Link to Department of Molecular Genetics homepage at UT Southwestern Dr.Michael S. Brown Lab
Molecular Genetics Department UT Southwestern
Link to Molecular Genetics Home Page
Link to Lab Overview
Link to Current Research
Link to Lab Overview
Link to Recent Publications
Link to Lab Personnel
Recent Publications of the Brown/Goldstein Laboratory in  the Molecular Genetics 
			 Department at the University of Texas Southwestern
Das, A., Goldstein, J.L., Anderson, D.D., Brown, M.S. and Radhakrishnan, A.: Use of mutant 125I-Perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells. Proc. Natl. Acad. Sci. USA, 110: 10580-10585, 2013.
Zhang, Y., Motamed, M., Seemann, J., Brown, M.S., and Goldstein, J.L.: Point mutation in luminal Loop 7 of Scap blocks interaction with Loop 1 and abolishes movement to Golgi. J. Biol. Chem. 288: 14059-14067, 2013.
Goldstein, J.L., and Brown, M.S.: A golden era of Nobel Laureates. Science, 338: 1033-1034, 2012.
Owen, J.L., Zhang, Y., Bae, S.-H., Farooqi, M.S., Liang, G., Hammer, R.E., Goldstein, J.L., and Brown, M.S.: Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proc. Natl. Acad. Sci. USA, 109: 16184-16189, 2012.
Brown, M.S. and Goldstein, J.L.: Reflections: Scientific side trips: six excursions from the beaten path. J. Biol. Chem., 287: 22418-22435, 2012.
Li, R.L, Sherbet, D. P., Elsbernd, B.L, Goldstein, J.L, Brown, M.S. and Zhao, T.-J.: Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. J. Biol. Chem., 287: 17942-17950, 2012.
Xie, X., Brown, M.S., Shelton, J.M., Richardson, J.A., Goldstein, J.L. and Liang, G.: Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice. Proc. Natl. Acad. Sci. USA 108: 15330-15335, 2011.
Goldstein, J.L., Zhao, T.-J., Li, R.L., Sherbet, D.P., Liang, G., and Brown, M.S.: Surviving starvation: essential role of the ghrelin-growth hormone axis. Cold Spring Harbor Symp. Quant. Biol. 76: doi: 10.1101/sqb.2011.76.010447, 2011.
Motamed, M., Zhang, Y., Wang, M.L., Seemann, J., Kwon, H.J., Goldstein, J.L. and Brown, M.S.: Identification of luminal loop 1 of Scap as the sterol sensor that maintains cholesterol homeostasis. J. Biol. Chem. 286: 18002-18012, 2011.
Zhao, T.-J., Sakata, I., Li, R.L., Liang, G., Richardson, J.A., Brown, M.S., Goldstein, J.L., and Zigman, J.M.: Ghrelin secretion stimulated by β1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc. Natl. Acad. Sci. USA 107: 15868-15873, 2010.
Brown, M.S., Ye, J., and Goldstein, J.L.: HDL miR-d down by SREBP introns. Science 328: 1495-1496, 2010.
Zhao, T.-J., Liang, G., Li, R.L., Xie, X., Sleeman, M.W., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Goldstein, J.L., and Brown, M.D.: Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc. Natl. Acad. Sci. USA 107: 7467-7472, 2010.
Li, S., Brown, M.S., Goldstein, J.L.: Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc. Natl. Acad. Sci. USA 107: 3441-3446, 2010.
Evers, B.M., Farooqi, M.S., Shelton, J.M., Richardson, J.A., Goldstein, J.L., Brown, M.S., Liang, G.: Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by Simvastatin. J. Invest. Dermatol. 130: 1237-1248, 2010.
Okazaki, H., Goldstein, J.L., Brown, M.S., Liang, G.: LXR - SREBP-1c - phospholipid transfer protein axis controls VLDL particle size., J. Biol. Chem. 285: 6801-6810, 2010.
Ikeda, Y., DeMartino, G.N., Brown, M.S., Lee, J.N., Goldstein, J.L. and Ye, J.: Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. J. Biol. Chem. 284: 34889-34900, 2009.
