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Recent Publications of  Dr. Jin Ye in the Molecular Genetics 
			 Department at the University of Texas Southwestern
HCV Model
Ye, J. “Proteasomes: Nrf1 to the rescue” eLife Sciences 3: 10.7554/eLife.e02062. (2014)
Kim, H. and Ye, J. “Cellular responses to excess fatty acids: focus on ubiquitin regulatory X domain-containing protein 8” Curr. Opin, Lipidol. In press. (2014)
Ye, J. "Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity." Biochim. Biophys. Acta 1828: 2926-32. (2013)
Kim, J., Lee, J.N., Ye, J., Hao, R., Debose-Boyd, R., Ye, J. "Sufficient Production of Geranylgeraniol Is Required to Maintain Endotoxin Tolerance in Macrophages." J. Lipid Res. 54: 3430-3437. (2013)
Kim, H., Zhang, H., Meng, D., Russell, G., Lee, J. and Ye, J. “UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long chain unsaturated fatty acids” J. Lipid Res. 54: 2144-2152. (2013)
Chen, Q., Denard, B., Huang, H., and Ye, J. “Epigenetic silencing of antiviral genes renders clones of Huh-7 cells permissive for hepatitis C virus replication” J. Virol. 87:659-665. (2013)
Denard, B., Lee, C., and Ye, J. “Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1” eLife Sciences 1: 10.7554/eLife.00090 (2012)
Chen, Z., and Ye, J. “Getting to grips with hepatitis” eLife Sciences 1: 10.7554/eLife.00301 (2012)
Ye, J. “Cellular responses to unsaturated fatty acids mediated by their sensor Ubxd8” Front. Biol. 7:397-403. (2012)
Ye, J. "Hepatitis C virus: a new class of virus associated with particles derived from very low-density lipoproteins." Arterioscler. Thromb. Vasc. Biol. 32: 1099-103. (2012)
Denard, B., Seemann, J., Chen, Q., Gay, A., Huang, H., Chen, Y., Ye, J. "The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells." Cell Host Microbe 10: 65-74, (2011).
Ye, J. "Cell biology. Protease sets site-1 on lysosomes." Science 333: 50-51, (2011).
Ye, J., DeBose-Boyd, R.A. "Regulation of cholesterol and fatty acid synthesis." Cold Spring Harb. Perspect. Biol. 3: a004754. (2011)
Lee, J.N., Kim, H., Yao, H., Chen, Y., Weng, K., Ye, J. "Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis." Proc Natl Acad Sci U S A. 107: 21424-21429, (2010).
Brown, M.S., Ye, J., Goldstein, J.L. "HDL miR-ed down by SREBP introns." Science 328: 1495-1496, (2010).
Ikeda, Y., Demartino, G.N., Brown, M.S., Lee, J.N., Goldstein, J.L., Ye, J. "Regulated erad of a polytopic protein: p97 recruits proteasomes to
insig-1 before extraction from membranes." J. Biol. Chem. 284: 34889-34900, (2009).
Owen, D.M., Huang, H., Ye, J., Gale, M. Jr. "Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor." Virology. 394: 99-108, (2009).
Lee, J.N., Zhang, X., Feramisco, J.D., Gong, Y., Ye, J. "Unsaturated fatty acids inhibit proteasomal degradation of insig-1 at a post-ubiquitination step." J. Biol. Chem. 283: 33772-33783 (2008).
Yao, H. and Ye, J. "Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells." J. Biol. Chem. 283: 849-854 (2008).
Huang, H., Chen, Y., and Ye, J. "Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E." Proc. Natl. Acad. Sci. USA 104: 18666-18670 (2007).
Ye, J. "Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus." PLoS Pathog. 3: 1017-1022 (2007).
Huang, H., Sun, F., Owen, D.M., Li, W., Chen, Y., Gale, M., Jr. and Ye, J. "Hepatitis C Virus production by human hepatocytes dependent on assembly and secretion of Very Low Density Lipoproteins." Proc. Natl. Acad. Sci. USA 104: 5848-5853 (2007).
Lee, J., Song, B., Debose-Boyd, R., and Ye, J. "Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78." J. Biol. Chem. 281: 39308-39315 (2006).
Gong, Y., Lee, J., Brown, M.S., Goldstein, J.L., and Ye, J. "Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis." Proc. Natl. Acad. Sci. USA 103: 6154-6159 (2006).
Lee, J., Gong, Y., Zhang, X., and Ye, J. "Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines." Proc. Natl. Acad. Sci. USA 103: 4958-4963 (2006).
Gong, Y., Lee, J., Lee, P., Goldstein, J.L., Brown, M.S. and Ye, J. "Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feed back control of cholesterol synthesis and uptake." Cell Metabolism 3: 15-24(2006).
Wang C., Hua, H., Gale, M., Brown, M.S., Goldstein, J.L., and Ye, J.
“Identification of FBL2 as a geranylgeranylated cellular protein required
for hepatitis C virus RNA replication” Mol. Cell 18: 425-434 (2005).
Lee, J. and Ye, J. “Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1”
J. Biol. Chem. 279: 45257-45265 (2004).
Ye, J., Wang, C., Sumpter, R., Brown, M.S., Goldstein, J.L., and Gale, M. “Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation” Proc. Natl. Acad. Sci. USA 100: 15865-15870 (2003).
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