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Recent Publications of the Brown/Goldstein Laboratory in the Molecular Genetics Department at the University of Texas Southwestern
Brown/Goldstein's Recent Publications
Goldstein, J.L. and Brown, M.S.: From fatty streak to fatty liver: 33 years of joint publications in the JCI. J. Clin. Invest., 118: 1220-1222, 2008.
Yang, J., Brown, M.S., Liang, G., Grishin, N.V., and Goldstein, J.L.: Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell, 132: 387-396, 2008.
Brown, M.S. and Goldstein, J.L.: Selective vs. total insulin resistance: A pathogenic paradox. Cell Metabolism, 7: 95-96, 2008.
Infante, R.E., Abi-Mosleh, L., Radhakrishnan, A., Dale, J.D., Brown, M.S., and Goldstein, J.L.: Purified NPC1 protein: I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J. Biol. Chem. 283: 1052-1063, 2008.
Infante, R.E., Radhakrishnan, A., Abi-Mosleh, L., Kinch, L.N., Wang, M.L., Grishin, N.V., Goldstein, J.L., and Brown, M.S.: Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J. Biol. Chem. 283: 1064-1075, 2008.
Sun, L.-P., Seemann, J., Goldstein, J.L., and Brown, M.S., Sterol-regulated transport of SREBPS from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc. Natl. Acad. Sci. USA, 104: 6519-6526, 2007.
Radhakrishnan, A., Ikeda, Y., Kwon, H.J., Brown, M.S., and Goldstein, J.L.: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig. Proc. Natl. Acad. Sci. USA, 104: 6511-6518, 2007.
Engelking, L.J., Evers, B.M., Richardson, J.A., Goldstein, J.L., Brown, M.S. and Liang, G.: Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J. Clin. Invest., 116: 2356-2365, 2006.
Brown, M.S. and Goldstein, J.L.: Lowering LDL – not only how low, but how long? Science, 311: 1721-1723, 2006.
Gong, Y., Lee, J.N., Brown, M.S., Goldstein, J.L. and Ye, J.: Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for regulating cholesterol homeostasis. Proc. Natl. Acad. Sci. USA, 103: 6154- 6159, 2006.
Goldstein, J.L., DeBose-Boyd, R.A. and Brown, M.S.: Protein sensors for membrane sterols. Cell, 124: 35-46, 2006.
SIGNIFICANT PUBLICATIONS
Brown, M.S., and Goldstein, J.L.: A receptor-mediated pathway for cholesterol homeostasis. Science 232: 34-47, 1986.
Reiss, Y., Goldstein, J.L., Seabra, M.C., Casey, P.J., and Brown, M.S. Inhibition of purified p21ras farnesyl:protein transferase by
Cys-AAX tetrapeptides. Cell 62: 81-88, 1990.
Seabra, M.C., Brown, M.S., and Goldstein, J.L. Retinal Degeneration in
Choroideremia: Deficiency of Rab Geranylgeranyl Transferase. Science 259:377-381, 1993.
Briggs, M.R., Yokoyama, C., Wang, X., Brown, M.S., and Goldstein, J.L. Nuclear Protein That Binds Sterol Regulatory Element of Low Density Lipoprotein Receptor Promoter, I. Identification of the Protein and Delineation of Its Target Nucleotide Sequence. J. Biol. Chem. 268:14490-14496, 1993.
Wang, X., Briggs, M.R., Hua, X., Yokoyama, C., Goldstein, J.L., and Brown, M.S., Nuclear Protein That Binds Sterol Regulatory Element of Low Density Lipoprotein Receptor Promoter, II. Purification and Characterization. J. Biol. Chem. 268: 14497-14504, 1993.
Brown, M.S. and Goldstein, J.L. Heart Attacks: Gone with the Century? Science 272: 629 (editorial), 1996.
Brown, M.S. and Goldstein, J.L.: The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor. Cell 89: 331-340, 1997
Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S., and Goldstein, J.L.: Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401: 73-76, 1999.
Brown, M.S., Ye, J., Rawson, R.B., and Goldstein, J.L.: Regulated Intramembrane Proteolysis: A Control Mechanism Conserved from Bacteria to Humans. Cell, 100: 391-398, 2000.
Nohturfft, A., Yabe, D., Goldstein, J.L., Brown, M.S., and Espenshade,P.J.: Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell, 102: 315-323, 2000.
Matsuda, M., Korn, B.S., Hammer, R.E., Moon, Y.-A., Komuro, R., Horton, J.D., Goldstein, J.L., Brown, M.S. and Shimomura, I.: SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev., 15: 1206-1216, 2001.
Goldstein, J.L., Rawson, R.B., and Brown, M.S.: Mutant mammalian cells as tools to delineate the sterol regulatory element-binding pathway forfeedback regulation of lipid synthesis. Arch. Biochem. Biophys., 397: 139-148, 2002.
Horton, J.D., Goldstein, J.L., and Brown, M.S.: SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in liver. J. Clin. Invest., 109: 1125-1131, 2002.
Yang, T., Espenshade, P.J., Wright, M.E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J.L., and Brown, M.S.: Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, amembrane protein that facilitates retention of SREBPs in the ER. Cell, 110: 489-500, 2002.
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