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Moon, Y.A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M.S., Goldstein, J.L., Horton, J.D. 2012. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab. 15: 240-246.
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Cohen, J.C., Horton, J.D., Hobbs, H.H. 2011. Human fatty liver disease: old questions and new insights. Science 332: 1519-1523. |
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Browning, J.D., Horton, J.D. 2010. Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans. J. Lipid Res. 51: 3359-63. |
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Kim, C.W., Moon, Y.A., Park, S.W., Cheng, D., Kwon, H.J., Horton, J.D. 2010. Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc. Natl. Acad. Sci. USA. 107:9626-31. |
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Lakoski, S.G., Lagace, T.A., Cohen, J.C., Horton, J.D., Hobbs, H.H. 2009. Genetic and metabolic determinants of plasma PCSK9 levels.
J. Clin. Endocrinol. Metab. 94: 2537-43. |
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McNutt, M.C., Kwon, H.J., Chen, C., Chen, J.R., Horton, J.D., Lagace, T.A. 2009. Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. J. Biol. Chem. 284:10561-70. |
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Horton, J.D., Cohen, J.C., Hobbs, H.H. 2009. PCSK9: a convertase that coordinates LDL catabolism.
J. Lipid Res. 50: Suppl:S172-7. |
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Y.A. Moon, R.E. Hammer, J.D. Horton. 2009. Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
J. Lipid Res. 50: 412-23. |
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J.D. Horton. 2008. Physiology: Unfolding Lipid Metabolism. Science 320:1433-4. |
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J.D. Horton, J.C. Cohen, H.H. Hobbs. 2007. Molecular biology of PCSK9: its role in LDL metabolism.
Trends Biochem Sci. 32:71-77.
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D.W. Zhang, T.A. Lagace, R. Garuti, Z. Zhao, M. McDonald, J.D. Horton, J.C. Cohen, H.H. Hobbs. 2007. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.
J. Biol. Chem. 282:18602-18612.
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M.C. McNutt, T.A. Lagace, J.D. Horton. 2007. Catalytic Activity Is Not Required for Secreted PCSK9 to Reduce Low Density Lipoprotein Receptors in HepG2 Cells.
J. Biol. Chem. 282:20799-20803. |
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T. A. Lagace, D. E. Curtis, R. Garuti, M. C. McNutt, S. W. Park, H. B. Prather, N. N. Anderson, Y. K. Ho, R. E. Hammer, and J. D. Horton. 2006. Secreted PCSK9 decreases LDL receptors in hepatocytes and livers of parabiotic mice. J. Clin. Invest. 116:2995-3005. |
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SIGNIFICANT PUBLICATIONS |
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J.D. Horton, Y. Bashmakov, I. Shimomura and H. Shimano. 1998. Regulation of sterol regulatory element binding
proteins in livers of fasted and refed mice. Proc. Natl. Acad. Sci. USA. 95:5987-5992.
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Y-A. Moon, N.A. Shah, S. Mohapatra,
J.A. Warrington and J.D. Horton. 2001. Identification of a
mammalian long chain fatty acyl elongase regulated by sterol
regulatory element-binding proteins. J. Biol. Chem.
276:45358-45366. |
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J.D. Horton, N.A. Shah, J.A. Warrington,
N.N. Anderson, S.W. Park, M.S. Brown, and J.L. Goldstein.
2003. Combined analysis of oligonucleotide microarray data
from transgenic and knockout mice identifies direct SREBP
target genes. Proc. Natl. Acad. Sci. USA. 100:12027-12032. |
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T.A. Lagace, D.E. Curtis, R. Garuti, M.C. McNutt, S.W. Park, H.B. Prather, N.N. Anderson, Y.K. Ho, R.E. Hammer, and J.D. Horton. 2006.
Secreted PCSK9 decreases LDL receptors in hepatocytes and livers of parabiotic mice. J. Clin. Invest. 116:2995-3005 .
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Kim, C.W., Moon, Y.A., Park, S.W., Cheng, D., Kwon, H.J., Horton, J.D. 2010. Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc. Natl. Acad. Sci. USA. 107:9626-31. |
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