Abi-Mosleh, L., Infante, R.E., Radhakrishnan, A., Goldstein, J.L., and Brown, M.S.: Cyclodextrin overcomes deficient lysosome-to-ER reticulum transport of cholesterol in Niemann-Pick type C cells. Proc. Natl. Acad. Sci. USA 106: 19316-19321, 2009.
Guan, H.-P., Goldstein, J.L., M.S. Brown, and Liang, G.: Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice. J. Biol. Chem. 284: 24644-24652, 2009.
Kwon, H.J., Abi-Mosleh, L., Wang, M.L., Deisenhofer, J., Goldstein, J.L., Brown, M.S., and Infante, R.E.: Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell 137: 1213-1224, 2009.
Radhakrishnan, A., Goldstein, J.L., McDonald, J.G., Brown, M.S.: Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: A delicate balance. Cell Metabolism 8: 512-521, 2008.
Infante, R.E., Wang, M.L., Radhakrishnan, A., Kwon, H.J., Brown, M.S. and Goldstein, J.L.: NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proc. Natl. Acad. Sci. USA 105: 15287-15292, 2008.
Yang, J., Zhao, T.-J., Goldstein, J.L., and Brown, M.S.: Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc. Natl. Acad. Sci. USA 105: 10750-10755, 2008.
Yang, J., Brown, M.S., Liang, G., Grishin, N.V., and Goldstein, J.L.: Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132: 387-396, 2008.
Infante, R.E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J.D., Brown, M.S., and Goldstein, J.L.: Purified NPC1 protein: I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J. Biol. Chem. 283: 1052-1063, 2008.
Infante, R.E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L.N., Wang, M.L., Grishin, N.V., Goldstein, J.L., and Brown, M.S.: Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J. Biol. Chem. 283: 1064-1075, 2008.
REVIEW ARTICLES (since 1986)
Brown, M.S., and Goldstein, J.L.: A receptor-mediated pathway for cholesterol homeostasis. Science 232: 34-47, 1986.
Brown, M.S. and Goldstein, J.L.: The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331-340, 1997.
Brown, M.S., Ye, J., Rawson, R.B., and Goldstein, J.L.: Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans. Cell 100: 391-398, 2000.
Goldstein, J.L., Rawson, R.B., and Brown, M.S.: Mutant mammalian cells as tools to delineate the sterol regulatory element-binding pathway for feedback regulation of lipid synthesis. Arch. Biochem. Biophys. 397: 139-148, 2002.
Horton, J.D., Goldstein, J.L., and Brown, M.S.: SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in liver. J. Clin. Invest. 109: 1125-1131, 2002.
Goldstein, J.L. and Brown, M.S.: Cholesterol: A century of research. Howard Hughes Medical Institute Bulletin 16: 18-19, 2003.
Brown, M.S. and Goldstein, J.L.: A tribute to Akira Endo, discoverer of a "penicillin" for cholesterol. Atherosclerosis Supplements 5: 13-16, 2004.
Goldstein, J.L., DeBose-Boyd, R.A., and Brown, M.S.: Protein sensors for membrane sterols. Cell 124: 35-46, 2006.
Brown, M.S., and Goldstein, J.L.: Lowering LDL - not only how low, but how long? Science 311: 1721-1723, 2006.
Brown, M.S., and Goldstein, J.L.: Selective versus total insulin resistance: A pathogenic paradox. Cell Metabolism 7: 95-96, 2008.
Goldstein, J.L. and Brown, M.S.: From fatty streak to fatty liver: 33 years of joint publications in the JCI. J. Clin. Invest. 118: 1220-1222, 2008.
Brown, M.S. and Goldstein, J.L.: Cholesterol feedback: from Schoenheimer’s bottle to Scap’s MELADL. J. Lipid. Res. S15-S27, 2009.
Goldstein, J.L. and Brown, M.S.: History of discovery: The LDL receptor. Arterioscler. Thromb. Vasc. Biol. 29: 431-438, 2009.
Brown, M.S., and Goldstein, J.L.: Richard G.W. Anderson (1940-2011) and the birth of receptor-mediated endocytosis. J. Cell Biol. 193: 601-603, 2011.
Copyright 2004. The University of Texas 
		Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75390
return to top