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Lakoski, S.G., Lagace, T.A., Cohen, J.C., Horton, J.D., Hobbs, H.H. 2009. Plasma levels of PCSK9 in a large multiethnic population.
J. Clin. Endocrinol. Metab. 2009 Apr 7. [Epub ahead of print] |
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McNutt, M.C., Kwon, H.J., Chen, C., Chen, J.R., Horton, J.D., Lagace, T.A. 2009. Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. J. Biol. Chem. 284:10561-70. |
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Cortés, V.A., Curtis, D.E., Sukumaran, S., Shao, X., Parameswara, V., Rashid, S., Smith, A.R., Ren, J., Esser, V., Hammer, R.E., Agarwal, A.K., Horton, J.D., Garg, A. 2009 Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 9:165-76. |
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Horton, J.D., Cohen, J.C., Hobbs, H.H. 2009. PCSK9: a convertase that coordinates LDL catabolism.
J. Lipid Res. 50: Suppl:S172-7. |
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Y.A. Moon, R.E. Hammer, J.D. Horton. 2009. Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
J. Lipid Res. 50: 412-23. |
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M. Frank-Kamenetsky, A. Grefhorst, N.N. Anderson, T.S. Racie, B. Bramlage, A. Akinc,
D. Butler, K. Charisse, R. Dorkin, Y. Fan, C. Gamba-Vitalo, P. Hadwiger, M. Jayaraman, M. John, K.N. Jayaprakash,
M. Maier, L. Nechev, K.G. Rajeev, T. Read, I. Röhl, J. Soutschek, P. Tan, J. Wong, G. Wang, T. Zimmermann,
A. de Fougerolles, H.P. Vornlocher, R. Langer, D. G. Anderson, M. Manoharan, V. Koteliansky, J.D. Horton, K. Fitzgerald.
2008. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.
Proc Natl Acad Sci USA 105:11915-20. |
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J.D. Horton. 2008. Physiology: Unfolding Lipid Metabolism.
Science. 320:1433-4. |
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K. Minehira, S.G. Young, C.J. Villanueva, L. Yetukuri, M. Oresic, M.K. Hellerstein, R.V. Farese, Jr., J.D. Horton, F. Preitner, B. Thorens, L. Tappy. 2008. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.
J. Lipid Res.
49: 2038-44. |
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J.D. Horton, J.C. Cohen, H.H. Hobbs. 2007. Molecular biology of PCSK9: its role in LDL metabolism.
Trends Biochem Sci. 32:71-77.
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D.W. Zhang, T.A. Lagace, R. Garuti, Z. Zhao, M. McDonald, J.D. Horton, J.C. Cohen, H.H. Hobbs. 2007. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.
J. Biol. Chem. 282:18602-18612.
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M.C. McNutt, T.A. Lagace, J.D. Horton. 2007. Catalytic Activity Is Not Required for Secreted PCSK9 to Reduce Low Density Lipoprotein Receptors in HepG2 Cells.
J. Biol. Chem. 282:20799-20803.
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M. John, R. Constien, A. Akinc, M. Goldberg, Y.A. Moon, M. Spranger, P. Hadwiger, J. Soutschek, H.P. Vomlocher, M. Manoharan, M. Stoffel, R. Langer, D.G. Anderson, J.D. Horton, V. Kotelianksky, and D. Bumcrot. 2007. Effective RNAi-mediated gene silencing without interruption of the endogenous
microRNA pathway.
Nature 449:745-747.
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| Z. Zhao, Y. Tuakli-Wosornu, T.A. Lagace, L. Kinch, N.V. Grishin, J.D. Horton, J.C. Cohen, H.H. Hobbs. 2006. Molecular characterization of loss-of-function mutations in PCSK9 and
identification of a compound heterozygote.
Am. J. Hum. Genet. 79:514-523. |
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T. A. Lagace, D. E. Curtis, R. Garuti, M. C. McNutt, S. W. Park, H. B. Prather, N. N. Anderson, Y. K. Ho, R. E. Hammer, and J. D. Horton. 2006. Secreted PCSK9 decreases LDL receptors in hepatocytes and livers of parabiotic mice. J. Clin. Invest. 116:2995-3005.
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SIGNIFICANT PUBLICATIONS
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J.D. Horton, Y. Bashmakov, I. Shimomura and H. Shimano. 1998. Regulation of sterol regulatory element binding
proteins in livers of fasted and refed mice. Proc. Natl. Acad. Sci. USA. 95:5987-5992.
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I. Shimomura, Y. Bashmakov and J.D. Horton. 1999. Increased levels of nuclear SREBP-1c associated with
fatty livers in two mouse models of diabetes mellitus. J. Biol. Chem. 274:30028-30032. |
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Y-A. Moon, N.A. Shah, S. Mohapatra,
J.A. Warrington and J.D. Horton. 2001. Identification of a
mammalian long chain fatty acyl elongase regulated by sterol
regulatory element-binding proteins. J. Biol. Chem.
276:45358-45366.
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J.D. Horton, N.A. Shah, J.A. Warrington,
N.N. Anderson, S.W. Park, M.S. Brown, and J.L. Goldstein.
2003. Combined analysis of oligonucleotide microarray data
from transgenic and knockout mice identifies direct SREBP
target genes. Proc. Natl. Acad. Sci. USA. 100:12027-12032.
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T.A. Lagace, D.E. Curtis, R. Garuti, M.C. McNutt, S.W. Park, H.B. Prather, N.N. Anderson, Y.K. Ho, R.E. Hammer, and J.D. Horton. 2006.
Secreted PCSK9 decreases LDL receptors in hepatocytes and livers of parabiotic mice. J. Clin. Invest. 116:2995-3005 .
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