and DeBose-Boyd, R.A. (2004) Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase. J. Biol. Chem. 279, 28798-28806.
Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A. (2003) Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain. Mol. Cell 11, 25-33.
DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. (1999) Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99, 703-712.
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