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Molecular Genetics Department UT Southwestern
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For a complete list of Dr. Herz's published work go to Herzlab.org
Dries, D.R., Yu, G., Herz, J. (2012) Extracting beta-amyloid from Alzheimer's disease. Proc. Natl. Acad. Sci. USA 109:3199-200.
Cenik, B., Sephtonm C.F., Dewey, C.M., Xian, X., Wei, S., Yu, K., Niu, W., Coppola, G., Coughlin, S.E., Lee, S.E., Dries, D.R., Almeida, S., Geschwind, D.H., Gao, F.B., Miller, B.L., Farese, R.V. Jr., Posner, B.A., Yu, G., Herz, J. (2011) Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J. Biol. Chem. 286: 16101-16108.
Boucher, P., Herz, J. (2011) Signaling through LRP1: Protection from atherosclerosis and beyond. Biochem Pharmacol. 81: 1-5.
Dieckmann, M., Dietrich, M.F., Herz, J. (2010) Lipoprotein receptors - an evolutionarily ancient multifunctional receptor family. Biol. Chem. 391: 1341-1363.
Chen, Y., Durakoglugil, M.S., Xian, X., Herz, J. (2010) ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc. Natl. Acad. Sci. USA. 107: 12011-6.
Dietrich, M.F., van der Weyden, L., Prosser, H.M., Bradley, A., Herz, J., Adams, D.J. (2010) Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS One 5:e9960.
Choi, H.Y., Dieckmann, M., Herz, J., Niemeier, A. (2009) Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. PLoS One. 4, e7930.
Durakoglugil, M.S., Chen, Y., White, C.L., Kavalali, E.T., Herz, J. (2009) Reelin signaling antagonizes beta-amyloid at the synapse. Proc. Natl. Acad. Sci. USA. 106, 15938-43.
Zhou, L., Takayama, Y., Boucher, P., Tallquist, M.D., Herz, J. (2009) LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One. 4, e6922.
Zhou, L., Choi, H.Y., Li, W.P., Xu, F., Herz, J. (2009) LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PLoS One. 4, e6853.
Herz, J. (2009) Apolipoprotein E receptors in the nervous system.
Curr. Opin. Lipidol. 20, 190-6.
Herz, J., Chen, Y., Masiulis, I., Zhou, L. (2009) Expanding functions of lipoprotein receptors. J. Lipid Res. 50 Suppl, S287-92.
Masiulis, I., Quill, T.A., Burk, R.F., Herz, J. (2009) Differential functions of the Apoer2 intracellular domain in selenium uptake and cell signaling. Biol. Chem. 390, 67-73.
Boucher, P., Li, W.P., Matz, R.L., Takayama, Y., Auwerx, J., Anderson, R.G., Herz, J. (2007) LRP1 Functions as an Atheroprotective Integrator of TGFbeta and PDFG Signals in the Vascular Wall: Implications for Marfan Syndrome. PLoS ONE 2, e448.
Herz, J. (2007) Overview: the long and winding road to understanding Alzheimer's disease. Neuron 53, 477-479.
Jones, C., Garuti, R., Michaely, P., Li, W.P., Maeda, N., Cohen, J.C., Herz, J., Hobbs, H.H. (2007) Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. J. Clin. Invest. 117, 165-174.
Beffert, U., Nematollah Farsian, F., Masiulis, I., Hammer, R.E., Yoon, S.O., Giehl, K.M., Herz, J. (2006) ApoE receptor 2 controls neuronal survival in the adult brain. Curr. Biol. 16, 2446-2452.
Herz, J., Chen, Y. (2006) Reelin, lipoprotein receptors and synaptic plasticity. Nat. Rev. Neurosci. 7, 850-859.
Johnson, E.B., Steffen, D.J., Lynch, K.W., Herz, J. (2006) Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease. Genomics. 88, 600-609.
Herz, J. (2006) The switch on the RAPper's necklace... Mol. Cell 23, 451-455.
Beffert, U., Durudas, A., Weeber, E.J., Stolt, P.C., Giehl, K.M., Sweatt, J.D., Hammer, R.E., Herz, J. (2006) Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity.
J. Neurosci. 26, 2041-2052.
Johnson, E.B., Hammer, R.E., Herz, J. (2005) Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum. Mol. Genet. 14, 3523-3538.
Garuti, R., Jones, C., Li, W.P., Michaely, P., Herz, J., Gerard, R.D., Cohen, J.C., Hobbs, H.H. (2005) The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits. J. Biol. Chem. 280, 40996-41004.
May, P., Herz, J., Bock, H.H. (2005) Molecular mechanisms of lipoprotein receptor signalling. Cell Mol. Life Sci. 62, 2325-2338.
Uwe Beffert, Edwin Weeber, Gerardo Morfini, Jane Ko, Scott T. Brady, Li-Huei Tsai, J. David Sweatt, and Joachim Herz (2004) Reelin and Cdk5 dependent signals cooperate in regulating neuronal migration and synaptic transmission. J. Neuroscience 24, 1897-1906.
Hans H. Bock and Joachim Herz (2003) Reelin Activates Src Family Tyrosine Kinases in Neurons. Current Biology 13, 18-26.
Philippe Boucher, Pingsheng Liu, Michael Gotthardt, Thomas Hiesberger, Richard G. W. Anderson, and Joachim Herz (2002) PDGF mediates tyrosine phosphorylation of the cytoplasmic domain of the LDL receptor-related protein (LRP) in caveolae. J. Biol. Chem., 277, 15507-13.
Joachim Herz and Hans. H. Bock (2002) Lipoprotein Receptors in the Nervous System. Ann. Rev. Biochem. 71, 405-34.
SIGNIFICANT PUBLICATIONS
Marion Trommsdorff, Michael Gotthardt, Thomas Hiesberger, John Shelton, Walter Stockinger, Johannes Nimpf, Robert E. Hammer, James A. Richardson, and Joachim Herz (1999) Reeler/Disabled-Like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL receptor and ApoE receptor-2. Cell 97, 689-701.
Thomas Hiesberger, Marion Trommsdorff, Brian W. Howell, Andre Goffinet, Marc C. Mumby, Jonathan A. Cooper, and Joachim Herz (1999) Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of the adaptor protein Disabled-1 and modulates tau phosphorylation. Neuron 24, 481-489.
Thomas E. Willnow, Zeqi Sheng, Shun Ishibashi, and Joachim Herz (1994) Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of A Receptor Antagonist. Science 264, 1471-1474.
Joachim Herz, Ute Hamann, Sissel Rogne, Ola Myklebost, Heinrich Gausepohl, and Keith K. Stanley (1988) Surface location and high affinity for calcium of a 500 kd liver membrane protein closely related to the LDL receptor suggest a physiological role as lipoprotein receptor. EMBO J. 7, 4119-4127.
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