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Bauman, D.R., Bitmansour, A.D., McDonald, J.G., Thompson, B.M., Liang, G., Russell, D.W. (2009) 25-Hydroxycholesterol Secreted by Macrophages in Response to Toll-like Receptor Activation Suppresses Immunoglobulin A Production. Proc. Natl. Acad. Sci. USA. 106: 16764-16769. |
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Stiles, A.R., McDonald, J.G., Bauman, D.R., Russell, D.W. (2009) CYP7B1: One Cytochrome P450, Two Human Genetic Diseases, and Multiple Physiological Functions. J. Biol. Chem. 284: 28485-28489.
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Russell, D.W., Halford, R.W., Ramirez, D.M., Shah, R., Kotti, T. (2009) Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain. Annu. Rev. Biochem. 78:1017-1040.
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Ramirez, D.M.O., Andersson, S., and Russell, D.W. (2008) Neuronal Expression and Subcellular Localization of Cholesterol 24-Hydroxylase in the Mouse Brain. J. Comp. Neurol. 507:1676-1693.
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Shea, H.C., Head, D.D., Setchell, K.D.R., and Russell, D.W. (2007) Analysis of HSD3B7 Knockout Mice Reveals that a 3a-Hydroxyl Stereochemistry is Required for Bile Acid Function. Proc. Natl. Acad. Sci. USA, 104:11526-11533.
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Chen, W., Chen, G., Head, D.L., Mangelsdorf, D.J., Russell, D.W. (2007)
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.
Cell Metab. 5:73-79.
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Yildiz, Y., Matern, H., Thompson, B., Allegood, J.C., Warren, R.L., Ramirez, D.M., Hammer, R.E., Hamra, F.K., Matern, S., Russell, D.W.
(2006) Mutation of B-glucosidase 2 causes glycolipid storage disease and impaired male fertility.
J. Clin. Invest. 116: 2985-2994.
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Kotti, T.J., Ramirez, D.M., Pfeiffer, B.E., Huber, K.M., Russell, D.W. (2006)
Brain cholesterol turnover required for geranylgeraniol production and learning in mice.
Proc. Natl. Acad. Sci. U.S.A., 103:3869-3874.
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SIGNIFICANT PUBLICATIONS
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Cali, J.J., Hsieh, C-L., Francke, U., and Russell, D.W.
(1991) Mutations in the Bile Acid Biosynthetic Enzyme Sterol
27-Hydroxylase Underlie Cerebrotendinous Xanthomatosis.
J. Biol. Chem. 266: 7779-7783 |
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Thigpen, A.E., Davis, D.L., Milatovich,
A., Mendonca, B.B., Imperato-McGinley, J., Griffin, J.E.,
Francke, U., Wilson, J.D., and Russell, D.W. (1992) The Molecular
Genetics of Steroid 5a-Reductase 2 Deficiency. J. Clin. Invest.
90: 799-809. |
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Setchell, K.D.R., Schwarz, M., O'Connell,
N.C., Lund, E.G., Davis, D.L., Lathe, R., Thompson, H.R.,
Tyson, R.W., Sokol, R.J., and Russell, D.W. (1998) Identification
of a New Inborn Error in Bile Acid Synthesis: Mutation of
the Oxysterol 7a-Hydroxylase Gene Causing Severe Neonatal
Liver Disease. J. Clin. Invest., 102:1690-1703.
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Schwarz, M., Wright, A.C., Davis,
D.L., Nazer, H., Bjõrkhem, I., and Russell, D.W. (2000) The
Bile Acid Synthetic Gene 3B-Hydroxy-D5-C27-Steroid Oxidoreductase
is Mutated in Progressive Intrahepatic Cholestasis. J. Clin.
Invest., 106:1175-1184. |
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Cheng, J.B., Levine, M.A., Bell, N.H.,
Mangelsdorf, D.J., and Russell, D.W. (2004) Genetic Evidence
that the Human CYP2R1 Enzyme Is A Key Vitamin D 25-Hydroxylase.
Proc. Natl. Acad. Sci. USA. 101:7711-7715.
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