Link to Department of Molecular Genetics homepage at UT Southwestern Dr. Jay Horton Lab
Molecular Genetics Department UT Southwestern
Link to Molecular Genetics Home Page
Link to Lab Overview
Link to Current Research
Link to Lab Overview
Link to Recent Publications
Link to Lab Personnel
Recent Publications of Dr. Jay Horton Lab in the Molecular Genetics 
			 Department at the University of Texas Southwestern
Dr. Jay Horton's Recent Publications
Debose-Boyd, R.A., Horton, J.D. 2013. Opening up new fronts in the fight against cholesterol. Elife 2: e00663.
Moon, Y.A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M.S., Goldstein, J.L., Horton, J.D. 2012. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab. 15: 240-246.
Cohen, J.C., Horton, J.D., Hobbs, H.H. 2011. Human fatty liver disease: old questions and new insights. Science 332: 1519-1523.
Browning, J.D., Horton, J.D. 2010. Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans. J. Lipid Res. 51: 3359-63.
Kim, C.W., Moon, Y.A., Park, S.W., Cheng, D., Kwon, H.J., Horton, J.D. 2010. Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc. Natl. Acad. Sci. USA. 107:9626-31.
Lakoski, S.G., Lagace, T.A., Cohen, J.C., Horton, J.D., Hobbs, H.H. 2009. Genetic and metabolic determinants of plasma PCSK9 levels. J. Clin. Endocrinol. Metab. 94: 2537-43.
McNutt, M.C., Kwon, H.J., Chen, C., Chen, J.R., Horton, J.D., Lagace, T.A. 2009. Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. J. Biol. Chem. 284:10561-70.
Horton, J.D., Cohen, J.C., Hobbs, H.H. 2009. PCSK9: a convertase that coordinates LDL catabolism. J. Lipid Res. 50: Suppl:S172-7.
Y.A. Moon, R.E. Hammer, J.D. Horton. 2009. Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice. J. Lipid Res. 50: 412-23.
J.D. Horton. 2008. Physiology: Unfolding Lipid Metabolism. Science 320:1433-4.
J.D. Horton, J.C. Cohen, H.H. Hobbs. 2007. Molecular biology of PCSK9: its role in LDL metabolism. Trends Biochem Sci. 32:71-77.
D.W. Zhang, T.A. Lagace, R. Garuti, Z. Zhao, M. McDonald, J.D. Horton, J.C. Cohen, H.H. Hobbs. 2007. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J. Biol. Chem. 282:18602-18612.
M.C. McNutt, T.A. Lagace, J.D. Horton. 2007. Catalytic Activity Is Not Required for Secreted PCSK9 to Reduce Low Density Lipoprotein Receptors in HepG2 Cells. J. Biol. Chem. 282:20799-20803.
T. A. Lagace, D. E. Curtis, R. Garuti, M. C. McNutt, S. W. Park, H. B. Prather, N. N. Anderson, Y. K. Ho, R. E. Hammer, and J. D. Horton. 2006. Secreted PCSK9 decreases LDL receptors in hepatocytes and livers of parabiotic mice. J. Clin. Invest. 116:2995-3005.
SIGNIFICANT PUBLICATIONS
J.D. Horton, Y. Bashmakov, I. Shimomura and H. Shimano. 1998. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc. Natl. Acad. Sci. USA. 95:5987-5992.

Y-A. Moon, N.A. Shah, S. Mohapatra, J.A. Warrington and J.D. Horton. 2001. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J. Biol. Chem.
276:45358-45366.
J.D. Horton, N.A. Shah, J.A. Warrington, N.N. Anderson, S.W. Park, M.S. Brown, and J.L. Goldstein. 2003. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci. USA. 100:12027-12032.
T.A. Lagace, D.E. Curtis, R. Garuti, M.C. McNutt, S.W. Park, H.B. Prather, N.N. Anderson, Y.K. Ho, R.E. Hammer, and J.D. Horton. 2006. Secreted PCSK9 decreases LDL receptors in hepatocytes and livers of parabiotic mice. J. Clin. Invest. 116:2995-3005 .
Kim, C.W., Moon, Y.A., Park, S.W., Cheng, D., Kwon, H.J., Horton, J.D. 2010. Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc. Natl. Acad. Sci. USA. 107:9626-31.
Copyright 2004. The University of Texas 
		Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75390
return to top