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Recent Publications of the Brown/Goldstein Laboratory in the Molecular Genetics Department at the University of Texas Southwestern
Goldstein, J.L., and Brown, M.S.: A golden era of Nobel Laureates. Science, 338: 1033-1034, 2012.
Owen, J.L., Zhang, Y., Bae, S.-H., Farooqi, M.S., Liang, G., Hammer, R.E., Goldstein, J.L., and Brown, M.S.: Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proc. Natl. Acad. Sci. USA, 109: 16184-16189, 2012.
Brown, M.S. and Goldstein, J.L.: Reflections: Scientific side trips: six excursions from the beaten path. J. Biol. Chem., 287: 22418-22435, 2012.
Li, R.L, Sherbet, D. P., Elsbernd, B.L, Goldstein, J.L, Brown, M.S. and Zhao, T.-J.: Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. J. Biol. Chem., 287: 17942-17950, 2012.
Xie, X., Brown, M.S., Shelton, J.M., Richardson, J.A., Goldstein, J.L. and Liang, G.: Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice. Proc. Natl. Acad. Sci. USA 108: 15330-15335, 2011.
Goldstein, J.L., Zhao, T.-J., Li, R.L., Sherbet, D.P., Liang, G., and Brown, M.S.: Surviving starvation: essential role of the ghrelin-growth hormone axis. Cold Spring Harbor Symp. Quant. Biol. 76: doi: 10.1101/sqb.2011.76.010447, 2011.
Motamed, M., Zhang, Y., Wang, M.L., Seemann, J., Kwon, H.J., Goldstein, J.L. and Brown, M.S.: Identification of luminal loop 1 of Scap as the sterol sensor that maintains cholesterol homeostasis. J. Biol. Chem. 286: 18002-18012, 2011.
Zhao, T.-J., Sakata, I., Li, R.L., Liang, G., Richardson, J.A., Brown, M.S., Goldstein, J.L., and Zigman, J.M.: Ghrelin secretion stimulated by β1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc. Natl. Acad. Sci. USA 107: 15868-15873, 2010.
Brown, M.S., Ye, J., and Goldstein, J.L.: HDL miR-d down by SREBP introns. Science 328: 1495-1496, 2010.
Zhao, T.-J., Liang, G., Li, R.L., Xie, X., Sleeman, M.W., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Goldstein, J.L., and Brown, M.D.: Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc. Natl. Acad. Sci. USA 107: 7467-7472, 2010.
Li, S., Brown, M.S., Goldstein, J.L.: Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc. Natl. Acad. Sci. USA 107: 3441-3446, 2010.
Evers, B.M., Farooqi, M.S., Shelton, J.M., Richardson, J.A., Goldstein, J.L., Brown, M.S., Liang, G.: Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by Simvastatin. J. Invest. Dermatol. 130: 1237-1248, 2010.
Okazaki, H., Goldstein, J.L., Brown, M.S., Liang, G.: LXR - SREBP-1c - phospholipid transfer protein axis controls VLDL particle size., J. Biol. Chem. 285: 6801-6810, 2010.
Ikeda, Y., DeMartino, G.N., Brown, M.S., Lee, J.N., Goldstein, J.L. and Ye, J.: Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. J. Biol. Chem. 284: 34889-34900, 2009.
Abi-Mosleh, L., Infante, R.E., Radhakrishnan, A., Goldstein, J.L., and Brown, M.S.: Cyclodextrin overcomes deficient lysosome-to-ER reticulum transport of cholesterol in Niemann-Pick type C cells. Proc. Natl. Acad. Sci. USA 106: 19316-19321, 2009.
Guan, H.-P., Goldstein, J.L., M.S. Brown, and Liang, G.: Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice. J. Biol. Chem. 284: 24644-24652, 2009.
Kwon, H.J., Abi-Mosleh, L., Wang, M.L., Deisenhofer, J., Goldstein, J.L., Brown, M.S., and Infante, R.E.: Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell 137: 1213-1224, 2009.
Radhakrishnan, A., Goldstein, J.L., McDonald, J.G., Brown, M.S.: Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: A delicate balance. Cell Metabolism 8: 512-521, 2008.
Infante, R.E., Wang, M.L., Radhakrishnan, A., Kwon, H.J., Brown, M.S. and Goldstein, J.L.: NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proc. Natl. Acad. Sci. USA 105: 15287-15292, 2008.
Yang, J., Zhao, T.-J., Goldstein, J.L., and Brown, M.S.: Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc. Natl. Acad. Sci. USA 105: 10750-10755, 2008.
Yang, J., Brown, M.S., Liang, G., Grishin, N.V., and Goldstein, J.L.: Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132: 387-396, 2008.
Infante, R.E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J.D., Brown, M.S., and Goldstein, J.L.: Purified NPC1 protein: I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J. Biol. Chem. 283: 1052-1063, 2008.
Infante, R.E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L.N., Wang, M.L., Grishin, N.V., Goldstein, J.L., and Brown, M.S.: Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J. Biol. Chem. 283: 1064-1075, 2008.
REVIEW ARTICLES (since 1986)
Brown, M.S., and Goldstein, J.L.: A receptor-mediated pathway for cholesterol homeostasis. Science 232: 34-47, 1986.
Brown, M.S. and Goldstein, J.L.: The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331-340, 1997.
Brown, M.S., Ye, J., Rawson, R.B., and Goldstein, J.L.: Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans. Cell 100: 391-398, 2000.
Goldstein, J.L., Rawson, R.B., and Brown, M.S.: Mutant mammalian cells as tools to delineate the sterol regulatory element-binding pathway for feedback regulation of lipid synthesis. Arch. Biochem. Biophys. 397: 139-148, 2002.
Horton, J.D., Goldstein, J.L., and Brown, M.S.: SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in liver. J. Clin. Invest. 109: 1125-1131, 2002.
Goldstein, J.L. and Brown, M.S.: Cholesterol: A century of research. Howard Hughes Medical Institute Bulletin 16: 18-19, 2003.
Brown, M.S. and Goldstein, J.L.: A tribute to Akira Endo, discoverer of a "penicillin" for cholesterol. Atherosclerosis Supplements 5: 13-16, 2004.
Goldstein, J.L., DeBose-Boyd, R.A., and Brown, M.S.: Protein sensors for membrane sterols. Cell 124: 35-46, 2006.
Brown, M.S., and Goldstein, J.L.: Lowering LDL - not only how low, but how long? Science 311: 1721-1723, 2006.
Brown, M.S., and Goldstein, J.L.: Selective versus total insulin resistance: A pathogenic paradox. Cell Metabolism 7: 95-96, 2008.
Goldstein, J.L. and Brown, M.S.: From fatty streak to fatty liver: 33 years of joint publications in the JCI. J. Clin. Invest. 118: 1220-1222, 2008.
Brown, M.S. and Goldstein, J.L.: Cholesterol feedback: from Schoenheimer’s bottle to Scap’s MELADL. J. Lipid. Res. S15-S27, 2009.
Goldstein, J.L. and Brown, M.S.: History of discovery: The LDL receptor. Arterioscler. Thromb. Vasc. Biol. 29: 431-438, 2009.
Brown, M.S., and Goldstein, J.L.: Richard G.W. Anderson (1940-2011) and the birth of receptor-mediated endocytosis. J. Cell Biol. 193: 601-603, 2011.
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