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Recent Publications of Dr. Jin Ye in the Molecular Genetics Department at the University of Texas Southwestern
HCV Model
Yao, H. and Ye, J. "Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells." J. Biol. Chem. 283: 849-854 (2008).
Huang, H., Chen, Y., and Ye, J. "Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E." Proc. Natl. Acad. Sci. USA 104: 18666-18670 (2007).
Ye, J. "Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus." PLoS Pathog. 3: 1017-1022 (2007).
Huang, H., Sun, F., Owen, D.M., Li, W., Chen, Y., Gale, M., Jr. and Ye, J. "Hepatitis C Virus production by human hepatocytes dependent on assembly and secretion of Very Low Density Lipoproteins." Proc. Natl. Acad. Sci. USA 104: 5848-5853 (2007).
Lee, J., Song, B., Debose-Boyd, R., and Ye, J. "Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78." J. Biol. Chem. 281: 39308-39315 (2006).
Gong, Y., Lee, J., Brown, M.S., Goldstein, J.L., and Ye, J. "Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis." Proc. Natl. Acad. Sci. USA 103: 6154-6159 (2006).
Lee, J., Gong, Y., Zhang, X., and Ye, J. "Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines." Proc. Natl. Acad. Sci. USA 103: 4958-4963 (2006).
Gong, Y., Lee, J., Lee, P., Goldstein, J.L., Brown, M.S. and Ye, J. "Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feed back control of cholesterol synthesis and uptake." Cell Metabolism 3: 15-24(2006).
Wang C., Hua, H., Gale, M., Brown, M.S., Goldstein, J.L., and Ye, J.
“Identification of FBL2 as a geranylgeranylated cellular protein required
for hepatitis C virus RNA replication” Mol. Cell 18: 425-434 (2005).
Lee, J. and Ye, J. “Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1”
J. Biol. Chem. 279: 45257-45265 (2004).
Ye, J., Wang, C., Sumpter, R., Brown, M.S., Goldstein, J.L., and Gale, M. “Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation” Proc. Natl. Acad. Sci. USA 100: 15865-15870 (2003).
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