Link to Department of Molecular Genetics homepage at UT Southwestern Dr. Rob Rawson Lab
Molecular Genetics Department UT Southwestern
Link to Molecular Genetics Home Page
Link to Lab Overview
Link to Current Research
Link to Lab Overview
Link to Recent Publications
Link to Lab Personnel
Recent Publications of  Dr. Rob Rawson in the Molecular Genetics 
			 Department at the University of Texas Southwestern
Dr. Rob Rawson's Recent Publications
Ozdemir, C., Rawson, R.B. "Other ways to skin a cat: Activating SREBP without scap." (2010) Fly (Austin) 5: [Epub ahead of print].
Matthews, K.A., Ozdemir, C., Rawson, R.B. "Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster." (2009) Genetics 185: 189-8.
Amarneh, B., Rawson, R.B. "Rhomboid proteases: familiar features in unfamiliar phases." (2009) Mol. Cell. 36: 922-3.
Rodriguez-Acebes, S., de la Cueva, P., Fernandez-Hernando, C., Ferruelo, A.J., Lasuncion, M.A., Rawson, R.B., Martinez-Botas, J., Gomez-Coronado, D. "Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line." (2009) Biochem. J. 420: 305-15.
Amarneh, B., Matthews, K.A., Rawson, R.B. "Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae. (2009) J. Biol. Chem. 284: 9674-82.
Matthews, K.A., Kunte, A.S., Tambe-Ebot, E., Rawson, R.B. "Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster." (2009) Genetics 181: 119-28.
Rawson, R.B. "Intriguing parasites and intramembrane proteases." (2008) Genes Dev. 22:1561-6.
Cherry, S., Kunte, A., Wang, H., Coyne, C., Rawson, R.B., Perrimon, N. "COPI activity coupled with fatty acid biosynthesis is required for viral replication." (2006) PLoS Pathog. 2:e102.
Rawson, R.B. "An ARC light on lipid metabolism." (2006) Cell Metab. 4: 181-183.
Kunte, A. S., Matthews, K. M., and Rawson, R. B. “Fatty acid auxotrophy in Drosophila larvae lacking SREBP.” (2006) Cell Metabolism, 3: 439-448.
Xu F., Rychnovsky, S.D., Belani, J.D., Hobbs H.H., Cohen J.C., Rawson R.B. "Dual roles for cholesterol in mammalian cells." (2005) PNAS, 102: 14551-14556.
Sever, N., Lee, P. C. W., Song, B.-L., Rawson, R. B., and DeBose-Boyd, R. A. “Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.” (2004) J Biol Chem., 279: 43136–43147.
Dobrosotskaya, I. Y. Goldstein, J. L., Brown, M. S., Rawson, R. B. "Reconstitution of sterol-regulated ER-to-golgi transport of SREBP-2 in insect cells by Co-expression of mammalian SCAP and insigs." (2003) J Biol Chem., 278: 35837-35843.
Yabe, D., Xia, Z.-P., Adams, C. M., and Rawson, R. B. "Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols." (2002) PNAS, 99: 16672-16677.
Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L., Rawson, R. B., “Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila.” (2002) Science, 269: 879-883
Seegmiller, A. C., Dobrosotskaya, I., Goldstein, J. L., Ho, Y. K., Brown, M. S., and Rawson, R. B., “The SREBP Pathway in Drosophila: Regulation by Palmitate, Not Sterols” (2002) Developmental Cell, 2: 229-238
Ye, J., Rawson, R. B., Komuro, R., Chen, X., Dave, U. P., Prywes, R., Brown, M. S., and Goldstein, J. L., "ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs.” (2000) Molecular Cell, 6, 1355-1364.
Rawson, R. B., DeBose-Boyd, R., Goldstein, J. L., and Brown, M. S., "Failure to Cleave Sterol Regulatory Element-Binding Proteins (SREBPs) Causes Cholesterol Auxotrophy in CHO Cells with Genetic Absence of SREBP cleavage-activating protein" (1999) J. Biol. Chem., 274: 28549-28556.
Rawson, R. B., Cheng, D., Brown, M. S., and Goldstein, J. L., “Isolation of Cholesterol-Requiring Mutant CHO Cells with Defects in Cleavage of Sterol-Regulatory Element Binding Proteins at Site-1.” (1998) J. Biol Chem, 273: 28261-28269.
Rawson, R. B., Zelenski, N. G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M. T., Chang, T. Y., Brown, M. S., and Goldstein, J. L., "Complementation Cloning of S2P, a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs.” (1997) Molecular Cell, 1: 47-57.
Copyright 2004. The University of Texas 
		Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75390
return to top