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Recent Publications of David W. Russell Lab in the Molecular Genetics 
			 Department at the University of Texas Southwestern
Cover Photo of the Journal of Biological Chemistry
McDonald, J.G., Smith, D.D., Stiles, A.R., Russell, D.W. (2012) A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. J. Lipid Res. 53: 1399-409.
McDonald, J.G., Russell, D.W. (2010) Editorial: 25-Hydroxycholesterol: a new life in immunology. J. Leukoc. Biol. 88: 1071-1072.
Stiles, A.R., Russell, D.W. (2010) SRD5A3: A surprising role in glycosylation. Cell 142: 196-198.
Bauman, D.R., Bitmansour, A.D., McDonald, J.G., Thompson, B.M., Liang, G., Russell, D.W. (2009) 25-Hydroxycholesterol Secreted by Macrophages in Response to Toll-like Receptor Activation Suppresses Immunoglobulin A Production. Proc. Natl. Acad. Sci. USA. 106: 16764-16769.
Stiles, A.R., McDonald, J.G., Bauman, D.R., Russell, D.W. (2009) CYP7B1: One Cytochrome P450, Two Human Genetic Diseases, and Multiple Physiological Functions. J. Biol. Chem. 284: 28485-28489.
Russell, D.W., Halford, R.W., Ramirez, D.M., Shah, R., Kotti, T. (2009) Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain. Annu. Rev. Biochem. 78:1017-1040.
Halford, R.W., Russell, D.W. (2009) Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan. Proc. Natl. Acad. Sci. USA. 106:3502-3506.
Russell, D.W. (2009) Fifty years of advances in bile acid synthesis and metabolism. J. Lipid. Res. 50 Suppl: S120-125.
Kotti, T., Head, D.D., McKenna, C.E., Russell, D.W. (2008) Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. Proc. Natl. Acad. Sci. USA. 105:11394-11399.
Ramirez, D.M.O., Andersson, S., and Russell, D.W. (2008) Neuronal Expression and Subcellular Localization of Cholesterol 24-Hydroxylase in the Mouse Brain. J. Comp. Neurol. 507:1676-1693.
Shea, H.C., Head, D.D., Setchell, K.D.R., and Russell, D.W. (2007) Analysis of HSD3B7 Knockout Mice Reveals that a 3a-Hydroxyl Stereochemistry is Required for Bile Acid Function. Proc. Natl. Acad. Sci. USA, 104:11526-11533.
Chen, W., Chen, G., Head, D.L., Mangelsdorf, D.J., Russell, D.W. (2007) Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab. 5:73-79.
Yildiz, Y., Matern, H., Thompson, B., Allegood, J.C., Warren, R.L., Ramirez, D.M., Hammer, R.E., Hamra, F.K., Matern, S., Russell, D.W. (2006) Mutation of B-glucosidase 2 causes glycolipid storage disease and impaired male fertility. J. Clin. Invest. 116: 2985-2994.
Kotti, T.J., Ramirez, D.M., Pfeiffer, B.E., Huber, K.M., Russell, D.W. (2006) Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc. Natl. Acad. Sci. U.S.A., 103:3869-3874.
Cali, J.J., Hsieh, C-L., Francke, U., and Russell, D.W. (1991) Mutations in the Bile Acid Biosynthetic Enzyme Sterol 27-Hydroxylase Underlie Cerebrotendinous Xanthomatosis. J. Biol. Chem. 266: 7779-7783
Thigpen, A.E., Davis, D.L., Milatovich, A., Mendonca, B.B., Imperato-McGinley, J., Griffin, J.E., Francke, U., Wilson, J.D., and Russell, D.W. (1992) The Molecular Genetics of Steroid 5a-Reductase 2 Deficiency. J. Clin. Invest. 90: 799-809.
Setchell, K.D.R., Schwarz, M., O'Connell, N.C., Lund, E.G., Davis, D.L., Lathe, R., Thompson, H.R., Tyson, R.W., Sokol, R.J., and Russell, D.W. (1998) Identification of a New Inborn Error in Bile Acid Synthesis: Mutation of the Oxysterol 7a-Hydroxylase Gene Causing Severe Neonatal Liver Disease. J. Clin. Invest., 102:1690-1703.
Schwarz, M., Wright, A.C., Davis, D.L., Nazer, H., Bjõrkhem, I., and Russell, D.W. (2000) The Bile Acid Synthetic Gene 3B-Hydroxy-D5-C27-Steroid Oxidoreductase is Mutated in Progressive Intrahepatic Cholestasis. J. Clin. Invest., 106:1175-1184.
Cheng, J.B., Levine, M.A., Bell, N.H., Mangelsdorf, D.J., and Russell, D.W. (2004) Genetic Evidence that the Human CYP2R1 Enzyme Is A Key Vitamin D 25-Hydroxylase. Proc. Natl. Acad. Sci. USA. 101:7711-7715.
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